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UMC Repository: Recent submissions

  • De effectiviteit van verplichte zorg bij een stoornis in middelengebruik 
    Neven, A; Dik, M P W; de Haan, H A; Batalla, A (Uitgeverij Boom, 2024-09)
    BACKGROUND: In a minority of patients with substance use disorders, there is both unwillingness to treat and serious harm or damage to the patient or society. In these situations, compulsory treatment may be considered. ...
  • Relationship between peripheral and intracoronary blood flow in patients with angina and nonobstructive coronary arteries 
    the IMPRESS consortium (American Physiological Society, 2024-10)
    Coronary vasomotor dysfunction, an important underlying cause of angina and nonobstructive coronary arteries (ANOCA), encompassing coronary vasospasm, coronary endothelial dysfunction, and/or coronary microvascular ...
  • Neuropathological spectrum of anti-IgLON5 disease and stages of brainstem tau pathology: updated neuropathological research criteria of the disease-related tauopathy 
    Gelpi, Ellen; Reinecke, Raphael; Gaig, Carles; Iranzo, Alex; Sabater, Lidia; Molina-Porcel, Laura; Aldecoa, Iban; Endmayr, Verena; Högl, Birgit; Schmutzhard, Erich; Poewe, Werner; Pfausler, Bettina; Popovic, Mara; Pretnar-Oblak, Janja; Leypoldt, Frank; Matschke, Jakob; Glatzel, Markus; Erro, Elena Maria; Jerico, Ivonne; Caballero, Maria Cristina; Zelaya, Maria Victoria; Mariotto, Sara; Heidbreder, Anna; Kalev, Ognian; Weis, Serge; Macher, Stefan; Berger-Sieczkowski, Evelyn; Ferrari, Julia; Reisinger, Christoph; Klupp, Nikolaus; Tienari, Pentti; Rautila, Osma; Niemelä, Marja; Yilmazer-Hanke, Deniz; Guasp, Mar; Bloem, Bas; Van Gaalen, Judith; Kusters, Benno; Titulaer, Maarten; Fransen, Nina L.; Santamaria, Joan; Dawson, Thimoty; Holton, Janice L.; Ling, Helen; Revesz, Tamas; Myllykangas, Liisa; Budka, Herbert; Kovacs, Gabor G.; Lewerenz, Jan; Dalmau, Josep; Graus, Francesc; Koneczny, Inga; Höftberger, Romana (Springer, 2024-10-14)
    Anti-IgLON5 disease is a unique condition that bridges autoimmunity and neurodegeneration. Since its initial description 10 years ago, an increasing number of autopsies has led to the observation of a broader spectrum of ...
  • Phases in Novice university teachers’ development of self-efficacy across and within teacher tasks: a Rasch Analysis 
    van Dijk, Esther E.; van Tartwijk, Jan; van der Schaaf, Marieke F.; Jansen, Renée S.; Kluijtmans, Manon (Routledge, 2024)
    Supporting academics’ initial development as university teachers is important for improving their ability to contribute to high-quality education and for reducing anxiety and stress around teaching. Focusing on tasks ...
  • Graded transthoracic contrast echocardiography after pulmonary arteriovenous malformation embolization: Can Chest CT Scan Be Avoided in Patients With a Low-Grade Shunt? 
    Hessels, J; Klompmaker, S; van den Heuvel, D A F; Boerman, S; Mager, J J; Post, M C (Elsevier, 2025-03)
    Background: Pulmonary arteriovenous malformations (PAVMs) are direct connections between the pulmonary artery and vein, creating a right-to-left shunt (RLS). Embolization is indicated to prevent complications. Guidelines ...
  • Combining patient-reported outcome measures to screen for active disease in rheumatoid arthritis and psoriatic arthritis 
    Looijen, Agnes E M; Snoeck Henkemans, Selinde V J; van der Helm-van Mil, Annette H M; Welsing, Paco M J; Koc, Gonul Hazal; Luime, Jolanda J; Kok, Marc R; Tchetverikov, Ilja; Korswagen, Lindy-Anne; Baudoin, Paul; Vis, Marijn; de Jong, Pascal H P (BMJ Publishing Group, 2024-10-18)
    Objectives To investigate whether a combination of general health (Visual Analogue Scale (VAS)), Health Assessment Questionnaire-Disability Index (HAQ-DI), pain (VAS/Numerical Rating Scale (NRS)), quality of life (EQ-5D), ...
  • Physical Activity Levels, Cardiorespiratory Fitness, and Physical Literacy in Children with a Chronic Medical Condition 
    Noordstar, Johannes J.; Sprong, Maaike C.A.; Slieker, Martijn G.; Takken, Tim; Van Der Ent, Cornelis K.; Van Brussel, Marco; Bartels, Marije; Hulzebos, Erik H.J. (Lippincott Williams & Wilkins, 2025-01-01)
    PURPOSE: This study investigated differences in cardiorespiratory fitness (CRF) and other physical literacy domains between children with a chronic medical condition (CMC) who adhered to with the physical activity guideline ...
  • Thermal Shrinking of Biopolymeric Hydrogels for High Resolution 3D Printing of Kidney Tubules 
    Viola, Martina; Valverde, Marta G.; Bernal, Paulina Nuñez; van Trijp, Jacobus P.; Hak, Jaimie; Marco, Greta Di; Neumann, Myriam; Schuurmans, Carl C.L.; van Nostrum, Cornelus F.; Masereeuw, Rosalinde; Mihăilă, Silvia M.; Malda, Jos; Levato, Riccardo; Vermonden, Tina (Wiley-VCH Verlag, 2024-11-12)
    The effective replication of microtubular structures in tissue engineering remains a great challenge. In this study, the temperature-responsive characteristics of poly(N-isopropylacrylamide) (pNIPAM) to create intricate, ...
  • Expanding the Phenotype Associated with NAA10-Related N-Terminal Acetylation Deficiency 
    Saunier, Chloé; Støve, Svein Isungset; Popp, Bernt; Gérard, Bénédicte; Blenski, Marina; AhMew, Nicholas; de Bie, Charlotte; Goldenberg, Paula; Isidor, Bertrand; Keren, Boris; Leheup, Bruno; Lampert, Laetitia; Mignot, Cyril; Tezcan, Kamer; Mancini, Grazia M S; Nava, Caroline; Wasserstein, Melissa; Bruel, Ange-Line; Thevenon, Julien; Masurel, Alice; Duffourd, Yannis; Kuentz, Paul; Huet, Frédéric; Rivière, Jean-Baptiste; van Slegtenhorst, Marjon; Faivre, Laurence; Piton, Amélie; Reis, André; Arnesen, Thomas; Thauvin-Robinet, Christel; Zweier, Christiane (John Wiley & Sons Inc., 2016-08)
    N-terminal acetylation is a common protein modification in eukaryotes associated with numerous cellular processes. Inherited mutations in NAA10, encoding the catalytic subunit of the major N-terminal acetylation complex ...
  • A Novel Variant in TPM3 Causing Muscle Weakness and Concomitant Hypercontractile Phenotype 
    Robaszkiewicz, Katarzyna; Siatkowska, Małgorzata; Wadman, Renske I; Kamsteeg, Erik-Jan; Chen, Zhiyong; Merve, Ashirwad; Parton, Matthew; Bugiardini, Enrico; de Bie, Charlotte; Moraczewska, Joanna (Multidisciplinary Digital Publishing Institute (MDPI), 2023-11-09)
    A novel variant of unknown significance c.8A > G (p.Glu3Gly) in TPM3 was detected in two unrelated families. TPM3 encodes the transcript variant Tpm3.12 (NM_152263.4), the tropomyosin isoform specifically expressed in slow ...
  • Heterozygous variants in CTR9, which encodes a major component of the PAF1 complex, are associated with a neurodevelopmental disorder 
    Meuwissen, Marije; Verstraeten, Aline; Ranza, Emmanuelle; Iwaszkiewicz, Justyna; Bastiaansen, Maaike; Mateiu, Ligia; Nemegeer, Merlijn; Meester, Josephina A N; Afenjar, Alexandra; Amaral, Michelle; Ballhausen, Diana; Barnett, Sarah; Barth, Magalie; Asselbergh, Bob; Spaas, Katrien; Heeman, Bavo; Bassetti, Jennifer; Blackburn, Patrick; Schaer, Marie; Blanc, Xavier; Zoete, Vincent; Casas, Kari; Courtin, Thomas; Doummar, Diane; Guerry, Frédéric; Keren, Boris; Pappas, John; Rabin, Rachel; Begtrup, Amber; Shinawi, Marwan; Vulto-van Silfhout, Anneke T; Kleefstra, Tjitske; Wagner, Matias; Ziegler, Alban; Schaefer, Elise; Gerard, Benedicte; De Bie, Charlotte I; Holwerda, Sjoerd J B; Abbot, Mary Alice; Antonarakis, Stylianos E; Loeys, Bart (Lippincott Williams & Wilkins, 2022-07)
    PURPOSE: CTR9 is a subunit of the PAF1 complex (PAF1C) that plays a crucial role in transcription regulation by binding CTR9 to RNA polymerase II. It is involved in transcription-coupled histone modification through promoting ...
  • Central venous catheter insertion site and infection prevention in 2024 
    de Grooth, Harm-Jan; Hagel, Stefan; Mimoz, Olivier (Springer-Verlag, 2024-11)
  • Making AI’s Impact on Pathology Visible: Using Ethnographic Methods for Ethical and Epistemological Insights 
    Milota, Megan; Drogt, Jojanneke; Jongsma, Karin (Springer, 2023-10-27)
    The field of pathology is currently undergoing fundamental changes, including the transition from analog to digital workspaces and the integration of Artificial Intelligence (AI) into digital diagnostic workflows. Discussing ...
  • What makes a medical intervention invasive? 
    De Marco, Gabriel; Simons, Jannieke; Forsberg, Lisa; Douglas, Thomas (BMJ Publishing Group, 2024-03-20)
    The classification of medical interventions as either invasive or non-invasive is commonly regarded to be morally important. On the most commonly endorsed account of invasiveness, a medical intervention is invasive if and ...
  • Ethical guidance for reporting and evaluating claims of AI outperforming human doctors 
    Drogt, Jojanneke; Milota, Megan; van den Brink, Anne; Jongsma, Karin (Nature Publishing Group, 2024-10-02)
    Claims of AI outperforming medical practitioners are under scrutiny, as the evidence supporting many of these claims is not convincing or transparently reported. These claims often lack specificity, contextualization, and ...
  • Drug Survival of Dupilumab, Methotrexate, and Cyclosporine A in Children With Atopic Dermatitis 
    van der Rijst, Lisa P; Kamphuis, Esmé; Schuttelaar, Marie L A; Hurmuz, Rimoon; Seyger, Marieke M B; Caron, Anouk G M; Zuithoff, Nicolaas P A; Nguyen, N Tan; Kamsteeg, Marijke; de Bruin-Weller, Marjolein S; Pasmans, Suzanne G M A; Middelkamp-Hup, Maritza A; de Graaf, Marlies (American Medical Association, 2025-01-01)
    IMPORTANCE: Dupilumab, methotrexate (MTX), and cyclosporine A (CsA) are valuable treatment options for pediatric patients with refractory moderate to severe atopic dermatitis (AD). Yet, comparative data on these treatments ...
  • Integration of circadian rhythms and immunotherapy for enhanced precision in brain cancer treatment 
    Quist, Matthias; van Os, Maas; van Laake, Linda W.; Bovenschen, Niels; Crnko, Sandra (Elsevier, 2024-11)
    Circadian rhythms significantly impact (patho)physiological processes, with disruptions linked to neurodegenerative diseases and heightened cancer vulnerability. While immunotherapy has shown promise in treating various ...
  • Impact of the VTE-PREDICT calculator on clinicians’ decision making in fictional patients with venous thromboembolism: a randomized controlled trial 
    Duijzer, Daniël; de Winter, Maria A.; Carrier, Marc; Cohen, Alexander T.; Hansen, John Bjarne; Kaasjager, Karin A.H.; Kakkar, Ajay K.; Middeldorp, Saskia; Sørensen, Henrik T.; Visseren, Frank L.J.; Wells, Philip S.; Dorresteijn, Jannick A.N.; Nijkeuter, Mathilde (Elsevier, 2024-10)
    Background: After 3 months of anticoagulation for venous thromboembolism (VTE), the decision needs to be made whether to stop anticoagulation or extend treatment indefinitely. The VTE-PREDICT calculator can be used to ...
  • Information and Communication Technology to Enhance the Implementation of the Integrated Management of Childhood Illness: A Systematic Review and Meta-Analysis 
    Bernasconi, Andrea; Landi, Marco; Yah, Clarence S.; van der Sande, Marianne A.B. (2024-09)
    Objective: To evaluate the impact of Information and Communication Technology (ICT) on the implementation of Integrated Management of Childhood Illness (IMCI) and integrated Community Case Management (iCCM) through a ...
  • Uniting education, research, healthcare, and society to advance women's heart health 
    Schakelaar, Michael Y.; Maas, Annemieke; van Ommen, Anne Mar L.N.; Spiering, Anna E.; de Jonge, Roos; Wijchers, Patrick; van Rossum, Gerda; Heesters, Balthasar A.; de Jong, Olivier G.; Zandveld, Jelle; Rebel, Heggert G.; Meeldijk, Jan; Pijnappel, Emma W.; van Dijk, Suzanne; Di Maggio, Alessia; Nijssen, Olaf; Sanders, Jorine G.F.; Hoogerwerf, Lies; van Spaandonk, Mike; Crnko, Sandra; Koorman, Thijs; Jenniskens, Kevin; Onland-Moret, N. Charlotte; van Geelen, Stefan M.; Ten Broeke, Toine; van Royen-Kerkhof, Annet; Dilaver, Gönül; Oliveira, Sabrina; Kok, Robbert J.; van Laake, Linda W.; van der Harst, Pim; Spiering, Wilko; Rutten, Frans H.; van Brussel, Marco; den Ruijter, Hester M.; Bovenschen, Niels (Rockefeller University Press, 2024-11-04)
    Complex health challenges require professionals to operate across disciplines and to better connect with society. Here, we showcase a community-engaged and challenge-based educational model in which undergraduate students ...