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Now showing items 7781-7800 of 40729

Harnessing the Potential of Real-World Evidence in the Treatment of Colorectal Cancer: Where Do We Stand?

van Nassau, Sietske C M W; Bol, Guus M; van der Baan, Frederieke H; Roodhart, Jeanine M L; Vink, Geraldine R; Punt, Cornelis J A; May, Anne M; Koopman, Miriam; Derksen, Jeroen W G (2024-04)

Treatment guidelines for colorectal cancer (CRC) are primarily based on the results of randomized clinical trials (RCTs), the gold standard methodology to evaluate safety and efficacy of oncological treatments. However, ...
Mutagenesis of the Varicella-Zoster Virus Genome Demonstrates That VLT and VLT-ORF63 Proteins Are Dispensable for Lytic Infection

Braspenning, Shirley E; Lebbink, Robert Jan; Depledge, Daniel P; Schapendonk, Claudia M E; Anderson, Laura A; Verjans, Georges M G M; Sadaoka, Tomohiko; Ouwendijk, Werner J D (Multidisciplinary Digital Publishing Institute (MDPI), 2021-11-16)

Primary varicella-zoster virus (VZV) infection leads to varicella and the establishment of lifelong latency in sensory ganglion neurons. Reactivation of latent VZV causes herpes zoster, which is frequently associated with ...
Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor

Le-Trilling, Vu Thuy Khanh; Banchenko, Sofia; Paydar, Darius; Leipe, Pia Madeleine; Binting, Lukas; Lauer, Simon; Graziadei, Andrea; Klingen, Robin; Gotthold, Christine; Bürger, Jörg; Bracht, Thilo; Sitek, Barbara; Jan Lebbink, Robert; Malyshkina, Anna; Mielke, Thorsten; Rappsilber, Juri; Spahn, Christian Mt; Voigt, Sebastian; Trilling, Mirko; Schwefel, David (Springer Science and Business Media Deutschland GmbH, 2023-03-01)

Human cytomegalovirus (CMV) is a ubiquitously distributed pathogen whose rodent counterparts such as mouse and rat CMV serve as common infection models. Here, we conducted global proteome profiling of rat CMV-infected cells ...
Intermittent catheterization: A patient-centric approach is key to optimal management of neurogenic lower urinary tract dysfunction

Krassioukov, Andrei; Welk, Blayne; Vrijens, Desiree; Islamoska, Sabrina; Barken, Kim Bundvig; Keppenne, Veronique; Wyndaele, Michel; Walter, Matthias (2023-03-28)

The value of disposable, single-use catheters has come under scrutiny in recent years with a growing attention on environmental sustainability. Intermittent catheterization (IC) is a widely available and minimally invasive ...
The relationship of fat and muscle measurements with emphysema and bronchial wall thickening in smokers

Bunk, Stijn; Ipema, Jetty; Sidorenkov, Grigory; Bennink, E; Vliegenthart, Rozemarijn; de Jong, Pim; Pompe, Esther; Charbonnier, Jean-Paul; Luijk, B.; Aerts, Joachim; Groen, Harry; Mohamed Hoesein, Firdaus (European Respiratory Society, 2024-03-04)

Introduction Differences in body composition in patients with COPD may have important prognostic value and may provide opportunities for patient-specific management. We investigated the relation of thoracic fat and muscle ...
Modeling specific aneuploidies: from karyotype manipulations to biological insights

Truong, My Anh; Cané-Gasull, Paula; Lens, Susanne M.A. (Springer Netherlands, 2023-08-29)

An abnormal chromosome number, or aneuploidy, underlies developmental disorders and is a common feature of cancer, with different cancer types exhibiting distinct patterns of chromosomal gains and losses. To understand how ...
Real-world nudging, pricing, and mobile physical activity coaching was insufficient to improve lifestyle behaviours and cardiometabolic health: the Supreme Nudge parallel cluster-randomised controlled supermarket trial

Stuber, Josine M.; Mackenbach, Joreintje D.; de Bruijn, Gert Jan; Gillebaart, Marleen; Hoenink, Jody C.; Middel, Cédric N.H.; de Ridder, Denise T.D.; van der Schouw, Yvonne T.; Smit, Edith G.; Velema, Elizabeth; Vos, Anne L.; Waterlander, Wilma E.; Lakerveld, Jeroen; Beulens, Joline W.J. (BioMed Central Ltd., 2024-02-02)

Background: Context-specific interventions may contribute to sustained behaviour change and improved health outcomes. We evaluated the real-world effects of supermarket nudging and pricing strategies and mobile physical ...
Building a Sustainable Learning Health Care System for Pregnant and Lactating People: Interview Study Among Data Access Providers

Hollestelle, Marieke J; van der Graaf, Rieke; Sturkenboom, Miriam C J M; Cunnington, Marianne; van Delden, Johannes J M (JMIR Publications Inc., 2024-02-08)

BACKGROUND: In many areas of health care, learning health care systems (LHSs) are seen as promising ways to accelerate research and outcomes for patients by reusing health and research data. For example, considering pregnant ...
Sex Differences in the Primary Prevention of Cardiovascular Diseases in a Dutch Primary Care Setting

Kiss, Pauline A J; Uijl, Alicia; Betancur, Estefania; de Boer, Annemarijn R; Grobbee, Diederick E; Hollander, Monika; Onland-Moret, Charlotte N; Sturkenboom, Miriam C J M; Peters, Sanne A E (Elsevier Science & Technology, 2024-01-19)

BACKGROUND: Sex differences in the primary prevention of cardiovascular diseases (CVD) have been shown, but the evidence is mixed and fragmented. In this study, we assessed sex differences in cardiovascular risk factors ...
Cohort Event Monitoring of Adverse Reactions to COVID-19 Vaccines in Seven European Countries: Pooled Results on First Dose

Raethke, Monika; van Hunsel, Florence; Thurin, Nicolas H; Dureau-Pournin, Caroline; Mentzer, Dirk; Kovačić, Barbara; Mirošević Skvrce, Nikica; De Clercq, Evelien; Sabbe, Martine; Trifirò, Gianluca; Luxi, Nicoletta; Giovanazzi, Alexia; Shakir, Saad; Klungel, Olaf H; Schmikli, Sandor; Sturkenboom, Miriam (Adis, 2023-04)

INTRODUCTION: COVID-19 vaccines were rapidly authorised, thus requiring intense post-marketing re-evaluation of their benefit-risk profile. A multi-national European collaboration was established with the aim to prospectively ...
Assessing vaccine safety during a pandemic: Recent experience and lessons learned for the future

Black, Steven B; Chandler, Rebecca E; Edwards, Kathryn M; Sturkenboom, Miriam C J M (Elsevier, 2023-06-07)

During the roll out of vaccines during a pandemic, questions regarding vaccine safety often arise. This was surely true during the SARS-CoV-2 pandemic. Different tools and capabilities exist during the pre-authorization ...
Diagnosis-linked antibiotic prescribing quality indicators: demonstrating feasibility using practice-based routine primary care data, reliability, validity and their potential in antimicrobial stewardship

van den Eijnde, Sharon E J D; van der Linden, Paul D; van der Velden, Alike W (Oxford University Press, 2024-04)

BACKGROUND: Quality indicators (QIs) can be used to obtain valuable insights into prescribing quality. Five quantitative and nine diagnosis-linked QIs, aiming to provide general practitioners (GP) with feedback on their ...
Cross-sectional health centre and community-based evaluation of the impact of pneumococcal and malaria vaccination on antibiotic prescription and usage, febrile illness and antimicrobial resistance in young children in Malawi: the IVAR study protocol

Singleton, David; Ibarz-Pavon, Ana; Swarthout, Todd D.; Bonomali, Farouck; Cornick, Jennifer; Kalizang'oma, Akuzike; Ntiza, Noah; Brown, Comfort; Chipatala, Raphael; Nyangulu, Wongani; Chirombo, James; Kawalazira, Gift; Chibowa, Henry; Mwansambo, Charles; Maleta, Kenneth Mphatso; French, Neil; Heyderman, Robert S. (BMJ Publishing Group, 2023-05-12)

Introduction Vaccination is a potentially critical component of efforts to arrest development and dissemination of antimicrobial resistance (AMR), though little is known about vaccination impact within low-income and ...
Virological and immunological correlates of HIV posttreatment control after temporal antiretroviral therapy during acute HIV infection

Van Paassen, Pien M.; Van Pul, Lisa; Van Der Straten, Karlijn; Buchholtz, Ninée V.J.E.; Grobben, Marloes; Van Nuenen, Ad C.; Van Dort, Karel A.; Boeser-Nunnink, Brigitte D.; Van Den Essenburg, Mo D.; Burger, Judith A.; Van Luin, Matthijs; Jurriaans, Suzanne; Sanders, Rogier W.; Swelsen, Wendy T.; Symons, Jori; Klouwens, Michelle J.; Nijhuis, Monique; Van Gils, Marit J.; Prins, Jan M.; De Bree, Godelieve J.; Kootstra, Neeltje A. (Lippincott Williams & Wilkins, 2023-12-01)

Objective:People with HIV rarely control viral replication after cessation of antiretroviral therapy (ART). We present a person with HIV with extraordinary posttreatment control (PTC) for over 23 years after temporary ART ...
Busulfan Interlaboratory Proficiency Testing Program Revealed Worldwide Errors in Drug Quantitation and Dose Recommendations

Kweekel, D. M.; Mc Cune JS; Punt, Arjen; van Luin, Matthijs; Fransen, Erik (Lippincott Williams & Wilkins, 2023-12-01)

Background:The clinical outcomes of busulfan-based conditioning regimens for hematopoietic cell transplantation (HCT) have been improved by personalizing the doses to target narrow busulfan plasma exposure. An interlaboratory ...
The Delphi Delirium Management Algorithms: A practical tool for clinicians, the result of a modified Delphi expert consensus approach

Ottens, Thomas H; Hermes, Carsten; Page, Valerie; Oldham, Mark; Arora, Rakesh; Bienvenu, O Joseph; van den Boogaard, Mark; Caplan, Gideon; Devlin, John W; Friedrich, Michaela-Elena; van Gool, Willem A; Hanison, James; Hansen, Hans-Christian; Inouye, Sharon K; Kamholz, Barbara; Kotfis, Katarzyna; Maas, Matthew B; MacLullich, Alasdair M J; Marcantonio, Edward R; Morandi, Alessandro; van Munster, Barbara C; Müller-Werdan, Ursula; Negro, Alessandra; Neufeld, Karin J; Nydahl, Peter; Oh, Esther S; Pandharipande, Pratik; Radtke, Finn M; Raedt, Sylvie De; Rosenthal, Lisa J; Sanders, Robert; Spies, Claudia D; Vardy, Emma R L C; Wijdicks, Eelco F; Slooter, Arjen J C (2024)

Delirium is common in hospitalised patients, and there is currently no specific treatment. Identifying and treating underlying somatic causes of delirium is the first priority once delirium is diagnosed. Several international ...
Recording ten-fold larger I Kr conductances with automated patch clamping using equimolar Cs + solutions.

Bloothooft, Meye; Verbruggen, Bente; Seibertz, Fitzwilliam; van der Heyden, Marcel A G; Voigt, Niels; de Boer, Teun P (Frontiers Research Foundation, 2024-01-24)

Background: The rapid delayed rectifier potassium current (I Kr) is important for cardiac repolarization and is most often involved in drug-induced arrhythmias. However, accurately measuring this current can be challenging ...
'I am proud of how I handled it'. Exploring the impact of the COVID-19 pandemic and related restrictions on well-being of adults with severe mental illness using qualitative methods

van Rijn, L; Metz, M J; van der Velden, P R; Mathijsen, P; Swildens, W E; Schellekens, A F A; Cahn, W; Milota, M M; Zinkstok, J R (Wiley-Blackwell, 2024-02)

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic and related restrictions globally impacted mental health, particularly for those with pre-existing severe mental illness (SMI). This qualitative study examined ...
The metabolic, virulence and antimicrobial resistance profiles of colonising Streptococcus pneumoniae shift after PCV13 introduction in urban Malawi

Obolski, Uri; Swarthout, Todd D.; Kalizang’oma, Akuzike; Mwalukomo, Thandie S.; Chan, Jia Mun; Weight, Caroline M.; Brown, Comfort; Cave, Rory; Cornick, Jen; Kamng’ona, Arox Wadson; Msefula, Jacquline; Ercoli, Giuseppe; Brown, Jeremy S.; Lourenço, José; Maiden, Martin C.; French, Neil; Gupta, Sunetra; Heyderman, Robert S. (Nature Publishing Group, 2023-11-11)

Streptococcus pneumoniae causes substantial mortality among children under 5-years-old worldwide. Polysaccharide conjugate vaccines (PCVs) are highly effective at reducing vaccine serotype disease, but emergence of non-vaccine ...
A comparison of four epidemic waves of COVID-19 in Malawi; an observational cohort study

Blantyre COVID-19 Consortium (BioMed Central, 2023-12)

Background: Compared to the abundance of clinical and genomic information available on patients hospitalised with COVID-19 disease from high-income countries, there is a paucity of data from low-income countries. Our aim ...

Now showing items 7781-7800 of 40729