Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

Now showing items 10941-10960 of 40729

Practical Recommendations for the Manipulation of Kinase Inhibitor Formulations to Age-Appropriate Dosage Forms

Bernsen, Emma C; Hogenes, Valery J; Nuijen, Bastiaan; Hanff, Lidwien M; Huitema, Alwin D R; Diekstra, Meta H M (Multidisciplinary Digital Publishing Institute, 2022-12-17)

Over 75 kinase inhibitors (KIs) have been approved for the treatment of various cancers. KIs are orally administrated but mostly lack pediatric age-appropriate dosage forms or instructions for dose manipulation. This is ...
mTOR Signaling in BDNF-Treated Guinea Pigs after Ototoxic Deafening

Tisi, Annamaria; Ramekers, Dyan; Flati, Vincenzo; Versnel, Huib; Maccarone, Rita (MDPI AG, 2022-11-15)

The mammalian target of rapamycin (mTOR) signaling plays a critical role in cell homeostasis, growth and survival. Here, we investigated the localization of the main mTOR signaling proteins in the organ of Corti of ...
Combined brain-derived neurotrophic factor and neurotrophin-3 treatment is preferred over either one separately in the preservation of the auditory nerve in deafened guinea pigs

Vink, Henk A; Ramekers, Dyan; Thomeer, Hans G X M; Versnel, Huib (Frontiers Media S. A., 2022-09-26)

Severe hearing loss or deafness is often caused by cochlear hair cell loss and can be mitigated by a cochlear implant (CI). CIs target the auditory nerve, consisting of spiral ganglion cells (SGCs), which degenerate ...
Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort

Gil-Lespinard, Mercedes; Castañeda, Jazmín; Almanza-Aguilera, Enrique; Gómez, Jesús Humberto; Tjønneland, Anne; Kyrø, Cecilie; Overvad, Kim; Katzke, Verena; Schulze, Matthias B; Masala, Giovanna; Agnoli, Claudia; Santucci de Magistris, Maria; Tumino, Rosario; Sacerdote, Carlotta; Skeie, Guri; Lasheras, Cristina; Molina-Montes, Esther; Huerta, José María; Barricarte, Aurelio; Amiano, Pilar; Sonestedt, Emily; da Silva, Marisa; Johansson, Ingegerd; Hultdin, Johan; May, Anne M; Forouhi, Nita G; Heath, Alicia K; Freisling, Heinz; Weiderpass, Elisabete; Scalbert, Augustin; Zamora-Ros, Raul (Multidisciplinary Digital Publishing Institute (MDPI), 2022-12-08)

Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to ...
Changes in the Electrically Evoked Compound Action Potential over time After Implantation and Subsequent Deafening in Guinea Pigs

Ramekers, Dyan; Benav, Heval; Klis, Sjaak F L; Versnel, Huib (2022-12)

The electrically evoked compound action potential (eCAP) is a direct measure of the responsiveness of the auditory nerve to electrical stimulation from a cochlear implant (CI). CIs offer a unique opportunity to study the ...
Effect of physical exercise on the hippocampus and global grey matter volume in breast cancer patients: A randomized controlled trial (PAM study)

PAM study group (Elsevier, 2023-01)

BACKGROUND: Physical exercise in cancer patients is a promising intervention to improve cognition and increase brain volume, including hippocampal volume. We investigated whether a 6-month exercise intervention primarily ...
Direct comparison of non-osteoarthritic and osteoarthritic synovial fluid-induced intracellular chondrocyte signaling and phenotype changes

Housmans, B A C; van den Akker, G G H; Neefjes, M; Timur, U T; Cremers, A; Peffers, M J; Caron, M M J; van Rhijn, L W; Emans, P J; Boymans, T A E J; Feczko, P Z; van der Kraan, P M; Welting, T J M (W.B. Saunders Ltd, 2023-01)

OBJECTIVE: Since the joint microenvironment and tissue homeostasis are highly dependent on synovial fluid, we aimed to compare the essential chondrocyte signaling signatures of non-osteoarthritic vs end-stage osteoarthritic ...
Development of a cyclic-inverso AHSG/Fetuin A-based peptide for inhibition of calcification in osteoarthritis

van den Akker, G G H; Steijns, J S J J; Stassen, R H M J; Wasilewski, G B; Peeters, L C W; Wijnands, K A P; Schurgers, L J; Caron, M M J; van Rhijn, L W; Welting, T J M (W.B. Saunders Ltd, 2023-06)

OBJECTIVE: Ectopic calcification is an important contributor to chronic diseases, such as osteoarthritis. Currently, no effective therapies exist to counteract calcification. We developed peptides derived from the calcium ...
Process evaluation of the scale-up of integrated diabetes and hypertension care in Belgium, Cambodia and Slovenia (the SCUBY Project): a study protocol

Martens, Monika; Wouters, Edwin; van Olmen, Josefien; Klemenc Ketiš, Zalika; Chhim, Srean; Chham, Savina; Buffel, Veerle; Danhieux, Katrien; Stojnić, Nataša; Zavrnik, Črt; Poplas Susič, Antonija; Van Damme, Wim; Ir, Por; Remmen, Roy; Ku, Grace Marie V; Klipstein-Grobusch, Kerstin; Boateng, Daniel (BMJ Publishing Group, 2022-12-29)

INTRODUCTION: Integrated care interventions for type 2 diabetes (T2D) and hypertension (HT) are effective, yet challenges exist with regard to their implementation and scale-up. The 'SCale-Up diaBetes and hYpertension care' ...
Risk of osteoporosis in testicular germ cell tumour survivors: A systematic review of the literature

Vrouwe, Josephina P M; Hennus, Pauline M L; Hamdy, Neveen A T; Osanto, Susanne; Willemse, Peter-Paul M (John Wiley & Sons Inc., 2023-01)

CONTEXT: Testicular germ cell tumour (TGCT) survivors are potentially at risk of developing osteoporosis, because of increased risk for disturbed bone remodelling associated with hypogonadism and anti-cancer treatment. A ...
Multiomics of Colorectal Cancer Organoids Reveals Putative Mediators of Cancer Progression Resulting from SMAD4 Inactivation

Dijkstra, Jelmer J.; Neikes, Hannah K.; Rezaeifard, Somayeh; Ma, Xuhui; Voest, Emile E.; Tauriello, Daniele V.F.; Vermeulen, Michiel (American Chemical Society, 2023-01-06)

The development of metastasis severely reduces the life expectancy of patients with colorectal cancer (CRC). Although loss of SMAD4 is a key event in CRC progression, the resulting changes in biological processes in advanced ...
Author Correction: The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology

Cancer Core Europe consortium (Nature Research, 2022-05)

Correction to: Nature Cancer https://doi.org/10.1038/s43018-022-00332-x, published online 24 February 2022
Clinical Impact of Prospective Whole Genome Sequencing in Sarcoma Patients

Schipper, Luuk J.; Monkhorst, Kim; Samsom, Kris G.; Bosch, Linda J.W.; Snaebjornsson, Petur; Boven, Hester van; Roepman, Paul; van der Kolk, Lizet E.; van Houdt, Winan J.; van der Graaf, Winette T.A.; Meijer, Gerrit A.; Voest, Emile E. (Multidisciplinary Digital Publishing Institute (MDPI), 2022-01-16)

With more than 70 different histological sarcoma subtypes, accurate classification can be challenging. Although characteristic genetic events can largely facilitate pathological assessment, large-scale molecular profiling ...
The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology

Cancer Core Europe consortium (Nature Research, 2022-02)

There is a growing need for systems that efficiently support the work of medical teams at the precision-oncology point of care. Here, we present the implementation of the Molecular Tumor Board Portal (MTBP), an academic ...
Harmonising patient-access programmes: the Dutch DRUG Access Protocol platform

Zeverijn, Laurien J.; van Waalwijk van Doorn-Khosrovani, Sahar Barjesteh; van Roy, Anke A.M.G.Pisters; Timmers, Lonneke; Ly Tran, T. H.; de Boer, Jolanda E.; de Wit, Gijsbrecht F.; Geurts, Birgit S.; Gelderblom, Hans; Verheul, Henk M.W.; Blijlevens, Nicole; Wymenga, A. N.Machteld; Eskens, Ferry A.L.M.; Smit, Egbert F.; Bloemendal, Haiko J.; Voest, Emile E. (Elsevier Limited, 2022-02)
Delivering precision oncology to patients with cancer

Mateo, Joaquin; Steuten, Lotte; Aftimos, Philippe; André, Fabrice; Davies, Mark; Garralda, Elena; Geissler, Jan; Husereau, Don; Martinez-Lopez, Iciar; Normanno, Nicola; Reis-Filho, Jorge S.; Stefani, Stephen; Thomas, David M.; Westphalen, C. Benedikt; Voest, Emile (Nature Research, 2022-04)

With the increasing use of genomic profiling for diagnosis and therapy guidance in many tumor types, precision oncology is rapidly reshaping cancer care. However, the current trajectory of drug development in oncology ...
The DRUG Access Protocol: access inequality and European harmonisation – Authors' reply

van Waalwijk van Doorn-Khosrovani, Sahar Barjesteh; Zeverijn, Laurien J.; Voest, Emile E. (Elsevier Limited, 2022-05)
RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells

Zhang, Zhengkui; Kong, Xiangjun; Ligtenberg, Maarten A.; van Hal-van Veen, Susan E.; Visser, Nils L.; de Bruijn, Beaunelle; Stecker, Kelly; van der Helm, Pim W.; Kuilman, Thomas; Hoefsmit, Esmée P.; Vredevoogd, David W.; Apriamashvili, Georgi; Baars, Beau; Voest, Emile E.; Klarenbeek, Sjoerd; Altelaar, Maarten; Peeper, Daniel S. (Cell Press, 2022-06-21)

Tumor escape mechanisms for immunotherapy include deficiencies in antigen presentation, diminishing adaptive CD8+ T cell antitumor activity. Although innate natural killer (NK) cells are triggered by loss of MHC class I, ...
Can Drug Repurposing Accelerate Precision Oncology?

Schipper, Luuk J.; Zeverijn, Laurien J.; Garnett, Mathew J.; Voest, Emile E. (American Association for Cancer Research Inc., 2022-07-01)

UNLABELLED: Ongoing new insights in the field of cancer diagnostics, genomic profiling, and cancer behavior have raised the demand for novel, personalized cancer treatments. As the development of new cancer drugs is a ...
Incidence of unplanned excisions of soft tissue sarcomas in the Netherlands: A population-based study

Dutch Sarcoma Group (DSG) (W.B. Saunders Ltd, 2022-05)

Introduction: Timely recognition of soft tissue sarcomas (STS) remains challenging, potentially leading to unplanned excisions (also known as ‘whoops procedures’). This population-based study charted the occurrence of ...

Now showing items 10941-10960 of 40729