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Now showing items 2301-2320 of 40729

Differences in patient- and tumor characteristics, treatment and survival between patients with screen-detected versus clinically detected colorectal peritoneal metastases

Galanos, L. J.K.; Rijken, A.; Elferink, M. A.G.; Boerma, D.; Brandt-Kerkhof, A.; de Reuver, P. R.; Tuynman, J. B.; Kok, N. F.M.; Hemmer, P. H.J.; van Grevenstein, W. M.U.; Huysentruyt, C.; van Erning, F. N.; de Hingh, I. H.J.T. (W.B. Saunders Ltd, 2025-01)

Introduction: Screening for colorectal cancer has been implemented to improve cancer-specific survival. This study aims to compare patient- and tumor characteristics, treatment, and survival between patients with screen-detected ...
Phase Ib Study of the Immunocytokine Simlukafusp Alfa (FAP-IL2v) in Combination with Cetuximab in Patients with Head and Neck Squamous Cell Carcinoma

Hansen, Aaron R; Gomez-Roca, Carlos A; Robbrecht, Debbie G J; Verlingue, Loic; Italiano, Antoine; Bauman, Julie E; Steeghs, Neeltje; Prenen, Hans; Fayette, Jérôme; Spicer, James; Niu, Jiaxin; Habigt, Christin; Schneider, Meike; Evers, Stefan; Sleiman, Nassim; Dejardin, David; Ardeshir, Caroline; Schmid, Daniela; Boetsch, Christophe; Charo, Jehad; Kraxner, Anton; Teichgräber, Volker; Keshelava, Nino; Bonomi, Marcelo R (2024-12-16)

PURPOSE: This phase Ib trial evaluated fibroblast activation protein-α-targeted IL2 variant (FAP-IL2v), a novel immunocytokine engineered to minimize CD25-mediated toxicities, in combination with cetuximab, in patients ...
Neurological recovery after early versus delayed surgical decompression for acute traumatic spinal cord injury

Hosman, Allard J.F.; Barbagallo, G.; van Middendorp, Joost J.; Öner, F. Cumhur; the SCI-POEMStudy Group (British Editorial Society of Bone and Joint Surgery, 2023-04)

Methods Patients with tSCI requiring surgical spinal decompression presenting to 17 centres in Europe were recruited. Depending on the timing of decompression, patients were divided into early (≤ 12 hours after injury) and ...
Parents' experiences with sequencing of all known pediatric cancer predisposition genes in children with cancer

Bon, S. B.B.; Wouters, R.H.P.; Bakhuizen, J. J.; van den Heuvel-Eibrink, M. M.; Maurice-Stam, H.; Jongmans, M. C.J.; Grootenhuis, M. A. (Lippincott Williams & Wilkins, 2025-01)

Purpose: Germline DNA sequencing is increasingly used within pediatric oncology, yet parental experiences remain underexplored. Methods: Parents of children undergoing cancer predisposition gene panel sequencing (143 genes) ...
The BAF complex inhibitor pyrimethamine reverses HIV-1 latency in people with HIV-1 on antiretroviral therapy

Prins, Henrieke A.B.; Crespo, Raquel; Lungu, Cynthia; Rao, Shringar; Li, Letao; Overmars, Ronald J.; Papageorgiou, Grigorius; Mueller, Yvonne M.; Stoszko, Mateusz; Hossain, Tanvir; Kan, Tsung Wai; Rijnders, Bart J.A.; Bax, Hannelore I.; van Gorp, Eric C.M.; Nouwen, Jan L.; de Vries-Sluijs, Theodora E.M.S.; Schurink, Carolina A.M.; de Mendonça Melo, Mariana; van Nood, Els; Colbers, Angela; Burger, David; Palstra, Robert Jan; van Kampen, Jeroen J.A.; van de Vijver, David A.M.C.; Mesplède, Thibault; Katsikis, Peter D.; Gruters, Rob A.; Koch, Birgit C.P.; Verbon, Annelies; Mahmoudi, Tokameh; Rokx, Casper (American Association for the Advancement of Science, 2023-03)

Reactivation of the latent HIV-1 reservoir is a first step toward triggering reservoir decay. Here, we investigated the impact of the BAF complex inhibitor pyrimethamine on the reservoir of people living with HIV-1 (PLWH). ...
Prediction of the chance of successful immune tolerance induction in persons with severe hemophilia A and inhibitors: a clinical prediction model

Oomen, Ilja; Abdi, Amal; Camelo, Ricardo M.; Callado, Fábia M.R.A.; Carvalho, Luany E.M.; Calcaterra, Ilenia L.; Carcao, Manuel; Castaman, Giancarlo; Eikenboom, Jeroen C.J.; Fischer, Kathelijn; Franco, Vivian K.B.; Heymans, Martijn W.; Leebeek, Frank W.G.; Lillicrap, David; Lorenzato, Cláudia S.; Mancuso, Maria Elisa; Matino, Davide; Di Minno, Matteo N.D.; Mohseny, Alex B.; Oldenburg, Johannes; Rezende, Suely Meireles; Rivard, Georges Etienne; Rydz, Natalia; Schols, Saskia E.M.; Voorberg, Jan; Fijnvandraat, Karin; Gouw, Samantha C.; International Genetic and clinical determinants for the outcome of immune tolerance induction study group (Elsevier, 2024-10)

Background: Inhibitor eradication to restore factor (F)VIII efficacy is the treatment goal for persons with severe hemophilia A (HA) and inhibitors. Immune tolerance induction (ITI) is demanding and successful in about 70% ...
Identifying the prevalence and correlates of multimorbidity in middle-aged men and women: a cross-sectional population-based study in four African countries

Micklesfield, Lisa K.; Munthali, Richard; Agongo, Godfred; Asiki, Gershim; Boua, Palwende; Choma, Solomon S.R.; Crowther, Nigel J.; Fabian, June; Gómez-Olivé, Francesc Xavier; Kabudula, Chodziwadziwa; Maimela, Eric; Mohamed, Shukri F.; Nonterah, Engelbert A.; Raal, Frederick J.; Sorgho, Hermann; Tluway, Furahini D.; Wade, Alisha N.; Norris, Shane A.; Ramsay, Michele (BMJ Publishing Group, 2023-03-14)

Objectives To determine the prevalence of multimorbidity, to identify which chronic conditions cluster together and to identify factors associated with a greater risk for multimorbidity in sub-Saharan Africa (SSA). Design ...
An interrater reliability analysis of preoperative mortality risk calculators used for elective high-risk noncardiac surgical patients shows poor to moderate reliability

Vernooij, Jacqueline E.M.; Roovers, Lian; Zwan, René van der; Preckel, Benedikt; Kalkman, Cor J.; Koning, Nick J. (BioMed Central, 2024-10-30)

BACKGROUND: Multiple preoperative calculators are available online to predict preoperative mortality risk for noncardiac surgical patients. However, it is currently unknown how these risk calculators perform across different ...
Saturated fat and human health: a protocol for a methodologically innovative systematic review and meta-analysis to inform public health nutrition guidelines

Johnston, Bradley C.; Zeraatkar, Dena; Steen, Jeremy; de Jauregui, Diego Rada Fernandez; Zhu, Hongfei; Sun, Mingyao; Cooper, Matthew; Maraj, Malgorzata; Prokop-Dorner, Anna; Reyes, Boris Castro; Valli, Claudia; Storman, Dawid; Karam, Giorgio; Zajac, Joanna; Ge, Long; Swierz, Mateusz J.; Ghosh, Nirjhar; Vernooij, Robin W.M.; Chang, Yaping; Zhao, Yunli; Thabane, Lehana; Guyatt, Gordon H.; Alonso-Coello, Pablo; Hooper, Lee; Bala, Malgorzata M. (BioMed Central, 2023-12)

Background: The health effects of dietary fats are a controversial issue on which experts and authoritative organizations have often disagreed. Care providers, guideline developers, policy-makers, and researchers use ...
John Phair

Saag, Michael; Coutinho, Roel; Rowland-Jones, Sarah; Lichterfeld, Mathias; Levy, Jay (Lippincott Williams & Wilkins, 2024-11-15)
Rivaroxaban in patients with symptomatic peripheral artery disease after lower extremity bypass surgery with venous and prosthetic conduits

Govsyeyev, Nicholas; Nehler, Mark; Conte, Michael S.; Debus, Sebastian; Chung, Jayer; Dorigo, Walter; Gudz, Ivan; Krievins, Dainis; Mills, Joseph; Moll, Frans; Norgren, Lars; Piffaretti, Gabriele; Powell, Rick; Szalay, David; Sillesen, Henrik; Wohlauer, Max; Szarek, Michael; Bauersachs, Rupert M.; Anand, Sonia S.; Patel, Manesh R.; Capell, Warren H.; Jaeger, Nicole; Hess, Connie N.; Muehlhofer, Eva; Haskell, Lloyd P.; Berkowitz, Scott D.; Bonaca, Marc P. (Mosby Inc., 2023-04)

Background: Patients with peripheral artery disease (PAD) requiring lower extremity revascularization (LER) have a high risk of adverse limb and cardiovascular events. The results from the VOYAGER PAD (efficacy and safety ...
The burden of invasive meningococcal disease in the Netherlands, 2011–2020

Middeldorp, Marit; Steens, Anneke; Lagerweij, Giske; van Sorge, Nina M.; Freudenburg-de Graaf, Wieke; A. M. Sanders, Elisabeth; de Melker, Hester E.; Knol, Mirjam J. (Elsevier, 2023-04-17)

Introduction: Representative information on disease course and outcome of invasive meningococcal disease (IMD) is important because of the shift in meningococcal epidemiology that recently occurred in the Netherlands. With ...
Sound Localization in Single-Sided Deafness; Outcomes of a Randomized Controlled Trial on the Comparison Between Cochlear Implantation, Bone Conduction Devices, and Contralateral Routing of Signals Hearing Aids

van Heteren, Jan A.A.; van Oorschot, Hanneke D.; Wendrich, Anne W.; Peters, Jeroen P.M.; Rhebergen, Koenraad S.; Grolman, Wilko; Stokroos, Robert J.; Smit, Adriana L. (SAGE Publications Inc., 2024-01-01)

There is currently a lack of prospective studies comparing multiple treatment options for single-sided deafness (SSD) in terms of long-term sound localization outcomes. This randomized controlled trial (RCT) aims to compare ...
Lactuca super-pangenome reduces bias towards reference genes in lettuce research

van Workum, Dirk Jan M.; Mehrem, Sarah L.; Snoek, Basten L.; Alderkamp, Marrit C.; Lapin, Dmitry; Mulder, Flip F.M.; Van den Ackerveken, Guido; de Ridder, Dick; Schranz, M. Eric; Smit, Sandra (BioMed Central Ltd., 2024-10-28)

Background: Breeding of lettuce (Lactuca sativa L.), the most important leafy vegetable worldwide, for enhanced disease resistance and resilience relies on multiple wild relatives to provide the necessary genetic diversity. ...
DNA double-strand break movement in heterochromatin depends on the histone acetyltransferase dGcn5

Kendek, Apfrida; Sandron, Arianna; Lambooij, Jan Paul; Colmenares, Serafin U.; Pociunaite, Severina M.; Gooijers, Iris; de Groot, Lars; Karpen, Gary H.; Janssen, Aniek (Oxford University Press, 2024-10-28)

Cells employ diverse strategies to repair double-strand breaks (DSBs), a dangerous form of DNA damage that threatens genome integrity. Eukaryotic nuclei consist of different chromatin environments, each displaying distinct ...
Longitudinal Magnetic Resonance Imaging in Asymptomatic C9orf72 Mutation Carriers Distinguishes Phenoconverters to Amyotrophic Lateral Sclerosis or Amyotrophic Lateral Sclerosis With Frontotemporal Dementia

van Veenhuijzen, Kevin; Tan, Harold H.G.; Nitert, Abram D.; van Es, Michael A.; Veldink, Jan H.; van den Berg, Leonard H.; Westeneng, Henk Jan (John Wiley & Sons Inc., 2025-02)

Objective: We prospectively studied asymptomatic C9orf72 mutation carriers, identifying those developing amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD). Methods: We enrolled 56 asymptomatic family ...
Skin decontamination to prevent infections in the intensive care unit

Bonten, Marc; Tomazini, Bruno Martins; Harbarth, Stephan (Springer-Verlag, 2024-12)
Association Between the Regular Use of Vaginal Dilators and/or Sexual Activity and Vaginal Morbidity in Locally Advanced Cervical Cancer Survivors: An EMBRACE-I Study Report

Kirchheiner, Kathrin; Zaharie, Alexandru; Smet, Stéphanie; Spampinato, Sofia; Chargari, Cyrus; Haie-Meder, Christine; Mahantshetty, Umesh; Šegedin, Barbara; Bruheim, Kjersti; Rai, Bhavana; Cooper, Rachel; Van der Steen-Banasik, Elzbieta; Wiebe, Ericka; Pötter, Richard; Sturdza, Alina; Schmid, Maximilian P.; Tanderup, Kari; De Leeuw, Astrid; Jürgenliemk-Schulz, Ina M.; Nout, Remi A.; EMBRACE Collaborative Group (Elsevier, 2025-02-01)

Purpose: The purpose of this study was to provide risk estimations for vaginal morbidity with regard to vaginal dilation (summarizing the use of dilators and/or sexual activity) in patients with locally advanced cervical ...
Real-world treatment outcomes of systemic treatments for moderate-to-severe atopic dermatitis in children aged less than 12 years: 2-year results from PEDIatric STudy in Atopic Dermatitis

Paller, Amy S.; de Bruin-Weller, Marjolein; Marcoux, Danielle; Baselga, Eulalia; Oliveira de Carvalho, Vania; Ardusso, Ledit R.F.; Pasmans, Suzanne G.M.A.; Toledo-Bahena, Mirna; Rubin, Cory; Joyce, Joel C.; Wine Lee, Lara; Adams, Bryan; Gupta, Rajan; Ardeleanu, Marius; Zhang, Annie (Mosby Inc., 2025-02)

Background: The arrival of biologics and small-molecule therapies (eg Janus kinase inhibitors) changed atopic dermatitis treatment, but older systemic treatments continue to be prescribed. Objective: To provide real-world ...
The association of overweight, obesity, and long-term obesity with SARS-CoV-2 infection: a meta-analysis of 9 population-based cohorts from the Netherlands Cohorts Consortium

Loef, Bette; Boer, Jolanda M.A.; Beekman, Marian; Campman, Sophie L.; Hoogendijk, Emiel O.; Huider, Floris; Pagen, Demi M.E.; Splinter, Marije J.; van der Velde, Jeroen H.P.M.; Boomsma, Dorret I.; Dagnelie, Pieter C.; van Dongen, Jenny; de Geus, Eco J.C.; Huisman, Martijn; Ikram, M. Arfan; Koster, Annemarie; Licher, Silvan; Mierau, Jochen O.; de Mutsert, Renée; Picavet, H. Susan J.; Rosendaal, Frits R.; Schram, Miranda T.; Slagboom, P. Eline; van der Spoel, Evie; Stronks, Karien; Verschuren, W. M.Monique; van den Berg, Saskia W.; Lifelines Corona Research initiative (Springer Nature, 2025)

Background: Obesity may affect an individual’s immune response and subsequent risk of infection, such as a SARS-CoV-2 infection. It is less clear whether overweight and long-term obesity also constitute risk factors. We ...

Now showing items 2301-2320 of 40729