Recently added

DSpace/Manakin Repository

Utrecht University Repository: Recent submissions

Now showing items 5361-5380 of 95693

Treatment optimization of fluoropyrimidine-based chemotherapy

Knikman, Jonathan Emanuel (Utrecht University, 2024-01-31)

This thesis is focused on a group of anticancer agents known as fluoropyrimidines, vital in the treatment of several solid tumors. Although the extensive experience with fluoropyrimidines severe toxicity remains a major ...
Immunomodulation by specific HMOS and the relevance in allergy management: Towards advanced human in vitro mucosal immune models

Zuurveld, Marit (Utrecht University, 2024-01-31)

Early life is considered an essential period in life for the maturation of the immune system. Flawed immune maturation predisposes for immunological abnormalities later in life such as the development of disorders including ...
Carbon-Supported Silver Catalysts for Electrocatalytic Reduction of CO2 to CO

Mattarozzi, Francesco (Utrecht University, 2024-01-31)

The work described in this thesis was aimed at understanding the influence of structural properties of silver catalysts supported on carbon for the electrocatalytic reduction of CO2 to CO. This goal was achieved by rationally ...
Seasonal thermal energy storage of solar heat: Its role in the clean heating transition in China

Yang, Tianrun (Utrecht University, 2024-01-29)

Since the adoption of the Paris Agreement, countries and regions have been submitting their climate action plans, aiming to achieve carbon neutrality in the coming decades to combat climate change. Since fossil fuels are ...
Diels-Alder Hydrogels and Micelles for Ocular Drug Delivery: From Design to Preclinical Evaluation

Ilochonwu, Blessing Chidimma (Utrecht University, 2024-01-29)

This research aimed to improve how we treat eye diseases, like, macular degeneration, diabetic retinopathies, and ocular inflammation. The focus of the thesis was on discovering improved methods to deliver medication to ...
Transformative Research Niches (TRNs): Uncovering the Transformative Potential of the Science System

Romero Goyeneche, Oscar Yandy (Utrecht University, 2024-01-26)

This thesis aims to explore the role of science in building a sustainable future. Can we rely on the current science system to address the challenges we face, or does it need to undergo a transformation in order to achieve ...
EU policy enforcement through EU agencies and networks of national authorities: Case studies of aviation safety and medical products regulation

Kreij, Laurens van (Utrecht University, 2024-01-26)

This PhD thesis is about the involvement of EU agencies and EU networks of national authorities in the enforcement of EU policy. For several decades the EU's member states were the primary enforcers of EU regulation vis-à-vis ...
Targeted rainfall enhancement as an objective of forestation

Staal, Arie; Theeuwen, Jolanda J. E.; Wang‐Erlandsson, Lan; Wunderling, Nico; Dekker, Stefan C. (2024-01-01)

Forestation efforts are accelerating across the globe in the fight against global climate change, in order to restore biodiversity, and to improve local livelihoods. Yet, so far the non-local effects of forestation on ...
Forecasting to Welcome the Solar Era: Supporting the integration of solar photovoltaics in the electricity grid

Visser, Lennard Rogier (Utrecht University, 2024-01-25)

Solar Photovoltaic (PV) systems form a key technology to cut greenhouse gas emissions and decarbonize the energy system. In recent years, an unprecedented growth of the installed capacity of solar PV systems has been ...
Southern Ocean, Antarctic ice and climate interactions during Neogene cooling

Hou, Suning (Utrecht University, 2024-01-24)

The partial pressure of atmospheric carbon dioxide (pCO2) has increased from 280 to 420 ppm (parts per million) since the industrial revolution due to anthropogenic emissions. As a result, the Earth's atmosphere, ocean, ...
Heat Stress Challenges and Resilience: The good and the bad of strenuous exercise

Lian, Puqiao (Utrecht University, 2024-01-23)

Strenuous exercise alters intestinal function by inducing heat stress in the gut and unbalancing the gut microbiota. The resilient mechanisms of the body to oxidative stress and heat stress assist the gut to counteract the ...
Educational quality and inequality: The interplay between schools, families, and genes

Stienstra, Linnsey Kimberly (Utrecht University, 2024-01-19)

In many countries, the quality and equality of education are under pressure. Investigating the relationship between three key elements that shape pupils’ performance – schools, families, and genes – is essential to understand ...
Engineering of camelid VHHs: applications in structural studies, diagnosis and solid tumor therapeutics

Xenaki, Aikaterini-Titika (Utrecht University, 2024-01-17)

Biotechnological advances allow for the artificial production of antibodies and antibody fragments, in order to exploit their target recognition specificity in basic and translational research, and clinical practice. In ...
Taming Digital Influence: Hypernudging and the Role for European Competition Law

Morozovaitė, Viktorija (Utrecht University, 2024-01-17)

This dissertation examines hypernudging – a sophisticated form of user influencing online - within the context of big technology companies and their prominent role in shaping digital markets. Digital platforms are increasingly ...
Efficiently starting and preferentially filling a potato: Efficiently starting and preferentially filling a potato

Herik, Bastiaan Mees van den (Utrecht University, 2024-01-17)

In this thesis, a diverse range of models was employed to explore various aspects of source-sink dynamics in potato. The models allowed for an exploration of transport efficiency and sucrose allocation in the vasculature, ...
On The Edge Of HTA: Shaping the boundaries across borders and stakeholders to prepare HTA for future complex medicines

Hogervorst, Milou Amber (Utrecht University, 2024-01-12)

This thesis aimed to investigate how to prepare health technology assessment (HTA) organisations for the assessment of future complex medicines for reimbursement. The first part of the thesis studied the current challenges ...
Numerical methods in financial mathematics with applications to option pricing and anomaly detection

Souto Arias, Luis Antonio (Utrecht University, 2024-01-15)

In the wake of the 2008 global financial crisis, financial institutions confront intricate mathematical challenges in managing diverse risks. While many proposals to tackle these challenges can be found in the academic ...
Impacts of hunting on tree and vertebrate communities in French Guiana

Vaessen, Rens Willem (Utrecht University, 2024-01-15)

Vertebrates are hunted throughout the tropics, resulting in severe declines of their populations. These vertebrates play crucial roles in shaping tropical forests, through processes such as seed dispersal, seed predation ...
Making up incapacity for work? How government officials, medical experts and disabled workers brought incapacity for work into being in the first Dutch social security law (1901-1967)

Dijkstra, Nathanje Daniëlle (Utrecht University, 2024-01-12)

In 1901 the Ongevallenwet, the first act regulating the insurance of workers in cases of accidents, was introduced in the Netherlands. In the historiography of the welfare state, introductions of acts like the Ongevallenwet ...
Profiling epigenetic modifications and lineage specifications using single-cell multi-omics

Blotenburg, Marloes (Utrecht University, 2024-01-10)

Developmental biology studies the processes that take place when a fully formed organism arises from just one single cell. At the level of gene regulation, the correct genetic programs need to be switched on and alternative ...

Now showing items 5361-5380 of 95693