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UMC Repository: Recent submissions

  • Dropout from exercise trials among cancer survivors-An individual patient data meta-analysis from the POLARIS study 
    Western, Benedikte; Ivarsson, Andreas; Vistad, Ingvild; Demmelmaier, Ingrid; Aaronson, Neil K; Radcliffe, Gillian; van Beurden, Marc; Bohus, Martin; Courneya, Kerry S; Daley, Amanda J; Galvão, Daniel A; Garrod, Rachel; Goedendorp, Martine M; Griffith, Kathleen A; van Harten, Wim H; Hayes, Sandi C; Herrero-Roman, Fernando; Hiensch, Anouk E; Irwin, Melinda L; James, Erica; Kenkhuis, Marlou-Floor; Kersten, Marie José; Knoop, Hans; Lucia, Alejandro; May, Anne M; McConnachie, Alex; van Mechelen, Willem; Mutrie, Nanette; Newton, Robert U; Nollet, Frans; Oldenburg, Hester S; Plotnikoff, Ron; Schmidt, Martina E; Schmitz, Katie H; Schulz, Karl-Heinz; Short, Camille E; Sonke, Gabe S; Steindorf, Karen; Stuiver, Martijn M; Taaffe, Dennis R; Thorsen, Lene; Velthuis, Miranda J; Wenzel, Jennifer; Winters-Stone, Kerri M; Wiskemann, Joachim; Berntsen, Sveinung; Buffart, Laurien M (Blackwell Munksgaard, 2024-02)
    INTRODUCTION: The number of randomized controlled trials (RCTs) investigating the effects of exercise among cancer survivors has increased in recent years; however, participants dropping out of the trials are rarely ...
  • Perspectives on systematic review protocol registration: a survey amongst stakeholders in the clinical research publication process 
    van der Braak, Kim; Heus, Pauline; Orelio, Claudia; Netterström-Wedin, Fredh; Robinson, Karen A; Lund, Hans; Hooft, Lotty (BioMed Central, 2023-12-14)
    BACKGROUND: As systematic reviews (SRs) inform healthcare decisions, it is key that they address relevant questions and use rigorous methodology. Registration of SR protocols helps researchers identify relevant topics for ...
  • Non-Invasive Assessment of Multivalvular Heart Disease: A Comprehensive Review 
    De Zan, Giulia; van der Bilt, Ivo A.C.; Broekhuizen, Lysette N.; Cramer, Maarten J.; Danad, Ibrahim; van Osch, Dirk; Patti, Giuseppe; van Rosendael, Philippe J.; Teske, Arco J.; van der Harst, Pim; Guglielmo, Marco (IMR Press Limited, 2024-01-16)
    Multivalvular heart disease (MVD) implies the presence of concomitant valvular lesions on two or more heart valves. This condition has become common in the few last years, mostly due to population aging. Every combination ...
  • Barriers and facilitators that hospital clinicians perceive to discuss the personal values, wishes, and needs of patients in palliative care: a mixed-methods systematic review 
    de Vries, Sita; Verhoef, Mary Joanne; Vervoort, Sigrid Cornelia Johanna Maria; van der Linden, Yvette Milene; Teunissen, Saskia Cornelia Constantia Maria; de Graaf, Everlien (SAGE Publications Ltd, 2023-12-01)
    Background: The exploration and monitoring of the personal values, wishes, and needs (VWN) of patients in the palliative phase by hospital clinicians is essential for guiding appropriate palliative care. Objective: To ...
  • Clinical and electrophysiological features of SCN8A variants causing episodic or chronic ataxia 
    Lyu, Hang; Boßelmann, Christian M; Johannesen, Katrine M; Koko, Mahmoud; Ortigoza-Escobar, Juan Dario; Aguilera-Albesa, Sergio; Garcia-Navas Núñez, Deyanira; Linnankivi, Tarja; Gaily, Eija; van Ruiten, Henriette J A; Richardson, Ruth; Betzler, Cornelia; Horvath, Gabriella; Brilstra, Eva; Geerdink, Niels; Orsucci, Daniele; Tessa, Alessandra; Gardella, Elena; Fleszar, Zofia; Schöls, Ludger; Lerche, Holger; Møller, Rikke S; Liu, Yuanyuan (Elsevier, 2023-12)
    BACKGROUND: Variants in SCN8A are associated with a spectrum of epilepsies and neurodevelopmental disorders. Ataxia as a predominant symptom of SCN8A variation has not been well studied. We set out to investigate disease ...
  • Allogeneic Hematopoietic Cell Transplantation for VEXAS Syndrome: Results of a Multicenter Study of the EBMT 
    Gurnari, Carmelo; Koster, Linda; Baaij, Laurien Greetje Antoinette; Heiblig, Mael; Yakoub-Agha, Ibrahim; Collin, Matthew; Passweg, Jakob R; Bulabois, Claude-Eric; Khan, Anjum Bashir; Loschi, Michael; Carnevale-Schianca, Fabrizio; Crisà, Elena; Caravelli, Daniela; Kuball, Jürgen; Saraceni, Francesco; Olivieri, Attilio; Rambaldi, Alessandro; Kulasekararaj, Austin G; Hayden, Patrick; Badoglio, Manuela; Onida, Francesco; Scheid, Christof; Franceschini, Franco; Mékinian, Arsene; Savic, Sinisa; Voso, Maria Teresa; Drozd-Sokolowska, Joanna; Snowden, John; Raj, Kavita; Alexander, Tobias; Robin, Marie; Greco, Raffaela; McLornan, Donal P (The American Society of Hematology, 2024-03-26)
  • Competing risk analysis of cardiovascular disease risk in breast cancer patients receiving a radiation boost 
    Koop, Yvonne; Atsma, Femke; Batenburg, Marilot C T; Meijer, Hanneke; van der Leij, Femke; Gal, Roxanne; van Velzen, Sanne G M; Išgum, Ivana; Vermeulen, Hester; Maas, Angela H E M; Messaoudi, Saloua El; Verkooijen, Helena M (BioMed Central Ltd., 2024-02-09)
    BACKGROUND: Thoracic radiotherapy may damage the myocardium and arteries, increasing cardiovascular disease (CVD) risk. Women with a high local breast cancer (BC) recurrence risk may receive an additional radiation boost ...
  • Stereotactic Body and Conventional Radiotherapy for Painful Bone Metastases: A Systematic Review and Meta-Analysis 
    Bindels, Bas J J; Mercier, Carole; Gal, Roxanne; Verlaan, Jorrit-Jan; Verhoeff, Joost J C; Dirix, Piet; Ost, Piet; Kasperts, Nicolien; van der Linden, Yvette M; Verkooijen, Helena M; van der Velden, Joanne M (American Medical Association, 2024-02-12)
    IMPORTANCE: Conventional external beam radiotherapy (cEBRT) and stereotactic body radiotherapy (SBRT) are commonly used treatment options for relieving metastatic bone pain. The effectiveness of SBRT compared with cEBRT ...
  • Hormonal support in women with Asherman syndrome does not lead to better outcomes: A randomized trial 
    Hanstede, Miriam M F; van Stralen, Karlijn J; Molkenboer, Jan F M; Veersema, Sebastiaan; Emanuel, Mark Hans (John Wiley & Sons Inc., 2023-01-01)
    PURPOSE: The purpose of the study was to investigate if adjuvant hormones after successful adhesiolysis lead to a reduction in spontaneous recurrence of adhesions and influence reproductive outcomes. METHODS: A single-blind ...
  • Essure removal surgery: Are preoperative transvaginal ultrasound and pelvic X-ray necessary? 
    van Erp, Mirthe A J M; Maassen, Liselotte W; van Gastel, Danielle M; Koks, Carolien A M; Bongers, Marlies Y; Veersema, Sebastiaan (Elsevier Ireland Ltd, 2023-07)
    OBJECTIVE: The objective of this study was twofold. (1) To investigate the predictive characteristics of transvaginal ultrasonography for hysteroscopy necessity in Essure removal surgery. (2) To investigate the additional ...
  • Sexual quality of life of adolescents and young adult breast cancer survivors 
    Peeters, N. J.M.C.V.; Vlooswijk, C.; Bijlsma, R. M.; Kaal, S. E.J.; Kerst, J. M.; Tromp, J. M.; Bos, M. E.M.M.; van der Hulle, T.; Lalisang, R. I.; Nuver, J.; Kouwenhoven, M. C.M.; van der Ploeg, I. M.C.; van der Graaf, W. T.A.; Husson, O. (Elsevier, 2024-02)
    Background: With increasing survival rates of adolescents and young adults (AYAs) with breast cancer, health-related quality of life (HRQoL) becomes more important. An important aspect of HRQoL is sexual QoL. This study ...
  • BMI increase during early childhood in boys with cystic fibrosis and early adrenarche 
    Tamer, Gizem; Arets, Hubertus Gerardus Maria; van der Ent, Cornelis Kors; van Santen, Hanneke Margo; van der Kamp, Hetty Jacoba (John Wiley & Sons Inc., 2024-04)
    BACKGROUND: Increase in body mass index (BMI) in early childhood (1-6 years) was found to be a contributing factor for impaired final height in boys with Cystic Fibrosis (CF). Early adrenarche (before age 9 years in boys) ...
  • Quality of life and clinical outcomes in rectal cancer patients treated on a 1.5T MR-Linac within the MOMENTUM study 
    Daamen, L. A.; Westerhoff, J. M.; Couwenberg, A. M.; Braam, P. M.; Rütten, H.; den Hartogh, M. D.; Christodouleas, J. P.; Hall, W. A.; Verkooijen, H. M.; Intven, M. P.W. (Elsevier Ireland Ltd, 2024-03)
    Background and purpose: This study assessed quality of life (QoL) and clinical outcomes in rectal cancer patients treated with magnetic resonance (MR) guided short-course radiation therapy (SCRT) on a 1.5 Tesla (T) MR-Linac ...
  • Pre-existing subclones determine radioresistance in rectal cancer organoids 
    Andel, Daan; Viergever, Bas; Peters, Niek; Raats, Danielle; Schenning-van Schelven, Susanne; Intven, Martijn; Zandvliet, Maurice; Hagendoorn, Jeroen; Borel Rinkes, Inne; Kranenburg, Onno (Cell Press, 2024-02-27)
    More than half of all patients with cancer receive radiation therapy, but resistance is commonly observed. Currently, it is unknown whether resistance to radiation therapy is acquired or inherently present. Here, we employed ...
  • Treatment robustness of total body irradiation with volumetric modulated arc therapy 
    Seravalli, Enrica; Willemsen-Bosman, Mirjam; Zoetelief, Annelies; Roosenboom, Sanne; Harderwijk, Tessa; Krikke, Lean; Bol, Gijsbert; Kotte, Alexis; Huijboom, Eline; van Loon, Karel; Hoeben, Bianca (Elsevier, 2024-01)
    This study evaluated the robustness of multi-isocenter Volumetric Modulated Arc Therapy Total Body Irradiation dose distribution in the overlapping region between the head-first and feet-first computed tomography scans, ...
  • The role of heterochromatin in 3D genome organization during preimplantation development 
    Rang, Franka J.; Kind, Jop; Guerreiro, Isabel (Cell Press, 2023-04-25)
    During the early stages of mammalian development, the epigenetic state of the parental genome is completely reprogrammed to give rise to the totipotent embryo. An important aspect of this remodeling concerns the heterochromatin ...
  • Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvae 
    Allers, Maaike; Bakker, Petra A.; Hoeksma, Jelmer; Spaink, Herman P.; Den Hertog, Jeroen (Company of Biologists Ltd, 2023-02)
    PTPN6 encodes SHP1, a protein tyrosine phosphatase with an essential role in immune cell function. SHP1 mutations are associated with neutrophilic dermatoses and emphysema in humans, which resembles the phenotype seen in ...
  • Microtubule nucleation from the fibrous corona by LIC1-pericentrin promotes chromosome congression 
    Wu, Jingchao; Larreategui-Aparicio, Ainhoa; Lambers, Maaike L.A.; Bodor, Dani L.; Klaasen, Sjoerd J.; Tollenaar, Eveline; de Ruijter-Villani, Marta; Kops, Geert J.P.L. (Cell Press, 2023-03-13)
    Error-free chromosome segregation in mitosis and meiosis relies on the assembly of a microtubule-based spindle that interacts with kinetochores to guide chromosomes to the cell equator before segregation in anaphase. ...
  • Paecilomycone Inhibits Quorum Sensing in Gram-Negative Bacteria 
    Beenker, Wouter A.G.; Hoeksma, Jelmer; Bannier-Hélaouët, Marie; Clevers, Hans; Den Hertog, Jeroen (American Society for Microbiology, 2023-03)
    Pseudomonas aeruginosa is an opportunistic pathogen that causes major health care concerns due to its virulence and high intrinsic resistance to antimicrobial agents. Therefore, new treatments are greatly needed. An ...
  • Establishment, Maintenance, Differentiation, Genetic Manipulation, and Transplantation of Mouse and Human Lacrimal Gland Organoids 
    Bannier-Hélaouët, Marie; Geurts, Maarten H.; Korving, Jeroen; Begthel, Harry; Clevers, Hans (MYJoVE Corporation, 2023-02-01)
    The lacrimal gland is an essential organ for ocular surface homeostasis. By producing the aqueous part of the tear film, it protects the eye from desiccation stress and external insults. Little is known about lacrimal gland ...