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UMC Repository: Recent submissions

  • (Cost-)effectiveness and implementation of a combined lifestyle intervention for outpatients with severe mental illness (GOAL!): a hybrid quasi-experimental study protocol 
    Noortman-van Meteren, C R; van Schothorst, M M E; den Bleijker, N M; Braakhuis-Keuning, B; Houwert-Zuidema, W M H; van Amelsvoort, T A M J; Deenik, J (BioMed Central, 2024-11-14)
    BACKGROUND: People with severe mental illness (SMI) face not only impaired mental health, but also a greater risk of physical comorbidities and a shorter life expectancy compared to the general population. A poor lifestyle ...
  • Intensive 2-days training on perfused human placenta for microvascular anastomoses 
    Colombo, Elisa; Wolf, Fabian; Helg, Fiona; Höbner, Lara; Watson, Jennifer A; Sebök, Martina; Haslinger, Christian; van Doormaal, Tristan; Regli, Luca; Esposito, Giuseppe (Springer, 2024-11-15)
    Background and Purpose: We report on an intensive two-day training program on microanastomoses performed on perfused human placenta models. A specific scoring system was elaborated to evaluate the participants’ microsurgical ...
  • Clinical Subtype Trajectories in Sepsis Patients Admitted to the ICU: A Secondary Analysis of an Observational Study 
    Slim, Marleen A; van Amstel, Rombout B E; Müller, Marcella C A; Cremer, Olaf L; Vlaar, Alexander P J; van der Poll, Tom; Wiersinga, W Joost; Seymour, Christopher W; van Vught, Lonneke A (Lippincott Williams & Wilkins, 2024-11)
    OBJECTIVES: Sepsis is an evolving process and proposed subtypes may change over time. We hypothesized that previously established sepsis subtypes are dynamic, prognostic of outcome, and trajectories are associated with ...
  • Association between metabolomics-based biomarker scores and 10-year cognitive decline in men and women. The Doetinchem Cohort Study 
    Smit, Annelot P; Herber, Gerrie-Cor M; Kuiper, Lieke M; Rietman, M Liset; Wesenhagen, Kirsten E J; Picavet, H Susan J; Slagboom, P Eline; Verschuren, W M Monique (Oxford University Press, 2024-11-04)
    BACKGROUND: Metabolomic scores based on age (MetaboAge) and mortality (MetaboHealth) are considered indicators of overall health, but their association with cognition in the general population is unknown. Therefore, the ...
  • Radioiodine-refractory thyroid cancer-is it time to change the definition in light of novel redifferentiation therapies? 
    Petranović Ovčariček, Petra; de Keizer, Bart; Campennì, Alfredo; Kreissl, Michael C; Deandreis, Desiree; Tuncel, Murat; Giovanella, Luca (Springer-Verlag, 2025-01)
  • Accelerated production of human epithelial organoids in a miniaturized spinning bioreactor 
    Ye, Shicheng; Marsee, Ary; van Tienderen, Gilles S; Rezaeimoghaddam, Mohammad; Sheikh, Hafsah; Samsom, Roos-Anne; de Koning, Eelco J P; Fuchs, Sabine; Verstegen, Monique M A; van der Laan, Luc J W; van de Vosse, Frans; Malda, Jos; Ito, Keita; Spee, Bart; Schneeberger, Kerstin (Cell Press, 2024-11-18)
    Conventional static culture of organoids necessitates weekly manual passaging and results in nonhomogeneous exposure of organoids to nutrients, oxygen, and toxic metabolites. Here, we developed a miniaturized spinning ...
  • Menopause age and type and dementia risk: a pooled analysis of 233 802 women 
    Dobson, Annette J; Xu, Zhiwei; Wilson, Louise F; Chung, Hsin-Fang; Sandin, Sven; Van der Schouw, Yvonne T; Demakakos, Panayotes; Weiderpass, Elisabete; Mishra, Gita D (Oxford University Press, 2024-11-01)
    Objectives: It is not clear whether the association between younger age at menopause and increased risk of dementia is modified by type of menopause. We examined the association of age at menopause or hysterectomy with ...
  • Complement activation by IgM autoantibodies linked to immune-mediated neuropathies depends on C2 
    Budding, Kevin; Dijkxhoorn, Kim; de Zeeuw, Elisabeth; Bloemenkamp, Lauri M; van der Pol, W Ludo; Notermans, Nicolette C; Minnema, Monique C; Leusen, Jeanette H W; Hack, C Erik; Van de Walle, Inge (Wiley-Blackwell, 2025-01)
    BACKGROUND AND PURPOSE: Complement factor C2 is a potential therapeutic target in immune-mediated neuropathies. However, literature suggests that classical complement pathway activation may proceed to C3 in the absence of ...
  • Diagnostic and prognostic biomarkers for pancreatic neuroendocrine neoplasms 
    Sonnen, Andreas F.P.; Verschuur, Anna Vera D.; Brosens, Lodewijk A.A. (Springer Medizin, 2024)
    This review examines the diagnostic and prognostic biomarkers for pancreatic neuroendocrine neoplasms (PanNENs), a heterogeneous group of tumors with expression of neuroendocrine markers. PanNENs include both well-differentiated ...
  • Clinical parameters of death and heart failure hospitalization in biventricular systolic dysfunction assessed via cardiac magnetic resonance 
    Al'Aref, Subhi J; Gautam, Nitesh; Mansour, Munthir; Alqaisi, Omar; Tarun, Tushar; Devabhaktuni, Subodh; Atreya, Auras; Abete, Raffaele; Aquaro, Giovanni Donato; Baggiano, Andrea; Barison, Andrea; Bogaert, Jan; Camastra, Giovanni; Carigi, Samuela; Carrabba, Nazario; Casavecchia, Grazia; Censi, Stefano; Cicala, Gloria; De Cecco, Carlo N; De Lazzari, Manuel; Di Giovine, Gabriella; Calo, Leonardo; Dobrovie, Monica; Focardi, Marta; Fusini, Laura; Gaibazzi, Nicola; Gismondi, Annalaura; Gravina, Matteo; Guglielmo, Marco; Lanzillo, Chiara; Lombardi, Massimo; Lorenzoni, Valentina; Lozano-Torres, Jordi; Margonato, Davide; Martini, Chiara; Marzo, Francesca; Masci, Pier-Giorgio; Masi, Ambra; Moro, Claudio; Muscogiuri, Giuseppe; Mushtaq, Saima; Nese, Alberto; Palumbo, Alessandro; Pavon, Anna Giulia; Pedrotti, Patrizia; Marra, Martina Perazzolo; Pradella, Silvia; Presicci, Cristina; Rabbat, Mark G; Raineri, Claudia; Rodriguez-Palomares, Jose' F; Sbarbati, Stefano; Schoepf, U Joseph; Squeri, Angelo; Sverzellati, Nicola; Symons, Rolf; Tat, Emily; Timpani, Mauro; Todiere, Giancarlo; Valentini, Adele; Varga-Szemes, Akos; Volpe, Alessandra; Guaricci, Andrea Igoren; Schwitter, Juerg; Pontone, Gianluca (Elsevier Ireland Ltd, 2025-01-15)
    Aims: While factors associated with adverse events are well elucidated in setting of isolated left ventricular dysfunction, clinical and imaging-based prognosticators of adverse outcomes are lacking in context of biventricular ...
  • Presentation and outcome in carriers of pathogenic variants in SLC34A1 and SLC34A3 encoding sodium-phosphate transporter NPT 2a and 2c 
    Brunkhorst, Max; Brunkhorst, Lena; Martens, Helge; Papizh, Svetlana; Besouw, Martine; Grasemann, Corinna; Turan, Serap; Sikora, Przemyslaw; Chromek, Milan; Cornelissen, Elisabeth; Fila, Marc; Lilien, Marc; Allgrove, Jeremy; Neuhaus, Thomas J; Eltan, Mehmet; Espinosa, Laura; Schnabel, Dirk; Gokce, Ibrahim; González-Rodríguez, Juan David; Khandelwal, Priyanka; Keijzer-Veen, Mandy G; Lechner, Felix; Szczepańska, Maria; Zaniew, Marcin; Bacchetta, Justine; Emma, Francesco; Haffner, Dieter (Elsevier, 2025-01)
    Pathogenic variants in SLC34A1 and SLC34A3 encoding sodium-phosphate transporter 2a and 2c are rare causes of phosphate wasting. Since data on presentation and outcomes are scarce, we collected clinical, biochemical and ...
  • An international multi-institutional validation of T1 sub-staging of intraductal papillary mucinous neoplasm-derived pancreatic cancer 
    Habib, Joseph R.; Rompen, Ingmar F.; Campbell, Brady A.; Andel, Paul C.M.; Kinny-Köster, Benedict; Damaseviciute, Ryte; Brock Hewitt, D.; Sacks, Greg D.; Javed, Ammar A.; Besselink, Marc G.; van Santvoort, Hjalmar C.; Daamen, Lois A.; Loos, Martin; He, Jin; Quintus Molenaar, I.; Büchler, Markus W.; Wolfgang, Christopher L. (Oxford University Press, 2024-11-01)
    BACKGROUND: Intraductal papillary mucinous neoplasm (IPMN)-derived pancreatic ductal adenocarcinoma (PDAC) is resected at smaller sizes compared with its biologically distinct counterpart, pancreatic intraepithelial neoplasia ...
  • Regression calibration of self-reported mobile phone use to optimize quantitative risk estimation in the COSMOS study 
    The COSMOS Study Group (Oxford University Press, 2024-10-01)
    The Cohort Study of Mobile Phone Use and Health (COSMOS) has repeatedly collected self-reported and operator-recorded data on mobile phone use. Assessing health effects using self-reported information is prone to measurement ...
  • Confounder Adjustment Using the Disease Risk Score: A Proposal for Weighting Methods 
    Nguyen, Tri Long; Debray, Thomas P.A.; Youn, Bora; Simoneau, Gabrielle; Collins, Gary S. (Oxford University Press, 2024-02-01)
    Propensity score analysis is a common approach to addressing confounding in nonrandomized studies. Its implementation, however, requires important assumptions (e.g., positivity). The disease risk score (DRS) is an alternative ...
  • COVID-19 in pregnant women: a systematic review and meta-analysis on the risk and prevalence of pregnancy loss 
    van Baar, Janneke A.C.; Kostova, Elena B.; Allotey, John; Thangaratinam, Shakila; Zamora, Javier R.; Bonet, Mercedes; Kim, Caron Rahn; Mofenson, Lynne M.; Kunst, Heinke; Khalil, Asma; van Leeuwen, Elisabeth; Keijzer, Julia; Strikwerda, Marije; Clark, Bethany; Verschuuren, Maxime; Coomarasamy, Arri; Goddijn, Mariette; van Wely, Madelon; on behalf of the and PregCOV-19 Living Systematic Review Consortium (Oxford University Press, 2024-03-01)
    BACKGROUND: Pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more likely to experience preterm birth and their neonates are more likely to be stillborn or admitted to a neonatal ...
  • Bridging the Gap: Exploring the Role of Locus of Control in the Transition from Environmental Concerns to Organic Product Consumption in North Portugal, a SmartPLS Study 
    Penalba-Sánchez, Lucía; Di Gregorio, Elisa; Claro, Raquel; Pinto, Mafalda; Pinto, Elisabete; Oliveira-Silva, Patrícia (Multidisciplinary Digital Publishing Institute (MDPI), 2024-02-02)
    (1) Background: Exploring the drivers of organic food consumption is crucial for designing pro-environmental marketing strategies. This study aims to investigate elements associated with organic product consumption in North ...
  • Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries 
    García-Marín, Luis M.; Campos, Adrian I.; Diaz-Torres, Santiago; Rabinowitz, Jill A.; Ceja, Zuriel; Mitchell, Brittany L.; Grasby, Katrina L.; Thorp, Jackson G.; Agartz, Ingrid; Alhusaini, Saud; Ames, David; Amouyel, Philippe; Andreassen, Ole A.; Arfanakis, Konstantinos; Arias-Vasquez, Alejandro; Armstrong, Nicola J.; Athanasiu, Lavinia; Bastin, Mark E.; Beiser, Alexa S.; Bennett, David A.; Bis, Joshua C.; Boks, Marco P.M.; Boomsma, Dorret I.; Brodaty, Henry; Brouwer, Rachel M.; Buitelaar, Jan K.; Burkhardt, Ralph; Cahn, Wiepke; Calhoun, Vince D.; Carmichael, Owen T.; Chakravarty, Mallar; Chen, Qiang; Ching, Christopher R.K.; Cichon, Sven; Crespo-Facorro, Benedicto; Crivello, Fabrice; Dale, Anders M.; Smith, George Davey; de Geus, Eco J.C.; De Jager, Philip L.; de Zubicaray, Greig I.; Debette, Stéphanie; DeCarli, Charles; Depondt, Chantal; Desrivières, Sylvane; Djurovic, Srdjan; Ehrlich, Stefan; Erk, Susanne; Espeseth, Thomas; Fernández, Guillén; Filippi, Irina; Fisher, Simon E.; Fleischman, Debra A.; Fletcher, Evan; Fornage, Myriam; Forstner, Andreas J.; Francks, Clyde; Franke, Barbara; Ge, Tian; Goldman, Aaron L.; Grabe, Hans J.; Green, Robert C.; Grimm, Oliver; Groenewold, Nynke A.; Gruber, Oliver; Gudnason, Vilmundur; Håberg, Asta K.; Haukvik, Unn K.; Heinz, Andreas; Hibar, Derrek P.; Hilal, Saima; Himali, Jayandra J.; Ho, Beng Choon; Hoehn, David F.; Hoekstra, Pieter J.; Hofer, Edith; Hoffmann, Wolfgang; Holmes, Avram J.; Homuth, Georg; Hosten, Norbert; Ikram, M. Kamran; Ipser, Jonathan C.; Jack, Clifford R.; Jahanshad, Neda; Jönsson, Erik G.; Kahn, Rene S.; Kanai, Ryota; Klein, Marieke; Knol, Maria J.; Launer, Lenore J.; Lawrie, Stephen M.; Hellard, Stephanie Le; Lee, Phil H.; Lemaître, Hervé; Li, Shuo; Liewald, David C.M.; Lin, Honghuang; Longstreth, W. T.; Lopez, Oscar L.; Luciano, Michelle; Maillard, Pauline; Marquand, Andre F.; Martin, Nicholas G.; Martinot, Jean Luc; Mather, Karen A.; Mattay, Venkata S.; McMahon, Katie L.; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Mirza-Schreiber, Nazanin; Milaneschi, Yuri; Mosley, Thomas H.; Mühleisen, Thomas W.; Müller-Myhsok, Bertram; Maniega, Susana Muñoz; Nauck, Matthias; Nho, Kwangsik; Niessen, Wiro J.; Nöthen, Markus M.; Nyquist, Paul A.; Oosterlaan, Jaap; Pandolfo, Massimo; Paus, Tomas; Pausova, Zdenka; Penninx, Brenda W.J.H.; Pike, G. Bruce; Psaty, Bruce M.; Pütz, Benno; Reppermund, Simone; Rietschel, Marcella D.; Risacher, Shannon L.; Romanczuk-Seiferth, Nina; Romero-Garcia, Rafael; Roshchupkin, Gennady V.; Rotter, Jerome I.; Sachdev, Perminder S.; Sämann, Philipp G.; Saremi, Arvin; Sargurupremraj, Muralidharan; Saykin, Andrew J.; Schmaal, Lianne; Schmidt, Helena; Schmidt, Reinhold; Schofield, Peter R.; Scholz, Markus; Schumann, Gunter; Schwarz, Emanuel; Shen, Li; Shin, Jean; Sisodiya, Sanjay M.; Smith, Albert V.; Smoller, Jordan W.; Soininen, Hilkka S.; Steen, Vidar M.; Stein, Dan J.; Stein, Jason L.; Thomopoulos, Sophia I.; Toga, Arthur W.; Tordesillas-Gutiérrez, Diana; Trollor, Julian N.; Valdes-Hernandez, Maria C.; van ′t Ent, Dennis; van Bokhoven, Hans; van der Meer, Dennis; van der Wee, Nic J.A.; Vázquez-Bourgon, Javier; Veltman, Dick J.; Vernooij, Meike W.; Villringer, Arno; Vinke, Louis N.; Völzke, Henry; Walter, Henrik; Wardlaw, Joanna M.; Weinberger, Daniel R.; Weiner, Michael W.; Wen, Wei; Westlye, Lars T.; Westman, Eric; White, Tonya; Witte, A. Veronica; Wolf, Christiane; Yang, Jingyun; Zwiers, Marcel P.; Ikram, M. Arfan; Seshadri, Sudha; Thompson, Paul M.; Satizabal, Claudia L.; Medland, Sarah E.; Rentería, Miguel E. (Nature Research, 2024-11)
    Subcortical brain structures are involved in developmental, psychiatric and neurological disorders. Here we performed genome-wide association studies meta-analyses of intracranial and nine subcortical brain volumes (brainstem, ...
  • Cardiovascular Risks of Simultaneous Use of Alcohol and Cocaine—A Systematic Review 
    van Amsterdam, Jan; Gresnigt, Femke; van den Brink, Wim (Multidisciplinary Digital Publishing Institute (MDPI), 2024-03-01)
    Background: The simultaneous use of cocaine and alcohol is highly prevalent and is associated with high numbers of emergency department admissions, primarily due to cardiovascular complications. Aims: To answer the question ...
  • A digital dashboard for reporting mental, neurological and substance use disorders in Nairobi, Kenya: Implementing an open source data technology for improving data capture 
    EPInA Study Team (Public Library of Science, 2024-11-01)
    The availability of quality and timely data for routine monitoring of mental, neurological and substance use (MNS) disorders is a challenge, particularly in Africa. We assessed the feasibility of using an open-source data ...
  • Global, regional, and national burden of neck pain, 1990–2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021 
    GBD 2021 Neck Pain Collaborators (Elsevier Limited, 2024-03)
    Background: Neck pain is a highly prevalent condition that leads to considerable pain, disability, and economic cost. We present the most current estimates of neck pain prevalence and years lived with disability (YLDs) ...