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UMC Repository: Recent submissions

  • The new International Federation of Gynecology and Obstetrics (FIGO) ovulatory disorder classification: PRO and CON 
    Balen, Adam H.; Munro, Malcolm G.; O'Neill, Helen C.; Lunenfeld, Bruno; Fauser, Bart C.J.M. (Elsevier, 2023-04)
  • Which is more important for predicting de novo DSA production in donor-sensitized kidney transplant recipients, B-cell epitope or T-cell epitope analysis? 
    Ashimine, Satoshi; Sakamoto, Shintaro; Tomosugi, Toshihide; Spierings, Eric; Niemann, Matthias; Shizuku, Masato; Okada, Manabu; Miwa, Yuko; Iwasaki, Kenta; Hiramitsu, Takahisa; Goto, Norihiko; Narumi, Shunji; Watarai, Yoshihiko; Ishiyama, Kohei; Kobayashi, Takaaki (Elsevier, 2024-11)
    De novo donor-specific antibodies (dnDSA), particularly those against human leukocyte antigen (HLA) class II, can cause kidney allograft rejection, resulting in poor prognosis. Recently, HLA matching at both B-cell and ...
  • Compartment-specific small non-coding RNA changes and nucleolar defects in human mesial temporal lobe epilepsy 
    Vangoor, Vamshidhar R.; Giuliani, Giuliano; de Wit, Marina; Rangel, Carolina K.; Venø, Morten T.; Schulte, Joran T.; Gomes-Duarte, Andreia; Senthilkumar, Ketharini; Puhakka, Noora; Kjems, Jørgen; de Graan, Pierre N.E.; Pasterkamp, R. Jeroen (Springer, 2024-11-07)
    Mesial temporal lobe epilepsy (mTLE) is a debilitating disease characterized by recurrent seizures originating from temporal lobe structures such as the hippocampus. The pathogenic mechanisms underlying mTLE are incompletely ...
  • Health-Related Behaviors and Risk of Common Age-Related Brain Diseases Across Severities of Genetic Risk 
    Marini, Sandro; Kimball, Tamara N.; Mayerhofer, Ernst; Tack, Reinier W.P.; Senff, Jasper R.; Prapiadou, Savvina; Rivier, Cyprien A.; Duskin, Jonathan; Kourkoulis, Christina; Falcone, Guido J.; Yechoor, Nirupama; Tanzi, Rudolph E.; Rosand, Jonathan; Singh, Sanjula; Parodi, Livia; Anderson, Christopher D. (Lippincott Williams & Wilkins, 2024-11-26)
    Background and Objectives The 21-point Brain Care Score (BCS) is an index that ranks behaviors and clinical measurements with the aim of encouraging lifestyle adjustments to lower the incidence of age-related brain disease, ...
  • Invited commentary: It's not all about residual confounding - A plea for quantitative bias analysis for epidemiologic researchers and educators 
    Fox, Matthew P.; Adrien, Nedghie; Van Smeden, Maarten; Suarez, Elizabeth (Oxford University Press, 2024-11-01)
    Epidemiologists spend a great deal of time on confounding in our teaching, in our methods development, and in our assessment of study results. This may give the impression that uncontrolled confounding is the biggest problem ...
  • Development of a prediction model for clinically-relevant fatigue: a multi-cancer approach 
    Adiprakoso, Dhirendra; Katsimpokis, Dimitris; Oerlemans, Simone; Ezendam, Nicole P.M.; van Maaren, Marissa C.; van Til, Janine A.; van der Heijden, Thijs G.W.; Mols, Floortje; Aben, Katja K.H.; Vink, Geraldine R.; Koopman, Miriam; van de Poll-Franse, Lonneke V.; de Rooij, Belle H. (Springer Netherlands, 2025-01)
    Purpose: Fatigue is the most prevalent symptom across cancer types. To support clinicians in providing fatigue-related supportive care, this study aims to develop and compare models predicting clinically relevant fatigue ...
  • “Just listen to me”: Experiences of therapy after childhood sibling sexual abuse 
    van Berkel, Sheila R.; Bicanic, Iva A.E.; van der Voort, Anja (Elsevier Limited, 2025-04)
    Background: Sibling sexual abuse (SSA) is considered to occur more frequently than other types of intrafamilial sexual abuse and is related to numerous detrimental outcomes. Despite this, the literature on SSA is limited, ...
  • Practice visitations in primary care to improve performance of cardiovascular risk management: an observational study 
    Smits, Geert H.J.M.; Bots, Michiel L.; Hollander, Monika; de Wit, Ardine; van Doorn, Sander (Royal College of General Practitioners, 2024-10)
    Background: Despite programmatic protocolised care and structured support, considerable variation is observed in completeness of registration and achieving targets of cardiovascular risk management (CVRM) between individual ...
  • Prioritization of Psychopathological Symptoms and Clinical Characterization in Psychiatric Diagnoses: A Narrative Review 
    Leucht, Stefan; Van Os, Jim; Jäger, Markus; Davis, John M. (American Medical Association, 2024-11-06)
    Importance: Psychiatry mainly deals with conditions that are mediated by brain function but are not directly attributable to specific brain abnormalities. Given the lack of concrete biological markers, such as laboratory ...
  • Enhanced thrombin and plasmin generation profiles in alpha-2-antiplasmin–deficient patients: Data from the Rare Bleeding disorders in the Netherlands study 
    Haisma, Bauke; Rijpma, Sanna R.; Cnossen, Marjon H.; den Exter, Paul L.; Kruis, Ilmar C.; Meijer, Karina; Nieuwenhuizen, Laurens; van Es, Nick; Schutgens, Roger E.G.; Blijlevens, Nicole M.A.; van Heerde, Waander L.; Schols, Saskia E.M. (Elsevier, 2024-10)
    Background: α2-Antiplasmin (A2AP) deficiency is a rare and often unidentified disorder characterized by increased fibrinolysis and subsequent bleeding. Global hemostasis assays may increase insight into the altered coagulation ...
  • The effect of BCG vaccination in the elderly on infectious and non-infectious immune-mediated diseases 
    Dulfer, Elisabeth A.; Föhse, Konstantin; Taks, Esther J.M.; Moorlag, Simone J.C.F.M.; Koekenbier, Eva L.; van de Maat, Josephine S.; ten Oever, Jaap; Hoogerwerf, Jacobien J.; van Werkhoven, Cornelis H.; Bonten, Marc J.M.; van Hylckama Vlieg, Astrid; Rosendaal, Frits R.; Netea, Mihai G. (W.B. Saunders Ltd, 2024-12)
    Objectives: Previous research has suggested beneficial heterologous effects of the Bacillus Calmette-Guérin (BCG) vaccine on non-mycobacterial infections and other immune-mediated diseases. During the COVID-19 pandemic, ...
  • AGREE II Quality Assessment of National and International Clinical Practice Guidelines on Prostate Cancer Management by the OPTIMA Consortium 
    Sakalis, Vasileios; Bhattacharya, Yagnaseni; Beyer, Katharina; Murray, Charlotte; Smith, Emma Jane; Willemse, Peter Paul M.; Gandaglia, Giorgio; Boissier, Romain; Borkowetz, Angelika; Dabestani, Saeed; Leenen, Renee C.A.; Vilaseca, Antoni; Maresca, Gianluca; Teoh, Jeremy; Gómez Rivas, Juan; Rajwa, Pawel; Lardas, Michael; Grivas, Nikolas; Van den Broeck, Thomas; Pradere, Benjamin; Schouten, Natasha; Tandogdu, Zafer; Evans-Axelsson, Susan; Maclennan, Steven; Thomas, Marlene; Briganti, Alberto; Bjartell, Anders; Cornford, Phil; Kruger, Hagen; N'Dow, James; Roobol, Monique J.; Omar, Muhammad Imran; OPTIMA Consortium (Elsevier, 2024-12)
    Background and objective: Clinical practice guidelines for prostate cancer (PCa) are a valuable resource for everyday clinical practice. The clinical practice guidelines and recommendations produced by various societies ...
  • Silent brain ischemia within the TAXINOMISIS framework: association with clinical and advanced ultrasound metrics 
    Kigka, Vassiliki; Carrozzi, Alessandro; Gramegna, Laura Ludovica; Siogkas, Panagiotis K.; Potsika, Vassiliki; Tsakanikas, Vassilis; Kallmayer, Michael; Obach, Victor; Riambau, Vincente; Spinella, Giovanni; Pratesi, Giovanni; Cirillo, Luigi; Manners, David Neil; Pini, Rodolfo; Faggioli, Gianluca; de Borst, Gert J.; Galyfos, George; Sigala, Frangiska; Mutavdzic, Perica; Jovanovic, Marija; Koncar, Igor; Fotiadis, Dimitros I.; on behalf of the TAXINOMISIS Silent Ischemia Working Group (Frontiers Media S. A., 2024-10-11)
    Introduction: The relationship between carotid artery stenosis (CAS) and ipsilateral silent brain ischemia (SBI) remains unclear, with uncertain therapeutic implications. The present study, part of the TAXINOMISIS project ...
  • Promoting Equitable and Affordable Patient Access to Safe and Effective Innovations in Donation and Transplantation of Substances of Human Origin and Derived Therapies 
    Cuende, Natividad; Tullius, Stefan G.; Izeta, Ander; Plattner, Verena; Börgel, Martin; Ciccocioppo, Rachele; Correa-Rocha, Rafael; Koh, Mickey B.C.; De Angelis, Vincenzo; Gondolesi, Gabriel E.; Ten Ham, Renske; Porte, Robert J.; Hernández-Maraver, Dolores; Hawthorne, Wayne J.; Sureda, Anna; Orlando, Giuseppe; Haraldsson, Börje; Ascher, Nancy L.; Dominguez-Gil, Beatriz; Oniscu, Gabriel C. (Lippincott Williams & Wilkins, 2025-01)
    Innovation is a hallmark of organ, tissue, and cell transplantation. The development of new treatments derived from these substances of human origin (SoHO) has rapidly evolved in recent years. Despite the great benefits ...
  • Scalable purification of extracellular vesicles with high yield and purity using multimodal flowthrough chromatography 
    Bonner, Scott E.; van de Wakker, Simonides I.; Phillips, William; Willms, Eduard; Sluijter, Joost P.G.; Hill, Andrew F.; Wood, Matthew J.A.; Vader, Pieter (John Wiley & Sons Inc., 2024-02)
    Extracellular vesicles (EVs) are cell derived membranous nanoparticles. EVs are important mediators of cell–cell communication via the transfer of bioactive content and as such they are being investigated for disease ...
  • Gut Microbial Metabolites and Future Risk of Parkinson's Disease: A Metabolome-Wide Association Study 
    Zhao, Yujia; Lai, Yunjia; Darweesh, Sirwan K.L.; Bloem, Bastiaan R.; Forsgren, Lars; Hansen, Johnni; Katzke, Verena A.; Masala, Giovanna; Sieri, Sabina; Sacerdote, Carlotta; Panico, Salvatore; Zamora-Ros, Raul; Sánchez, Maria Jose; Huerta, José María; Guevara, Marcela; Vinagre-Aragon, Ana; Vineis, Paolo; Lill, Christina M.; Miller, Gary W.; Peters, Susan; Vermeulen, Roel (John Wiley & Sons Inc., 2025-03)
    Background: Alterations in gut microbiota are observed in Parkinson's disease (PD). Previous studies on microbiota-derived metabolites in PD were small-scale and post-diagnosis, raising concerns about reverse causality. ...
  • Neuroblastoma plasticity during metastatic progression stems from the dynamics of an early sympathetic transcriptomic trajectory 
    Villalard, Benjamin; Boltjes, Arjan; Reynaud, Florie; Imbaud, Olivier; Thoinet, Karine; Timmerman, Ilse; Croze, Séverine; Theoulle, Emy; Atzeni, Gianluigi; Lachuer, Joël; Molenaar, Jan J.; Tytgat, Godelieve A.M.; Delloye-Bourgeois, Céline; Castellani, Valérie (Nature Publishing Group, 2024-11-06)
    Despite their indisputable importance in neuroblastoma (NB) pathology, knowledge of the bases of NB plasticity and heterogeneity remains incomplete. They may be rooted in developmental trajectories of their lineage of ...
  • Informal caregiver burden in dialysis care and how it relates to patients' health-related quality of life and symptoms 
    Driehuis, Esmee; Janse, Roemer J.; Roeterdink, Anneke J.; Konijn, Wanda S.; Van Lieshout, Thomas S.; Vogels, Theodôr J.F.M.; Goto, Namiko A.; Broese Van Groenou, Marjolein I.; Dekker, Friedo W.; Van Jaarsveld, Brigit C.; Abrahams, Alferso C. (Oxford University Press, 2024-11-01)
    Background: Informal caregivers play a crucial role in dialysis care but may experience significant burden, potentially affecting both caregiver and patient outcomes. Research on caregiver burden and health-related quality ...
  • Hypoxia and TNF-alpha modulate extracellular vesicle release from human induced pluripotent stem cell-derived cardiomyocytes 
    Viola, Margarida; Bebelman, Maarten P.; Maas, Renee G.C.; de Voogt, Willemijn S.; Verweij, Frederik J.; Seinen, Cor S.; de Jager, Saskia C.A.; Vader, Pieter; Pegtel, Dirk Michiel; Petrus Gerardus Sluijter, Joost (John Wiley & Sons Inc., 2024-11)
    Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication in the heart under homeostatic and pathological conditions, such as myocardial infarction (MI). However, the basic mechanisms ...
  • Transient impact of chronic social stress on effort-based reward motivation in non-food restricted mice: Involvement of corticosterone 
    Evertse, Danina; Alves-Martinez, Pilar; Treccani, Giulia; Müller, Marianne B.; Meye, Frank J.; van der Kooij, Michael A. (Elsevier, 2024-11)
    Chronic stress has been connected to a reduced effort and motivational deficits. To study effort-based motivation in rodents, operant conditioning is often employed. However, caloric restriction is typically imposed ...