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UMC Repository: Recent submissions

  • Novel high-intensive cholesterol-lowering therapies do not ameliorate knee OA development in humanized dyslipidemic mice 
    van Gemert, Y.; Kozijn, A. E.; Pouwer, M. G.; Kruisbergen, N. N.L.; van den Bosch, M. H.J.; Blom, A. B.; Pieterman, E. J.; Weinans, H.; Stoop, R.; Princen, H. M.G.; van Lent, P. L.E.M. (W.B. Saunders Ltd, 2021-09)
    Objective: High systemic cholesterol levels have been associated with osteoarthritis (OA) development. Therefore, cholesterol lowering by statins has been suggested as a potential treatment for OA. We investigated whether ...
  • Effects of human articular cartilage constituents on simultaneous diffusion of cationic and nonionic contrast agents 
    Bhattarai, Abhisek; Mäkelä, Janne T.A.; Pouran, Behdad; Kröger, Heikki; Weinans, Harrie; Grinstaff, Mark W.; Töyräs, Juha; Turunen, Mikael J. (John Wiley & Sons Inc., 2021-04)
    Contrast-enhanced computed tomography is an emerging diagnostic technique for osteoarthritis. However, the effects of increased water content, as well as decreased collagen and proteoglycan concentrations due to cartilage ...
  • Statistical shape modeling of the hip and the association with hip osteoarthritis: a systematic review 
    van Buuren, M. M.A.; Arden, N. K.; Bierma-Zeinstra, S. M.A.; Bramer, W. M.; Casartelli, N. C.; Felson, D. T.; Jones, G.; Lane, N. E.; Lindner, C.; Maffiuletti, N. A.; van Meurs, J. B.J.; Nelson, A. E.; Nevitt, M. C.; Valenzuela, P. L.; Verhaar, J. A.N.; Weinans, H.; Agricola, R. (W.B. Saunders Ltd, 2021-05)
    Objective: To summarize available evidence on the association between hip shape as quantified by statistical shape modeling (SSM) and the incidence or progression of hip osteoarthritis. Design: We conducted a systematic ...
  • Inside-out regulation of E-cadherin conformation and adhesion 
    Koirala, Ramesh; Priest, Andrew Vae; Yen, Chi-Fu; Cheah, Joleen S; Pannekoek, Willem-Jan; Gloerich, Martijn; Yamada, Soichiro; Sivasankar, Sanjeevi (National Academy of Sciences, 2021-07-27)
    Cadherin cell-cell adhesion proteins play key roles in tissue morphogenesis and wound healing. Cadherin ectodomains bind in two conformations, X-dimers and strand-swap dimers, with different adhesive properties. However, ...
  • Decoding mechanical cues by molecular mechanotransduction 
    Swaminathan, Vinay; Gloerich, Martijn (Elsevier Limited, 2021-10)
    Cells are exposed to a variety of mechanical cues, including forces from their local environment and physical properties of the tissue. These mechanical cues regulate a vast number of cellular processes, relying on a ...
  • An asymmetric junctional mechanoresponse coordinates mitotic rounding with epithelial integrity 
    Monster, Jooske L; Donker, Lisa; Vliem, Marjolein J; Win, Zaw; Matthews, Helen K; Cheah, Joleen S; Yamada, Soichiro; de Rooij, Johan; Baum, Buzz; Gloerich, Martijn (Rockefeller University Press, 2021-05-03)
    Epithelia are continuously self-renewed, but how epithelial integrity is maintained during the morphological changes that cells undergo in mitosis is not well understood. Here, we show that as epithelial cells round up ...
  • Evaluation of lexical clarification by patients reading their clinical notes: a quasi-experimental interview study 
    van Mens, Hugo J.T.; van Eysden, Mirte M.; Nienhuis, Remko; van Delden, Johannes J.M.; de Keizer, Nicolette F.; Cornet, Ronald (BioMed Central, 2020-12)
    Background: Patients benefit from access to their medical records. However, clinical notes and letters are often difficult to comprehend for most lay people. Therefore, functionality was implemented in the patient portal ...
  • Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 deletion syndrome 
    Davies, Robert W.; Fiksinski, Ania M.; Breetvelt, Elemi J.; Williams, Nigel M.; Hooper, Stephen R.; Monfeuga, Thomas; Bassett, Anne S.; Owen, Michael J.; Gur, Raquel E.; Morrow, Bernice E.; McDonald-McGinn, Donna M.; Swillen, Ann; Chow, Eva W.C.; van den Bree, Marianne; Emanuel, Beverly S.; Vermeesch, Joris R.; van Amelsvoort, Therese; Arango, Celso; Armando, Marco; Campbell, Linda E.; Cubells, Joseph F.; Eliez, Stephan; Garcia-Minaur, Sixto; Gothelf, Doron; Kates, Wendy R.; Murphy, Kieran C.; Murphy, Clodagh M.; Murphy, Declan G.; Philip, Nicole; Repetto, Gabriela M.; Shashi, Vandana; Simon, Tony J.; Suñer, Damiàn Heine; Vicari, Stefano; Scherer, Stephen W.; Epstein, Michael P.; Warren, Stephen T.; Morrison, Sinead; Chawner, Samuel; Vingerhoets, Claudia; Breckpot, Jeroen; Vergaelen, Elfi; Vogels, Annick; Monks, Stephen; Prasad, Sarah E.; Schneider, Maude; Duijff, Sasja N.; Kahn, René S.; Houben, Michiel; Vorstman, Jacob A.S.; International 22q11.2 Brain and Behavior Consortium (Nature Research, 2020-12)
    The 22q11.2 deletion syndrome (22q11DS) is associated with a 20–25% risk of schizophrenia. In a cohort of 962 individuals with 22q11DS, we examined the shared genetic basis between schizophrenia and schizophrenia-related ...
  • Consensus Statement on Public Involvement and Engagement with Data Intensive Health Research 
    Aitken, Mhairi; Tully, Mary P; Porteous, Carol; Denegri, Simon; Cunningham-Burley, Sarah; Banner, Natalie; Black, Corri; Burgess, Michael; Cross, Lynsey; Ford, Elizabeth; Fox, Sarah; Fitzpatrick, Natalie K; Gallacher, Kay; Goddard, Catharine; Hassan, Lamiece; Jamieson, Ron; Jones, Kerina H; Kaarakainen, Minna; Lugg-Widger, Fiona; McGrail, Kimberlyn; McKenzie, Anne; Moran, Rosalyn; Murtagh, Madeleine J; Oswald, Malcolm; Paprica, Alison; Perrin, Nicola; Richards, Emma Victoria; Rouse, John; Webb, Joanne; Willison, Donald J; van Delden, J.J. (Swansea University, 2019-02-12)
  • Parental attitude toward the prenatal diagnosis of oral cleft: A prospective cohort study 
    Maarse, Wies; Boonacker, Chantal W.B.; De Veye, Henriette F.N.Swanenburg; Kon, Moshe; Breugem, Corstiaan C.; van der Molen, Aebele B.Mink; van Delden, Johannes J.M. (SAGE Publications Ltd, 2018-09)
    Objectives: The prenatal diagnosis of oral clefts (OCs) by ultrasound can pose an ethical dilemma. The purpose of this study was to obtain insight into the psychosocial and moral considerations of prospective parents ...
  • Trends in end-of-life practices before and after the enactment of the euthanasia law in the Netherlands from 1990 to 2010: A repeated cross-sectional survey 
    Onwuteaka-Philipsen, Bregje D.; Brinkman-Stoppelenburg, Arianne; Gwen, Corine Penning; De Jong-Krul, J. F.; Van Delden, Johannes J.M.; Van Der Heide, Agnes (Elsevier, 2012-09)
    Background In 2002, the euthanasia act came into eff ect in the Netherlands, which was followed by a slight decrease in the euthanasia frequency. We assessed frequency and characteristics of euthanasia, physician-assisted ...
  • Preemptive use of palliative sedation and amyotrophic lateral sclerosis 
    Rietjens, Judith A.C.; Swart, Siebe J.; Van Delden, Johannes J.M.; Van Der Heide, Agnes (Elsevier, 2012-09)
  • Effects of progestins on the proliferation of estrogen-dependent human breast cancer cells under growth factor-defined conditions 
    van der Burg, Bart; Kalkhoven, Eric; Isbrücker, Linda; de Laat, Siegfried W. (Elsevier Limited, 1992-06)
    The effect was studied of four different synthetic progestins (Org 30659, gestodene, 3-ketodesogestrel and levonorgestrel) on the proliferation of the 17β estradiol (E2)-dependent human breast cancer cell line MCF7. All ...
  • Response to the Letter by Frantz and Bauersachs 
    Timmers, Leo; De Kleijn, Dominique P.V. (Lippincott Williams & Wilkins, 2009-06-05)
  • The multidisciplinary team approach in cardiovascular care 
    Hendriks, Jeroen M; Jaarsma, Tiny (Elsevier, 2021-02-01)
  • Self-care research: How to grow the evidence base? (reprint) 
    Jaarsma, T; Strömberg, A; Dunbar, S B; Fitzsimons, D; Lee, C; Middleton, S; Vellone, E; Freedland, K E; Riegel, B (Elsevier Limited, 2021-04)
    BACKGROUND AND OBJECTIVE: The number of studies in the area of self-care is growing and international researchers are increasingly developing self-care interventions to improve outcomes of individual patients and communities. ...
  • Correction to: Patient Preferences in Rare Diseases: A Qualitative Study in Neuromuscular Disorders to Inform a Quantitative Preference Study 
    Jimenez-Moreno, A. Cecilia; van Overbeeke, Eline; Pinto, Cathy Anne; Smith, Ian; Sharpe, Jenny; Ormrod, James; Whichello, Chiara; de Bekker-Grob, Esther W.; Bullok, Kristin; Levitan, Bennett; Huys, Isabelle; de Wit, G. Ardine; Gorman, Grainne (ADIS INT LTD, 2021-09)
    The article Patient Preferences in Rare Diseases: A Qualitative Study in Neuromuscular Disorders to Inform a Quantitative Preference Study, written by A. Cecilia Jimenez- Moreno, Eline van Overbeeke, Cathy Anne Pinto4, Ian ...
  • Expanding lipid nanoparticle platforms for effective mRNA therapeutics 
    Estapé Sentí, Mariona (Utrecht University, 2024-10-18)
    Small molecule drugs have been the cornerstone of drug development for decades, offering treatments for various conditions and significantly improving countless lives. However, traditional drug development faces challenges ...
  • Efficacy of Biphasic Calcium Phosphate Ceramic With a Needle-shaped Surface Topography Versus Autograft in Instrumented Posterolateral Spinal Fusion: A Randomized Trial 
    Stempels, Hilde W; Lehr, A Mechteld; Delawi, Diyar; Hoebink, Eric A; Wiljouw, Inge A A A; Kempen, Diederik H R; van Susante, Job L C; Kruyt, Moyo C; Dutch Clinical Spine Research Group (Lippincott Williams & Wilkins, 2024-10-01)
    Study Design. A multicenter randomized controlled noninferiority trial with intrapatient comparisons. Objective. The aim of this study was to determine noninferiority of a slowly resorbable biphasic calcium phosphate with ...
  • Access to highly effective long-acting RSV-monoclonal antibodies for children in LMICs—reducing global inequity 
    Zar, Heather J.; Piccolis, Manuele; Terstappen, Jonne; Mazur, Natalie I.; Gaayeb, Lobna; Morin, Sébastien; Bont, Louis (Elsevier, 2024-10)