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UMC Repository: Recent submissions

  • Lower haemoglobin concentrations are associated with impaired cognition in patients with carotid artery occlusion 
    Heart-Brain Connection Consortium (Elsevier, 2023-06-24)
    Background: Patients with carotid artery occlusion (CAO) are vulnerable to cognitive impairment (CI). Anaemia is associated with CI in the general population. We hypothesized that lower haemoglobin is associated with ...
  • Cerebral microinfarcts revisited: Detection, causes, and clinical relevance 
    Huang, Jiannan; Biessels, Geert Jan; de Leeuw, Frank-Erik; Ii, Yuichiro; Skoog, Ingmar; Mok, Vincent; Chen, Christopher; Hilal, Saima (SAGE Publications Ltd, 2024-01)
    Cerebral microinfarcts (CMIs) are small ischemic lesions invisible to the naked eye at brain autopsy, while the larger ones (0.5-4 mm in diameter) have been visualized in-vivo on magnetic resonance imaging (MRI). CMIs can ...
  • Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment 
    Heart-Brain Connection Consortium (John Wiley & Sons Inc., 2024-01)
    INTRODUCTION: Chronic cerebral hypoperfusion is one of the assumed pathophysiological mechanisms underlying vascular cognitive impairment (VCI). We investigated the association between baseline cerebral blood flow (CBF) ...
  • Major complications and mortality after resection of intrahepatic cholangiocarcinoma: A systematic review and meta-analysis 
    van Keulen, Anne Marleen; Büttner, Stefan; Erdmann, Joris I.; Hagendoorn, Jeroen; Hoogwater, Frederik J.H.; IJzermans, Jan N.M.; Neumann, Ulf P.; Polak, Wojciech G.; De Jonge, Jeroen; Olthof, Pim B.; Koerkamp, Bas Groot (Mosby Inc., 2023-04)
    Background: Evaluation of morbidity and mortality after hepatic resection often lacks stratification by extent of resection or diagnosis. Although a liver resection for different indications may have technical similarities, ...
  • Predicting early extrahepatic recurrence after local treatment of colorectal liver metastases 
    Wensink, G. E.; Bolhuis, Karen; Elferink, Marloes A.G.; Fijneman, Remond J.A.; Kranenburg, Onno; Borel Rinkes, Inne H.M.; Koopman, Miriam; Swijnenburg, Rutger Jan; Vink, Geraldine R.; Hagendoorn, Jeroen; Punt, Cornelis J.A.; Roodhart, Jeanine M.L.; Elias, Sjoerd G. (John Wiley & Sons Inc., 2023-03-01)
    Background: Patients who develop early extrahepatic recurrence (EHR) may not benefit from local treatment of colorectal liver metastases (CRLMs). This study aimed to develop a prediction model for early EHR after local ...
  • Novel Benchmark Values for Open Major Anatomic Liver Resection in Non-Cirrhotic Patients. A Multicentric Study of 44 International Expert Centers 
    Sousa Da Silva, Richard X; Breuer, Eva; Shankar, Sadhana; Kawakatsu, Shoji; Hołówko, Wacław; Coelho, João Santos; Jeddou, Heithem; Sugiura, Teiichi; Ghallab, Mohammed; Da Silva, Doris; Watanabe, Genki; Botea, Florin; Sakai, Nozomu; Addeo, Pietro F; Tzedakis, Stylianos; Bartsch, Fabian; Balcer, Kaja; Lim, Chetana; Werey, Fabien; López, Victor; Montero, Luciana Peralta; Claria, Rodrigo Sanchez; Leiting, Jennifer; Vachharajani, Neeta; Hopping, Eve; Torres, Orlando J M; Hirano, Satoshi; Andel, Daan; Hagendoorn, Jeroen; Psica, Alicja; Ravaioli, Matteo; Ahn, Keun S; Reese, Tim; Montes, Leonardo Agustin; Gunasekaran, Ganesh; Alcázar, Cándido; Lim, Jin H; Haroon, Muhammad; Lu, Qian; Castaldi, Antonio; Orimo, Tatsuya; Moeckli, Beat; Abadía, Teresa; Ruffolo, Luis; Hasan, Josefina Dib; Ratti, Francesca; Kaufmann, Emmanuele F; de Wilde, Roeland; Polak, Wojciech G; Boggi, Ugo; Aldrighetti, Luca; McCormack, Lucas; Hernandez-Alejandro, Roberto; Serrablo, Alejandro; Toso, Christian; Taketomi, Akinobu; Gugenheim, Jean; Dong, Jiahong; Hanif, Faisal; Park, Joon S; Ramia, José M; Schwartz, Myron; Ramisch, Diego; De Oliveira, Michelle; Oldhafer, Karl J; Kang, Koo J; Cescon, Matteo; Lodge, Peter; Rinkes, Inne H M Borel; Noji, Takehiro; Thomson, John-Edwin; Goh, Su K; Chapman, William C; Cleary, Sean P; Pekolj, Juan; Regimbeau, Jean-Marc; Scatton, Olivier; Truant, Stéphanie; Lang, Hauke; Fuks, David; Bachellier, Philippe; Otsuka, Masayuki; Popescu, Irinel; Hasegawa, Kiyoshi; Lesurtel, Mickaël; Adam, René; Cherqui, Daniel; Uesaka, Katsuhiko; Boudjema, Karim; Marques, Hugo Pinto; Grąt, Micha; Petrowsky, Henrik; Ebata, Tomoki; Prachalias, Andreas; Robles-Campos, Ricardo; Clavien, Pierre-Alain (Lippincott Williams & Wilkins, 2023-11-01)
    OBJECTIVE: This study aims at establishing benchmark values for best achievable outcomes following open major anatomic hepatectomy for liver tumors of all dignities. BACKGROUND: Outcomes after open major hepatectomies vary ...
  • Predicting futility of upfront surgery in perihilar cholangiocarcinoma: Machine learning analytics model to optimize treatment allocation 
    Perihilar Cholangiocarcinoma Collaboration Group (John Wiley & Sons Inc., 2024-02-01)
    Background: While resection remains the only curative option for perihilar cholangiocarcinoma, it is well known that such surgery is associated with a high risk of morbidity and mortality. Nevertheless, beyond facing ...
  • What are Effective Strategies to Reduce Low-Value Care?: An Analysis of 121 Randomized Deimplementation Studies 
    Heus, Pauline; van Dulmen, Simone A; Weenink, Jan-Willem; Naaktgeboren, Christiana A; Takada, Toshihiko; Verkerk, Eva W; Kamm, Isabelle; van der Laan, Maarten J; Hooft, Lotty; Kool, Rudolf B (Lippincott Williams and Wilkins Ltd., 2023-09-01)
    BACKGROUND: Low-value care is healthcare leading to no or little clinical benefit for the patient. The best (combinations of) interventions to reduce low-value care are unclear. PURPOSE: To provide an overview of randomized ...
  • Reporting the early stage clinical evaluation of virtual-reality-based intervention trials: RATE-VR 
    Vlake, Johan H.; van Bommel, Jasper; Riva, Giuseppe; Wiederhold, Brenda K.; Cipresso, Pietro; Rizzo, Albert Skip; Botella, Cristina; Hooft, Lotty; Bienvenu, O. Joseph; Geerts, Bart; Wils, Evert Jan; Gommers, Diederik; van Genderen, Michel E. (Nature Research, 2023-01)
  • The Adoption of a COVID-19 Contact-Tracing App: Cluster Analysis 
    Hengst, Tessi M.; Lechner, Lilian; van der Laan, Laura Nynke; Hommersom, Arjen; Dohmen, Daan; Hooft, Lotty; Metting, Esther; Ebbers, Wolfgang; Bolman, Catherine A.W. (JMIR Publications Inc., 2023-06-20)
    Background: During the COVID-19 pandemic, there was limited adoption of contact-tracing apps (CTAs). Adoption was particularly low among vulnerable people (eg, people with a low socioeconomic position or of older age), ...
  • Direct-to-participant investigational medicinal product supply in clinical trials in Europe: Exploring the experiences of sponsors, site staff and couriers 
    the Trials@Home Consortium (Wiley-Blackwell, 2023-12)
    Aims: Insights into the current practice of direct-to-participant (DtP) supply of investigational medicinal product (IMP) in the context of clinical trials conducted in Europe are needed, as regulations are unharmonized. ...
  • Purkinje cell microzones mediate distinct kinematics of a single movement 
    Blot, François G.C.; White, Joshua J.; van Hattem, Amy; Scotti, Licia; Balaji, Vaishnavi; Adolfs, Youri; Pasterkamp, R. Jeroen; De Zeeuw, Chris I.; Schonewille, Martijn (Nature Publishing Group, 2023-07-19)
    The classification of neuronal subpopulations has significantly advanced, yet its relevance for behavior remains unclear. The highly organized flocculus of the cerebellum, known to fine-tune multi-axial eye movements, is ...
  • Identifying multivariate disease trajectories and potential phenotypes of early knee osteoarthritis in the CHECK cohort 
    Altamirano, Sara; Jansen, Mylène P.; Oberski, Daniel L.; Eijkemans, Marinus J.C.; Mastbergen, Simon C.; Lafeber, Floris P.J.G.; van Spil, Willem E.; Welsing, Paco M.J. (Public Library of Science, 2023-07-14)
    Objective To gain better understanding of osteoarthritis (OA) heterogeneity and its predictors for distinguishing OA phenotypes. This could provide the opportunity to tailor prevention and treatment strategies and thus ...
  • The relevance of competing risk adjustment in cardiovascular risk prediction models for clinical practice 
    Hageman, Steven H J; Dorresteijn, Jannick A N; Pennells, Lisa; van Smeden, Maarten; Bots, Michiel L; Di Angelantonio, Emanuele; Visseren, Frank L J (Oxford University Press, 2023-11-01)
    BACKGROUND: Many models developed for predicting the risk of cardiovascular disease (CVD) are adjusted for the competing risk of non-CVD mortality, which has been suggested to reduce potential overestimation of cumulative ...
  • Compartment-driven imprinting of intestinal CD4 T cells in inflammatory bowel disease and homeostasis 
    Lutter, Lisanne; Ter Linde, José J M; Brand, Eelco C; Hoytema van Konijnenburg, David P; Roosenboom, Britt; Talabur-Horje, Carmen Horjus; Oldenburg, Bas; van Wijk, Femke (Wiley-Blackwell, 2023-12-13)
    The mucosal immune system is implicated in the etiology and progression of inflammatory bowel diseases. The lamina propria and epithelium of the gut mucosa constitute two separate compartments, containing distinct T-cell ...
  • Complex subsets but redundant clonality after B cells egress from spontaneous germinal centers 
    Castrillon, Carlos; Simoni, Lea; van den Broek, Theo; van der Poel, Cees; Akama-Garren, Elliot H; Ma, Minghe; Carroll, Michael C (eLife Sciences Publications, 2023-06-21)
    Affinity matured self-reactive antibodies are found in autoimmune diseases like systemic lupus erythematous. Here, we used fate-mapping reporter mice and single-cell transcriptomics coupled to antibody repertoire analysis ...
  • Design, validation and implementation of an automated e-alert for acute kidney injury: 6-month pilot study shows increased awareness 
    Niemantsverdriet, Michael S A; Tiel Groenestege, Wouter M; Khairoun, M; Hoefer, Imo E; van Solinge, Wouter W; Bellomo, Domenico; van Vliet, Martin H; Kaasjager, Karin A H; Haitjema, Saskia (BioMed Central, 2023-07-27)
    BACKGROUND: Acute kidney injury (AKI) is defined as a sudden episode of kidney failure but is known to be under-recognized by healthcare professionals. The Kidney Disease Improving Global Outcome (KDIGO) guidelines have ...
  • Anti-thymocyte globulin exposure in patients with diffuse cutaneous systemic sclerosis undergoing autologous haematopoietic stem cell transplantation 
    Chiu, Yu Hsiang; Drijver, Anouk; Admiraal, Rick; van Rhenen, Anna; Nierkens, Stefan; van Laar, Jacob M.; Spierings, Julia (SAGE Publications Ltd, 2023-10)
    Introduction: Autologous haematopoietic stem cell transplantation improves event-free survival and lung function and reduces skin thickening in patients with progressive diffuse cutaneous systemic sclerosis. Anti-thymocyte ...
  • Stereotactic Arrhythmia Radioablation (STAR): Assessment of cardiac and respiratory heart motion in ventricular tachycardia patients - A STOPSTORM.eu consortium review 
    Stevens, Raoul R F; Hazelaar, Colien; Fast, Martin F; Mandija, Stefano; Grehn, Melanie; Cvek, Jakub; Knybel, Lukas; Dvorak, Pavel; Pruvot, Etienne; Verhoeff, Joost; Blanck, Oliver; van Elmpt, Wouter (Elsevier Ireland Ltd, 2023-11)
    Aim: To identify the optimal STereotactic Arrhythmia Radioablation (STAR) strategy for individual patients, cardiorespiratory motion of the target volume in combination with different treatment methodologies needs to be ...
  • Diagnostic accuracy of endoscopic ultrasonography-guided tissue acquisition prior to resection of pancreatic carcinoma: a nationwide analysis 
    Dutch Pancreatic Cancer Group (DPCG) and QUality in EndoSonography Team (QUEST) (John Wiley & Sons Inc., 2023-11)
    Introduction: Endoscopic ultrasonography guided tissue acquisition (EUS + TA) is used to provide a tissue diagnosis in patients with suspected pancreatic cancer. Key performance indicators (KPI) for these procedures are ...