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A human leukocyte antigen imputation study uncovers possible genetic interplay between gut inflammatory processes and autism spectrum disorders

Lombardi, Laura; Le Clerc, Sigrid; Wu, Ching-Lien; Bouassida, Jihène; Boukouaci, Wahid; Sugusabesan, Sobika; Richard, Jean-Romain; Lajnef, Mohamed; Tison, Maxime; Le Corvoisier, Philippe; Barau, Caroline; Banaschewski, Tobias; Holt, Rosemary; Durston, Sarah; Persico, Antonio M; Oakley, Bethany; Loth, Eva; Buitelaar, Jan; Murphy, Declan; Leboyer, Marion; Zagury, Jean-François; Tamouza, Ryad (Nature Publishing Group, 2023-07-06)

Autism spectrum disorders (ASD) are neurodevelopmental conditions that are for subsets of individuals, underpinned by dysregulated immune processes, including inflammation, autoimmunity, and dysbiosis. Consequently, the ...
Stepwise treatment of uncontrolled HyperTensioN (Stepwise-HTN): Study design of a cluster randomised controlled trial in primary care

Kiliç, Birsen; Biermans, Marion C.J.; Rutten, Frans H.; Deinum, Jaap; Spiering, Wilko; van der Wel, Mark C.; de Grauw, Wim J.C.; Bots, Michiel L.; Hollander, Monika (Elsevier, 2023-03)

Background: Uncontrolled hypertension is a major health problem, and a key risk factor for cardiovascular disease. Most patients are detected and managed in primary care, but approximately 50% remains uncontrolled. Our aim ...
Patterns in the Use of Heart Failure Telemonitoring: Post Hoc Analysis of the e-Vita Heart Failure Trial

Brons, Maaike; Klooster, Iris ten; Gemert-Pijnen, Lisette van; Jaarsma, Tiny; Asselbergs, Folkert W.; Oerlemans, Marish I.F.J.; Koudstaal, Stefan; Rutten, Frans H. (JMIR Publications Inc., 2023-01-31)

BACKGROUND: Research on the use of home telemonitoring data and adherence to it can provide new insights into telemonitoring for the daily management of patients with heart failure (HF). OBJECTIVE: We described the use of ...
Evaluation of SGLT-2 inhibitor treatment in type 2 diabetes patients with very high cardiovascular risk

Hart, Huberta E.; Kievits, Olivier; Rutten, Frans H.; Hollander, Monika H. (Elsevier, 2023-04)

AIMS: To evaluate whether the prescription of SGLT2-inhibitors in primary care patients with type 2 diabetes (T2DM) and a very high risk was according to the newest updated Dutch general practitioners' practice guidelines ...
Estimation of Respiratory Rate from Functional Near-Infrared Spectroscopy (fNIRS): A New Perspective on Respiratory Interference

Hakimi, Naser; Shahbakhti, Mohammad; Sappia, Sofia; Horschig, Jörn M.; Bronkhorst, Mathijs; Floor-Westerdijk, Marianne; Valenza, Gaetano; Dudink, Jeroen; Colier, Willy N.J.M. (Multidisciplinary Digital Publishing Institute (MDPI), 2022-12-14)

OBJECTIVE: Respiration is recognized as a systematic physiological interference in functional near-infrared spectroscopy (fNIRS). However, it remains unanswered as to whether it is possible to estimate the respiratory rate ...
Feasibility of automated early postnatal sleep staging in extremely and very preterm neonates using dual-channel EEG

Wang, Xiaowan; Bik, Anne; de Groot, Eline R.; Tataranno, Maria Luisa; Benders, Manon J.N.L.; Dudink, Jeroen (Elsevier Ireland Ltd, 2023-02)

Objective: To investigate the feasibility of automated sleep staging based on quantitative analysis of dual-channel electroencephalography (EEG) for extremely and very preterm infants during their first postnatal days. ...
A Scoping Review of Cerebral Doppler Arterial Waveforms in Infants

Jarmund, Anders Hagen; Pedersen, Sindre Andre; Torp, Hans; Dudink, Jeroen; Nyrnes, Siri Ann (Elsevier, 2023-04)

Cerebral Doppler ultrasound has been an important tool in pediatric diagnostics and prognostics for decades. Although the Doppler spectrum can provide detailed information on cerebral perfusion, the measured spectrum is ...
Respiratory Rate Extraction from Neonatal Near-Infrared Spectroscopy Signals

Hakimi, Naser; Shahbakhti, Mohammad; Horschig, Jörn M; Alderliesten, Thomas; Van Bel, Frank; Colier, Willy N J M; Dudink, Jeroen (Multidisciplinary Digital Publishing Institute (MDPI), 2023-05-05)

Background: Near-infrared spectroscopy (NIRS) relative concentration signals contain 'noise' from physiological processes such as respiration and heart rate. Simultaneous assessment of NIRS and respiratory rate (RR) using ...
Nuclear segmentation facilitates neutrophil migration

Shen, Connie; Mulder, Eva; Buitenwerf, Wiebe; Postat, Jérémy; Jansen, Aron; Kox, Matthijs; Mandl, Judith N; Vrisekoop, Nienke (Company of Biologists Ltd, 2023-06-01)

Neutrophils are among the fastest-moving immune cells. Their speed is critical to their function as 'first responder' cells at sites of damage or infection, and it has been postulated that the unique segmented nucleus of ...
Tuberculosis services during the COVID-19 pandemic: A qualitative study on the impact of COVID-19 and practices for continued services delivery in Eswatini

Williams, Victor; Vos-Seda, Alinda G.; Calnan, Marianne; Mdluli-Dlamini, Lindiwe; Haumba, Samson; Grobbee, Diederick E.; Klipstein-Grobusch, Kerstin; Otwombe, Kennedy (Elsevier, 2023-12)

Objectives To describe the impact of the COVID-19 pandemic on tuberculosis services and the different approaches healthcare workers adopted to ensure continued tuberculosis service delivery in Eswatini. Study design This ...
Subgroups of adult-onset diabetes: a data-driven cluster analysis in a Ghanaian population

Danquah, Ina; Mank, Isabel; Hampe, Christiane S; Meeks, Karlijn A C; Agyemang, Charles; Owusu-Dabo, Ellis; Smeeth, Liam; Klipstein-Grobusch, Kerstin; Bahendeka, Silver; Spranger, Joachim; Mockenhaupt, Frank P; Schulze, Matthias B; Rolandsson, Olov (Nature Publishing Group, 2023-07-04)

Adult-onset diabetes mellitus (here: aDM) is not a uniform disease entity. In European populations, five diabetes subgroups have been identified by cluster analysis using simple clinical variables; these may elucidate ...
SARS-CoV-2 incidence in secondary schools; the role of national and school-initiated COVID-19 measures

Jonker, L; Linde, K J; de Boer, A R; Ding, E; Zhang, D; de Hoog, M L A; Herfst, S; Heederik, D J J; Fraaij, P L A; Bluyssen, P M; Wouters, I M; Bruijning-Verhagen, P C J L (BioMed Central, 2023-06-27)

INTRODUCTION: Our aim was to gain insight into the effect of COVID-19 measures on SARS-CoV-2 incidence in secondary schools and the association with classroom CO 2 concentration and airborne contamination. METHODS: Between ...
Long term sequelae after SARS-CoV-2 infection in children: a household study

Sluiter-Post, Judith G C; Fourie, Elandri; Wildenbeest, Joanne G; van Lelyveld, Steven F L; Bruijning-Verhagen, Patricia C J L; van Houten, Marianne A (BioMed Central, 2023-06-28)

BACKGROUND: In children persistent symptoms after SARS-CoV-2 infection have been reported, however, duration and characteristics of symptoms in previously healthy children remain unclear. Therefore this study aimed to ...
Predictive performance of multiple organ dysfunction in asphyxiated newborns treated with therapeutic hypothermia on 24-month outcome: a cohort study

PharmaCool study group (BMJ Publishing Group, 2024-01-01)

Background: Perinatal asphyxia may be followed by multiple organ dysfunction (MOD) and is often included in prognostication of the individual patient, but evidence of discriminating accuracy is lacking. The aim of this ...
The Association of Dexamethasone and Hydrocortisone with Cerebellar Growth in Premature Infants

Warmerdam, Laura A; van Wezel-Meijler, Gerda; de Vries, Linda S; Groenendaal, Floris; Steggerda, Sylke J (S. Karger AG, 2023)

Objectives: Corticosteroids are used to prevent or treat lung disease of prematurity. While neurological side effects have been reported, detailed effects on cerebellar growth are unknown. This study aimed to compare ...
Evolutionary implications of SARS-CoV-2 vaccination for the future design of vaccination strategies

Rouzine, Igor M; Rozhnova, Ganna (Springer Nature, 2023-06-19)

Once the first SARS-CoV-2 vaccine became available, mass vaccination was the main pillar of the public health response to the COVID-19 pandemic. It was very effective in reducing hospitalizations and deaths. Here, we discuss ...
Neurobiological basis and risk factors of persistent fatigue and concentration problems after COVID-19: study protocol for a prospective case-control study (VeCosCO)

Verveen, Anouk; Verfaillie, Sander C J; Visser, Denise; Csorba, Irene; Coomans, Emma M; Koch, Dook W; Appelman, Brent; Barkhof, Frederik; Boellaard, Ronald; de Bree, Godelieve; van de Giessen, Elsmarieke M; Golla, Sandeep; van Heugten, Caroline M; Horn, Janneke; Hulst, Hanneke E; de Jong, Menno D; Kuut, Tanja A; van der Maaden, Tessa; van Os, Yvonne M G; Prins, Maria; Slooter, Arjen J C; Visser-Meily, Johanna M A; van Vugt, Michele; van den Wijngaard, Cees C; Nieuwkerk, P T; Knoop, H; Tolboom, Nelleke; van Berckel, Bart N M (BMJ Publishing Group, 2023-06-30)

INTRODUCTION: The risk factors for persistent fatigue and cognitive complaints after infection with SARS-CoV-2 and the underlying pathophysiology are largely unknown. Both clinical factors and cognitive-behavioural factors ...
Association of endothelial to mesenchymal transition and cellular senescence with fibrosis in skin biopsies of systemic sclerosis patients: a cross-sectional study

Chiu, Yu Hsiang; Spierings, Julia; van Laar, Jacob M.; de Vries-Bouwstra, Jeska K.; van Dijk, Marijke; Goldschmeding, Roel (Clinical and Experimental Rheumatology S.A.S., 2023-08-01)

Objective Fibrosis is the dominant hallmark of systemic sclerosis (SSc). Several mechanisms have been proposed to drive the disease process, but how these relate to skin fibrosis is poorly understood. Methods We performed ...
3D ultrasound strain imaging of puborectal muscle with and without unilateral avulsion

Das, Shreya; Hendriks, Gijs A G M; van den Noort, Frieda; Manzini, Claudia; van der Vaart, C H; de Korte, Chris L (Springer Nature, 2023-09)

INTRODUCTION AND HYPOTHESIS: The puborectal muscle (PRM), one of the female pelvic floor (PF) muscles, can get damaged during vaginal delivery, leading to disorders such as pelvic organ prolapse. Current diagnosis involves ...
Anti-β2-glycoprotein I and anti-phosphatidylserine/prothrombin antibodies interfere with cleavage of factor V(a) by activated protein C

Noordermeer, Tessa; Chemlal, Soumaya; Jansma, Janna J; van der Vegte, Vossa; Schutgens, Roger E G; Limper, Maarten; de Groot, Philip G; Meijers, Joost C M; Urbanus, Rolf T (Wiley-Blackwell, 2023-09)

BACKGROUND: The acquired thrombotic risk factor known as lupus anticoagulant (LA) interferes with laboratory clotting assays and can be caused by autoantibodies against β2-glycoprotein I (β2GPI) and prothrombin. LA is ...

Now showing items 9621-9640 of 40729