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UMC Repository: Recent submissions

  • The European Registry for Patients with Mechanical Circulatory Support of the European Association for Cardio-Thoracic Surgery: third report 
    de By, Theo M M H; Schoenrath, Felix; Veen, Kevin M; Mohacsi, Paul; Stein, Julia; Alkhamees, Khalid M M; Anastasiadis, Kyriakos; Berhnardt, Alexander; Beyersdorf, Friedhelm; Caliskan, Kadir; Reineke, David; Damman, Kevin; Fiane, Arnt; Gkouziouta, Angeliki; Gollmann-Tepeköylü, Can; Gustafsson, Finn; Hulman, Michal; Iacovoni, Attilio; Loforte, Antonio; Merkely, Bela; Musumeci, Francesco; Němec, Petr; Netuka, Ivan; Özbaran, Mustafa; Potapov, Evgenij; Pya, Yuri; Rábago, Gregorio; Ramjankhan, Faiz; Reichenspurner, Hermann; Saeed, Diyar; Sandoval, Elena; Stockman, Bernard; Vanderheyden, Marc; Tops, Laurens; Wahlers, Thorsten; Zembala, Michael; Zimpfer, Daniel; Carrel, Thierry; Gummert, Jan; Meyns, Bart (Elsevier, 2022-07-01)
    OBJECTIVES: In the third report of the European Registry for Patients with Mechanical Circulatory Support of the European Association for Cardio-Thoracic Surgery, outcomes of patients receiving mechanical circulatory support ...
  • The European Registry for Patients with Mechanical Circulatory Support (EUROMACS): third Paediatric (Paedi-EUROMACS) report 
    de By, Theo M M H; Schweiger, Martin; Hussain, Hina; Amodeo, Antonio; Martens, Thomas; Bogers, Ad J J C; Damman, Kevin; Gollmann-Tepeköylü, Can; Hulman, Michael; Iacovoni, Attilio; Krämer, Ulrike; Loforte, Antonio; Napoleone, Carlo Pace; Němec, Petr; Netuka, Ivan; Özbaran, Mustafa; Polo, Luz; Pya, Yuri; Ramjankhan, Faiz; Sandica, Eugen; Sliwka, Joanna; Stiller, Brigitte; Kadner, Alexander; Franceschini, Alessio; Thiruchelvam, Timothy; Zimpfer, Daniel; Meyns, Bart; Berger, Felix; Miera, Oliver (Elsevier, 2022-08-01)
    OBJECTIVES: A third paediatric report has been generated from the European Registry for Patients with Mechanical Circulatory Support (EUROMACS). The purpose of EUROMACS, which is operated by the European Association for ...
  • Radiological Screening Methods in Deceased Organ Donation: An Overview of Guidelines Worldwide 
    Chotkan, K A; Mensink, J W; Pol, R A; Van Der Kaaij, N P; Beenen, L F M; Nijboer, W N; Schaefer, B; Alwayn, I P J; Braat, A E (Wiley-Blackwell, 2022-05-19)
    Organ transplantation is performed worldwide, but policies regarding donor imaging are not uniform. An overview of the policies in different regions is missing. This study aims to investigate the various protocols worldwide ...
  • Data-driven monitoring in patients on left ventricular assist device support 
    Numan, Lieke; Moazeni, Mehran; Oerlemans, Marish I F J; Aarts, Emmeke; Van Der Kaaij, Niels P; Asselbergs, Folkert W; Van Laake, Linda W (Taylor and Francis Ltd., 2022-09)
    INTRODUCTION: Despite an increasing population of patients supported with a left ventricular assist device (LVAD), it remains a complex therapy, and patients are frequently admitted. Therefore, a strict follow-up including ...
  • Application of three-dimensional computed tomography imaging and reconstructive techniques in lung surgery: A mini-review 
    Vervoorn, Mats T; Wulfse, Maaike; Mohamed Hoesein, Firdaus A A; Stellingwerf, Margriet; van der Kaaij, Niels P; de Heer, Linda M (Frontiers Media S. A., 2022-12-26)
    BACKGROUND: Pulmonary surgery is an innovative discipline with increasing demands for minimally invasive techniques in complicated anatomical resections, warranting adequate preoperative imaging of relevant surgical anatomy ...
  • Negation detection in Dutch clinical texts: an evaluation of rule-based and machine learning methods 
    van Es, Bram; Reteig, Leon C; Tan, Sander C; Schraagen, Marijn; Hemker, Myrthe M; Arends, Sebastiaan R S; Rios, Miguel A R; Haitjema, Saskia (BioMed Central, 2023-12)
    When developing models for clinical information retrieval and decision support systems, the discrete outcomes required for training are often missing. These labels need to be extracted from free text in electronic health ...
  • Care Needs and Provision in Dutch Hospices: A Retrospective Cross- Sectional Study Focusing on Care Across the Three Different Hospice Types in The Netherlands 
    de Graaf, Everlien; Grant, Matthew; van der Baan, FH; Verboeket-Crul, Cathelijne; Ausems, M.; Leget, Carlo; Teunissen, Saskia C.C.M. (SAGE Publications Ltd, 2022-07)
  • Cerebral hemodynamics during atrial fibrillation: Computational fluid dynamics analysis of lenticulostriate arteries using 7 T high-resolution magnetic resonance imaging 
    Scarsoglio, S.; Saglietto, A.; Tripoli, F.; Zwanenburg, J. J.M.; Biessels, G. J.; De Ferrari, G. M.; Anselmino, M.; Ridolfi, L. (American Institute of Physics, 2022-12)
    Atrial fibrillation (AF) is the most common cardiac arrhythmia, inducing irregular and faster heart beating. Aside from disabling symptoms - such as palpitations, chest discomfort, and reduced exercise capacity - there is ...
  • Precautionary allergen labeling: Current communication problems and potential for future improvements 
    Linders, Yvette F.M.; Lentz, Leo R.; Blom, W. Marty; Michelsen-Huisman, Anouska; Strikwerda, Jelle; van Dijk, Liselotte M.; Knulst, André C.; Houben, Geert F.; van Os-Medendorp, Harmieke; Holleman, Bregje C. (Elsevier, 2023-05)
    While there are EU laws for priority allergenic ingredients information on food product packaging, there is no legislation about Precautionary Allergen Labelling (PAL) for unintended allergen presence (UAP). As a result, ...
  • A machine learning approach using endpoint adjudication committee labels for the identification of sepsis predictors at the emergency department 
    Niemantsverdriet, Michael; de Hond, Titus; Höfer, IE; van Solinge, W.W.; Bellomo, Domenico; Oosterheert, JJ; Kaasjager, Karin; Haitjema, Saskia (BioMed Central, 2022-12-23)
    Accurate sepsis diagnosis is paramount for treatment decisions, especially at the emergency department (ED). To improve diagnosis, clinical decision support (CDS) tools are being developed with machine learning (ML) ...
  • Inclusion and diversity within medical education: a focus group study of students' experiences 
    Verbree, Anne-Roos; Isik, Ulviye; Janssen, J. J. H. M.; Dilaver, G (BioMed Central, 2023-12)
    Background/introduction As patient populations become more diverse, it is imperative that future physicians receive proper training in order to provide the best quality of care. This study examines medical students' ...
  • Impact of Thyroglobulin and Thyroglobulin Antibody Assay Performance on the Differential Classification of DTC Patients 
    Schoonen, Lise; Neele, Marjolein; van Toor, Hans; van Kinschot, Caroline M J; van Noord, Charlotte; Visser, W Edward; Groen, Joost; Boesten, Lianne S M; Lentjes, Eef G W M; van den Berg, Sjoerd A A; Kos, Snjezana (Endocrine Society, 2022-01-01)
    CONTEXT: Measurements of thyroglobulin (Tg) and Tg antibodies are crucial in the follow-up of treated differentiated thyroid cancer (DTC) patients. Interassay differences may significantly impact follow-up. OBJECTIVE: The ...
  • Diurnal salivary androstenedione and 17-hydroxyprogesterone levels in healthy volunteers for monitoring treatment efficacy of patients with congenital adrenal hyperplasia 
    Adriaansen, Bas P H; Kamphuis, Johannes S; Schröder, Mariska A M; Olthaar, André J; Bock, Carina; Brandt, André; Stikkelbroeck, Nike M M L; Lentjes, Eef G W M; Span, Paul N; Sweep, Fred C G J; Claahsen-van der Grinten, Hedi L; van Herwaarden, Antonius E (Wiley-Blackwell, 2022-07)
    OBJECTIVE: Treatment of congenital adrenal hyperplasia (CAH) patients with glucocorticoids is often challenging since there is a delicate balance between over- and undertreatment. Treatment can be monitored noninvasively ...
  • Testosterone analysis in castrated prostate cancer patients: suitability of the castration cut-off and analytical accuracy of the present-day clinical immunoassays 
    van Winden, Lennart Jan; Lentjes, Eef G W M; Demir, Ayse Y; Huijgen, Henk J; Bergman, Andries Marinus; van der Poel, Henk G; van Rossum, Huub H (Walter de Gruyter GmbH, 2022-09-01)
    OBJECTIVES: Testosterone testing is relevant for evaluating castration adequacy and diagnosis of castration-resistant prostate cancer (PCa). However, the recommended testosterone cut-off of 1.7 nmol/L (50 ng/dL) to define ...
  • scChIX-seq infers dynamic relationships between histone modifications in single cells 
    Yeung, Jake; Florescu, Maria; Zeller, Peter; de Barbanson, Buys Anton; Wellenstein, Max D.; van Oudenaarden, Alexander (Nature Research, 2023-06)
    Regulation of chromatin states involves the dynamic interplay between different histone modifications to control gene expression. Recent advances have enabled mapping of histone marks in single cells, but most methods are ...
  • A living biobank of matched pairs of patient-derived xenografts and organoids for cancer pharmacology 
    Xu, Xiaoxi; Kumari, Rajendra; Zhou, Jun; Chen, Jing; Mao, Binchen; Wang, Jingjing; Zheng, Meiling; Tu, Xiaolong; An, Xiaoyu; Chen, Xiaobo; Zhang, Likun; Tian, Xiaoli; Wang, Haojie; Dong, Xin; Bao, Zhengzheng; Guo, Sheng; Ouyang, Xuesong; Shang, Limei; Wang, Fei; Yan, Xuefei; Zhang, Rui; Vries, Robert G.J.; Clevers, Hans; Li, Qi Xiang (Public Library of Science, 2023-01)
    Patient-derived tumor xenograft (PDX)/organoid (PDO), driven by cancer stem cells (CSC), are considered the most predictive models for translational oncology. Large PDX collections reflective of patient populations have ...
  • Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation 
    Mokry, Michal; Boltjes, Arjan; Slenders, Lotte; Bel-Bordes, Gemma; Cui, Kai; Brouwer, Eli; Mekke, Joost M.; Depuydt, Marie A. C.; Timmerman, Nathalie; Waissi, Farahnaz; Verwer, Maarten C.; Turner, Adam W.; Khan, Mohammad Daud; Hodonsky, Chani J.; Diez Benavente, Ernest; Hartman, Robin J. G.; van den Dungen, Noortje A. M.; Lansu, Nico; Nagyova, Emilia; Prange, Koen H. M.; Kovacic, Jason C.; Björkegren, Johan L. M.; Pavlos, Eleftherios; Andreakos, Evangelos; Schunkert, Heribert; Owens, Gary K.; Monaco, Claudia; Finn, Aloke V.; Virmani, Renu; Leeper, Nicholas J.; de Winther, Menno P. J.; Kuiper, Johan; de Borst, Gert J.; Stroes, Erik S. G.; Civelek, Mete; de Kleijn, Dominique P. V.; den Ruijter, Hester M.; Asselbergs, Folkert W.; van der Laan, Sander W.; Miller, Clint L.; Pasterkamp, Gerard (Nature Publishing Group, 2022-12)
    Histopathological studies have revealed key processes of atherosclerotic plaque thrombosis. However, the diversity and complexity of lesion types highlight the need for improved subphenotyping. Here, we analyzed the gene ...
  • PlaqView 2.0: A comprehensive web portal for cardiovascular single-cell genomics 
    Ma, Wei Feng; Turner, Adam W; Gancayco, Christina; Wong, Doris; Song, Yipei; Mosquera, Jose Verdezoto; Auguste, Gaëlle; Hodonsky, Chani J; Prabhakar, Ajay; Ekiz, H Atakan; van der Laan, Sander W; Miller, Clint L (Frontiers Media S. A., 2022-08-08)
    Single-cell RNA-seq (scRNA-seq) is a powerful genomics technology to interrogate the cellular composition and behaviors of complex systems. While the number of scRNA-seq datasets and available computational analysis tools ...
  • Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis 
    Kanoni, Stavroula; Graham, Sarah E; Wang, Yuxuan; Surakka, Ida; Ramdas, Shweta; Zhu, Xiang; Clarke, Shoa L; Bhatti, Konain Fatima; Vedantam, Sailaja; Winkler, Thomas W; Locke, Adam E; Marouli, Eirini; Zajac, Greg J M; Wu, Kuan-Han H; Ntalla, Ioanna; Hui, Qin; Klarin, Derek; Hilliard, Austin T; Wang, Zeyuan; Xue, Chao; Thorleifsson, Gudmar; Helgadottir, Anna; Gudbjartsson, Daniel F; Holm, Hilma; Olafsson, Isleifur; Hwang, Mi Yeong; Han, Sohee; Akiyama, Masato; Sakaue, Saori; Terao, Chikashi; Kanai, Masahiro; Zhou, Wei; Brumpton, Ben M; Rasheed, Humaira; Havulinna, Aki S; Veturi, Yogasudha; Pacheco, Jennifer Allen; Rosenthal, Elisabeth A; Lingren, Todd; Feng, QiPing; Kullo, Iftikhar J; Narita, Akira; Takayama, Jun; Martin, Hilary C; Hunt, Karen A; Trivedi, Bhavi; Haessler, Jeffrey; Giulianini, Franco; Bradford, Yuki; Miller, Jason E; Campbell, Archie; Lin, Kuang; Millwood, Iona Y; Rasheed, Asif; Hindy, George; Faul, Jessica D; Zhao, Wei; Weir, David R; Turman, Constance; Huang, Hongyan; Graff, Mariaelisa; Choudhury, Ananyo; Sengupta, Dhriti; Mahajan, Anubha; Brown, Michael R; Zhang, Weihua; Yu, Ketian; Schmidt, Ellen M; Pandit, Anita; Gustafsson, Stefan; Yin, Xianyong; Luan, Jian'an; Zhao, Jing-Hua; Matsuda, Fumihiko; Jang, Hye-Mi; Yoon, Kyungheon; Medina-Gomez, Carolina; Pitsillides, Achilleas; Hottenga, Jouke Jan; Wood, Andrew R; Ji, Yingji; Gao, Zishan; Haworth, Simon; Yousri, Noha A; Mitchell, Ruth E; Chai, Jin Fang; Aadahl, Mette; Bjerregaard, Anne A; Yao, Jie; Manichaikul, Ani; Hwu, Chii-Min; Hung, Yi-Jen; Warren, Helen R; Ramirez, Julia; Bork-Jensen, Jette; Kårhus, Line L; Goel, Anuj; Sabater-Lleal, Maria; Noordam, Raymond; Mauro, Pala; Matteo, Floris; McDaid, Aaron F; Marques-Vidal, Pedro; Wielscher, Matthias; Trompet, Stella; Sattar, Naveed; Møllehave, Line T; Munz, Matthias; Zeng, Lingyao; Huang, Jianfeng; Yang, Bin; Poveda, Alaitz; Kurbasic, Azra; Lamina, Claudia; Forer, Lukas; Scholz, Markus; Galesloot, Tessel E; Bradfield, Jonathan P; Ruotsalainen, Sanni E; Daw, EWarwick; Zmuda, Joseph M; Mitchell, Jonathan S; Fuchsberger, Christian; Christensen, Henry; Brody, Jennifer A; Vazquez-Moreno, Miguel; Feitosa, Mary F; Wojczynski, Mary K; Wang, Zhe; Preuss, Michael H; Mangino, Massimo; Christofidou, Paraskevi; Verweij, Niek; Benjamins, Jan W; Engmann, Jorgen; Tsao, Noah L; Verma, Anurag; Slieker, Roderick C; Lo, Ken Sin; Zilhao, Nuno R; Le, Phuong; Kleber, Marcus E; Delgado, Graciela E; Huo, Shaofeng; Ikeda, Daisuke D; Iha, Hiroyuki; Yang, Jian; Liu, Jun; Demirkan, Ayşe; Leonard, Hampton L; Marten, Jonathan; Frank, Mirjam; Schmidt, Börge; Smyth, Laura J; Cañadas-Garre, Marisa; Wang, Chaolong; Nakatochi, Masahiro; Wong, Andrew; Hutri-Kähönen, Nina; Sim, Xueling; Xia, Rui; Huerta-Chagoya, Alicia; Fernandez-Lopez, Juan Carlos; Lyssenko, Valeriya; Nongmaithem, Suraj S; Bayyana, Swati; Stringham, Heather M; Irvin, Marguerite R; Oldmeadow, Christopher; Kim, Han-Na; Ryu, Seungho; Timmers, Paul R H J; Arbeeva, Liubov; Dorajoo, Rajkumar; Lange, Leslie A; Prasad, Gauri; Lorés-Motta, Laura; Pauper, Marc; Long, Jirong; Li, Xiaohui; Theusch, Elizabeth; Takeuchi, Fumihiko; Spracklen, Cassandra N; Loukola, Anu; Bollepalli, Sailalitha; Warner, Sophie C; Wang, Ya Xing; Wei, Wen B; Nutile, Teresa; Ruggiero, Daniela; Sung, Yun Ju; Chen, Shufeng; Liu, Fangchao; Yang, Jingyun; Kentistou, Katherine A; Banas, Bernhard; Nardone, Giuseppe Giovanni; Meidtner, Karina; Bielak, Lawrence F; Smith, Jennifer A; Hebbar, Prashantha; Farmaki, Aliki-Eleni; Hofer, Edith; Lin, Maoxuan; Concas, Maria Pina; Vaccargiu, Simona; van der Most, Peter J; Pitkänen, Niina; Cade, Brian E; van der Laan, Sander W; Chitrala, Kumaraswamy Naidu; Weiss, Stefan; Bentley, Amy R; Doumatey, Ayo P; Adeyemo, Adebowale A; Lee, Jong Young; Petersen, Eva R B; Nielsen, Aneta A; Choi, Hyeok Sun; Nethander, Maria; Freitag-Wolf, Sandra; Southam, Lorraine; Rayner, Nigel W; Wang, Carol A; Lin, Shih-Yi; Wang, Jun-Sing; Couture, Christian; Lyytikäinen, Leo-Pekka; Nikus, Kjell; Cuellar-Partida, Gabriel; Vestergaard, Henrik; Hidalgo, Bertha; Giannakopoulou, Olga; Cai, Qiuyin; Obura, Morgan O; van Setten, Jessica; Li, Xiaoyin; Liang, Jingjing; Tang, Hua; Terzikhan, Natalie; Shin, Jae Hun; Jackson, Rebecca D; Reiner, Alexander P; Martin, Lisa Warsinger; Chen, Zhengming; Li, Liming; Kawaguchi, Takahisa; Thiery, Joachim; Bis, Joshua C; Launer, Lenore J; Li, Huaixing; Nalls, Mike A; Raitakari, Olli T; Ichihara, Sahoko; Wild, Sarah H; Nelson, Christopher P; Campbell, Harry; Jäger, Susanne; Nabika, Toru; Al-Mulla, Fahd; Niinikoski, Harri; Braund, Peter S; Kolcic, Ivana; Kovacs, Peter; Giardoglou, Tota; Katsuya, Tomohiro; de Kleijn, Dominique; de Borst, Gert J; Kim, Eung Kweon; Adams, Hieab H H; Ikram, M Arfan; Zhu, Xiaofeng; Asselbergs, Folkert W; Kraaijeveld, Adriaan O; Beulens, Joline W J; Shu, Xiao-Ou; Rallidis, Loukianos S; Pedersen, Oluf; Hansen, Torben; Mitchell, Paul; Hewitt, Alex W; Kähönen, Mika; Pérusse, Louis; Bouchard, Claude; Tönjes, Anke; Chen, Yii-Der Ida; Pennell, Craig E; Mori, Trevor A; Lieb, Wolfgang; Franke, Andre; Ohlsson, Claes; Mellström, Dan; Cho, Yoon Shin; Lee, Hyejin; Yuan, Jian-Min; Koh, Woon-Puay; Rhee, Sang Youl; Woo, Jeong-Taek; Heid, Iris M; Stark, Klaus J; Zimmermann, Martina E; Völzke, Henry; Homuth, Georg; Evans, Michele K; Zonderman, Alan B; Polasek, Ozren; Pasterkamp, Gerard; Hoefer, Imo E; Redline, Susan; Pahkala, Katja; Oldehinkel, Albertine J; Snieder, Harold; Biino, Ginevra; Schmidt, Reinhold; Schmidt, Helena; Bandinelli, Stefania; Dedoussis, George; Thanaraj, Thangavel Alphonse; Kardia, Sharon L R; Peyser, Patricia A; Kato, Norihiro; Schulze, Matthias B; Girotto, Giorgia; Böger, Carsten A; Jung, Bettina; Joshi, Peter K; Bennett, David A; De Jager, Philip L; Lu, Xiangfeng; Mamakou, Vasiliki; Brown, Morris; Caulfield, Mark J; Munroe, Patricia B; Guo, Xiuqing; Ciullo, Marina; Jonas, Jost B; Samani, Nilesh J; Kaprio, Jaakko; Pajukanta, Päivi; Tusié-Luna, Teresa; Aguilar-Salinas, Carlos A; Adair, Linda S; Bechayda, Sonny Augustin; de Silva, H Janaka; Wickremasinghe, Ananda R; Krauss, Ronald M; Wu, Jer-Yuarn; Zheng, Wei; Hollander, Anneke Iden; Bharadwaj, Dwaipayan; Correa, Adolfo; Wilson, James G; Lind, Lars; Heng, Chew-Kiat; Nelson, Amanda E; Golightly, Yvonne M; Wilson, James F; Penninx, Brenda; Kim, Hyung-Lae; Attia, John; Scott, Rodney J; Rao, D C; Arnett, Donna K; Hunt, Steven C; Walker, Mark; Koistinen, Heikki A; Chandak, Giriraj R; Mercader, Josep M; Costanzo, Maria C; Jang, Dongkeun; Burtt, Noël P; Villalpando, Clicerio Gonzalez; Orozco, Lorena; Fornage, Myriam; Tai, EShyong; van Dam, Rob M; Lehtimäki, Terho; Chaturvedi, Nish; Yokota, Mitsuhiro; Liu, Jianjun; Reilly, Dermot F; McKnight, Amy Jayne; Kee, Frank; Jöckel, Karl-Heinz; McCarthy, Mark I; Palmer, Colin N A; Vitart, Veronique; Hayward, Caroline; Simonsick, Eleanor; van Duijn, Cornelia M; Jin, Zi-Bing; Qu, Jia; Hishigaki, Haretsugu; Lin, Xu; März, Winfried; Gudnason, Vilmundur; Tardif, Jean-Claude; Lettre, Guillaume; Hart, Leen M 't; Elders, Petra J M; Damrauer, Scott M; Kumari, Meena; Kivimaki, Mika; van der Harst, Pim; Spector, Tim D; Loos, Ruth J F; Province, Michael A; Parra, Esteban J; Cruz, Miguel; Psaty, Bruce M; Brandslund, Ivan; Pramstaller, Peter P; Rotimi, Charles N; Christensen, Kaare; Ripatti, Samuli; Widén, Elisabeth; Hakonarson, Hakon; Grant, Struan F A; Kiemeney, Lambertus A L M; de Graaf, Jacqueline; Loeffler, Markus; Kronenberg, Florian; Gu, Dongfeng; Erdmann, Jeanette; Schunkert, Heribert; Franks, Paul W; Linneberg, Allan; Jukema, J Wouter; Khera, Amit V; Männikkö, Minna; Jarvelin, Marjo-Riitta; Kutalik, Zoltan; Francesco, Cucca; Mook-Kanamori, Dennis O; van Dijk, Ko Willems; Watkins, Hugh; Strachan, David P; Grarup, Niels; Sever, Peter; Poulter, Neil; Chuang, Lee-Ming; Rotter, Jerome I; Dantoft, Thomas M; Karpe, Fredrik; Neville, Matt J; Timpson, Nicholas J; Cheng, Ching-Yu; Wong, Tien-Yin; Khor, Chiea Chuen; Li, Hengtong; Sabanayagam, Charumathi; Peters, Annette; Gieger, Christian; Hattersley, Andrew T; Pedersen, Nancy L; Magnusson, Patrik K E; Boomsma, Dorret I; Willemsen, Allegonda H M; Cupples, LAdrienne; van Meurs, Joyce B J; Ghanbari, Mohsen; Gordon-Larsen, Penny; Huang, Wei; Kim, Young Jin; Tabara, Yasuharu; Wareham, Nicholas J; Langenberg, Claudia; Zeggini, Eleftheria; Kuusisto, Johanna; Laakso, Markku; Ingelsson, Erik; Abecasis, Goncalo; Chambers, John C; Kooner, Jaspal S; de Vries, Paul S; Morrison, Alanna C; Hazelhurst, Scott; Ramsay, Michèle; North, Kari E; Daviglus, Martha; Kraft, Peter; Martin, Nicholas G; Whitfield, John B; Abbas, Shahid; Saleheen, Danish; Walters, Robin G; Holmes, Michael V; Black, Corri; Smith, Blair H; Baras, Aris; Justice, Anne E; Buring, Julie E; Ridker, Paul M; Chasman, Daniel I; Kooperberg, Charles; Tamiya, Gen; Yamamoto, Masayuki; van Heel, David A; Trembath, Richard C; Wei, Wei-Qi; Jarvik, Gail P; Namjou, Bahram; Hayes, M Geoffrey; Ritchie, Marylyn D; Jousilahti, Pekka; Salomaa, Veikko; Hveem, Kristian; Åsvold, Bjørn Olav; Kubo, Michiaki; Kamatani, Yoichiro; Okada, Yukinori; Murakami, Yoshinori; Kim, Bong-Jo; Thorsteinsdottir, Unnur; Stefansson, Kari; Zhang, Jifeng; Chen, YEugene; Ho, Yuk-Lam; Lynch, Julie A; Rader, Daniel J; Tsao, Philip S; Chang, Kyong-Mi; Cho, Kelly; O'Donnell, Christopher J; Gaziano, John M; Wilson, Peter W F; Frayling, Timothy M; Hirschhorn, Joel N; Kathiresan, Sekar; Mohlke, Karen L; Sun, Yan V; Morris, Andrew P; Boehnke, Michael; Brown, Christopher D; Natarajan, Pradeep; Deloukas, Panos; Willer, Cristen J; Assimes, Themistocles L; Peloso, Gina M (BioMed Central, 2022-12-27)
    BACKGROUND: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding ...
  • PolarMorphism enables discovery of shared genetic variants across multiple traits from GWAS summary statistics 
    von Berg, Joanna; Ten Dam, Michelle; van der Laan, Sander W; de Ridder, Jeroen (Oxford University Press, 2022-07-01)
    MOTIVATION: Pleiotropic SNPs are associated with multiple traits. Such SNPs can help pinpoint biological processes with an effect on multiple traits or point to a shared etiology between traits. We present PolarMorphism, ...