The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology

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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology
 
Cancer Core Europe consortium
(2022) Nature Cancer, volume 3, issue 2, pp. 251 - 261
(Article)
Abstract
There is a growing need for systems that efficiently support the work of medical teams at the precision-oncology point of care. Here, we present the implementation of the Molecular Tumor Board Portal (MTBP), an academic clinical decision support system developed under the umbrella of Cancer Core Europe that creates a ... read more
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Keywords: Decision Support Systems, Clinical, High-Throughput Nucleotide Sequencing/methods, Humans, Medical Oncology/methods, Neoplasms/diagnosis, Precision Medicine/methods, Oncology, Cancer Research, Research Support, Non-U.S. Gov't, Journal Article
DOI: https://doi.org/10.1038/s43018-022-00332-x
ISSN: 2662-1347
Publisher: Nature Research
Note: Funding Information: We acknowledge the Ensembl team at EMBL-EBI and W. Zhou for the development and support of the Ensembl Variant Effect Predictor and TransVar tools, respectively; the IT department at SciLifeLab for their technical support in deploying the portal; the developers and curators of publicly available knowledge bases for their work in these resources; the OncoKB team for facilitating the use of their web API in the public-MTBP website; and H. Zhang for technical support. The project has received support from the Personalized Cancer Medicine program at Karolinska funded by The Cancer Research Funds of Radiumhemmet, Swedish Foundation of Strategic Research (principal investigator, J.L.), Stockholm County Council (ALF funding, principal investigator, J.L.), from Cancer Research UK in the Cambridge Centre, from the CaixaResearch Advanced Oncology Research Program supported by ”la Caixa” Foundation, and from the European Union’s Horizon 2020 research and innovation program under grant agreement 965397 (CCE_DART). We also acknowledge F. Hoffmann-La Roche for their support in the Basket of Baskets trial (NCT03767075). Funding Information: We acknowledge the Ensembl team at EMBL-EBI and W. Zhou for the development and support of the Ensembl Variant Effect Predictor and TransVar tools, respectively; the IT department at SciLifeLab for their technical support in deploying the portal; the developers and curators of publicly available knowledge bases for their work in these resources; the OncoKB team for facilitating the use of their web API in the public-MTBP website; and H. Zhang for technical support. The project has received support from the Personalized Cancer Medicine program at Karolinska funded by The Cancer Research Funds of Radiumhemmet, Swedish Foundation of Strategic Research (principal investigator, J.L.), Stockholm County Council (ALF funding, principal investigator, J.L.), from Cancer Research UK in the Cambridge Centre, from the CaixaResearch Advanced Oncology Research Program supported by ”la Caixa” Foundation, and from the European Union’s Horizon 2020 research and innovation program under grant agreement 965397 (CCE_DART). We also acknowledge F. Hoffmann-La Roche for their support in the Basket of Baskets trial (NCT03767075). Publisher Copyright: © 2022, The Author(s). © 2022. The Author(s).
(Peer reviewed)