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UMC Repository: Recent submissions

  • The relation between prediction model performance measures and patient selection outcomes for proton therapy in head and neck cancer 
    Leeuwenberg, Artuur Marijn; Reitsma, Johannes Bernardus; Van den Bosch, Lisa Griet Lydia Jozef; Hoogland, Jeroen; van der Schaaf, Arjen; Hoebers, Frank Jozef Pieter; Wijers, Oda Bemadette; Langendijk, Johannes Albertus; Moons, Karel Gerardus Maria; Schuit, Ewoud (Elsevier Ireland Ltd, 2023-02)
    Background: Normal-tissue complication probability (NTCP) models predict complication risk in patients receiving radiotherapy, considering radiation dose to healthy tissues, and are used to select patients for proton ...
  • Antibiotic treatment of bacterial vaginosis to prevent preterm delivery: Systematic review and individual participant data meta-analysis 
    Klebanoff, Mark A.; Schuit, Ewoud; Lamont, Ronald F.; Larsson, Per Göran; Odendaal, Hein J.; Ugwumadu, Austin; Kiss, Herbert; Petricevic, Ljubomir; Andrews, William W.; Hoffman, Matthew K.; Shennan, Andrew; Seed, Paul T.; Goldenberg, Robert L.; Emel, Lynda M.; Bhandaru, Vinay; Weiner, Steven; Larsen, Michael D. (Wiley-Blackwell, 2023-03)
    Background: Bacterial vaginosis (BV) increases preterm delivery (PTD) risk, but treatment trials showed mixed results in preventing PTD. Objectives: Determine, using individual participant data (IPD), whether BV treatment ...
  • Consortium for the Study of Pregnancy Treatments (Co-OPT): An international birth cohort to study the effects of antenatal corticosteroids 
    Frier, Emily M; Lin, Chun; Reynolds, Rebecca M; Allegaert, Karel; Been, Jasper V; Fraser, Abigail; Gissler, Mika; Einarsdóttir, Kristjana; Florian, Lani; Jacobsson, Bo; Vogel, Joshua P; Zoega, Helga; Bhattacharya, Sohinee; Krispin, Eyal; Henning Pedersen, Lars; Roberts, Devender; Kuhle, Stefan; Fahey, John; Mol, Ben W; Burgner, David; Schuit, Ewoud; Sheikh, Aziz; Wood, Rachael; Gyamfi-Bannerman, Cynthia; Miller, Jessica E; Duhig, Kate; Lahti-Pulkkinen, Marius; Hadar, Eran; Wright, John; Murray, Sarah R; Stock, Sarah J (Public Library of Science, 2023-03-02)
    BACKGROUND: Antenatal corticosteroids (ACS) are widely prescribed to improve outcomes following preterm birth. Significant knowledge gaps surround their safety, long-term effects, optimal timing and dosage. Almost half of ...
  • Efficacy, safety and biomarker analysis of durvalumab in patients with mismatch-repair deficient or microsatellite instability-high solid tumours 
    Geurts, Birgit S; Battaglia, Thomas W; van Berge Henegouwen, J Maxime; Zeverijn, Laurien J; de Wit, Gijs F; Hoes, Louisa R; van der Wijngaart, Hanneke; van der Noort, Vincent; Roepman, Paul; de Leng, Wendy W J; Jansen, Anne M L; Opdam, Frans L; de Jonge, Maja J A; Cirkel, Geert A; Labots, Mariette; Hoeben, Ann; Kerver, Emile D; Bins, Adriaan D; Erdkamp, Frans G L; van Rooijen, Johan M; Houtsma, Danny; Hendriks, Mathijs P; de Groot, Jan-Willem B; Verheul, Henk M W; Gelderblom, Hans; Voest, Emile E (BioMed Central, 2023-12)
    BACKGROUND: In this study we aimed to evaluate the efficacy and safety of the PD-L1 inhibitor durvalumab across various mismatch repair deficient (dMMR) or microsatellite instability-high (MSI-H) tumours in the Drug ...
  • Sex-specifics of ECT outcome 
    blanken (Elsevier, 2023-04-01)
    OBJECTIVE: Electroconvulsive therapy (ECT) is the most effective treatment for patients with severe major depressive disorder (MDD). Given the known sex differences in MDD, improved knowledge may provide more sex-specific ...
  • BrainAge of patients with severe late-life depression referred for electroconvulsive therapy 
    Wagenmakers, Margot J; Oudega, Mardien L; Klaus, Federica; Wing, David; Orav, Gwendolyn; Han, Laura K M; Binnewies, Julia; Beekman, Aartjan T F; Veltman, Dick J; Rhebergen, Didi; van Exel, Eric; Eyler, Lisa T; Dols, Annemieke (Elsevier, 2023-06-01)
    Background: Severe depression is associated with accelerated brain aging. BrainAge gap, the difference between predicted and observed BrainAge, was investigated in patients with late-life depression (LLD). We aimed to ...
  • Prescribing, deprescribing and potential adverse effects of proton pump inhibitors in older patients with multimorbidity: an observational study 
    Aubert, Carole E; Blum, Manuel R; Gastens, Viktoria; Dalleur, Olivia; Vaillant, Fanny; Jennings, Emma; Aujesky, Drahomir; Thompson, Wade; Kool, Tijn; Kramers, Cornelius; Knol, Wilma; O'Mahony, Denis; Rodondi, Nicolas (Canadian Medical Association, 2023-01-01)
    BACKGROUND: Proton pump inhibitors (PPIs) contribute to polypharmacy and are associated with adverse effects. As prospective data on longitudinal patterns of PPI prescribing in older patients with multimorbidity are lacking, ...
  • PITX2 induction leads to impaired cardiomyocyte function in arrhythmogenic cardiomyopathy 
    van Kampen, Sebastiaan J; Han, Su Ji; van Ham, Willem B; Kyriakopoulou, Eirini; Stouthart, Elizabeth W; Goversen, Birgit; Monshouwer-Kloots, Jantine; Perini, Ilaria; de Ruiter, Hesther; van der Kraak, Petra; Vink, Aryan; van Laake, Linda W; Groeneweg, Judith A; de Boer, Teun P; Tsui, Hoyee; Boogerd, Cornelis J; van Veen, Toon A B; van Rooij, Eva (Cell Press, 2023-03-14)
    Arrhythmogenic cardiomyopathy (ACM) is an inherited progressive disease characterized by electrophysiological and structural remodeling of the ventricles. However, the disease-causing molecular pathways, as a consequence ...
  • Bendamustine plus rituximab for the treatment of Waldenström Macroglobulinemia: patient outcomes and impact of bendamustine dosing 
    Arulogun, Suzanne O; Brian, Duncan; Goradia, Harshita; Cooney, Aaron; Menne, Tobias; Koo, RayMun; O'Neill, Aideen T; Vos, Josephine M I; Pratt, Guy; Turner, Deborah; Marshall, Kirsty; Manos, Kate; Anderson, Claire; Gavriatopoulou, Maria; Kyriakou, Charalampia; Kersten, Marie J; Minnema, Monique C; Koutoumanou, Eirini; El-Sharkawi, Dima; Linton, Kim; Talaulikar, Dipti; McCarthy, Helen; Bishton, Mark; Follows, George; Wechalekar, Ashutosh; D'Sa, Shirley P (John Wiley & Sons Inc., 2023-05)
    Bendamustine and rituximab (BR) therapy is commonly used in the treatment of Waldenström Macroglobulinemia (WM). The impact dose of Bendamustine dose on response and survival outcomes is not well-established, and the impact ...
  • Trends in best-case, typical and worst-case survival scenarios of patients with non-metastatic esophagogastric cancer between 2006 and 2020: a population-based study 
    Kuijper, Steven C; Pape, Marieke; Vissers, Pauline A J; Jeene, Paul M; Kouwenhoven, Ewout A; Haj Mohammad, Nadia; Ruurda, Jelle P; Sosef, Meindert N; Verhoeven, Rob H A; van Laarhoven, Hanneke W M (John Wiley & Sons Inc., 2023-07-01)
    New treatment options and centralization of surgery have improved survival for patients with non-metastatic esophageal or gastric cancer. It is unknown, however, which patients benefitted the most from treatment advances. ...
  • Endoscopic vs. microscopic stapes surgery: An anatomical feasibility study 
    Blijleven, Esther E.; Willemsen, Koen; Bleys, Ronald L.A.W.; Stokroos, Robert J.; Wegner, Inge; Thomeer, Henricus G.X.M. (Frontiers Media S. A., 2022-11-23)
    Objectives: To investigate the feasibility of the endoscopic approach vs. microscopic approach during stapes surgery, focusing on the visualization of the important anatomical structures of the middle ear, the volume of ...
  • Clustering of antipsychotic-naïve patients with schizophrenia based on functional connectivity from resting-state electroencephalography 
    Ambrosen, Karen S.; Fredriksson, Fanny; Anhøj, Simon; Bak, Nikolaj; van Dellen, Edwin; Dominicus, Livia; Lemvigh, Cecilie K.; Sørensen, Mikkel E.; Nielsen, Mette; Bojesen, Kirsten B.; Fagerlund, Birgitte; Glenthøj, Birte Y.; Oranje, Bob; Hansen, Lars K.; Ebdrup, Bjørn H. (D. Steinkopff-Verlag, 2023-12)
    Schizophrenia is associated with aberrations in the Default Mode Network (DMN), but the clinical implications remain unclear. We applied data-driven, unsupervised machine learning based on resting-state electroencephalography ...
  • In patients with hemophilia, a decreased thrombin generation profile is associated with a severe bleeding phenotype 
    Verhagen, Marieke J A; van Heerde, Waander L; van der Bom, Johanna G; Beckers, Erik A M; Blijlevens, Nicole M A; Coppens, Michiel; Gouw, Samantha C; Jansen, Joop H; Leebeek, Frank W G; van Vulpen, Lize F D; Meijer, Daniëlle; Schols, Saskia E M (Elsevier, 2023-02)
    Background: Heterogeneity in clinical bleeding phenotype has been observed in hemophilia patients with similar FVIII or FIX activity levels. Thrombin generation and plasmin generation, as a global hemostasis assay, may ...
  • Effectiveness of analgesic ear drops as add-on treatment to oral analgesics in children with acute otitis media: study protocol of the OPTIMA pragmatic randomised controlled trial 
    de Sévaux, Joline L H; Damoiseaux, Roger A M J; Hullegie, Saskia; Sanders, Elisabeth A M; de Wit, G Ardine; Zuithoff, Nicolaas P A; Yardley, Lucy; Anthierens, Sibyl; Little, Paul; Hay, Alastair D; Schilder, Anne G M; Venekamp, Roderick P (BMJ Publishing Group, 2023-02-22)
    Introduction Ear pain is the most prominent symptom of childhood acute otitis media (AOM). To control the pain and reduce reliance on antibiotics, evidence of effectiveness for alternative interventions is urgently needed. ...
  • Advances in erectile function-preserving radiotherapy for prostate cancer 
    Teunissen, Frederik R.; van der Voort van Zyp, Jochem R.N.; Wortel, Ruud C. (2023-02-14)
  • Do cancer detection rates differ between transperineal and transrectal micro-ultrasound mpMRI-fusion-targeted prostate biopsies?: A propensity score-matched study 
    Rakauskas, Arnas; Peters, Max; Martel, Paul; van Rossum, Peter S.N.; La Rosa, Stefano; Meuwly, Jean Yves; Roth, Beat; Valerio, Massimo (Public Library of Science, 2023-01)
    Introduction High-resolution micro-ultrasound (micro-US) is a novel precise imaging modality that allows targeted prostate biopsies and multiparametric magnet resonance imaging (mpMRI) fusion. Its high resolution relying ...
  • Imaging in rhabdomyosarcoma: a patient journey 
    de Vries, Isabelle S A; van Ewijk, Roelof; Adriaansen, Laura M E; Bohte, Anneloes E; Braat, Arthur J A T; Fajardo, Raquel Dávila; Hiemcke-Jiwa, Laura S; Hol, Marinka L F; Ter Horst, Simone A J; de Keizer, Bart; Knops, Rutger R G; Meister, Michael T; Schoot, Reineke A; Smeele, Ludi E; van Scheltinga, Sheila Terwisscha; Vaarwerk, Bas; Merks, Johannes H M; van Rijn, Rick R (Springer-Verlag, 2023-04)
    Rhabdomyosarcoma, although rare, is the most frequent soft tissue sarcoma in children and adolescents. It can present as a mass at nearly any site in the body, with most common presentations in the head and neck, genitourinary ...
  • COVID-19 machine learning model predicts outcomes in older patients from various European countries, between pandemic waves, and in a cohort of Asian, African, and American patients 
    Mamandipoor, Behrooz; Bruno, Raphael Romano; Wernly, Bernhard; Wolff, Georg; Fjølner, Jesper; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C; Kelm, Malte; Beil, Michael; Sigal, Sviri; Leaver, Susannah; De Lange, Dylan W; Guidet, Bertrand; Flaatten, Hans; Szczeklik, Wojciech; Jung, Christian; Osmani, Venet (Public Library of Science, 2022-11)
    COVID-19 remains a complex disease in terms of its trajectory and the diversity of outcomes rendering disease management and clinical resource allocation challenging. Varying symptomatology in older patients as well as ...
  • Impact of reduced antibiotic treatment duration on antimicrobial resistance in critically ill patients in the randomized controlled SAPS-trial 
    Shajiei, Arezoo; Berends, Matthijs S; Luz, Christian F; van Oers, Jos A; Harmsen, Hermie J M; Vos, Piet; Klont, Rob; Loef, Bert G; Reidinga, Auke C; Bormans-Russell, Laura; Linsen, Kitty; Dormans, Tom; Otten, Martine; van der Bij, Akke; Beishuizen, Albertus; de Lange, Dylan W; de Jong, Evelien; Nijsten, Maarten W (Frontiers Media S. A., 2023-02-02)
    BACKGROUND: In the previously reported SAPS trial (https://clinicaltrials.gov/ct2/show/NCT01139489), procalcitonin-guidance safely reduced the duration of antibiotic treatment in critically ill patients. We assessed the ...
  • Isolated neurological presentations of mevalonate kinase deficiency 
    Hoytema van Konijnenburg, Eva M.M.; Oussoren, Esmeralda; Frenkel, Joost; van Hasselt, Peter M. (Springer Berlin, 2023-01)
    Mevalonate kinase (MK) deficiency is a rare autosomal recessive metabolic disorder caused by pathogenic variants in the MVK gene with a broad phenotypic spectrum including autoinflammation, developmental delay and ataxia. ...