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Now showing items 8641-8660 of 40729

Fulminant myocarditis proven by early biopsy and outcomes

FULLMOON Study Group (Oxford University Press, 2023-12-21)

Background and While endomyocardial biopsy (EMB) is recommended in adult patients with fulminant myocarditis, the clinical impact of its Aims timing is still unclear. . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
What’s new?

Kurusz, Mark; Donker, Dirk W. (SAGE Publications Ltd, 2024-01)
Association of Cardiovascular Health With Risk of Clinically Relevant Depressive Symptoms

van Sloten, Thomas T; Valentin, Eugénie; Climie, Rachel E; Jouven, Xavier; Lemogne, Cedric; Goldberg, Marcel; Zins, Marie; Empana, Jean-Philippe (American Medical Association, 2023-04-05)

IMPORTANCE: Cardiovascular health may be used for prevention of depressive symptoms. However, data on the association of cardiovascular health across midlife with depressive symptoms are lacking. OBJECTIVE: To evaluate ...
Association of Midlife Cardiovascular Health and Subsequent Change in Cardiovascular Health With Incident Cancer

Van Sloten, Thomas; Valentin, Eugénie; Climie, Rachel E; Deraz, Omar; Weiderpass, Elisabete; Jouven, Xavier; Goldberg, Marcel; Zins, Marie; Empana, Jean-Philippe (Elsevier, 2023-02)

BACKGROUND: The commonality of risk factors between cancer and cardiovascular disease suggests that primordial prevention (preventing the onset of risk factors) is a relevant strategy for cancer prevention. OBJECTIVES: ...
Changes in Cardiovascular Health Across Midlife and Late-Life and Magnetic Resonance Imaging Markers of Cerebral Vascular Disease in Late-Life

Sedaghat, Sanaz; Ji, Yuekai; Empana, Jean-Philippe; Hughes, Timothy M; Mosley, Thomas H; Gottesman, Rebecca F; Griswold, Michael; Jack, Clifford R; Lutsey, Pamela L; van Sloten, Thomas T (Lippincott Williams & Wilkins, 2023-05)

BACKGROUND: Cardiovascular health may be used for prevention of cerebral vascular disease; however, data on the association of cardiovascular health across midlife and late-life with late-life cerebral vascular disease are ...
Person-centered and measured life's simple 7 cardiovascular health concordance and association with incident cardiovascular disease

Deraz, Omar; Van Sloten, Thomas; Climie, Rachel; Debras, Charlotte; Fezeu, Léopold K; Deschasaux-Tanguy, Mélanie; Jouven, Xavier; Kesse-Guyot, Emmanuelle; Galan, Pilar; Hercberg, Serge; Touvier, Mathilde; Empana, Jean-Philippe (Nature Publishing Group, 2023-12)

Person-centered cardiovascular health (CVH) may facilitate cardiovascular disease primordial prevention in low resources settings. The study aims to assess the validity of person-centered CVH compared to gold standard ...
De PROMINENT-studie: zwanenzang van de fibraten

van Sloten, Thomas T.; Martens, Fabrice M.A.C.; Visseren, Frank L.J. (Bohn Stafleu van Loghum, 2023-04-05)

Post hoc analyses of previous fibrate trials have suggested that individuals with type 2 diabetes mellitus with high triglyceride levels and low HDL-cholesterol levels benefit from fibrate therapy even when the overall ...
Associations of plasma NfL, GFAP, and t-tau with cerebral small vessel disease and incident dementia: longitudinal data of the AGES-Reykjavik Study

van Gennip, April C E; Satizabal, Claudia L; Tracy, Russell P; Sigurdsson, Sigurdur; Gudnason, Vilmundur; Launer, Lenore J; van Sloten, Thomas T (Springer International Publishing AG, 2024-02)

We investigated the associations of plasma neurofilament light (NfL), glial fibrillary acidic protein (GFAP), and total tau (t-tau) with markers of cerebral small vessel disease (SVD) and with incident dementia. We also ...
Association of type 2 diabetes according to the number of risk factors within the recommended range with incidence of major depression and clinically relevant depressive symptoms: a prospective analysis

van Gennip, April C E; Schram, Miranda T; Köhler, Sebastian; Kroon, Abraham A; Koster, Annemarie; Eussen, Simone J P M; de Galan, Bastiaan E; van Sloten, Thomas T; Stehouwer, Coen D A (Elsevier, 2023-02)

BACKGROUND: Type 2 diabetes is associated with an increased risk of depression, but the extent to which risk factor modification can mitigate this risk is unclear. We aimed to examine the association between the incidence ...
The HeMoVal study protocol: a prospective international multicenter cohort study to validate cerebrospinal fluid hemoglobin as a monitoring biomarker for aneurysmal subarachnoid hemorrhage related secondary brain injury

HeMoVal Research Group (BioMed Central, 2022-12)

Introduction: Preclinical studies provided a strong rationale for a pathophysiological link between cell-free hemoglobin in the cerebrospinal fluid (CSF-Hb) and secondary brain injury after subarachnoid hemorrhage (SAH-SBI). ...
Histological and magnetic resonance imaging assessment of Liqoseal in a spinal in vivo pig model

Slot, Emma M.H.; Bergmann, Wilhelmina; Kinaci, Ahmet; de Boer, Bart; Moayeri, Nizar; Redegeld, Saskia; van Thoor, Sander; van Doormaal, Tristan P.C. (John Wiley & Sons Inc., 2023-02)

Background: Liqoseal (Polyganics, B.V.) is a dural sealant patch for preventing postoperative cerebrospinal fluid (CSF) leakage. It has been extensively tested preclinically and CE (Conformité Européenne) approved for human ...
Ex vivo and in vivo evaluation of transsphenoidal Liqoseal application to prevent cerebrospinal fluid leakage

Slot, Emma M.H.; Colmer, Nadia; Serra, Carlo; Holzmann, David; Regli, Luca; van Doormaal, Tristan P.C. (Springer, 2023-06)

Background: Despite improvements in closure techniques by using a vital nasoseptal flap, the use of sealing materials, and improved neurosurgical techniques, cerebrospinal fluid (CSF) leak after transsphenoidal surgery ...
A novel missense variant in ATP11C is associated with reduced red blood cell phosphatidylserine flippase activity and mild hereditary hemolytic anemia

van Dijk, Myrthe J.; van Oirschot, Brigitte A.; Harrison, Alexander N.; Recktenwald, Steffen M.; Qiao, Min; Stommen, Amaury; Cloos, Anne Sophie; Vanderroost, Juliette; Terrasi, Romano; Dey, Kuntal; Bos, Jennifer; Rab, Minke A.E.; Bogdanova, Anna; Minetti, Giampaolo; Muccioli, Giulio G.; Tyteca, Donatienne; Egée, Stéphane; Kaestner, Lars; Molday, Robert S.; van Beers, Eduard J.; van Wijk, Richard (John Wiley & Sons Inc., 2023-12)

Adenosine Triphosphatase (ATPase) Phospholipid Transporting 11C gene (ATP11C) encodes the major phosphatidylserine (PS) flippase in human red blood cells (RBCs). Flippases actively transport phospholipids (e.g., PS) from ...
Patients with moderate hemophilia A and B with a severe bleeding phenotype have an increased burden of disease

Verhagen, Marieke J A; van Balen, Erna C; Blijlevens, Nicole M A; Coppens, Michiel; van Heerde, Waander L; Leebeek, Frank W G; Rijpma, Sanna R; van Vulpen, Lize F D; Gouw, Samantha C; Schols, Saskia E M (Wiley-Blackwell, 2024-01)

BACKGROUND: Patients with moderate hemophilia express varying bleeding phenotypes. OBJECTIVES: To assess the burden of disease in patients with moderate hemophilia and a mild or severe phenotype incorporating the thrombin ...
Do summative entrustment decisions actually lead to entrustment?

Sigurdsson, Vigfús; Ten Cate, Olle (Wiley-Blackwell, 2024-02)

BACKGROUND: Entrustable professional activities (EPAs) were introduced across Dutch postgraduate programmes between 2017 and 2019. We aimed to understand the extent to which residents actually were granted increased clinical ...
Development and validation of a machine learning-supported strategy of patient selection for osteoarthritis clinical trials: the IMI-APPROACH study

Widera, Paweł; Welsing, Paco M.J.; Danso, Samuel O.; Peelen, Sjaak; Kloppenburg, Margreet; Loef, Marieke; Marijnissen, Anne C.; van Helvoort, Eefje M.; Blanco, Francisco J.; Magalhães, Joana; Berenbaum, Francis; Haugen, Ida K.; Bay-Jensen, Anne Christine; Mobasheri, Ali; Ladel, Christoph; Loughlin, John; Lafeber, Floris P.J.G.; Lalande, Agnès; Larkin, Jonathan; Weinans, Harrie; Bacardit, Jaume (Elsevier, 2023-12)

Objectives: To efficiently assess the disease-modifying potential of new osteoarthritis treatments, clinical trials need progression-enriched patient populations. To assess whether the application of machine learning results ...
Clinical Validation of a Primary Antibody Deficiency Screening Algorithm for Primary Care

Messelink, Marianne A.; Welsing, Paco M.J.; Devercelli, Giovanna; Marsden, Jan Willem N.; Leavis, Helen L. (Springer New York, 2023-11)

Purpose: The diagnostic delay of primary antibody deficiencies (PADs) is associated with increased morbidity, mortality, and healthcare costs. Therefore, a screening algorithm was previously developed for the early detection ...
Establishing a Diagnosis of Pulmonary Sarcoidosis

Grutters, Jan C (Multidisciplinary Digital Publishing Institute (MDPI), 2023-11-02)

Pulmonary sarcoidosis is the most prevalent manifestation of sarcoidosis and the commonest diagnosis in clinics for ILD. Due to the lack of a simple and reliable test, making the diagnosis is often challenging. There are ...
Basics of advanced therapy medicinal product development in academic pharma and the role of a GMP simulation unit

Johanna, I.; Daudeij, A.; Devina, F.; Nijenhuis, C.; Nuijen, B.; Romberg, B.; de Haar, C.; Haanen, J.; Dolstra, H.; Bremer, E.; Sebestyen, Z.; Straetemans, T.; Jedema, I.; Kuball, J. (Elsevier, 2023-12)

Following successes of authorized chimeric antigen receptor T-cell products being commercially marketed in the United States and European Union, product development of T-cell-based cancer immunotherapy consisting of ...
The impact of the COVID-19 pandemic on pediatric rheumatology practice: an international, cross-sectional survey study

Batu, Ezgi D.; Demirkan, Fatma Gül; Sag, Erdal; Lamot, Lovro; Faleye, Ayodele; Marrani, Edoardo; Ziv, Amit; Ardalan, Kaveh; Gmuca, Sabrina; Swart, Joost F.; Uziel, Yosef (W.B. Saunders, 2023-12)

Objective: The COVID-19 pandemic has affected patient care in general. We aimed to analyze the impact of the pandemic on pediatric rheumatology practice. Methods: An online survey including 22 questions was created by the ...

Now showing items 8641-8660 of 40729