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UMC Repository: Recent submissions

  • Complex housing in adulthood state-dependently affects the excitation-inhibition balance in the infralimbic prefrontal cortex of male C57Bl/6 mice 
    Karst, Henk; Riera Llobet, Arianna; Joëls, Marian; van der Veen, Rixt (Elsevier, 2025-01-05)
    The prefrontal cortex (PFC) plays an important role in social behavior and is sensitive to stressful circumstances. Challenging life conditions might change PFC function and put individuals at risk for maladaptive social ...
  • Investigation of advanced mindfulness meditation “cessation” experiences using EEG spectral analysis in an intensively sampled case study 
    Chowdhury, Avijit; van Lutterveld, Remko; Laukkonen, Ruben E.; Slagter, Heleen A.; Ingram, Daniel M.; Sacchet, Matthew D. (Elsevier Limited, 2023-11-05)
    Mindfulness meditation is a contemplative practice informed by Buddhism that targets the development of present-focused awareness and non-judgment of experience. Interest in mindfulness is burgeoning, and it has been shown ...
  • A Framework for the Empirical Investigation of Mindfulness Meditative Development 
    Galante, Julieta; Grabovac, Andrea; Wright, Malcolm; Ingram, Daniel M.; Van Dam, Nicholas T.; Sanguinetti, Joseph L.; Sparby, Terje; van Lutterveld, Remko; Sacchet, Matthew D. (Springer-Verlag, 2023-05)
    Millions of people globally have learned mindfulness meditation with the goal of improving health and well-being outcomes in both clinical and non-clinical contexts. An estimated half of these practitioners follow mindfulness ...
  • Clostridioides difficile infection (CDI): A pan-European multi-center cost and resource utilization study, results from the Combatting Bacterial Resistance in Europe CDI (COMBACTE-CDI) 
    Wingen-Heimann, Sebastian M.; Davies, Kerrie; Viprey, Virginie F.; Davis, Georgina; Wilcox, Mark H.; Vehreschild, Maria J.G.T.; Lurienne, Lise; Bandinelli, Pierre Alain; Cornely, Oliver A.; Vilken, Tuba; Hopff, Sina M.; Vehreschild, Jörg Janne; Bonten, Marc; COMBACTE-CDI consortium (Elsevier, 2023-05)
    Objectives: Clostridioides difficile infection (CDI) is one of the leading nosocomial infections worldwide, resulting in a significantly increasing burden on the healthcare systems. However, Pan-European data about cost ...
  • An advanced in vitro human mucosal immune model to predict food sensitizing allergenicity risk: A proof of concept using ovalbumin as model allergen 
    Zuurveld, Marit; Díaz, Cristina Bueno; Redegeld, Frank; Folkerts, Gert; Garssen, Johan; van’t Land, Belinda; Willemsen, Linette E.M. (Frontiers Media S. A., 2023-01-09)
    Background: The global demand of sustainable food sources leads to introduction of novel foods on the market, which may pose a risk of inducing allergic sensitization. Currently there are no validated in vitro assays ...
  • SCUBA Diving in Adult Congenital Heart Disease 
    Kauling, Robert M.; Rienks, Rienk; Cuypers, Judith A.A.E.; Jorstad, Harald T.; Roos-Hesselink, Jolien W. (MDPI AG, 2023-01)
    Conventionally, scuba diving has been discouraged for adult patients with congenital heart disease (ACHD). This restrictive sports advice is based on expert opinion in the absence of high-quality diving-specific studies. ...
  • Possible nephrotoxic effects of high dose statin therapy; current knowledge 
    Ahmadizar, Fariba; Rahmanian, Mehrdad; Jalali, Zahra; Joseph, Akshaya; Foroutan, Majid (Society of Diabetic Nephropathy Prevention, 2023)
    Implication for health policy/practice/research/medical education: The 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) inhibitors (i.e., statins) offer several cardiovascular health benefits, however, ...
  • CD4+ and CD8+ T cell behavior in the landscape of intestinal damage 
    Cutilli, A (Utrecht University, 2024-10-17)
    Intestinal damage can be the result of different types of injury, for instance resulting from chemotherapy or sustained inflammation. This thesis investigates the behavior of CD4+ and CD8+ T lymphocytes in the context of ...
  • Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure 
    Hollestein, Viola; Poelmans, Geert; Forde, Natalie J.; Beckmann, Christian F.; Ecker, Christine; Mann, Caroline; Schäfer, Tim; Moessnang, Carolin; Baumeister, Sarah; Banaschewski, Tobias; Bourgeron, Thomas; Loth, Eva; Dell’Acqua, Flavio; Murphy, Declan G.M.; Puts, Nicolaas A.; Tillmann, Julian; Charman, Tony; Jones, Emily J.H.; Mason, Luke; Ambrosino, Sara; Holt, Rosemary; Bölte, Sven; Buitelaar, Jan K.; Naaijen, Jilly (Nature Publishing Group, 2023-12)
    The excitatory/inhibitory (E/I) imbalance hypothesis posits that imbalance between excitatory (glutamatergic) and inhibitory (GABAergic) mechanisms underlies the behavioral characteristics of autism. However, how E/I ...
  • Comparing Remote Speckle Plethysmography and Finger-Clip Photoplethysmography with Non-Invasive Finger Arterial Pressure Pulse Waves, Regarding Morphology and Arrival Time 
    Herranz Olazabal, Jorge; Wieringa, Fokko; Hermeling, Evelien; Van Hoof, Chris (MDPI AG, 2023-01)
    Objective: The goal was to compare Speckle plethysmography (SPG) and Photoplethysmography (PPG) with non-invasive finger Arterial Pressure (fiAP) regarding Pulse Wave Morphology (PWM) and Pulse Arrival Time (PAT). Methods: ...
  • Updated clinical practice recommendations for managing children with 22q11.2 deletion syndrome 
    Óskarsdóttir, Sólveig; Boot, Erik; Crowley, Terrence Blaine; Loo, Joanne C.Y.; Arganbright, Jill M.; Armando, Marco; Baylis, Adriane L.; Breetvelt, Elemi J.; Castelein, René M.; Chadehumbe, Madeline; Cielo, Christopher M.; de Reuver, Steven; Eliez, Stephan; Fiksinski, Ania M.; Forbes, Brian J.; Gallagher, Emily; Hopkins, Sarah E.; Jackson, Oksana A.; Levitz-Katz, Lorraine; Klingberg, Gunilla; Lambert, Michele P.; Marino, Bruno; Mascarenhas, Maria R.; Moldenhauer, Julie; Moss, Edward M.; Nowakowska, Beata Anna; Orchanian-Cheff, Ani; Putotto, Carolina; Repetto, Gabriela M.; Schindewolf, Erica; Schneider, Maude; Solot, Cynthia B.; Sullivan, Kathleen E.; Swillen, Ann; Unolt, Marta; Van Batavia, Jason P.; Vingerhoets, Claudia; Vorstman, Jacob; Bassett, Anne S.; McDonald-McGinn, Donna M. (Lippincott Williams & Wilkins, 2023-03)
    This review aimed to update the clinical practice guidelines for managing children and adolescents with 22q11.2 deletion syndrome (22q11.2DS). The 22q11.2 Society, the international scientific organization studying chromosome ...
  • Risk factors for cerebral palsy and movement difficulties in 5-year-old children born extremely preterm 
    Aubert, Adrien M.; Costa, Raquel; Johnson, Samantha; Aden, U.; Cuttini, M.; Koopman-Esseboom, C.; Lebeer, Jo; Varendi, H.; Zemlin, Michael; Pierrat, V.; Zeitlin, Jennifer; the SHIPS Research group (Lippincott Williams & Wilkins, 2023-08)
    Background: Motor impairment is common after extremely preterm (EPT, <28 weeks’ gestational age (GA)) birth, with cerebral palsy (CP) affecting about 10% of children and non-CP movement difficulties (MD) up to 50%. This ...
  • Updated clinical practice recommendations for managing adults with 22q11.2 deletion syndrome 
    Boot, Erik; Óskarsdóttir, Sólveig; Loo, Joanne C.Y.; Crowley, Terrence Blaine; Orchanian-Cheff, Ani; Andrade, Danielle M.; Arganbright, Jill M.; Castelein, René M.; Cserti-Gazdewich, Christine; de Reuver, Steven; Fiksinski, Ania M.; Klingberg, Gunilla; Lang, Anthony E.; Mascarenhas, Maria R.; Moss, Edward M.; Nowakowska, Beata Anna; Oechslin, Erwin; Palmer, Lisa; Repetto, Gabriela M.; Reyes, Nikolai Gil D.; Schneider, Maude; Silversides, Candice; Sullivan, Kathleen E.; Swillen, Ann; van Amelsvoort, Therese A.M.J.; Van Batavia, Jason P.; Vingerhoets, Claudia; McDonald-McGinn, Donna M.; Bassett, Anne S. (Lippincott Williams & Wilkins, 2023-03)
    This review aimed to update the clinical practice guidelines for managing adults with 22q11.2 deletion syndrome (22q11.2DS). The 22q11.2 Society recruited expert clinicians worldwide to revise the original clinical practice ...
  • Predictors of adverse diastolic remodeling in non-diabetic patients presenting with ST-elevation myocardial infarction 
    Al Ali, Lawien; Groot, Hilde E.; Assa, Solmaz; Lipsic, Erik; Hummel, Yoran M.; van Veldhuisen, Dirk J.; Voors, Adriaan A.; van der Horst, Iwan C.C.; Lam, Carolyn S.; van der Harst, Pim (BioMed Central, 2023-12)
    Background: Adverse systolic remodeling after ST-elevation myocardial infarction (STEMI) is associated with poor clinical outcomes. However, little is known about diastolic remodeling. The purpose of this study was to ...
  • Frequent hemodialysis versus standard hemodialysis for people with kidney failure: Systematic review and meta-analysis of randomized controlled trials 
    Natale, Patrizia; Green, Suetonia C; Rose, Matthias; Bots, Michiel L; Blankestijn, Peter J; Vernooij, Robin W M; Gerittsen, Karin; Woodward, Mark; Hockham, Carinna; Cromm, Krister; Barth, Claudia; Davenport, Andrew; Hegbrant, Jörgen; Sarafidis, Pantelis; Das, Partha; Wanner, Christoph; Nissenson, Allan R; Sautenet, Benedicte; Török, Marietta; Strippoli, Giovanni (Public Library of Science, 2024-09-06)
    BACKGROUND: Frequent hemodialysis provided more than three times per week may lower mortality and improve health-related quality of life. Yet, the evidence is inconclusive. We evaluated the benefits and harms of frequent ...
  • Integrative genetic analysis illuminates ALS heritability and identifies risk genes 
    Megat, Salim; Mora, Natalia; Sanogo, Jason; Roman, Olga; Catanese, Alberto; Alami, Najwa Ouali; Freischmidt, Axel; Mingaj, Xhuljana; De Calbiac, Hortense; Muratet, François; Dirrig-Grosch, Sylvie; Dieterle, Stéphane; Van Bakel, Nick; Müller, Kathrin; Sieverding, Kirsten; Weishaupt, Jochen; Andersen, Peter Munch; Weber, Markus; Neuwirth, Christoph; Margelisch, Markus; Sommacal, Andreas; Van Eijk, Kristel R.; Veldink, Jan H.; Lautrette, Géraldine; Couratier, Philippe; Camuzat, Agnès; Le Ber, Isabelle; Grassano, Maurizio; Chio, Adriano; Boeckers, Tobias; Ludolph, Albert C.; Roselli, Francesco; Yilmazer-Hanke, Deniz; Millecamps, Stéphanie; Kabashi, Edor; Storkebaum, Erik; Sellier, Chantal; Dupuis, Luc; Project MinE ALS Sequencing Consortium (Nature Publishing Group, 2023-12)
    Amyotrophic lateral sclerosis (ALS) has substantial heritability, in part shared with fronto-temporal dementia (FTD). We show that ALS heritability is enriched in splicing variants and in binding sites of 6 RNA-binding ...
  • Prediction Models for Tinnitus Presence and the Impact of Tinnitus on Daily Life: A Systematic Review 
    Rademaker, Maaike M.; Meijers, Sebastiaan M.; Smit, Adriana L.; Stegeman, Inge (Multidisciplinary Digital Publishing Institute (MDPI), 2023-01)
    The presence of tinnitus does not necessarily imply associated suffering. Prediction models on the impact of tinnitus on daily life could aid medical professionals to direct specific medical resources to those (groups of) ...
  • Drug Metabolism of Hepatocyte-like Organoids and Their Applicability in In Vitro Toxicity Testing 
    Bouwmeester, Manon C.; Tao, Yu; Proença, Susana; van Steenbeek, Frank G.; Samsom, Roos Anne; Nijmeijer, Sandra M.; Sinnige, Theo; van der Laan, Luc J.W.; Legler, Juliette; Schneeberger, Kerstin; Kramer, Nynke I.; Spee, Bart (Multidisciplinary Digital Publishing Institute (MDPI), 2023-01)
    Emerging advances in the field of in vitro toxicity testing attempt to meet the need for reliable human-based safety assessment in drug development. Intrahepatic cholangiocyte organoids (ICOs) are described as a donor-derived ...
  • Biotinylated Platelets: A Promising Labeling Technique? 
    van Wonderen, Stefan F.; van Baarle, Floor L.F.; de Bruin, Sanne; Peters, Anna L.; de Korte, Dirk; van Bruggen, Robin; Vlaar, Alexander P.J. (W.B. Saunders, 2023-04)
    Labeling of platelets (PLTs) is essential for research purposes, in order to measure the recovery and survival of transfused PLTs in vivo. Biotinylation is a promising new alternative to the gold standard of radioactive ...
  • Adherence to statin treatment in patients with familial hypercholesterolemia: A dynamic prediction model 
    Cupido, Arjen J.; Hof, Michel H.; de Boer, Lotte M.; Huijgen, Roeland; Stroes, Erik S.G.; Kastelein, John J.P.; Hovingh, G. Kees; Hutten, Barbara A. (Elsevier, 2023-03)
    Background: Statins are the primary therapy in patient with heterozygous familial hypercholesterolemia (HeFH). Non-adherence to statin therapy is associated with increased cardiovascular risk. Objective: We constructed a ...