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UMC Repository: Recent submissions

  • The association between skeletal muscle mass and sensorineural hearing loss upon cisplatin-based chemoradiotherapy in patients with head and neck squamous cell carcinoma 
    Schaeffers, Anouk W M A; Burger, Anouk V M; Duinkerken, Charlotte W; van Sluis, Klaske E; de Boer, Jan Paul; van der Molen, Lisette; Hoetink, Alex E; Al-Mamgani, Abrahim; Jóźwiak, Katarzyna; Devriese, Lot A; de Bree, Remco; Zuur, Charlotte L (John Wiley & Sons Inc., 2025-01)
    INTRODUCTION: Patients with head and neck squamous cell carcinoma (HNSCC) treated with cisplatin-based chemoradiotherapy (CRT) frequently experience irreversible sensorineural hearing loss (SNHL). Patients with low lumbar ...
  • Electrical vagus nerve stimulation is a promising approach to reducing pulmonary complications after an esophagectomy: an experimental rodent model 
    Janssen, Henricus J B; Geraedts, Tessa C M; Fransen, Laura F C; van Ark, Ingrid; Leusink-Muis, Thea; Folkerts, Gert; Garssen, Johan; Ruurda, Jelle P; Nieuwenhuijzen, Grard A P; van Hillegersberg, Richard; Luyer, Misha D P (American Association for Cancer Research Inc., 2024)
    After esophagectomy, an imbalanced inflammatory response increases the risk of postoperative morbidity. The vagus nerve modulates local and systemic inflammatory responses, but its pulmonary branches are transected during ...
  • Prenatal assessment of brain malformations on neuroimaging: an expert panel review 
    Pogledic, Ivana; Mankad, Kshitij; Severino, Mariasavina; Lerman-Sagie, Tally; Jakab, Andras; Hadi, Efrat; Jansen, Anna C; Bahi-Buisson, Nadia; Di Donato, Natalya; Oegema, Renske; Mitter, Christian; Capo, Ivan; Whitehead, Matthew T; Haldipur, Parthiv; Mancini, Grazia; Huisman, Thierry A G M; Righini, Andrea; Dobyns, Bill; Barkovich, James A; Jovanov Milosevic, Natasa; Kasprian, Gregor; Lequin, Maarten (Oxford University Press, 2024-12)
    Brain malformations represent a heterogeneous group of abnormalities of neural morphogenesis, often associated with aberrations of neuronal connectivity and brain volume. Prenatal detection of brain malformations requires ...
  • The Innate Immune Landscape of dMMR/MSI Cancers Predicts the Outcome of Nivolumab Treatment: Results from the Drug Rediscovery Protocol 
    Zeverijn, Laurien J; Geurts, Birgit S; Battaglia, Thomas W; van Berge Henegouwen, Jade M; de Wit, Gijs F; Hoes, Louisa R; van der Wijngaart, Hanneke; van der Noort, Vincent; Roepman, Paul; de Leng, Wendy W J; Jansen, Anne M L; Chalabi, Myriam; van Herpen, Carla M L; Devriese, Lot A; Erdkamp, Frans L G; Labots, Mariette; de Jonge, Maja J A; Kerver, Emile D; Bins, Adriaan D; Leek, Lindsay V M; Notohardjo, Jessica C L; van den Eertwegh, Alfonsus J M; Wessels, Lodewyk F A; Verheul, Henk M W; Gelderblom, Hans; van de Haar, Joris; Voest, Emile E (American Association for Cancer Research Inc., 2024-10-01)
    Purpose: The treatment efficacy of nivolumab was evaluated in patients with advanced, treatment-refractory solid mismatch repair deficiency/microsatellite-instable (dMMR/MSI) tumors, and in-depth biomarker analyses were ...
  • The effect of fat model variation on muscle fat fraction quantification in a cross-sectional cohort 
    Froeling, Martijn; Heskamp, Linda (John Wiley & Sons Inc., 2024-12)
    Spectroscopic imaging, rooted in Dixon's two-echo spin sequence to distinguish water and fat, has evolved significantly in acquisition and processing. Yet precise fat quantification remains a persistent challenge in ongoing ...
  • Supervised, structured and individualized exercise in metastatic breast cancer: a randomized controlled trial 
    Hiensch, Anouk E; Depenbusch, Johanna; Schmidt, Martina E; Monninkhof, Evelyn M; Pelaez, Mireia; Clauss, Dorothea; Gunasekara, Nadira; Zimmer, Philipp; Belloso, Jon; Trevaskis, Mark; Rundqvist, Helene; Wiskemann, Joachim; Müller, Jana; Sweegers, Maike G; Fremd, Carlo; Altena, Renske; Gorecki, Maciej; Bijlsma, Rhodé; van Leeuwen-Snoeks, Lobke; Ten Bokkel Huinink, Daan; Sonke, Gabe; Lahuerta, Ainhara; Mann, G Bruce; Francis, Prudence A; Richardson, Gary; Malter, Wolfram; van der Wall, Elsken; Aaronson, Neil K; Senkus, Elzbieta; Urruticoechea, Ander; Zopf, Eva M; Bloch, Wilhelm; Stuiver, Martijn M; Wengstrom, Yvonne; Steindorf, Karen; May, Anne M (Nature Research, 2024)
    Physical exercise both during and after curative cancer treatment has been shown to reduce side effects. Evidence in the metastatic cancer setting is scarce, and interventions that improve health-related quality of life ...
  • Developing technologies to assess vascular ageing: a roadmap from VascAgeNet 
    Zanelli, Serena; Agnoletti, Davide; Alastruey, Jordi; Allen, John; Bianchini, Elisabetta; Bikia, Vasiliki; Boutouyrie, Pierre; Bruno, Rosa Maria; Climie, Rachel; Djamaleddine, Djeldjli; Gkaliagkousi, Eugenia; Giudici, Alessandro; Gopcevic, Kristina; Grillo, Andrea; Guala, Andrea; Hametner, Bernhard; Joseph, Jayaraj; Karimpour, Parmis; Kodithuwakku, Vimarsha; Kyriacou, Panayiotis A; Lazaridis, Antonios; Lonnebakken, Mai Tone; Martina, Maria Raffaella; Mayer, Christopher Clemens; Nabeel, P M; Navickas, Petras; Nemcsik, Janos; Orter, Stefan; Park, Chloe; Pereira, Telmo; Pucci, Giacomo; Amado Rey, Ana Belen; Salvi, Paolo; Gonçalves Seabra, Ana Carolina; Seeland, Ute; van Sloten, Thomas; Spronck, Bart; Stansby, Gerard; Steens, Indra; Stieglitz, Thomas; Tan, Isabella; Veerasingam, Dave; Wassertheurer, Siegfried; Weber, Thomas; Westerhof, Berend E; Charlton, Peter H (IOP Publishing Ltd., 2024-12-01)
    Vascular ageing (vascular ageing) is the deterioration of arterial structure and function which occurs naturally with age, and which can be accelerated with disease. Measurements of vascular ageing are emerging as markers ...
  • Retinal microvascular function and incidence and trajectories of clinically relevant depressive symptoms: the Maastricht Study 
    van Gennip, April C E; Gupta, Monideepa D; Houben, Alfons J H M; Berendschot, Tos T J M; Webers, Carroll A B; van Greevenbroek, Marleen M J; van der Kallen, Carla J H; Koster, Annemarie; Wesselius, Anke; Eussen, Simone J P M; Schalkwijk, Casper G; de Galan, Bastiaan E; Köhler, Sebastian; Schram, Miranda T; Stehouwer, Coen D A; van Sloten, Thomas T (Cambridge University Press, 2024-07)
    BACKGROUND: Cerebral microvascular dysfunction may contribute to depression via disruption of brain structures involved in mood regulation, but evidence is limited. We investigated the association of retinal microvascular ...
  • Barriers and facilitators to the implementation of a new European eHealth solution (SurPass v2.0): the PanCareSurPass Open Space study 
    de Beijer, Ismay A.E.; Hardijzer, Emma C.; Haupt, Riccardo; Grabow, Desiree; Balaguer, Julia; Bardi, Edit; Cañete Nieto, Adela; Ciesiūniene, Audronė; Düster, Vanessa; Filbert, Anna Liesa; Gsell, Hannah; Kapitančukė, Monika; Ladenstein, Ruth; Langer, Thorsten; Muraca, Monica; van den Oever, Selina R.; Prikken, Sofie; Rascon, Jelena; Tormo, Maria Teresa; Uyttebroeck, Anne; Vercruysse, Gertrui; van der Pal, Helena J.H.; Kremer, Leontien C.M.; Pluijm, Saskia M.F. (Springer, 2025-04)
    Purpose: To identify barriers and facilitators for implementing the Survivorship Passport (SurPass) v2.0 in six long-term follow-up (LTFU) care centres in Europe. Methods: Stakeholders including childhood cancer survivors ...
  • Associations of light exposure patterns with sleep among Dutch children: The ABCD cohort study 
    Stefanopoulou, Magdalini; Ruhé, Naomi; Portengen, Lützen; van Wel, Luuk; Vrijkotte, Tanja G.M.; Vermeulen, Roel; Huss, Anke (Wiley-Blackwell, 2024-12)
    Light exposure affects the circadian system and consequently can affect sleep quality. Only few studies examined this relationship in children. We evaluated associations between light exposure patterns and sleep metrics ...
  • Assessing supervisor versus trainee viewpoints of entrustment through cognitive and affective lenses: an artificial intelligence investigation of bias in feedback 
    Gin, Brian C.; ten Cate, Olle; O’Sullivan, Patricia S.; Boscardin, Christy (Springer Netherlands, 2024-11)
    The entrustment framework redirects assessment from considering only trainees’ competence to decision-making about their readiness to perform clinical tasks independently. Since trainees and supervisors both contribute to ...
  • Current treatment in macrophage activation syndrome worldwide: a systematic literature review to inform the METAPHOR project 
    PReS MAS/sJIA Working Party and Paediatric Rheumatology International Trial Organization (Oxford University Press, 2025-01)
    Objective: To assess current treatment in macrophage activation syndrome (MAS) worldwide and to highlight any areas of major heterogeneity of practice. Methods: A systematic literature search was performed in both EMBASE ...
  • A practical approach to uveitis screening in children with juvenile idiopathic arthritis 
    Foeldvari, Ivan; Bohn, Marcela; Petrushkin, Harry; Han, S. Angeles; Bangsgaard, Regitze; Calzada-Hernández, Joan; Constantin, Tamas; de Boer, Joke H.; Díaz-Cascajosa, Jesus; Edelsten, Clive; Glerup, Mia; Ingels, Helene; Kramer, Sebastian; Miserocchi, Elisabetta; Nordal, Ellen; Saurenmann, Rotraud K.; Simonini, Gabriele; Solebo, Ameenat Lola; Titz, Jan; Anton, Jordi (BMJ Publishing Group, 2025-02-24)
    Background Juvenile idiopathic arthritis (JIA)associated uveitis typically presents as a silent chronic anterior uveitis and can lead to blindness. Adherence to current screening guidelines is hampered by complex protocols ...
  • 'What Happened?': Perceptions of Patients with Hypertension of Conflicting Results between Self-Reported Medication Adherence and Chemical Adherence Testing: A Qualitative Study 
    Soldan, Sara; Flint, Corien; Jaarsma, Tiny; Westland, Heleen (Elsevier, 2024-11-01)
    AIMS: To explore the perceptions of outpatients with hypertension regarding the conflicting results between their self-reported medication adherence and chemical adherence testing. METHODS AND RESULTS: An exploratory generic ...
  • Understanding recovery of people recovering from COVID-19 receiving treatment from primary care allied health professionals: a mixed-methods study 
    Slotegraaf, Anne I.; de Kruif, Anja J.Th C.M.; Agasi-Idenburg, Carla S.; van Oers, Sonja M.D.; Ronteltap, Amber; Veenhof, Cindy; Gerards, Marissa H.G.; Verburg, Arie C.; Hoogeboom, Thomas J.; de van der Schueren, Marian A.E. (Informa Healthcare, 2024)
    Purpose: To quantitatively assess changes in recovery of people recovering from COVID-19 treated by a primary care allied health professional, and to qualitatively describe how they dealt with persistent complaints. Materials ...
  • First-in-human feasibility study of the aXess graft (aXess-FIH): 6-Month results 
    Tozzi, Matteo; De Letter, Jan; Krievins, Dainis; Jushinskis, Janis; D’Haeninck, Annick; Rucinskas, Kestutis; Miglinas, Marius; Baltrunas, Tomas; Nauwelaers, Sigi; De Vriese, An S.; Moll, Frans; Vermassen, Frank (Wichtig Publishing, 2025-03)
    Objective: The creation of an arteriovenous fistula (AVF) is considered the most effective hemodialysis (HD) vascular access. For patients who are not suitable for AVF, arteriovenous grafts (AVGs) are the best access option ...
  • Struggling in the dehumanized world of COVID—An exploratory mixed-methods study of frontline healthcare workers' experiences 
    Carnesten, Hillewi; von Heideken Wågert, Petra; Gustin, Lena Wiklund; Toivanen, Susanna; Skoglund, Karin; Jaarsma, Tiny; Andreae, Christina (Wiley-Blackwell, 2024-10)
    Aim: To explore healthcare workers' experiences of the changed caring reality during the COVID-19 pandemic in Sweden. Design: An online fully mixed-methods design. Methods: A web-based self-reported questionnaire with fixed ...
  • Putting the SWORD to the Test: Finding Workarounds with Process Mining 
    van der Waal, Wouter; van de Weerd, Inge; Beerepoot, Iris; Lu, Xixi; Kappen, Teus; Haitjema, Saskia; Reijers, Hajo A. (Springer Gabler, 2025)
    Workarounds, or deviations from standardized operating procedures, can indicate discrepancies between theory and practice in work processes. Traditionally, observations and interviews have been used to identify workarounds, ...
  • Performance of high-dose omalizumab in chronic urticaria is predicted by initial improvement to standard dose 
    Simons, Juliette V.L.; Soegiharto, Reineke; Knulst, André C.; van den Reek, Juul M.P.A.; Röckmann, Heike (Elsevier, 2024-11)
  • Fostering the clinician as teacher: A realist review 
    Brouwer, Hiske Joanna; Barry, Margot; Kluijtmans, Manon; Damoiseaux, Roger Anna Maria Joseph; de Groot, Esther (Wiley-Blackwell, 2025-02)
    BACKGROUND: Clinician-teachers, physicians with educational responsibilities in either classroom or clinical setting, are assumed to add value by virtue of their dual role. The clinical responsibilities are often prioritised ...