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UMC Repository: Recent submissions

  • Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL-10 
    Richter, Felix Clemens; Friedrich, Matthias; Kampschulte, Nadja; Piletic, Klara; Alsaleh, Ghada; Zummach, Ramona; Hecker, Julia; Pohin, Mathilde; Ilott, Nicholas; Guschina, Irina; Wideman, Sarah Karin; Johnson, Errin; Borsa, Mariana; Hahn, Paula; Morriseau, Christophe; Hammock, Bruce D; Schipper, Henk Simon; Edwards, Claire M; Zechner, Rudolf; Siegmund, Britta; Weidinger, Carl; Schebb, Nils Helge; Powrie, Fiona; Simon, Anna Katharina (Springer Science and Business Media Deutschland GmbH, 2023-03-15)
    Lipids play a major role in inflammatory diseases by altering inflammatory cell functions, either through their function as energy substrates or as lipid mediators such as oxylipins. Autophagy, a lysosomal degradation ...
  • Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity 
    HUNT All-In Stroke, CADISP group, International Consortium for Blood Pressure, International Headache Genetics Consortium, International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group (Lippincott Williams & Wilkins, 2023-03-01)
    BACKGROUND: Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to ...
  • Lithium carbonate in amyotrophic lateral sclerosis patients homozygous for the C-allele at SNP rs12608932 in UNC13A: protocol for a confirmatory, randomized, group-sequential, event-driven, double-blind, placebo-controlled trial 
    Willemse, Sean W.; Roes, Kit C.B.; Van Damme, Philip; Hardiman, Orla; Ingre, Caroline; Povedano, Monica; Wray, Naomi R.; Gijzen, Marleen; de Pagter, Mirjam S.; Demaegd, Koen C.; Janse, Annemarie F.C.; Vink, Roel G.; Sleutjes, Boudewijn T.H.M.; Chiò, Adriano; Corcia, Philippe; Reviers, Evy; Al-Chalabi, Ammar; Kiernan, Matthew C.; van den Berg, Leonard H.; van Es, Michael A.; van Eijk, Ruben P.A. (BioMed Central, 2022-12)
    Background: Given the large genetic heterogeneity in amyotrophic lateral sclerosis (ALS), it seems likely that genetic subgroups may benefit differently from treatment. An exploratory meta-analysis identified that patients ...
  • Rhabdomyolysis after COVID-19 Comirnaty Vaccination: A Case Report 
    Ruijters, Veerle J.; Van Der Meulen, Marjon F.G.; Van Es, Michael A.; Smit, Tessa; Hoogendijk, Jessica E. (S. Karger AG, 2022-11-04)
    Rhabdomyolysis is an acute disruption in skeletal muscle integrity, leading to the rapid release of 4 muscle contents into the bloodstream, such as creatine kinase (CK). It can have various causes, including infections. ...
  • Longitudinal Effects of Asymptomatic C9orf72 Carriership on Brain Morphology 
    van Veenhuijzen, Kevin; Westeneng, Henk Jan; Tan, Harold H.G.; Nitert, Abram D.; van der Burgh, Hannelore K.; Gosselt, Isabel; van Es, Michael A.; Nijboer, Tanja C.W.; Veldink, Jan H.; van den Berg, Leonard H. (John Wiley & Sons Inc., 2023-04)
    Objective: We investigated effects of C9orf72 repeat expansion and gene expression on longitudinal cerebral changes before symptom onset. Methods: We enrolled 79 asymptomatic family members (AFMs) from 9 families with ...
  • Whole genome sequencing analysis reveals post-zygotic mutation variability in monozygotic twins discordant for amyotrophic lateral sclerosis 
    Tazelaar, Gijs H.P.; Hop, Paul J.; Seelen, Meinie; van Vugt, Joke J.F.A.; van Rheenen, Wouter; Kool, Lindy; van Eijk, Kristel R.; Gijzen, Marleen; Dooijes, Dennis; Moisse, Matthieu; Calvo, Andrea; Moglia, Cristina; Brunetti, Maura; Canosa, Antonio; Nordin, Angelica; Pardina, Jesus S.Mora; Ravits, John; Al-Chalabi, Ammar; Chio, Adriano; McLaughlin, Russell L.; Hardiman, Orla; Van Damme, Philip; de Carvalho, Mamede; Neuwirth, Christoph; Weber, Markus; Andersen, Peter M.; van den Berg, Leonard H.; Veldink, Jan H.; van Es, Michael A. (Elsevier, 2023-02)
    Amyotrophic lateral sclerosis is a heterogeneous, fatal neurodegenerative disease, characterized by motor neuron loss and in 50% of cases also by cognitive and/or behavioral changes. Mendelian forms of ALS comprise ...
  • Evaluating the influence of alcohol intoxication on the pre-hospital identification of severe head injury: a multi-center, cohort study 
    Triage Research Collaborative(pttrc) (Informa Healthcare, 2023-03-21)
    OBJECTIVE: To determine the influence of intoxication on the pre-hospital recognition of severely head-injured patients by Emergency Medical Services (EMS) professionals and to investigate the relationship between suspected ...
  • Editorial: Is two better than one? Exploring tissue microstructure with multi-modal imaging: Quantitative MRI and beyond 
    De Luca, Alberto; Schilling, Kurt G.; Ianus, Andrada (Frontiers Media S. A., 2023-02-08)
  • EffectiveNess of a multimodal preHAbilitation program in patieNts with bladder canCEr undergoing radical cystectomy: protocol of the ENHANCE multicentre randomised controlled trial 
    Akdemir, Emine; Sweegers, Maike G.; Vrieling, Alina; Rundqvist, Helene; Meijer, Richard P.; Leliveld-Kors, Annemarie M.; Van Der Heijden, Antoine G.; Rutten, Vera C.; Koldewijn, Evert L.; Bos, Siebe D.; Wijburg, Carl J.; Marcelissen, Tom A.T.; Bongers, Bart C.; Retèl, Valesca P.; Van Harten, Wim H.; May, Anne M.; Groen, Wim G.; Stuiver, Martijn M. (BMJ Publishing Group, 2023-03-07)
    Introduction Radical cystectomy (RC) is the standard treatment for patients with non-metastatic muscle-invasive bladder cancer, as well as for patients with therapy refractory high-risk non-muscle invasive bladder cancer. ...
  • Acinar Cystic Transformation of the Pancreas: Histomorphology and Molecular Analysis to Unravel its Heterogeneous Nature 
    Luchini, Claudio; Mattiolo, Paola; Basturk, Olca; Mafficini, Andrea; Ozcan, Kerem; Lawlor, Rita T.; Hong, Seung Mo; Brosens, Lodewijk A.; Marchegiani, Giovanni; Pea, Antonio; Manfrin, Erminia; Sciacca, Giuseppe; Zampieri, Federica; Polati, Rita; De Robertis, Riccardo; Milella, Michele; D'Onofrio, Mirko; Malleo, Giuseppe; Salvia, Roberto; Adsay, Volkan; Scarpa, Aldo (Lippincott Williams & Wilkins, 2023-03-01)
    Acinar cystic transformation (ACT) of the pancreas, previously called acinar cell cystadenoma, is a poorly understood and rare entity among pancreatic cystic lesions. This study aims to clarify its real nature. This research ...
  • Common genetic variants improve risk stratification after the atrial switch operation for transposition of the great arteries 
    Woudstra, Odilia I.; Skoric-Milosavljevic, Doris; Mulder, Barbara J.M.; Meijboom, Folkert J.; Post, Marco C.; Jongbloed, Monique R.M.; van Dijk, Arie P.J.; van Melle, Joost P.; Konings, Thelma C.; Postma, Alex V.; Bezzina, Connie R.; Bouma, Berto J.; Tanck, Michael W.T. (Elsevier Ireland Ltd, 2023-01-15)
    Background: Clinical factors are used to estimate late complication risk in adults after atrial switch operation (AtrSO) for transposition of the great arteries (TGA), but heterogeneity in clinical course remains. We studied ...
  • Evolution of Pulmonary Arteriovenous Malformations: The Role of Contrast Echocardiography: The Role of Contrast Echocardiography 
    Hessels, J.; Kroon, S.; Vorselaars, V. V.M.; Boerman, S.; Mager, J. J.; Post, M. C. (Elsevier, 2023-03)
    Background: Pulmonary arteriovenous malformations (PAVMs) are direct connections between the pulmonary artery and the pulmonary vein, mostly associated with hereditary hemorrhagic telangiectasia (HHT). PAVMs can lead to ...
  • Prednisone vs methotrexate in treatment naïve cardiac sarcoidosis 
    Vis, Roeland; Mathijssen, Harold; Keijsers, Ruth G.M.; van de Garde, Ewoudt M.W.; Veltkamp, Marcel; Akdim, Fatima; Post, Marco C.; Grutters, Jan C. (Springer New York, 2023-08)
    Background: Side effects limit the long-term use of glucocorticoids in cardiac sarcoidosis (CS), and methotrexate has gained attention as steroid sparing agent although the supporting evidence is poor. This study compared ...
  • Factors Influencing the Adoption of Magnetic Resonance-Guided High-Intensity Focused Ultrasound for Painful Bone Metastases in Europe, A Group Concept Mapping Study 
    Simões Corrêa Galendi, Julia; Siefen, Ann Cathrine; Moretti, Debora M.; Yeo, Sin Yuin; Grüll, Holger; Bratke, Grischa; Morganti, Alessio Giuseppe; Bazzocchi, Alberto; Gasperini, Chiara; De Felice, Francesca; Blanco Sequeiros, Roberto; Huhtala, Mira; Nijholt, Ingrid M.; Boomsma, Martijn F.; Bos, Clemens; Verkooijen, Helena M.; Müller, Dirk; Stock, Stephanie (Multidisciplinary Digital Publishing Institute (MDPI), 2023-01)
    Magnetic resonance imaging-guided high-intensity focused ultrasound (MR-HIFU) is an innovative treatment for patients with painful bone metastases. The adoption of MR-HIFU will be influenced by several factors beyond its ...
  • Patient preferences for treatment modalities for localised prostate cancer 
    Teunissen, Frederik R; Hehakaya, Charisma; Meijer, Richard P; van Melick, Harm H E; Verkooijen, Helena M; van der Voort van Zyp, Jochem R N (John Wiley & Sons Inc., 2023-03)
    OBJECTIVES: To assess the patient preferences and utility scores for the different conventional and innovative treatment modalities for localised prostate cancer (PCa). SUBJECTS AND METHODS: Patients treated for localised ...
  • ELITE: Rationale and design of a longitudinal elite athlete, extreme cardiovascular phenotyping, prospective cohort study 
    Van Hattum, Juliette C.; Verwijs, Sjoerd M.; Boekholdt, S. Matthijs; Groenink, Maarten; Planken, R. Nils; Van Randen, Adrienne; Nederveen, Aart J.; Moen, Maarten H.; Wijne, Cornelis A.C.M.; Daems, Joelle J.N.; Velthuis, Birgitta K.; Van De Sande, Danny A.J.; Spee, Ruud; De Vries, Suzanna T.; Van Der Veen, Maurits J.; Pinto, Yigal M.; Wilde, Arthur A.M.; Jorstad, Harald T. (BMJ Publishing Group, 2023-02-03)
    Introduction The cardiovascular benefits of physical exercise are well-known. However, vigorous exercise has also been associated with adverse cardiac effects. To improve our understanding of cardiovascular adaptation to ...
  • Chronic Disease in Low-Resource Settings: Prevention and Management Throughout the Continuum of Care-A Call for Papers 
    Heine, Martin; Hanekom, Susan (Multidisciplinary Digital Publishing Institute (MDPI), 2023-02-17)
    Multimorbidity, defined as the presence of two or more chronic conditions in an individual, has become a global public health challenge [...].
  • Towards functional spin-echo BOLD line-scanning in humans at 7T 
    Raimondo, Luisa; Heij, Jurjen; Knapen, Tomas; Dumoulin, Serge O.; van der Zwaag, Wietske; Siero, Jeroen C.W. (Springer-Verlag, 2023-04)
    Objective: Neurons cluster into sub-millimeter spatial structures and neural activity occurs at millisecond resolutions; hence, ultimately, high spatial and high temporal resolutions are required for functional MRI. In ...
  • Author Correction: Regulatory T cells in psoriatic arthritis: an IL-17A-producing, Foxp3intCD161 + RORγt + ICOS + phenotype, that associates with the presence of ADAMTSL5 autoantibodies 
    Pouw, Juliëtte N.; Olde Nordkamp, Michel A.M.; van Kempen, Tessa; Concepcion, Arno N.; van Laar, Jacob M.; van Wijk, Femke; Spierings, Julia; Leijten, Emmerik F.A.; Boes, Marianne (Nature Publishing Group, 2023-01-24)
    Correction to: Scientific Reports https://doi.org/10.1038/s41598-022-24924-w, published online 30 November 2022
  • STereotactic Arrhythmia Radioablation (STAR): the Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe 
    Grehn, Melanie; Mandija, Stefano; Miszczyk, Marcin; Krug, David; Tomasik, Bartłomiej; Stickney, Kristine E; Alcantara, Pino; Alongi, Filippo; Anselmino, Matteo; Aranda, Ricardo Salgado; Balgobind, Brian V; Boda-Heggemann, Judit; Boldt, Leif-Hendrik; Bottoni, Nicola; Cvek, Jakub; Elicin, Olgun; De Ferrari, Gaetano Maria; Hassink, Rutger J; Hazelaar, Colien; Hindricks, Gerhard; Hurkmans, Coen; Iotti, Cinzia; Jadczyk, Tomasz; Jiravsky, Otakar; Jumeau, Raphaël; Buus Kristiansen, Steen; Levis, Mario; López, Manuel Algara; Martí-Almor, Julio; Mehrhof, Felix; Møller, Ditte Sloth; Molon, Giulio; Ouss, Alexandre; Peichl, Petr; Plasek, Jiri; Postema, Pieter G; Quesada, Aurelio; Reichlin, Tobias; Rordorf, Roberto; Rudic, Boris; Saguner, Ardan M; Ter Bekke, Rachel M A; Torrecilla, José López; Troost, Esther G C; Vitolo, Viviana; Andratschke, Nicolaus; Zeppenfeld, Katja; Blamek, Slawomir; Fast, Martin; de Panfilis, Ludovica; Blanck, Oliver; Pruvot, Etienne; Verhoeff, Joost J C (Oxford University Press, 2023-04-15)
    The EU Horizon 2020 Framework-funded Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary (STOPSTORM) consortium has been established as a large research ...