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UMC Repository: Recent submissions

  • Occupational Benzene Exposure and Cancer Risk among Chinese Men: A Report from the Shanghai Men's Health Study 
    DeMoulin, Douglas; Cai, Hui; Vermeulen, Roel; Zheng, Wei; Lipworth, Loren; Shu, Xiao Ou (American Association for Cancer Research Inc., 2024-11-01)
    BACKGROUND: Benzene exposure has been associated with increased risk of leukemia and other cancers; however, epidemiologic evidence is inconsistent for the latter, and confounding from smoking and alcohol was rarely adjusted. ...
  • The Role of Genetic Variations in the FAAH rs324420 Polymorphism and its Interaction with CRHR1 rs110402 and CNR1 rs2180619 in Anxiety and- Trauma Related Symptoms After Military Deployment 
    Leen, Nadia; de Weijer, Antoin; Boks, Marco; Baas, Johanna; Vermetten, Eric; Geuze, Elbert (SAGE Publications Inc., 2024)
    Background: During military deployment, stress regulation is vital to protect against the development of anxiety and trauma-related symptoms. Brain endocannabinoids play an important role in stress regulation and previous ...
  • Thermoforming for Small Feature Replication in Melt Electrowritten Membranes to Model Kidney Proximal Tubule 
    G Valverde, Marta; Stampa Zamorano, Claudia; Kožinec, Dora; Benito Zarza, Laura; van Genderen, Anne Metje; Janssen, Robine; Castilho, Miguel; Hrynevich, Andrei; Vermonden, Tina; Malda, Jos; de Ruijter, Mylene; Masereeuw, Rosalinde; Mihăilă, Silvia M. (John Wiley & Sons Inc., 2025-01-03)
    A novel approach merging melt electrowriting (MEW) with matched die thermoforming to achieve scaffolds with micron-sized curvatures (200 – 800 µm versus 1000 µm of mandrel printing) for in vitro modeling of the kidney ...
  • Correction to: A genome-wide association analysis reveals new pathogenic pathways in gout (Nature Genetics, (2024), 10.1038/s41588-024-01921-5) 
    Major, Tanya J.; Takei, Riku; Matsuo, Hirotaka; Leask, Megan P.; Sumpter, Nicholas A.; Topless, Ruth K.; Shirai, Yuya; Wang, Wei; Cadzow, Murray J.; Phipps-Green, Amanda J.; Li, Zhiqiang; Ji, Aichang; Merriman, Marilyn E.; Morice, Emily; Kelley, Eric E.; Wei, Wen Hua; McCormick, Sally P.A.; Bixley, Matthew J.; Reynolds, Richard J.; Saag, Kenneth G.; Fadason, Tayaza; Golovina, Evgenia; O’Sullivan, Justin M.; Stamp, Lisa K.; Dalbeth, Nicola; Abhishek, Abhishek; Doherty, Michael; Roddy, Edward; Jacobsson, Lennart T.H.; Kapetanovic, Meliha C.; Melander, Olle; Andrés, Mariano; Pérez-Ruiz, Fernando; Torres, Rosa J.; Radstake, Timothy; Jansen, Timothy L.; Janssen, Matthijs; Joosten, Leo A.B.; Liu, Ruiqi; Gaal, Orsolya I.; Crişan, Tania O.; Rednic, Simona; Kurreeman, Fina; Huizinga, Tom W.J.; Toes, René; Lioté, Frédéric; Richette, Pascal; Bardin, Thomas; Ea, Hang Korng; Pascart, Tristan; FAST Study Group; Japan Gout Genomics Consortium; Asia Pacific Gout Consortium; GlobalGout Genetics Consortium; 23andMe Research Team (Nature Research, 2024-11)
    Correction to: Nature Geneticshttps://doi.org/10.1038/s41588-024-01921-5. Published online 15 October 2024. In the version of the article originally published, there were errors in the consortium lists at the end of the ...
  • Artificial Intelligence-Based Sentinel Lymph Node Metastasis Detection in Cervical Cancer † 
    Baeten, Ilse G.T.; Hoogendam, Jacob P.; Stathonikos, Nikolas; Gerestein, Cornelis G.; Jonges, Geertruida N.; van Diest, Paul J.; Zweemer, Ronald P. (Multidisciplinary Digital Publishing Institute (MDPI), 2024-11)
    Currently, pathologists use ultrastaging to detect whether cancer has spread to the lymph nodes. This process is time-consuming and expensive. Our pilot study explored the use of a deep learning algorithm to help detect ...
  • Single- and two-pollutant concentration-response functions for PM2.5 and NO2 for quantifying mortality burden in health impact assessments 
    Chen, Xuan; Gehring, Ulrike; Dyer, Georgia M.C.; Khomenko, Sasha; de Hoogh, Kees; Tonne, Cathryn; Tatah, Lambed; Vermeulen, Roel; Khreis, Haneen; Nieuwenhuijsen, Mark; Hoek, Gerard (Academic Press Inc., 2024-12-15)
    Objective: Health Impact Assessments (HIAs) for air pollutant mixtures are challenging because risk estimates are primarily derived from single-pollutant models. Combining risk estimates from multiple pollutants requires ...
  • Molecular diversity and migration of GABAergic neurons in the developing ventral midbrain 
    Düdükcü, Özge; Raj, Divya D.A.; van de Haar, Lieke L.; Grossouw, Laurens M.; Linders, Louisa E.; Garritsen, Oxana; Adolfs, Youri; van Kronenburg, Nicky C.H.; Broekhoven, Mark H.; Kapteijns, Troy H.W.; Meye, Frank J.; Pasterkamp, R. Jeroen (Elsevier, 2024-11-15)
    Dopaminergic neurons in the ventral midbrain (mDA) are surrounded by GABAergic neurons. The full extent of GABAergic neuron subtypes occupying this region and the mechanisms that underlie their development and function are ...
  • Simplification of a registry-based algorithm for ejection fraction prediction in heart failure patients: Applicability in cardiology centres of the Netherlands 
    Canto, Elisa Dal; Uijl, Alicia; Onland-Moret, N. Charlotte; Bots, Sophie H.; Hofstra, Leonard; Tulevski, Igor; Asselbergs, Folkert W.; van der Harst, Pim; Somsen, G. Aernout; den Ruijter, Hester M. (Public Library of Science, 2024-11)
    Background Left ventricular ejection fraction (EF) is used to categorize heart failure (HF) into phenotypes but this information is often missing in electronic health records or non-HF registries. Methods We tested the ...
  • Timing of cerebral damage in molybdenum cofactor deficiency: A meta-analysis of case reports 
    Ferreira, Elise A.; Hofstede, Floris C.; Haijes-Siepel, Hanneke A.; Lichtenbelt, Klaske D.; Pistorius, Lou; de Sain-van der Velden, Monique G.M.; Nikkels, Peter G.J.; Lequin, Maarten H.; de Vries, Linda S.; van der Crabben, Saskia N.; van Hasselt, Peter M. (2024-01)
    Purpose: Molybdenum cofactor deficiency (MoCD) classically presents shortly after birth, with neurological symptoms ascribed to postnatal toxicity of accumulating sulphite. Case reports suggest that cerebral damage associated ...
  • Impact of Pseudomonas aeruginosa carriage on intensive care unit-acquired pneumonia: a European multicentre prospective cohort study 
    Recanatini, Claudia; van Werkhoven, Cornelis H; van der Schalk, Thomas E; Paling, Fleur; Hazard, Derek; Timbermont, Leen; Torrens, Gabriel; DiGiandomenico, Antonio; Esser, Mark T; Wolkewitz, Martin; Sifakis, Frangiscos; Goossens, Herman; Bonten, Marc; Oliver, Antonio; Malhotra-Kumar, Surbhi; Kluytmans, Jan; ASPIRE-ICU Study Team (Elsevier, 2025-03)
    Objectives: Pseudomonas aeruginosa (PA) is a common causative pathogen of pneumonia acquired in the intensive care unit (ICU). The aim of this study was to determine the incidence of PA ICU pneumonia (PAIP) and to quantify ...
  • Can We Better Understand, Diagnose, and Treat Ketamine-Induced Uropathy, and Can It Be Reversed?: Ici-rs 2024 
    Hervé, François; Aronsson, Patrik; Ochoa, D Carolina; Van Koeveringe, Gommert; Mosiello, Giovanni; Averbeck, Marcio Augusto; Bou Kheir, George; Wyndaele, Michel; Abrams, Paul (John Wiley & Sons Inc., 2025-03)
    INTRODUCTION: Ketamine, a versatile anesthetic, has seen increased recreational use, leading to significant health issues, including ketamine-induced uropathy (KIU). KIU manifests with lower urinary tract symptoms (LUTS) ...
  • Colonoscopy Assisted Laparoscopic Wedge Resection for Colonic Lesions: Impact on Quality of LifE: Results from the LIMERIC Study 
    Brink, Amber G; Hanevelt, Julia; Leicher, Laura W; Moons, Leon M G; Vleggaar, Frank P; Huisman, Jelle F; de Vos Tot Nederveen Cappel, Wouter; van Westreenen, Henderik L; LIMERIC study group (Lippincott Williams & Wilkins, 2025-02-01)
    BACKGROUND: The LIMERIC study has proven that colonoscopy-assisted laparoscopic wedge resection effectively and safely removes benign colonic lesions unsuitable for endoscopic removal, thereby avoiding the need for major ...
  • Postanaesthesia care and discharge practice: A survey of European hospitals 
    De Korte, Marcel; De Korte-De Boer, Dianne; Chew, Michelle S.; De Hert, Stefan; Harlet, Pierre; Fuchs-Buder, Thomas; Luratibuse, Giovanna; Buhre, Wolfgang (Lippincott Williams & Wilkins, 2023-05-01)
  • Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities 
    Paassen, Irene; Williams, Justin; Ríos Arceo, Carla; Ringnalda, Femke; Mercer, Kimberly Shea; Buhl, Juliane L.; Moreno, Natalia; Federico, Aniello; Franke, Niels E.; Kranendonk, Mariette; Upadhyaya, Santhosh A.; Kerl, Kornelius; van de Wetering, Marc; Clevers, Hans; Kool, Marcel; Hoving, Eelco W.; Roussel, Martine F.; Drost, Jarno (Nature Publishing Group, 2023-05-12)
    Atypical teratoid/rhabdoid tumors (ATRTs) represent a rare, but aggressive pediatric brain tumor entity. They are genetically defined by alterations in the SWI/SNF chromatin remodeling complex members SMARCB1 or SMARCA4. ...
  • Adipose Tissue-Derived Components: From Cells to Tissue Glue to Treat Dermal Damage 
    Vriend, Linda; van der Lei, Berend; Harmsen, Martin C.; van Dongen, Joris A. (MDPI AG, 2023-03)
    In recent decades, adipose tissue transplantation has become an essential treatment modality for tissue (volume) restoration and regeneration. The regenerative application of adipose tissue has only recently proven its ...
  • Development of a Multiplex qPCR Assay for Fast Detection and Differentiation of Paracoccidioidomycosis Agents 
    Pinheiro, Breno Gonçalves; Pôssa, Ana Paula; Ricci, Giannina; Nishikaku, Angela Satie; Hagen, Ferry; Hahn, Rosane Christine; de Camargo, Zoilo Pires; Rodrigues, Anderson Messias (Multidisciplinary Digital Publishing Institute (MDPI), 2023-03)
    Classic paracoccidioidomycosis (PCM) is a potentially deadly neglected tropical systemic mycosis caused by members of the Paracoccidioides brasiliensis complex (P. brasiliensis s. str., P. americana, P. restrepiensis, and ...
  • Proteome2virus: Shotgun mass spectrometry data analysis pipeline for virus identification 
    Balvers, Manon; Gordijn, Isabelle F.; Voskamp-Visser, Ingrid A.I.; Schelling, Merel F.A.; Schuurman, Rob; Heikens, Esther; Braakman, Rene; Stingl, Christoph; van Leeuwen, Hans C.; Luider, Theo M.; Dekker, Lennard J.; Levin, Evgeni; Paauw, Armand (Elsevier, 2023-06)
    Objectives: Shotgun proteomics is a generic method enabling detection of multiple viral species in one assay. The reliable and accurate identification of these viral species by analyzing peptides from MS-spectra is a ...
  • ALL-tRNAseq enables robust tRNA profiling in tissue samples 
    Scheepbouwer, Chantal; Aparicio-Puerta, Ernesto; Gomez-Martin, Cristina; Verschueren, Heleen; van Eijndhoven, Monique; Wedekind, Laurine E.; Giannoukakos, Stavros; Hijmering, Nathalie; Gasparotto, Lisa; van der Galien, Hilde T.; van Rijn, Roos S.; Aronica, Eleonora; Kibbelaar, Robby; Heine, Vivi M.; Wesseling, Pieter; Noske, David P.; Vandertop, W. Peter; de Jong, Daphne; Pegtel, D. Michiel; Hackenberg, Michael; Wurdinger, Tom; Gerber, Alan; Koppers-Lalic, Danijela (Cold Spring Harbor Laboratory Press, 2023-03-01)
    Transfer RNAs (tRNAs) are small adaptor RNAs essential for mRNA translation. Alterations in the cellular tRNA population can directly affect mRNA decoding rates and translational efficiency during cancer development and ...
  • Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction 
    Chen, Jia Yun; Hug, Clemens; Reyes, José; Tian, Chengzhe; Gerosa, Luca; Fröhlich, Fabian; Ponsioen, Bas; Snippert, Hugo J.G.; Spencer, Sabrina L.; Jambhekar, Ashwini; Sorger, Peter K.; Lahav, Galit (Cell Press, 2023-03-28)
    Oncogene-induced senescence is a phenomenon in which aberrant oncogene expression causes non-transformed cells to enter a non-proliferative state. Cells undergoing oncogenic induction display phenotypic heterogeneity, with ...
  • Development of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis 
    Gunasekera, Kenneth S.; Marcy, Olivier; Muñoz, Johanna; Lopez-Varela, Elisa; Sekadde, Moorine P.; Franke, Molly F.; Bonnet, Maryline; Ahmed, Shakil; Amanullah, Farhana; Anwar, Aliya; Augusto, Orvalho; Aurilio, Rafaela Baroni; Banu, Sayera; Batool, Iraj; Brands, Annemieke; Cain, Kevin P.; Carratalá-Castro, Lucía; Caws, Maxine; Click, Eleanor S.; Cranmer, Lisa M.; García-Basteiro, Alberto L.; Hesseling, Anneke C.; Huynh, Julie; Kabir, Senjuti; Lecca, Leonid; Mandalakas, Anna; Mavhunga, Farai; Myint, Aye Aye; Myo, Kyaw; Nampijja, Dorah; Nicol, Mark P.; Orikiriza, Patrick; Palmer, Megan; Sant'Anna, Clemax Couto; Siddiqui, Sara Ahmed; Smith, Jonathan P.; Song, Rinn; Thuong Thuong, Nguyen Thuy; Ung, Vibol; van der Zalm, Marieke M.; Verkuijl, Sabine; Viney, Kerri; Walters, Elisabetta G.; Warren, Joshua L.; Zar, Heather J.; Marais, Ben J.; Graham, Stephen M.; Debray, Thomas P.A.; Cohen, Ted; Seddon, James A. (Elsevier, 2023-05)
    Background: Many children with pulmonary tuberculosis remain undiagnosed and untreated with related high morbidity and mortality. Recent advances in childhood tuberculosis algorithm development have incorporated prediction ...