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Now showing items 4261-4280 of 40729

Associations between lifestyle and amyotrophic lateral sclerosis stratified by C9orf72 genotype: a longitudinal, population-based, case-control study

Westeneng, Henk Jan; van Veenhuijzen, Kevin; van der Spek, Rick A.; Peters, Susan; Visser, Anne E.; van Rheenen, Wouter; Veldink, Jan H.; van den Berg, Leonard H. (Elsevier Limited, 2021-05)

Background: Amyotrophic lateral sclerosis (ALS) is considered to be caused by both genetic and environmental factors. The causal cascade is, however, not known. We aimed to assess lifestyle during the presymptomatic phase ...
Allele-specific expression of GATA2 due to epigenetic dysregulation in CEBPA double-mutant AML

Mulet-Lazaro, Roger; van Herk, Stanley; Erpelinck, Claudia; Bindels, Eric; Sanders, Mathijs A.; Vermeulen, Carlo; Renkens, Ivo; Valk, Peter; Melnick, Ari M.; de Ridder, Jeroen; Rehli, Michael; Gebhard, Claudia; Delwel, Ruud; Wouters, Bas J. (Elsevier, 2021-07-15)

Transcriptional deregulation is a central event in the development of acute myeloid leukemia (AML). To identify potential disturbances in gene regulation, we conducted an unbiased screen of allele-specific expression (ASE) ...
Predicting pathogenic non-coding SVs disrupting the 3D genome in 1646 whole cancer genomes using multiple instance learning

Nieboer, Marleen M.; Nguyen, Luan; de Ridder, Jeroen (Nature Publishing Group, 2021-12)

Over the past years, large consortia have been established to fuel the sequencing of whole genomes of many cancer patients. Despite the increased abundance in tools to study the impact of SNVs, non-coding SVs have been ...
Developing new ways to listen: the value of narrative approaches in empirical (bio)ethics

Roest, Bernadette; Milota, Megan; Leget, Carlo (BioMed Central, 2021-09-16)

The use of qualitative research in empirical bioethics is becoming increasingly popular, but its implementation comes with several challenges, such as difficulties in aligning moral epistemology and methods. In this paper, ...
Emerging roles for chemokines and cytokines as orchestrators of immunopathology in Sjögren's syndrome

Blokland, Sofie L.M.; Flessa, Christina Maria; Van Roon, Joel A.G.; Mavragani, Clio P. (Oxford University Press, 2021-07-01)

In primary SS (pSS), chemokines and cytokines orchestrate immunopathology driven by a complex network of interacting inflammatory cells. In recent years, the importance of chemotactic and non-chemotactic cytokines that ...
An exploration of available methods and tools to improve the efficiency of systematic review production: a scoping review

Affengruber, Lisa; van der Maten, Miriam M.; Spiero, Isa; Nussbaumer-Streit, Barbara; Mahmić-Kaknjo, Mersiha; Ellen, Moriah E.; Goossen, Käthe; Kantorova, Lucia; Hooft, Lotty; Riva, Nicoletta; Poulentzas, Georgios; Lalagkas, Panagiotis Nikolaos; Silva, Anabela G.; Sassano, Michele; Sfetcu, Raluca; Marqués, María E.; Friessova, Tereza; Baladia, Eduard; Pezzullo, Angelo Maria; Martinez, Patricia; Gartlehner, Gerald; Spijker, René (BioMed Central, 2024-09-18)

Background: Systematic reviews (SRs) are time-consuming and labor-intensive to perform. With the growing number of scientific publications, the SR development process becomes even more laborious. This is problematic because ...
Synergistic effects of oxidative and acid stress on bacterial membranes of Escherichia coli and Staphylococcus simulans

Xie, Min; Koch, Eveline H.W.; Walree, Cornelis A.van; Sobota, Ana; Sonnen, Andreas F.P.; Killian, J. Antoinette; Breukink, Eefjan; Lorent, Joseph H. (Springer Nature, 2024-09-17)

Oxidative stress in combination with acid stress has been shown to inactivate a wide spectrum of microorganisms, including multi-resistant bacteria. This occurs e.g. in phagolysosomes or during treatment by cold atmospheric ...
Evidence of survival bias in the association between APOE-Є4 and age at ischemic stroke onset

von Berg, Joanna; McArdle, Patrick F.; Häppölä, Paavo; Haessler, Jeffrey; Kooperberg, Charles; Lemmens, Robin; Pezzini, Alessandro; Thijs, Vincent; Pulit, Sara L.; Kittner, Steven J.; Mitchell, Braxton D.; de Ridder, Jeroen; van der Laan, Sander W.; SiGN, FinnGen, Women’s Health Initiative (Frontiers Media S. A., 2024-09-02)

Introduction: Large genome-wide association studies (GWASs) using case–control study designs have now identified tens of loci associated with ischemic stroke (IS). As a complement to these studies, we performed GWAS in a ...
Additional predictors of stroke and transient ischaemic attack in BEFAST positive patients in out-of-hours emergency primary care

van Royen, Florien S; Geersing, Geert-Jan; Erkelens, Daphne C; Delissen, Mathé; Rutten, Jorn V F; Zwart, Dorien L; van Smeden, Maarten; Rutten, Frans H; van Doorn, Sander (Public Library of Science, 2024-09)

Introduction In patients suspected of stroke or transient ischemic attack (TIA), rapid triaging is imperative to improve clinical outcomes. For this purpose, balance-eye-face-arm-speech-time (BEFAST) items are used in ...
An assessment of the moral value of neuronal cell models and brain organoids

van Till, Sietske A.L.; Maksimova, Mariia; van Thiel, Ghislaine JMW; Bunnik, Eline M. (2023-07-10)

Advances in stem cell technology enable neuroscientists to develop induced pluripotent stem cell (iPSC)-based neuronal models of varying complexity, ranging from single human brain cells to two-dimensional neuronal cell ...
“Your brain can’t wait”: perspectives of children and adolescents with acquired brain injury and their parents on physical rehabilitation during the subacute phase

Gmelig Meyling, Christiaan; Verschuren, Olaf; Rentinck, Ingrid C.M.; van Driel, Dimara; te Slaa, Esmée; Engelbert, Raoul H.; Gorter, Jan Willem (Informa Healthcare, 2024)

Purpose: Physical interventions during subacute rehabilitation have potential to improve functional recovery. This study explored the perspectives of children and adolescents with acquired brain injury (ABI) and their ...
Voice Outcome After Carbon Dioxide Transoral Laser Microsurgery for Glottic Cancer According to the European Laryngological Society Classification of Cordectomy Types - A Systematic Review

Sjogren, Elisabeth; Hendriksma, Martine; Piazza, Cesare; Hartl, Dana M; Suarez, Carlos; Cohen, Oded; de Bree, Remco; Quer, Miquel; Poorten, Vincent Vander; Rodrigo, Juan Pablo; Civantos, Francisco; Genden, Eric; Kowalski, Luiz P; Makitie, Antti; Shaha, Ashok; Takes, Robert P; Sanabria, Alvaro; Guntinas-Lichius, Orlando; Rinaldo, Alessandra; Ferlito, Alfio (Mosby Inc., 2024-09)

BACKGROUND: Voice outcome after carbon dioxide transoral laser microsurgery (CO2TOLMS) for glottic cancer is of prime importance. However, a comprehensive overview according to the European Laryngological Society (ELS) ...
Sex Differences in Mortality Risk after the First Hospitalisation with Lower Extremity Peripheral Arterial Disease

Porras, Cindy P; de Boer, Annemarijn R; Koop, Yvonne; Vaartjes, Ilonca; Teraa, Martin; Hazenberg, Constantijn E V B; Verhaar, Marianne C; Vernooij, Robin W M (W.B. Saunders Ltd, 2024-09)

OBJECTIVE: Lower extremity peripheral arterial disease (PAD) is a severe condition that increases the risk of major adverse cardiovascular events, major adverse limb events, and all cause mortality. This study aimed to ...
National registry insights on genetic aortopathies and thoracic endovascular aortic interventions

Gomez-Mayorga, Jorge L.; Yadavalli, Sai Divya; Allievi, Sara; Wang, Sophie X.; Rastogi, Vinamr; Straus, Sabrina; Mandigers, Tim J.; Black, James H.; Zettervall, Sara L.; Schermerhorn, Marc L. (Mosby Inc., 2024-10)

Objective: Thoracic endovascular aortic repair (TEVAR) in patients with genetic aortopathies (GA) is controversial, given concerns of durability. We describe characteristics and outcomes after TEVAR in patients with GA. ...
What is the Safety of COVID-19 Vaccines in Immunocompromised Patients? Results from the European “Covid Vaccine Monitor” Active Surveillance Study

Bellitto, Chiara; Luxi, Nicoletta; Ciccimarra, Francesco; L’Abbate, Luca; Raethke, Monika; van Hunsel, Florence; Lieber, Thomas; Mulder, Erik; Riefolo, Fabio; Villalobos, Felipe; Thurin, Nicolas H.; Marques, Francisco B.; Morton, Kathryn; O’Shaughnessy, Fergal; Sonderlichová, Simona; Farcas, Andreea; Giele-Eshuis, Janneke; Sturkenboom, Miriam C.; Trifirò, Gianluca (Adis, 2024-10)

Background: The safety profile of COVID-19 vaccines in immunocompromised patients has not been comprehensively evaluated. Aim: To measure the frequency of patient-reported adverse drug reactions (ADRs) related to the ...
Expect the unexpected: Ablation of an atypically located atrial tachycardia

Teunissen, Cas; Cox, Moniek G.; Kassenberg, Wil; Loh, Peter (Elsevier, 2024-09)
Modulating organelle distribution using light-inducible heterodimerization in C. elegans

Dansen, Tobias B.; De Henau, Sasha (Cell Press, 2021-03-19)

The relative positioning of organelles underlies fundamental cellular processes, including signaling, polarization, and cellular growth. Here, we describe the usage of a light-dependent heterodimerization system, LOVpep-ePDZ, ...
Response by Waissi et al Regarding Article, "Elevated Lp(a) (Lipoprotein[a]) Levels Increase Risk of 30-Day Major Adverse Cardiovascular Events in Patients Following Carotid Endarterectomy"

Waissi, Farahnaz; De Kleijn, Dominique P.V.; Kroon, Jeffrey (Lippincott Williams & Wilkins, 2021-02-01)
Sustained intra-articular release and biocompatibility of tacrolimus (Fk506) loaded monospheres composed of [pdla-peg1000]-b-[plla] multi-block copolymers in healthy horse joints

Cokelaere, Stefan M.; Groen, Wilhelmina M.G.A.C.; Plomp, Saskia G.M.; de Grauw, Janny C.; van Midwoud, Paul M.; Weinans, Harrie H.; van de Lest, Chris H.A.; Tryfonidou, Marianna A.; René van Weeren, P.; Korthagen, Nicoline M. (Multidisciplinary Digital Publishing Institute, 2021-09)

There is an increasing interest in controlled release systems for local therapy in the treatment of human and equine joint diseases, aiming for optimal intra-articular concentrations with no systemic side effects. In this ...
Regenerating Critical Size Rat Segmental Bone Defects with a Self-Healing Hybrid Nanocomposite Hydrogel: Effect of Bone Condition and BMP-2 Incorporation

van Houdt, Claire I.A.; Koolen, Marianne K.E.; Lopez-Perez, Paula M.; Ulrich, Dietmar J.O.; Jansen, John A.; Leeuwenburgh, Sander C.G.; Weinans, Harrie H.; van den Beucken, Jeroen J.J.P. (Wiley-VCH Verlag, 2021-08)

The aim of the current study is to assess the biological performance of self-healing hydrogels based on calcium phosphate (CaP) nanoparticles and bisphosphonate (BP) conjugated hyaluronan (HA) in a critical size segmental ...

Now showing items 4261-4280 of 40729