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UMC Repository: Recent submissions

  • Longitudinal profile of circulating endothelial cells in post-acute coronary syndrome patients 
    de Bakker, Marie; Kraan, Jaco; Akkerhuis, K. Martijn; Oemrawsingh, Rohit; Asselbergs, Folkert W.; Hoefer, Imo; Kardys, Isabella; Boersma, Eric (Informa Healthcare, 2023-03)
    Introduction Patients who have experienced an acute coronary syndrome (ACS) are at risk of a recurrent event, but their level of risk varies. Because of their close temporal relationship with vascular injury, longitudinal ...
  • Optimizing Antiviral Dosing for HSV and CMV Treatment in Immunocompromised Patients 
    Huntjens, Daan W.; Dijkstra, Jacob A.; Verwiel, Lisanne N.; Slijkhuis, Mirjam; Elbers, Paul; Welkers, Matthijs R.A.; Veldkamp, Agnes I.; Kuijvenhoven, Marianne A.; de Leeuw, David C.; Abdullah-Koolmees, Heshu; Kuipers, Maria T.; Bartelink, Imke H. (Multidisciplinary Digital Publishing Institute, 2023-01)
    Herpes simplex virus (HSV) and cytomegalovirus (CMV) are DNA viruses that are common among humans. Severely immunocompromised patients are at increased risk of developing HSV or CMV disease due to a weakened immune system. ...
  • Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine 
    Heinken, Almut; Hertel, Johannes; Acharya, Geeta; Ravcheev, Dmitry A.; Nyga, Malgorzata; Okpala, Onyedika Emmanuel; Hogan, Marcus; Magnúsdóttir, Stefanía; Martinelli, Filippo; Nap, Bram; Preciat, German; Edirisinghe, Janaka N.; Henry, Christopher S.; Fleming, Ronan M.T.; Thiele, Ines (Nature Research, 2023-09)
    The human microbiome influences the efficacy and safety of a wide variety of commonly prescribed drugs. Designing precision medicine approaches that incorporate microbial metabolism would require strain- and molecule-resolved, ...
  • A surprising finding: The curious case of a tongue lesion misdiagnosed as paracoccidioidomycosis 
    Gerrits van den Ende, Bert; Rodrigues, Anderson Messias; Hahn, Rosane Christine; Hagen, Ferry (Asociacion Espanola de Micologia, 2023-01)
    Background: Paracoccidioidomycosis is an endemic mycosis caused by members of the Paracoccidioides genus. Brazil remains the focus area and, to a lesser extent, the disease has been reported from Argentina, Colombia and ...
  • Alternatives and reduced need for sentinel lymph node biopsy (SLNB) staging for melanoma 
    van Akkooi, Alexander C.J.; Schadendorf, Dirk; Center München, Munich, Germany, Comprehensive (Elsevier Limited, 2023-03)
    Sentinel lymph node biopsy (SLNB) has been introduced in the 1990s to identify patients who might benefit from completion lymph node dissection. Neither SLNB nor CLND improved survival, but SLNB staging did provide the ...
  • Genome-wide RNA polymerase stalling shapes the transcriptome during aging 
    Gyenis, Akos; Chang, Jiang; Demmers, Joris J.P.G.; Bruens, Serena T.; Barnhoorn, Sander; Brandt, Renata M.C.; Baar, Marjolein P.; Raseta, Marko; Derks, Kasper W.J.; Hoeijmakers, Jan H.J.; Pothof, Joris (Nature Research, 2023-02)
    Gene expression profiling has identified numerous processes altered in aging, but how these changes arise is largely unknown. Here we combined nascent RNA sequencing and RNA polymerase II chromatin immunoprecipitation ...
  • Protocol for an extended scoping review on the use of virtual nominal group technique in research 
    Humphrey-Murto, Susan; Lee, Seung Ho; Gottlieb, Michael; Horsley, Tanya; Shea, Bev; Fournier, Karine; Tran, Christopher; Chan, Teresa; Wood, Timothy J.; Ten Cate, Olle (Public Library of Science, 2023-01)
    Introduction Consensus group methods such as the Nominal Group Technique (NGT) and Delphi method are commonly used in research to elicit and synthesize expert opinions when evidence is lacking. Traditionally, the NGT ...
  • Subjective outcomes 12 years after transvaginal mesh versus native tissue repair in women with recurrent pelvic organ prolapse; a randomized controlled trial 
    Kluivers, Kirsten B.; Kamping, Metteke; Milani, Alfredo L.; IntHout, Joanna; Withagen, Mariella I. (Springer Nature, 2023-07)
    Introduction and hypothesis: The present study describes an extended follow-up study after 12 years and focusses on subjective outcomes of women who underwent surgery for recurrent pelvic organ prolapse in the randomized ...
  • Catecholaminergic and cholinergic neuromodulation in autism spectrum disorder: A comparison to attention-deficit hyperactivity disorder 
    Koevoet, Damian; Deschamps, P. K.H.; Kenemans, J. L. (Frontiers Media S. A., 2023-01-06)
    Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterized by social impairments and restricted, repetitive behaviors. Treatment of ASD is notoriously difficult and might benefit from ...
  • The orchestration of gene expression and the editing role of microRNA 
    Fossum, M.; Kaefer, M.; Herbst, K. W.; Harper, L.; Beckers, G. M.A.; Nelson, C. P.; Garriboli, M.; Nieuwhof-Leppink, A.; Bagli, D.; Kalfa, N.; ESPU Research Committee (Elsevier, 2023-06)
    In this short educational communication the ESPU Research Committee presents the role of non-coding RNA and how these can affect gene expression. In particular we discuss the role of microRNA on post transcriptional changes ...
  • Oral microbiota analyses of Saudi sickle cell anemics with dental caries 
    Alyousef, Yousef M.; Alonaizan, Faisal A.; Alsulaiman, Ahmed A.; Aldarwish, Mohammed I.; Alali, Ali A.; Almasood, Naif N.; Vatte, Chittibabu; Cyrus, Cyril; Habara, Alawi H.; Koeleman, Bobby P.C. (Elsevier, 2023-02)
    Objectives: The objectives of this study were to identify the composition of oral microbiota in a cohort of patients with sickle cell anemia (SCA) and a high mean number of decayed, missing, and filled permanent teeth ...
  • Diabetes patient preferences for glucose-monitoring technologies: Results from a discrete choice experiment in Poland and the Netherlands 
    Smith, Ian P.; Whichello, Chiara L.; Veldwijk, Jorien; Rutten-Van Mölken, Maureen P.M.H.; Groothuis-Oudshoorn, C. G.M.; Vos, Rimke C.; De Bekker-Grob, Esther W.; De Wit, G. Ardine (BMJ Publishing Group, 2023-01-17)
    Introduction New glucose-monitoring technologies have different cost-benefit profiles compared with traditional finger-prick tests, resulting in a preference-sensitive situation for patients. This study aimed to assess the ...
  • Assessing Performance and Clinical Usefulness in Prediction Models with Survival Outcomes: Practical Guidance for Cox Proportional Hazards Models 
    McLernon, David J.; Giardiello, Daniele; Van Calster, Ben; Wynants, Laure; van Geloven, Nan; van Smeden, Maarten; Therneau, Terry; Steyerberg, Ewout W.; Topic Groups 6 and 8 of The STRATOS Initiative (American College of Physicians, 2023-01-01)
    Risk prediction models need thorough validation to assess their performance. Validation of models for survival outcomes poses challenges due to the censoring of observations and the varying time horizon at which predictions ...
  • Surgery and Behavioral Testing in the Tibial Neuroma Transposition Model in Rats 
    Brakkee, Elisabeth Maria; Devinney, Erick; Eijkelkamp, Niels; Coert, J. Henk (MYJoVE Corporation, 2023-01)
    The tibial neuroma transposition (TNT) is a rat model in which allodynia at the neuroma site (tibial nerve) can be independently evaluated from allodynia at the plantar surface of the hind paw innervated by the intact sural ...
  • Muscle strength trajectories and their association with postoperative health-related quality of life in patients undergoing coronary artery bypass grafting surgery: a prospective cohort study 
    Hartog, Johanneke; Dijkstra, Sandra; Dieperink, Willem; Hoekstra, Trynke; Fleer, Joke; van der Woude, Lucas H.V.; van der Harst, Pim; Nijsten, Maarten; Mariani, Massimo A.; Blokzijl, Fredrike (BioMed Central, 2023-12)
    Background: Patients with sarcopenia have a higher risk of poor recovery after coronary artery bypass grafting (CABG). Little is known about the impact of changes in muscle strength (the primary indicator for sarcopenia) ...
  • Risk prediction of atrial fibrillation and its complications in the community using hs troponin I 
    Börschel, Christin S.; Geelhoed, Bastiaan; Niiranen, Teemu; Camen, Stephan; Donati, Maria Benedetta; Havulinna, Aki S.; Gianfagna, Francesco; Palosaari, Tarja; Jousilahti, Pekka; Kontto, Jukka; Vartiainen, Erkki; Ojeda, Francisco M.; den Ruijter, Hester M.; Costanzo, Simona; de Gaetano, Giovanni; Di Castelnuovo, Augusto; Linneberg, Allan; Vishram-Nielsen, Julie K.; Løchen, Maja Lisa; Koenig, Wolfgang; Jørgensen, Torben; Kuulasmaa, Kari; Blankenberg, Stefan; Iacoviello, Licia; Zeller, Tanja; Söderberg, Stefan; Salomaa, Veikko; Schnabel, Renate B. (Wiley-Blackwell, 2023-05)
    Aims: Atrial fibrillation (AF) is becoming increasingly common. Traditional cardiovascular risk factors (CVRF) do not explain all AF cases. Blood-based biomarkers reflecting cardiac injury such as high-sensitivity troponin ...
  • Intrinsic capacity and resilience: Taking frailty to the next level 
    Hamaker, Marije; Gijzel, Sanne; Rostoft, Siri; van den Bos, Frederiek (Elsevier, 2023-03)
    In addition to frailty, two novel concepts have been introduced in the field of geriatrics to capture the heterogeneous ageing process: the first is intrinsic capacity, which uses a community-based, holistic approach and ...
  • Outcomes of COVID-19 in peritoneal dialysis patients: A report by the European Renal Association COVID-19 Database 
    Abrahams, Alferso C.; Noordzij, Marlies; Goffin, Eric; Sanchez, J. Emilio; Franssen, Casper F.M.; Vart, Priya; Jager, Kitty J.; van Agteren, Madelon; Covic, Adrian; Mitra, Sandip; Basile, Carlo; Konings, Constantijn; Hemmelder, Marc H.; Duivenvoorden, Raphaël; Hilbrands, Luuk B.; Gansevoort, Ron T.; ERACODA Collaborators (Multimed Inc., 2023-01)
    Background: The clinical course of COVID-19 in peritoneal dialysis (PD) patients has so far only been analysed in relatively small, often single-centre case series. Therefore, we studied patient- and disease-related ...
  • PRISMA AI reporting guidelines for systematic reviews and meta-analyses on AI in healthcare 
    Cacciamani, Giovanni E.; Chu, Timothy N.; Sanford, Daniel I.; Abreu, Andre; Duddalwar, Vinay; Oberai, Assad; Kuo, C. C.Jay; Liu, Xiaoxuan; Denniston, Alastair K.; Vasey, Baptiste; McCulloch, Peter; Wolff, Robert F.; Mallett, Sue; Mongan, John; Kahn, Charles E.; Sounderajah, Viknesh; Darzi, Ara; Dahm, Philipp; Moons, Karel G.M.; Topol, Eric; Collins, Gary S.; Moher, David; Gill, Inderbir S.; Hung, Andrew J. (Nature Research, 2023-01-16)
  • Sex-stratified differences in early antithrombotic treatment response in patients presenting with ST-segment elevation myocardial infarction 
    Delewi, Ronak; Vogel, Rosanne F.; Wilschut, Jeroen M.; Lemmert, Miguel E.; Diletti, Roberto; van Vliet, Ria; van der Waarden, Nancy W.P.L.; Nuis, Rutger Jan; Paradies, Valeria; Alexopoulos, Dimitrios; Zijlstra, Felix; Montalescot, Gilles; Angiolillo, Dominick J.; Krucoff, Mitchell W.; Doevendans, Pieter A.; Van Mieghem, Nicolas M.; Smits, Pieter C.; Vlachojannis, Georgios J. (Mosby Inc., 2023-04)
    Background: The mechanisms underlying the increased risk of bleeding that female patients with ST-segment Elevation Myocardial Infarction (STEMI) exhibit, remains unclear. The present report assessed sex-related differences ...