STereotactic Arrhythmia Radioablation (STAR): the Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe
Grehn, Melanie; Mandija, Stefano; Miszczyk, Marcin; Krug, David; Tomasik, Bartłomiej; Stickney, Kristine E; Alcantara, Pino; Alongi, Filippo; Anselmino, Matteo; Aranda, Ricardo Salgado; Balgobind, Brian V; Boda-Heggemann, Judit; Boldt, Leif-Hendrik; Bottoni, Nicola; Cvek, Jakub; Elicin, Olgun; De Ferrari, Gaetano Maria; Hassink, Rutger J; Hazelaar, Colien; Hindricks, Gerhard; Hurkmans, Coen; Iotti, Cinzia; Jadczyk, Tomasz; Jiravsky, Otakar; Jumeau, Raphaël; Buus Kristiansen, Steen; Levis, Mario; López, Manuel Algara; Martí-Almor, Julio; Mehrhof, Felix; Møller, Ditte Sloth; Molon, Giulio; Ouss, Alexandre; Peichl, Petr; Plasek, Jiri; Postema, Pieter G; Quesada, Aurelio; Reichlin, Tobias; Rordorf, Roberto; Rudic, Boris; Saguner, Ardan M; Ter Bekke, Rachel M A; Torrecilla, José López; Troost, Esther G C; Vitolo, Viviana; Andratschke, Nicolaus; Zeppenfeld, Katja; Blamek, Slawomir; Fast, Martin; de Panfilis, Ludovica; Blanck, Oliver; Pruvot, Etienne; Verhoeff, Joost J C
(2023) Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, volume 25, issue 4, pp. 1284 - 1295
(Article)
Abstract
The EU Horizon 2020 Framework-funded Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary (STOPSTORM) consortium has been established as a large research network for investigating STereotactic Arrhythmia Radioablation (STAR) for ventricular tachycardia (VT). The aim is to provide a pooled treatment database to evaluate
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patterns of practice and outcomes of STAR and finally to harmonize STAR within Europe. The consortium comprises 31 clinical and research institutions. The project is divided into nine work packages (WPs): (i) observational cohort; (ii) standardization and harmonization of target delineation; (iii) harmonized prospective cohort; (iv) quality assurance (QA); (v) analysis and evaluation; (vi, ix) ethics and regulations; and (vii, viii) project coordination and dissemination. To provide a review of current clinical STAR practice in Europe, a comprehensive questionnaire was performed at project start. The STOPSTORM Institutions' experience in VT catheter ablation (83% ≥ 20 ann.) and stereotactic body radiotherapy (59% > 200 ann.) was adequate, and 84 STAR treatments were performed until project launch, while 8/22 centres already recruited VT patients in national clinical trials. The majority currently base their target definition on mapping during VT (96%) and/or pace mapping (75%), reduced voltage areas (63%), or late ventricular potentials (75%) during sinus rhythm. The majority currently apply a single-fraction dose of 25 Gy while planning techniques and dose prescription methods vary greatly. The current clinical STAR practice in the STOPSTORM consortium highlights potential areas of optimization and harmonization for substrate mapping, target delineation, motion management, dosimetry, and QA, which will be addressed in the various WPs.
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Keywords: Arrhythmias, Cardiac, Catheter Ablation/adverse effects, Heart Ventricles, Humans, Prospective Studies, Tachycardia, Ventricular, Treatment Outcome, Stereotactic body radiotherapy, Cardiac arrhythmias, Ventricular tachycardia, EU Horizon 2020, Consortium, Stereotactic arrhythmia radioablation, Cardiology and Cardiovascular Medicine, Physiology (medical), Review, Journal Article
ISSN: 1099-5129
Publisher: Oxford University Press
Note: Funding Information: The authors would like to thank all members of the STOPSTORM consortium (see https://stopstorm.eu/en/consortium). Special thanks to Marcus Both and the advisory board members Matthew Bates, Matthew Hatton, Phillip Cuculich, Clifford Robinson, Paul C. Zei, Jan Smook, Reinier Versluis, Annette Rogge, Rieke van der Graaf, Dick Enge, Juan Carlos Miembro, Stephanie Hellwig, and Denis Janssen. The following STOPSTORM participants were part of the Delphi consensus37: David Krug, Oliver Blanck, Nicolaus Andratschke, Raphael Jumeau, Felix Mehrhof, Judit Boda-Heggemann, Etienne Pruvot, Ardan M. Saguner, Boris Rudic, and Leif-Hendrik Boldt. This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 945119. Publisher Copyright: © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.
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