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UMC Repository: Recent submissions

  • To treat or not to treat pulmonary arteries: epinephrine provocation to unmask right ventricular load 
    Conijn, M.; Dekkers, T. H.P.M.; Molenschot, M. M.; Breur, J. M.P.; Slieker, M. G.; Haas, F.; Krings, G. J. (Elsevier, 2022-03)
    Background: Pulmonary artery stenosis (PAS) is common in congenital heart disease (CHD). The indication for treatment of PAS is primarily based on invasively measured pressure gradients. Anesthetics used during cardiac ...
  • RNA helicase DDX3 regulates RAD51 localization and DNA damage repair in Ewing sarcoma 
    Randolph, Matthew E.; Afifi, Marwa; Gorthi, Aparna; Weil, Rachel; Wilky, Breelyn A.; Weinreb, Joshua; Ciero, Paul; Hoeve, Natalie ter; van Diest, Paul J.; Raman, Venu; Bishop, Alexander J.R.; Loeb, David M. (Elsevier, 2024-02-16)
    We previously demonstrated that RNA helicase DDX3X (DDX3) can be a therapeutic target in Ewing sarcoma (EWS), but its role in EWS biology remains unclear. The present work demonstrates that DDX3 plays a unique role in DNA ...
  • Remission versus low disease activity as treatment targets in rheumatoid arthritis: how to strike the right balance between too strict and too lenient targets? A meta-epidemiological study of individual patient data 
    Duarte, Catia; Jacobs, Johannes W G; Ferreira, Ricardo J O; Welsing, Paco M J; Gossec, Laure; Machado, Pedro M; van der Heijde, Désirée; da Silva, Jose Antonio Pereira (BMJ Publishing Group, 2024-11-07)
    OBJECTIVES: To evaluate the impact of using Simplified Disease Activity Index (SDAI)-LDA (low disease activity) versus different definitions of remission as a treatment target in established rheumatoid arthritis. METHODS: ...
  • Responsiveness of the International Spinal Cord Injury Quality of Life Basic Data Set V2.0: An international longitudinal study 
    Post, Marcel W.M.; Forchheimer, Martin; Charlifue, Susan; D'Andréa Greve, Julia; New, Peter; Tate, Denise G. (Maney Publishing, 2023-09)
    Context/Objective: Examine the sensitivity of the International Spinal Cord Injury Quality of Life Basic Data Set V2.0 (QoL-BDS V2.0) to reflect changes in mobility and secondary health conditions (SHCs) between inpatient ...
  • Deciphering the mechanism of PSORI-CM02 in suppressing keratinocyte proliferation through the mTOR/HK2/glycolysis axis 
    Wang, Maojie; Tang, Bin; Huang, Huanjie; Wu, Xiaodong; Deng, Hao; Chen, Haiming; Mei, Liyan; Chen, Xiumin; Burgering, Boudewijn; Lu, Chuanjian (Frontiers Media S. A., 2023)
    Hyperplasia of epidermal keratinocytes that depend on glycolysis is a new hallmark of psoriasis pathogenesis. Our previous studies demonstrated that PSORI-CM02 could halt the pathological progression of psoriasis by targeting ...
  • Radiographic outcome after vertebral body tethering of the lumbar spine 
    Trobisch, Per D.; Castelein, Rene; Da Paz, Stephanie (Springer-Verlag, 2023-06)
    Introduction: Multiple studies have analyzed the outcome after thoracic Vertebral Body Tethering (VBT). The results seem reproducible with most studies reporting coronal correction rates around 50% and a tether breakage ...
  • Sex comparisons in the association of prediabetes and type 2 diabetes with cognitive function, depression, and quality of life: The Maastricht study 
    de Ritter, Rianneke; Sep, Simone J.S.; van der Kallen, Carla J.H.; van Greevenbroek, Marleen M.J.; Koster, Annemarie; Eussen, Simone J.P.M.; Dagnelie, Pieter C.; van Boxtel, Martin; Schram, Miranda T.; Köhler, Sebastian; Martens, Jordi A.J.; Snobl, Lucia; Vos, Rimke C.; Stehouwer, Coen D.A.; Peters, Sanne A.E. (Wiley-Blackwell, 2023-07)
    Aims: There are sex differences in the excess risk of diabetes-associated cardiovascular disease. However, it is not clear whether these sex differences exist with regard to other complications like mental health aspects. ...
  • Engaging European society at the forefront of cancer research and care: How discussions at the 5th Gago Conference on European Science policy led to the Heidelberg Manifesto 
    Baumann, Michael; Celis, Julio; Ringborg, Ulrik; Heitor, Manuel; Berns, Anton; Albreht, Tit; Arabadjiev, Jeliazko; Boutros, Michael; Brandenburg, Mario; Canhao, Helena; Carneiro, Fatima; Chomienne, Christine; De Lorenzo, Francesco; Eggermont, Alexander M.M.; Font, Angel; Garralda, Elena; Goulart, Margarida; Henrique, Rui; Lawler, Mark; Maier-Hein, Lena; Meunier, Francoise; Oberst, Simon; Oliveira, Pedro; Papatriantafyllou, Maria; Schüz, Joachim; Solary, Eric; Valencia, Alfonso; Vargas, Rosalia; Weiderpass, Elisabete; Wilking, Nils (Elsevier, 2023-06)
    European cancer research stakeholders met in October 2022 in Heidelberg, Germany, at the 5th Gago conference on European Cancer Policy, to discuss the current cancer research and cancer care policy landscape in Europe. ...
  • Machine Learning and Statistics in Clinical Research Articles - Moving Past the False Dichotomy 
    Finlayson, Samuel G.; Beam, Andrew L.; Van Smeden, Maarten (American Medical Association, 2023-05-01)
  • Three-dimensional ultrasonography could be a potential non-ionizing tool to evaluate vertebral rotation of subjects with adolescent idiopathic scoliosis 
    Lee, Tin Yan; Yang, De; Lai, Kelly Ka Lee; Castelein, Rene M.; Schlosser, Tom P.C.; Chu, Winnie; Lam, Tsz Ping; Zheng, Yong Ping (Wiley-Blackwell Publishing Ltd, 2023-09)
    Background: Three-dimensional (3D) ultrasonography is nonionizing and has been demonstrated to be a reliable tool for scoliosis assessment, including coronal and sagittal curvatures. It shows a great potential for axial ...
  • The coronavirus disease pandemic among adult congenital heart disease patients and the lessons learnt – results of a prospective multicenter european registry 
    Ruperti-Repilado, Francisco Javier; Baumgartner, Helmut; Bouma, Berto; Bouchardy, Judith; Budts, Werner; Campens, Laurence; Chessa, Massimo; Jesús del Cerro Marin, Maria; Gabriel, Harald; Gallego, Pastora; González, Elvira Ana; Jensen, Annette Schophuus; Ladouceur, Magalie; Lockhart, Christopher; Miranda-Barrio, Berta; Morissens, Marielle; Escobar, Eduardo Moreno; Pasquet, Agnès; Soriano, Joaquin Rueda; Elise van den Bosch, Annemien; Berdina van der Zwaan, Heleen; Tobler, Daniel; Greutmann, Matthias; Schwerzmann, Markus (Elsevier, 2023-03)
    Background: At the beginning of the COVID-19 pandemic, professionals in charge of particularly vulnerable populations, such as adult congenital heart disease (ACHD) patients, were confronted with difficult decision-making. ...
  • Identifying spin bias of nonsignificant findings in biomedical studies 
    O’Leary, Renée; La Rosa, Giusy Rita Maria; Vernooij, Robin; Polosa, Riccardo (BioMed Central, 2023-12)
    Objective: The purpose of this research note is to share a technique for the identification of spin bias that we developed as part of a living systematic review on the cardiovascular testing of e-cigarette substitution for ...
  • Identification of biomarkers for glycaemic deterioration in type 2 diabetes 
    Slieker, Roderick C.; Donnelly, Louise A.; Akalestou, Elina; Lopez-Noriega, Livia; Melhem, Rana; Güneş, Ayşim; Abou Azar, Frederic; Efanov, Alexander; Georgiadou, Eleni; Muniangi-Muhitu, Hermine; Sheikh, Mahsa; Giordano, Giuseppe N.; Åkerlund, Mikael; Ahlqvist, Emma; Ali, Ashfaq; Banasik, Karina; Brunak, Søren; Barovic, Marko; Bouland, Gerard A.; Burdet, Frédéric; Canouil, Mickaël; Dragan, Iulian; Elders, Petra J.M.; Fernandez, Celine; Festa, Andreas; Fitipaldi, Hugo; Froguel, Phillippe; Gudmundsdottir, Valborg; Gudnason, Vilmundur; Gerl, Mathias J.; van der Heijden, Amber A.; Jennings, Lori L.; Hansen, Michael K.; Kim, Min; Leclerc, Isabelle; Klose, Christian; Kuznetsov, Dmitry; Mansour Aly, Dina; Mehl, Florence; Marek, Diana; Melander, Olle; Niknejad, Anne; Ottosson, Filip; Pavo, Imre; Duffin, Kevin; Syed, Samreen K.; Shaw, Janice L.; Cabrera, Over; Pullen, Timothy J.; Simons, Kai; Solimena, Michele; Suvitaival, Tommi; Wretlind, Asger; Rossing, Peter; Lyssenko, Valeriya; Legido Quigley, Cristina; Groop, Leif; Thorens, Bernard; Franks, Paul W.; Lim, Gareth E.; Estall, Jennifer; Ibberson, Mark; Beulens, Joline W.J.; ’t Hart, Leen M.; Pearson, Ewan R.; Rutter, Guy A. (Nature Publishing Group, 2023-05-03)
    We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic ...
  • Molecular mechanisms underlying adverse effects of dexamethasone and betamethasone in the developing cardiovascular system 
    Garrud, Tessa A.C.; Teulings, Noor E.W.D.; Niu, Youguo; Skeffington, Katie L.; Beck, Christian; Itani, Nozomi; Conlon, Fiona G.; Botting, Kimberley J.; Nicholas, Lisa M.; Tong, Wen; Derks, Jan B.; Ozanne, Susan E.; Giussani, Dino A. (John Wiley & Sons Inc., 2023-06)
    Antenatal glucocorticoids accelerate fetal lung maturation and reduce mortality in preterm babies but can trigger adverse effects on the cardiovascular system. The mechanisms underlying off-target effects of the synthetic ...
  • Clinical decision rules in primary care: Necessary investments for sustainable healthcare 
    Heerink, Jorn S.; Oudega, Ruud; Hopstaken, Rogier; Koffijberg, Hendrik; Kusters, Ron (Cambridge University Press, 2023-05-01)
    Clinical judgement in primary care is more often decisive than in the hospital. Clinical decision rules (CDRs) can help general practitioners facilitating the work-through of differentials that follows an initial suspicion, ...
  • 10 clinical tips for advancing patient safety when using syringe pump systems for microinfusion intravenous drug therapy 
    Weiss, Markus; Van Der Eijk, Anne; Lönnqvist, Per Arne; Lucchini, Alberto; Timmerman, Annemoon (Lippincott Williams & Wilkins, 2023-06-01)
  • Metabolic profile of complete spinal cord injury in pons and cerebellum: A 3T 1H MRS study 
    Richter, Johannes K.; Vallesi, Vanessa; Zölch, Niklaus; Chan, Kimberly L.; Hunkeler, Nadine; Abramovic, Mihael; Hashagen, Claus; Christiaanse, Ernst; Shetty, Ganesh; Verma, Rajeev K.; Berger, Markus F.; Frotzler, Angela; Eisenlohr, Heidrun; Eriks Hoogland, Inge; Scheel-Sailer, Anke; Wyss, Patrik O. (Nature Publishing Group, 2023-12)
    The aim of this exploratory study was the assessment of the metabolic profiles of persons with complete spinal cord injury (SCI) in three region-of-interests (pons, cerebellar vermis, and cerebellar hemisphere), with ...
  • The use and misuse of sonographic reference values in neuromuscular disease 
    Goedee, H. Stephan; van Alfen, Nens (John Wiley & Sons Inc., 2023-07)
  • Small-Molecule Cyclophilin Inhibitors Potently Reduce Platelet Procoagulant Activity 
    Van Bael, Jens; Vandenbulcke, Aline; Ahmed-Belkacem, Abdelhakim; Guichou, Jean François; Pawlotsky, Jean Michel; Samyn, Jelle; Barendrecht, Arjan D.; Maas, Coen; De Meyer, Simon F.; Vanhoorelbeke, Karen; Tersteeg, Claudia (Multidisciplinary Digital Publishing Institute (MDPI), 2023-04)
    Procoagulant platelets are associated with an increased risk for thrombosis. Procoagulant platelet formation is mediated via Cyclophilin D (CypD) mediated opening of the mitochondrial permeability transition pore. Inhibiting ...
  • Neuropathological signatures revealed by transcriptomic and proteomic analysis in Pten-deficient mouse models 
    Cheung, Stanley K.K.; Kwok, Jacinda; Or, Penelope M.Y.; Wong, Chi Wai; Feng, Bo; Choy, Kwong Wai; Chang, Raymond C.C.; Burbach, J. Peter H.; Cheng, Alfred S.L.; Chan, Andrew M. (Nature Publishing Group, 2023-12)
    PTEN hamartoma tumour syndrome is characterised by mutations in the human PTEN gene. We performed transcriptomic and proteomic analyses of neural tissues and primary cultures from heterozygous and homozygous Pten-knockout ...