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UMC Repository: Recent submissions

  • Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies 
    O'Keefe, James H; Tintle, Nathan L; Harris, William S; O'Keefe, Evan L; Sala-Vila, Aleix; Attia, John; Garg, G Manohar; Hure, Alexis; Bork, Christian Sørensen; Schmidt, Erik Berg; Venø, Stine Krogh; Chien, Kuo-Liong; Chen, Yun-Yu Amelia; Egert, Sarah; Feldreich, Tobias Rudholm; Ärnlöv, Johan; Lind, Lars; Forouhi, Nita G; Geleijnse, Johanna M; Pertiwi, Kamalita; Imamura, Fumiaki; de Mello Laaksonen, Vanessa; Uusitupa, W Matti; Tuomilehto, Jaakko; Laakso, Markku; Lankinen, Maria Anneli; Laurin, Danielle; Carmichael, Pierre-Hugues; Lindsay, Joan; Leander, Karin; Laguzzi, Federica; Swenson, Brenton R; Longstreth, William T; Manson, JoAnn E; Mora, Samia; Cook, Nancy R; Marklund, Matti; Melo van Lent, Debora; Murphy, Rachel; Gudnason, Vilmundur; Ninomiya, Toshihara; Hirakawa, Yoichiro; Qian, Frank; Sun, Qi; Hu, Frank; Ardisson Korat, Andres V; Risérus, Ulf; Lázaro, Iolanda; Samieri, Cecilia; Le Goff, Mélanie; Helmer, Catherine; Steur, Marinka; Voortman, Trudy; Ikram, M Kamran; Tanaka, Toshiko; Das, Jayanta K; Ferrucci, Luigi; Bandinelli, Stefania; Tsai, Michael; Guan, Weihua; Garg, Parveen; Verschuren, W M Monique; Boer, Jolanda M A; Biokstra, Anneke; Virtanen, Jyrki; Wagner, Michael; Westra, Jason; Albuisson, Luc; Yamagishi, Kazumasa; Siscovick, David S; Lemaitre, Rozenn N; Mozaffarian, Dariush (Lippincott Williams & Wilkins, 2024-01)
    BACKGROUND: The effect of marine omega-3 PUFAs on risk of stroke remains unclear. METHODS: We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and ...
  • Discovering Distinct Phenotypical Clusters in Heart Failure Across the Ejection Fraction Spectrum: a Systematic Review 
    Meijs, Claartje; Handoko, M Louis; Savarese, Gianluigi; Vernooij, Robin W M; Vaartjes, Ilonca; Banerjee, Amitava; Koudstaal, Stefan; Brugts, Jasper J; Asselbergs, Folkert W; Uijl, Alicia (Current Science, Inc., 2023-10)
    Review Purpose: This systematic review aims to summarise clustering studies in heart failure (HF) and guide future clinical trial design and implementation in routine clinical practice. Findings: 34 studies were identified ...
  • Multimorbidity in Heart Failure: Leveraging Cluster Analysis to Guide Tailored Treatment Strategies 
    van de Veerdonk, Mariëlle C; Savarese, Gianluigi; Handoko, M Louis; Beulens, Joline W J; Asselbergs, Folkert; Uijl, Alicia (Current Science, Inc., 2023-10)
    Review Purpose: This review summarises key findings on treatment effects within phenotypical clusters of patients with heart failure (HF), making a distinction between patients with preserved ejection fraction (HFpEF) and ...
  • Digital consults to optimize guideline-directed therapy: design of a pragmatic multicenter randomized controlled trial 
    Man, Jelle P; Dijkgraaf, Marcel G W; Handoko, M Louis; de Lange, Frederik J; Winter, Michiel M; Schijven, Marlies P; Stienen, Susan; Meregalli, Paola; Kok, Wouter E M; Kuipers, Dorianne I; van der Harst, Pim; Koole, Maarten A C; Chamuleau, Steven A J; Schuuring, Mark J (John Wiley & Sons Inc., 2024-02)
    AIMS: Many heart failure (HF) patients do not receive optimal guideline-directed medical therapy (GDMT) despite clear benefit on morbidity and mortality outcomes. Digital consults (DCs) have the potential to improve ...
  • Embedding routine health care data in clinical trials: with great power comes great responsibility 
    Handoko, M Louis; de Man, Frances S; Brugts, Jasper J; van der Meer, Peter; Rhodius-Meester, Hanneke F M; Schaap, Jeroen; van de Kamp, H J Rik; Houterman, Saskia; van Veghel, Dennis; Uijl, Alicia; Asselbergs, Folkert W (Bohn Stafleu van Loghum, 2024-03)
    Randomised clinical trials (RCTs) are vital for medical progress. Unfortunately, 'traditional' RCTs are expensive and inherently slow. Moreover, their generalisability has been questioned. There is considerable overlap in ...
  • Epidemiology of heart failure in diabetes: a disease in disguise 
    Hoek, Anna G; Dal Canto, Elisa; Wenker, Eva; Bindraban, Navin; Handoko, M Louis; Elders, Petra J M; Beulens, Joline W J (Springer-Verlag, 2024-04)
    Left ventricular diastolic dysfunction (LVDD) without symptoms, and heart failure (HF) with preserved ejection fraction (HFpEF) represent the most common phenotypes of HF in individuals with type 2 diabetes mellitus, and ...
  • Changes in Health-Related Quality of Life following Surgery in Patients with High-Grade Extremity Soft-Tissue Sarcoma: A Prospective Longitudinal Study 
    Kruiswijk, Anouk A.; van de Sande, Michiel A.J.; Verhoef, Cornelis; Schrage, Yvonne M.; Haas, Rick L.; Bemelmans, Marc H.A.; van Ginkel, Robert J.; Bonenkamp, Johannes J.; Witkamp, Arjen J.; van den Akker-van Marle, M. Elske; Marang-van de Mheen, Perla J.; van Bodegom-Vos, Leti (Multidisciplinary Digital Publishing Institute (MDPI), 2024-02)
    Introduction: Changes in health-related quality of life (HRQoL) during the diagnostic and treatment trajectory of high-grade extremity soft-tissue sarcoma (eSTS) has rarely been investigated for adults (18–65 y) and the ...
  • The effect of physical exercise during radiotherapy on physical performance in patients with head and neck cancer: a trial within cohorts study protocol, the vital study 
    Kriellaars, Yvette; Vermaire, Jorine Ariane; Beugeling, Maaike; Poorter, Robert; Drijvers, Janneke; Speksnijder, Caroline Margina (BioMed Central, 2024-04-01)
    BACKGROUND: During the last decade, twelve studies have been published investigating physical exercise interventions (PEIs) in patients with head and neck cancer (HNC) during radiotherapy (RT), chemoradiation (CRT) or ...
  • Management and Outcomes of Necrotizing Otitis Externa: A Retrospective Cohort Study in a Tertiary Referral Center 
    Vosbeek, Eleonora G M; Straatman, Louise V; Braat, Arthur J A T; de Keizer, Bart; Thomeer, Hans G X M; Smit, Adriana L (2023-12)
    OBJECTIVES: Necrotizing otitis externa (NOE) is a rare infection of the ear that causes osteomyelitis. We aimed to evaluate treatment outcomes and the role of imaging in diagnosing and monitoring disease resolution in a ...
  • A phase II, multicenter, open-label study of abemaciclib and letrozole in patients with estrogen receptor-positive rare ovarian cancer: ALEPRO trial 
    Ottenbourgs, Tine; van Gorp, Toon; Kridelka, Frédéric; Baert, Thaïs; Denys, Hannelore; Selle, Frédéric; Baas, Inge; Van Rompuy, Anne Sophie; Lambrechts, Diether; Van Nieuwenhuysen, Els (Lippincott Williams & Wilkins, 2024-03-06)
    Background Low-grade serous and endometrioid ovarian cancers and adult-type granulosa cell tumors are rare ovarian malignancies that show high estrogen receptor positivity. Recurrences of these subtypes of ovarian cancer ...
  • Surgery for advanced pancreatic neuroendocrine neoplasms: recommendations based on a consensus meeting of the European Society of Endocrine Surgeons (ESES) 
    Van Beek, Dirk-Jan; Van Den Heede, Klaas; Borel Rinkes, Inne; Norlén, Olov; Van Slycke, Sam; Stålberg, Peter; Nordenström, Erik (John Wiley & Sons Inc., 2024-02-01)
  • Implementation of Nationwide Evidence- and Consensus-Based Guidelines to Harmonize Neonatal Care in The Netherlands 
    Talsma, Elise; de Jonge, Rogier; Cassel, Florian; van de Loo, Moniek; de Bijl-Marcus, Karen; Mulder, Estelle; Niemarkt, Hendrik; Prins, Sandra; van der Putten, Mayke; van Stuijvenberg, Margriet; Visser, Remco; Oerlemans, Anke; Hogeveen, Marije (Springer India, 2022-05)
    Background: A Dutch committee for National Guidelines in Neonatology developed nineteen evidence- and consensus-based guidelines to be used in all Dutch neonatal intensive care units (NICUs). The primary goal was to make ...
  • Neo-LVOT measurement in TMVR: time for Multimodality? 
    Guglielmo, Marco; Pavon, Anna Giulia (Wiley-Blackwell, 2024-03)
  • Cardiac Magnetic Resonance to Predict Cardiac Mass Malignancy: The CMR Mass Score 
    Paolisso, Pasquale; Bergamaschi, Luca; Angeli, Francesco; Belmonte, Marta; Foà, Alberto; Canton, Lisa; Fedele, Damiano; Armillotta, Matteo; Sansonetti, Angelo; Bodega, Francesca; Amicone, Sara; Suma, Nicole; Gallinoro, Emanuele; Attinà, Domenico; Niro, Fabio; Rucci, Paola; Gherbesi, Elisa; Carugo, Stefano; Musthaq, Saima; Baggiano, Andrea; Pavon, Anna Giulia; Guglielmo, Marco; Conte, Edoardo; Andreini, Daniele; Pontone, Gianluca; Lovato, Luigi; Pizzi, Carmine (Lippincott Williams & Wilkins, 2024-03-01)
    BACKGROUND: Multimodality imaging is currently suggested for the noninvasive diagnosis of cardiac masses. The identification of cardiac masses' malignant nature is essential to guide proper treatment. We aimed to develop ...
  • Targeting pediatric cancers via T-cell recognition of the monomorphic MHC class I-related protein MR1 
    Cornel, Annelisa M; van der Sman, Loutje; van Dinter, Jip T; Arrabito, Marta; Dunnebach, Ester; van Hoesel, Marliek; Kluiver, Thomas A; Lopes, Ana P; Dautzenberg, Noël M M; Dekker, Linde; van Rijn, Jorik M; van den Beemt, Denise A M H; Buhl, Juliane L; du Chatinier, Aimee; Barneh, Farnaz; Lu, Yuyan; Lo Nigro, Luca; Krippner-Heidenreich, Anja; Sebestyén, Zsolt; Kuball, Jurgen; Hulleman, Esther; Drost, Jarno; van Heesch, Sebastiaan; Heidenreich, Olaf T; Peng, Weng Chuan; Nierkens, Stefan (BioMed Central Ltd., 2024-03-21)
    Human leukocyte antigen (HLA) restriction of conventional T-cell targeting introduces complexity in generating T-cell therapy strategies for patients with cancer with diverse HLA-backgrounds. A subpopulation of atypical, ...
  • Predictors of 30-Day Mortality Among Dutch Patients Undergoing Colorectal Cancer Surgery, 2011-2016 
    the Dutch ColoRectal Audit (American Medical Association, 2021-04-26)
    IMPORTANCE Quality improvement programs for colorectal cancer surgery have been introduced with benchmarking based on quality indicators, such as mortality. Detailed (pre)operative characteristics may offer relevant ...
  • Dominance of Tau Burden in Cortical Over Subcortical Regions Mediates Glymphatic Activity and Clinical Severity in PSP 
    Hsu, Jung-Lung; Wei, Yi-Chia; Hsiao, Ing-Tsung; Lin, Kun-Ju; Yen, Tzu-Chen; Lu, Chin-Song; Wang, Han-Cheng; Leemans, Alexander; Weng, Yi-Hsin; Huang, Kuo-Lun (Lippincott Williams & Wilkins, 2024-05-01)
    Background: Progressive supranuclear palsy (PSP) is a tauopathy that involves subcortical regions but also extends to cortical areas. The clinical impact of different tau protein sites and their influence on glymphatic ...
  • Prognostic factors and prediction models for hospitalisation and all-cause mortality in adults presenting to primary care with a lower respiratory tract infection: a systematic review 
    Rijk, Merijn H.; Platteel, Tamara N.; van den Berg, Teun M.C.; Geersing, Geert Jan; Little, Paul; Rutten, Frans H.; van Smeden, Maarten; Venekamp, Roderick P. (BMJ Publishing Group, 2024-03-23)
    Objective To identify and synthesise relevant existing prognostic factors (PF) and prediction models (PM) for hospitalisation and all-cause mortality within 90 days in primary care patients with acute lower respiratory ...
  • A Cardioprotective perfusion protocol limits myocardial functional decline during ex situ heart perfusion 
    Vervoorn, Mats T.; Ballan, Elisa M.; van Tuijl, Sjoerd; de Jager, Saskia C.A.; Kaffka genaamd Dengler, Selma E.; Sluijter, Joost P.G.; Doevendans, Pieter A.; van der Kaaij, Niels P. (2024)
    Background Ex situ heart perfusion is associated with a significant decline in graft quality related to oxidative stress, inflammation, endothelial dysfunction, and metabolic perturbations. We assessed the effects of a ...
  • Diagnostic accuracy of MRI, CT, and [18F]FDG-PET-CT in detecting lymph node metastases in clinically early-stage cervical cancer: a nationwide Dutch cohort study 
    Olthof, Ester P; Bergink-Voorthuis, Brenda J; Wenzel, Hans H B; Mongula, Jordy; van der Velden, Jacobus; Spijkerboer, Anje M; Adam, Judit A; Bekkers, Ruud L M; Beltman, Jogchum J; Slangen, Brigitte F M; Nijman, Hans W; Smolders, Ramon G V; van Trommel, Nienke E; Zusterzeel, Petra L M; Zweemer, Ronald P; Stalpers, Lukas J A; Mom, Constantijne H; van der Aa, Maaike A (Springer Science and Business Media Deutschland GmbH, 2024-02-08)
    Objectives: Imaging is increasingly used to assess lymph node involvement in clinically early-stage cervical cancer. This retrospective study aimed to evaluate the diagnostic accuracy of MRI, CT, and [18F]FDG-PET-CT. ...