Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

  • R-spondin-3 is an oncogenic driver of poorly differentiated invasive breast cancer 
    Ter Steege, Eline J; Boer, Mandy; Timmer, Nikki C; Ammerlaan, Carola Me; Song, Ji-Ying; Derksen, Patrick Wb; Hilkens, John; Bakker, Elvira Rm (John Wiley & Sons Inc., 2022-11)
    R-spondins (RSPOs) are influential signaling molecules that promote the Wnt/β-catenin pathway and self-renewal of stem cells. Currently, RSPOs are emerging as clinically relevant oncogenes, being linked to cancer development ...
  • Clinical Relevance of Random Biopsies From the Esophagogastric Junction After Complete Eradication of Barrett's Esophagus is Low 
    Dutch Barrett Expert Centers (W.B. Saunders, 2023-08)
    BACKGROUND & AIMS: Although random histological sampling from the esophagogastric junction (EGJ) after complete eradication of Barrett's esophagus (BE) is recommended, its clinical relevance is questionable. This study ...
  • Emotion regulation and the salience network: a hypothetical integrative model of fibromyalgia 
    Pinto, Ana Margarida; Geenen, Rinie; Wager, Tor D.; Lumley, Mark A.; Häuser, Winfried; Kosek, Eva; Ablin, Jacob N.; Amris, Kirstine; Branco, Jaime; Buskila, Dan; Castelhano, João; Castelo-Branco, Miguel; Crofford, Leslie J.; Fitzcharles, Mary Ann; López-Solà, Marina; Luís, Mariana; Marques, Tiago Reis; Mease, Philip J.; Palavra, Filipe; Rhudy, Jamie L.; Uddin, Lucina Q.; Castilho, Paula; Jacobs, Johannes W.G.; da Silva, José A.P. (Nature Research, 2023-01)
    Fibromyalgia is characterized by widespread pain, fatigue, sleep disturbances and other symptoms, and has a substantial socioeconomic impact. Current biomedical and psychosocial treatments are unsatisfactory for many ...
  • Including measures of chronic kidney disease to improve cardiovascular risk prediction by SCORE2 and SCORE2-OP 
    Matsushita, Kunihiro; Kaptoge, Stephen; Hageman, Steven H.J.; Sang, Yingying; Ballew, Shoshana H.; Grams, Morgan E.; Surapaneni, Aditya; Sun, Luanluan; Arnlov, Johan; Bozic, Milica; Brenner, Hermann; Brunskill, Nigel J.; Chang, Alex R.; Chinnadurai, Rajkumar; Cirillo, Massimo; Correa, Adolfo; Ebert, Natalie; Eckardt, Kai Uwe; Gansevoort, Ron T.; Gutierrez, Orlando; Hadaegh, Farzad; He, Jiang; Hwang, Shih Jen; Jafar, Tazeen H.; Jassal, Simerjot K.; Kayama, Takamasa; Kovesdy, Csaba P.; Landman, Gijs W.; Levey, Andrew S.; Lloyd-Jones, Donald M.; Major, Rupert W.; Miura, Katsuyuki; Muntner, Paul; Nadkarni, Girish N.; Nowak, Christoph; Ohkubo, Takayoshi; Pena, Michelle J.; Polkinghorne, Kevan R.; Sairenchi, Toshimi; Schaeffner, Elke; Schneider, Markus P.; Shalev, Varda; Shlipak, Michael G.; Solbu, Marit D.; Stempniewicz, Nikita; Tollitt, James; Valdivielso, José M.; Van Der Leeuw, Joep; Dorresteijn, Jannick A.N.; Visseren, Frank L.J. (Oxford University Press, 2023-01-01)
    Aims: The 2021 European Society of Cardiology (ESC) guideline on cardiovascular disease (CVD) prevention categorizes moderate and severe chronic kidney disease (CKD) as high and very-high CVD risk status regardless of other ...
  • Estimating individual lifetime risk of incident cardiovascular events in adults with Type 2 diabetes: an update and geographical calibration of the DIAbetes Lifetime perspective model (DIAL2) 
    Østergaard, Helena Bleken; Hageman, Steven H J; Read, Stephanie H; Taylor, Owen; Pennells, Lisa; Kaptoge, Stephen; Petitjean, Carmen; Xu, Zhe; Shi, Fanchao; McEvoy, John William; Herrington, William; Visseren, Frank L J; Wood, Angela; Eliasson, Björn; Sattar, Naveed; Wild, Sarah; Di Angelantonio, Emanuele; Dorresteijn, Jannick A N (Oxford University Press, 2023-01-01)
    AIMS: The 2021 European Society of Cardiology cardiovascular disease (CVD) prevention guidelines recommend the use of (lifetime) risk prediction models to aid decisions regarding intensified preventive treatment options ...
  • Development and Validation of a Lifetime Risk Model for Kidney Failure and Treatment Benefit in Type 2 Diabetes: 10-Year and Lifetime Risk Prediction Models 
    Østergaard, Helena Bleken; Read, Stephanie H; Sattar, Naveed; Franzén, Stefan; Halbesma, Nynke; Dorresteijn, Jannick A N; Westerink, Jan; Visseren, Frank L J; Wild, Sarah H; Eliasson, Björn; van der Leeuw, Joep (Lippincott Williams & Wilkins, 2022-12)
    Background and objectives Individuals with type 2 diabetes are at a higher risk of developing kidney failure. The objective of this study was to develop and validate a decision support tool for estimating 10-year and ...
  • Conventional dendritic cells type 1 are strongly enriched, quiescent and relatively tolerogenic in local inflammatory arthritis 
    Boltjes, Arjan; Samat, Anoushka Ashok Kumar; Plantinga, Maud; Mokry, Michal; Castelijns, Bas; Swart, Joost F.; Vastert, Sebastiaan J.; Creyghton, Menno; Nierkens, Stefan; van Loosdregt, Jorg; van Wijk, Femke (Frontiers Media S. A., 2023-01-04)
    Introduction: Dendritic cells (DC) are crucial for initiating and shaping immune responses. So far, little is known about the functional specialization of human DC subsets in (local) inflammatory conditions. We profiled ...
  • Compartmentalization and persistence of dominant (regulatory) T cell clones indicates antigen skewing in juvenile idiopathic arthritis 
    Mijnheer, Gerdien; Servaas, Nila Hendrika; Leong, Jing Yao; Boltjes, Arjan; Spierings, Eric; Chen, Phyllis; Lai, Liyun; Petrelli, Alessandra; Vastert, Sebastiaan; de Boer, Rob J; Albani, Salvatore; Pandit, Aridaman; van Wijk, Femke (eLife Sciences Publications, 2023)
    Autoimmune inflammation is characterized by tissue infiltration and expansion of antigen-specific T cells. Although this inflammation is often limited to specific target tissues, it remains yet to be explored whether ...
  • Hersenonderzoek biedt inzicht in MS 
    Fransen, Nina (2022-10)
  • Accumulation of meningeal lymphocytes correlates with white matter lesion activity in progressive multiple sclerosis 
    Ahmed, Shanzeh; Fransen, Nina; Touil, Hanane; michailidou, Iliana; Huitinga, Inge; Gommerman, Jennifer; Bar-Or, Amit; Ramaglia, Valeria (American Society for Clinical Investigation, 2022-03-08)
    Subpial cortical demyelination is an important component of multiple sclerosis (MS) pathology contributing to disease progression, yet mechanism(s) underlying its development remain unclear. Compartmentalized inflammation ...
  • KL-6 as a Biomarker of Interstitial Lung Disease Development in Patients with Sjögren Syndrome: A Retrospective Case–Control Study 
    Chiu, Yu Hsiang; Chu, Chen Chih; Lu, Chun Chi; Liu, Feng Cheng; Tang, Shin En; Chu, Shi Jye; Kuo, San Yuan; Chen, Hsiang Cheng (Dove Medical Press Ltd, 2022)
    Objective: Krebs von den Lungen-6 (KL-6) is expressed on regenerating type II pneumocytes and has been recognized as biomarkers in interstitial lung disease (ILD). We aim to identify the role of the serum KL-6 level in ...
  • Nanoparticles for Inducing Antigen-Specific T Cell Tolerance in Autoimmune Diseases 
    Benne, Naomi; ter Braake, Daniëlle; Stoppelenburg, Arie Jan; Broere, Femke (Frontiers Media S. A., 2022-03-22)
    Autoimmune diseases affect many people worldwide. Current treatment modalities focus on the reduction of disease symptoms using anti-inflammatory drugs which can lead to side effects due to systemic immune suppression. ...
  • A meta-analysis of methotrexate polyglutamates in relation to efficacy and toxicity of methotrexate in inflammatory arthritis, colitis and dermatitis 
    van de Meeberg, Maartje M.; Hebing, Renske C.F.; Nurmohamed, Michael T.; Fidder, Herma H.; Heymans, Martijn W.; Bouma, Gerd; de Bruin-Weller, Marjolein S.; Tekstra, Janneke; van den Bemt, Bart; de Jonge, Robert; Bulatović Ćalasan, Maja (Wiley-Blackwell, 2023-01)
    Aims: In immune-mediated inflammatory diseases (IMIDs), early symptom control is a key therapeutic goal. Methotrexate (MTX) is the first-line treatment across IMIDs. However, MTX is underutilized and suboptimally dosed, ...
  • Small molecules to regulate the GH/IGF1 axis by inhibiting the growth hormone receptor synthesis 
    van der Velden, Lieke M; Maas, Peter; van Amersfoort, Miranda; Timmermans-Sprang, Elpetra P M; Mensinga, Anneloes; van der Vaart, Elisabeth; Malergue, Fabrice; Viëtor, Henk; Derksen, Patrick W B; Klumperman, Judith; van Agthoven, Andreas; Egan, David A; Mol, Jan A; Strous, Ger J (Frontiers Media S. A., 2022-07-28)
    Growth hormone (GH) and insulin-like growth factor-1 (IGF1) play an important role in mammalian development, cell proliferation and lifespan. Especially in cases of tumor growth there is an urgent need to control the GH/IGF1 ...
  • LGR6-dependent conditional inactivation of E-cadherin and p53 leads to invasive skin and mammary carcinomas in mice 
    Ter Steege, Eline J; Sijnesael, Thijmen; Enserink, Lotte; Klarenbeek, Sjoerd; Haakma, Wisse E; Bakker, Elvira R M; Derksen, Patrick W B (Elsevier, 2023-01)
    Tissue-specific inactivation of E-cadherin combined with tumor suppressor loss leads to invasive and metastatic cancers in mice. While epidermal E-cadherin loss in mice induces squamous cell carcinomas, inactivation of ...
  • Acute severe hepatitis outbreak in children: A perfect storm. What do we know, and what questions remain? 
    and ESCMID Study Group for Viral Hepatitis (ESGVH) (Frontiers Media S. A., 2022-11-25)
    During the first half of 2022, the World Health Organization reported an outbreak of acute severe hepatitis of unknown aetiology (AS-Hep-UA) in children, following initial alerts from the United Kingdom (UK) where a cluster ...
  • Survival of patients who opt for dialysis versus conservative care: a systematic review and meta-analysis 
    Voorend, Carlijn G.N.; van Oevelen, Mathijs; Verberne, Wouter R.; van denWittenboer, Iris D.; Dekkers, Olaf M.; Dekker, Friedo; Abrahams, Alferso C.; van Buren, Marjolijn; Mooijaart, Simon P.; Bos, Willem Jan W. (Oxford University Press, 2022-08-01)
    Background: Non-dialytic conservative care (CC) has been proposed as a treatment option for patients with kidney failure. This systematic review and meta-analysis aims at comparing survival outcomes between dialysis and ...
  • A dynamic flow model mimicking duodenoscope reprocessing after bacterial contamination for translational research 
    Heuvelmans, Maarten; Woudstra, Willem; Wunderink, Herman F; Monkelbaan, Jan F; van der Mei, Henny C (Cambridge University Press, 2022-09-13)
    OBJECTIVE: Duodenoscopy-associated infections and outbreaks are reported globally despite strict adherence to duodenoscope reprocessing protocols. Therefore, new developments in the reprocessing procedure are needed. DESIGN: ...
  • Association of change in cardiovascular risk factors with incident dementia 
    Sedaghat, Sanaz; Lutsey, Pamela L; Ji, Yuekai; Empana, Jean-Philippe; Sorond, Farzaneh; Hughes, Timothy M; Mosley, Thomas H; Gottesman, Rebecca F; Knopman, David S; Walker, Keenan A; Gudnason, Vilmundur; Launer, Lenore J; van Sloten, Thomas T (John Wiley & Sons Inc., 2023-05)
    INTRODUCTION: We evaluated whether better cardiovascular health at midlife and improvement of cardiovascular health within midlife were associated with dementia risk. METHODS: Two longitudinal population-based studies were ...
  • Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy 
    the EAACI Food Allergy Guidelines Expert Group, the EAACI Research, Outreach Committee Food Allergy Group (Blackwell Munksgaard, 2022-01)
    Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of updating the guidelines on the diagnosis and management of food allergy. The existing guidelines are based on a systematic ...