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UMC Repository: Recent submissions

  • Common Idiopathic Mononeuropathies of the Upper Extremity 
    Kortlever, Joost T P (Utrecht University, 2024-05-23)
    This thesis focuses on conditions where a nerve is affected (neuropathy) by compression in the wrist or elbow. For most of these conditions, the cause is unknown (idiopathic). The two most common conditions in the arm are ...
  • Minimum and Optimal CA19-9 Response After Two Months Induction Chemotherapy in Patients with Locally Advanced Pancreatic Cancer: A Nationwide Multicenter Study 
    Dutch Pancreatic Cancer Group (Lippincott Williams & Wilkins, 2024-05-01)
    Objective: This nationwide multicenter study aimed to define clinically relevant thresholds of relative serum CA19-9 response after 2 months of induction chemotherapy in patients with locally advanced pancreatic cancer ...
  • Predictors of anastomotic leak and conduit necrosis after oesophagectomy: Results from the oesophago-gastric anastomosis audit (OGAA) 
    Griffiths, E. A.; Data Analysis; Steering committee; National Leads; Site Leads; Collaborators; Oesophago-Gastric Anastomotic Audit (OGAA) Collaborative (W.B. Saunders Ltd, 2024-06)
    Background: Both anastomotic leak (AL) and conduit necrosis (CN) after oesophagectomy are associated with high morbidity and mortality. Therefore, the identification of preoperative, modifiable risk factors is desirable. ...
  • A narrative review of 35 years of meta-[131I]iodobenzylguanidine therapy in neuroblastoma 
    Samim, Atia; Bleeker, Gitta; Kraal, Kathelijne C.J.M.; van Noesel, Max M.; de Keizer, Bart; Tytgat, Godelieve A.M. (Elsevier, 2024-06)
    Neuroblastoma is the most common extracranial solid malignancy of childhood. Approximately half of the patients have high-risk neuroblastoma (HR-NBL), typically presenting as widespread metastatic disease at diagnosis. ...
  • Implementation of Best Practices in Pancreatic Cancer Care in the Netherlands: A Stepped-Wedge Randomized Clinical Trial 
    Dutch Pancreatic Cancer Group (American Medical Association, 2024-04-10)
    Importance: Implementation of new cancer treatment strategies as recommended by evidence-based guidelines is often slow and suboptimal. Objective: To improve the implementation of guideline-based best practices in the ...
  • Increased Intracranial Arterial Pulsatility and Microvascular Brain Damage in Pseudoxanthoma Elasticum 
    Bartstra, J. W.; van den Beukel, T.; Kranenburg, G.; Geurts, L. J.; den Harder, A. M.; Witkamp, T.; Wolterink, J. M.; Zwanenburg, J. J.M.; van Valen, Evelien; Koek, H.L.; Mali, W. P.T.M.; de Jong, P. A.; Hendrikse, J.; Spiering, W. (American Society of Neuroradiology, 2024-04-01)
    BACKGROUND AND PURPOSE: Carotid siphon calcification might contribute to the high prevalence of cerebrovascular disease in pseudoxanthoma elasticum through increased arterial flow pulsatility. This study aimed to compare ...
  • Hyperbaric Oxygen Therapy and Late Local Toxic Effects in Patients With Irradiated Breast Cancer: A Randomized Clinical Trial 
    Mink van der Molen, Dieuwke R; Batenburg, Marilot C T; Maarse, Wiesje; van den Bongard, Desiree H J G; Doeksen, Annemiek; de Lange, Marjoleine Y; van der Pol, Carmen C; Evers, Daniel J; Lansdorp, Corine A; van der Laan, Jacco; van de Ven, Peter M; van der Leij, Femke; Verkooijen, Helena M (American Medical Association, 2024-04-01)
    IMPORTANCE: Hyperbaric oxygen therapy (HBOT) is proposed as treatment for late local toxic effects after breast irradiation. Strong evidence of effectiveness is lacking. OBJECTIVE: To assess effectiveness of HBOT for late ...
  • Fetal indusium griseum is a possible biomarker of the regularity of brain midline development in 3T MR imaging: A retrospective observational study 
    Pogledic, Ivana; Bobić-Rasonja, Mihaela; Mitter, Christian; Štajduhar, Andrija; Schwartz, Ernst; Milković-Periša, Marija; Baltzer, Pascal A; Lequin, Maarten; Krampl-Bettelheim, Elisabeth; Kasprian, Gregor; Judaš, Miloš; Prayer, Daniela; Jovanov-Milosevic, Natasa (Wiley-Blackwell, 2024-05)
    INTRODUCTION: This study aimed to assess the visibility of the indusium griseum (IG) in magnetic resonance (MR) scans of the human fetal brain and to evaluate its reliability as an imaging biomarker of the normality of ...
  • The impact of unilateral pulmonary artery stenosis on right ventricular to pulmonary arterial coupling in patients with transposition of the great arteries 
    Joosen, Renée S.; Voskuil, Michiel; Krings, Gregor J.; Handoko, M. Louis; Dickinson, Michael G.; van de Veerdonk, Marielle C.; Breur, Johannes M.P.J. (John Wiley & Sons Inc., 2024-05-01)
    Background: Unilateral pulmonary artery (PA) stenosis is common in the transposition of the great arteries (TGA) after arterial switch operation (ASO) but the effects on the right ventricle (RV) remain unclear. Aims: To ...
  • Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer (Nature Medicine, (2023), 29, 6, (1340-1348), 10.1038/s41591-023-02339-y) 
    the International Childhood Cancer Outcome Project participants (Nature Research, 2023-12-13)
    Correction to: Nature Medicinehttps://doi.org/10.1038/s41591-023-02339-y, published online 15 June 2023. In the version of the article initially published, the surname of Andishe Attarbaschi was misspelled (Atterbaschi) ...
  • Genetic landscape of pediatric acute liver failure of indeterminate origin 
    Lenz, Dominic; Schlieben, Lea D; Shimura, Masaru; Bianzano, Alyssa; Smirnov, Dmitrii; Kopajtich, Robert; Berutti, Riccardo; Adam, Rüdiger; Aldrian, Denise; Baric, Ivo; Baumann, Ulrich; Bozbulut, Neslihan Eksi; Brugger, Melanie; Brunet, Theresa; Bufler, Philip; Burnytė, Birutė; Calvo, Pier Luigi; Crushell, Ellen; Dalgıç, Buket; Das, Anibh M; Dezsőfi, Antal; Distelmaier, Felix; Fichtner, Alexander; Freisinger, Peter; Garbade, Sven F; Gaspar, Harald; Goujon, Louise; Hadzic, Nedim; Hartleif, Steffen; Hegen, Bianca; Hempel, Maja; Henning, Stephan; Hoerning, Andre; Houwen, Roderick; Hughes, Joanne; Iorio, Raffaele; Iwanicka-Pronicka, Katarzyna; Jankofsky, Martin; Junge, Norman; Kanavaki, Ino; Kansu, Aydan; Kaspar, Sonja; Kathemann, Simone; Kelly, Deidre; Kırsaçlıoğlu, Ceyda Tuna; Knoppke, Birgit; Kohl, Martina; Kölbel, Heike; Kölker, Stefan; Konstantopoulou, Vassiliki; Krylova, Tatiana; Kuloğlu, Zarife; Kuster, Alice; Laass, Martin W; Lainka, Elke; Lurz, Eberhard; Mandel, Hanna; Mayerhanser, Katharina; Mayr, Johannes A; McKiernan, Patrick; McLean, Patricia; McLin, Valerie; Mention, Karine; Müller, Hanna; Pasquier, Laurent; Pavlov, Martin; Pechatnikova, Natalia; Peters, Bianca; Petković Ramadža, Danijela; Piekutowska-Abramczuk, Dorota; Pilic, Denisa; Rajwal, Sanjay; Rock, Nathalie; Roetig, Agnès; Santer, René; Schenk, Wilfried; Semenova, Natalia; Sokollik, Christiane; Sturm, Ekkehard; Taylor, Robert W; Tschiedel, Eva; Urbonas, Vaidotas; Urreizti, Roser; Vermehren, Jan; Vockley, Jerry; Vogel, Georg-Friedrich; Wagner, Matias; van der Woerd, Wendy; Wortmann, Saskia B; Zakharova, Ekaterina; Hoffmann, Georg Friedrich; Meitinger, Thomas; Murayama, Kei; Staufner, Christian; Prokisch, Holger (John Wiley & Sons Inc., 2024-05-01)
    BACKGROUND AND AIMS: Pediatric acute liver failure (PALF) is a life-threatening condition. In Europe, the main causes are viral infections (12%-16%) and inherited metabolic diseases (14%-28%). Yet, in up to 50% of cases ...
  • The cumulative burden of self-reported, clinically relevant outcomes in long-term childhood cancer survivors and implications for survivorship care: A DCCSS LATER study 
    Streefkerk, Nina; Teepen, Jop C.; Feijen, Elizabeth A.M.; Jóźwiak, Katarzyna; van der Pal, Helena J.H.; Ronckers, Cecile M.; De Vries, Andrica C.H.; Van der Heiden-van Der Loo, Margriet; Hollema, Nynke; van den Berg, Marleen; Loonen, Jacqueline; Grootenhuis, Martha A.; Bresters, Dorine; Versluys, A. Brigitta; van Dulmen-den Broeder, Eline; van den Heuvel-Eibrink, Marry M.; van Leeuwen, Flora E.; Neggers, Sebastian J.C.M.M.; Van Santen, Hanneke M.; Hawkins, Mike; Hauptmann, Michael; Yoneoka, Daisuke; Korevaar, Joke C.; Tissing, Wim J.E.; Kremer, Leontien C.M. (John Wiley & Sons Inc., 2024-04-15)
    Background: The aim of this study is to evaluate how cumulative burden of clinically relevant, self-reported outcomes in childhood cancer survivors (CCSs) compares to a sibling control group and to explore how the burden ...
  • External validation of the RSNA 2020 pulmonary embolism detection challenge winning deep learning algorithm 
    Langius-Wiffen, Eline; Slotman, Derk J.; Groeneveld, Jorik; AC van Osch, Jochen; Nijholt, Ingrid M.; de Boer, Erwin; Nijboer-Oosterveld, Jacqueline; Veldhuis, Wouter B.; de Jong, Pim A.; Boomsma, Martijn F. (Elsevier Ireland Ltd, 2024-04)
    Purpose: To evaluate the diagnostic performance and generalizability of the winning DL algorithm of the RSNA 2020 PE detection challenge to a local population using CTPA data from two hospitals. Materials and Methods: ...
  • Healthcare Resource Utilization and Cost-of-Illness in Systemic Light Chain (AL) Amyloidosis in Europe: Results From the Real-World, Retrospective EMN23 Study 
    Jaccard, Arnaud; Bridoux, Frank; Roeloffzen, Wilfried; Minnema, Monique C; Bergantim, Rui; Hájek, Roman; João, Cristina; Cibeira, M Teresa; Palladini, Giovanni; Schönland, Stefan; Merlini, Giampaolo; Milani, Paolo; Dimopoulos, Meletios A; Ravichandran, Sriram; Hegenbart, Ute; Agis, Hermine; Gros, Blanca; Asra, Aisha; Magarotto, Valeria; Cheliotis, Giorgos; Psarros, Giorgos; Sonneveld, Pieter; Wechalekar, Ashutosh; Kastritis, Efstathios (Elsevier, 2024-05)
    OBJECTIVES: To report healthcare resource utilization (HCRU) and safety outcomes in systemic light chain (AL) amyloidosis from the EMN23 study. MATERIALS AND METHODS: The retrospective, observational, multinational EMN23 ...
  • Correction: Consensus statement on standards and guidelines for the molecular diagnostics of Alport syndrome: refining the ACMG criteria(European Journal of Human Genetics, (2021), 29, 8, (1186-1197), 10.1038/s41431-021-00858-1) 
    Savige, Judy; Storey, Helen; Watson, Elizabeth; Hertz, Jens Michael; Deltas, Constantinos; Renieri, Alessandra; Mari, Francesca; Hilbert, Pascale; Plevova, Pavlina; Byers, Peter; Cerkauskaite, Agne; Gregory, Martin; Cerkauskiene, Rimante; Ljubanovic, Danica Galesic; Becherucci, Francesca; Errichiello, Carmela; Massella, Laura; Aiello, Valeria; Lennon, Rachel; Hopkinson, Louise; Koziell, Ania; Lungu, Adrian; Rothe, Hansjorg Martin; Hoefele, Julia; Zacchia, Miriam; Martic, Tamara Nikuseva; Gupta, Asheeta; van Eerde, Albertien; Gear, Susie; Landini, Samuela; Palazzo, Viviana; al-Rabadi, Laith; Claes, Kathleen; Corveleyn, Anniek; Van Hoof, Evelien; van Geel, Micheel; Williams, Maggie; Ashton, Emma; Belge, Hendica; Ars, Elisabeth; Bierzynska, Agnieszka; Gangemi, Concetta; Lipska-Ziętkiewicz, Beata S. (Springer Nature, 2024-01)
    Correction to: European Journal of Human Genetics (2021) 29:1186–1197 The following Acknowledgement was missing: This research has been supported not financially by “European Reference Network for Rare Kidney Disease, ...
  • Deep Learning Approaches Applied to Image Classification of Renal Tumors: A Systematic Review 
    Amador, Sandra; Beuschlein, Felix; Chauhan, Vedant; Favier, Judith; Gil, David; Greenwood, Phillip; de Krijger, R. R.; Kroiss, Matthias; Ortuño-Miquel, Samanta; Patocs, Attila; Stell, Anthony; Walch, Axel (Springer Netherlands, 2024-03)
    Renal cancer is one of the ten most common cancers in the population that affects 65,000 new patients a year. Nowadays, to predict pathologies or classify tumors, deep learning (DL) methods are effective in addition to ...
  • Predictability of human exposure by human-CYP3A4-transgenic mouse models: A meta-analysis 
    Damoiseaux, David; Schinkel, Alfred H; Beijnen, Jos H; Huitema, Alwin D R; Dorlo, Thomas P C (John Wiley & Sons Inc., 2024-01)
    First-in-human dose predictions are primarily based on no-observed-adverse-effect levels in animal studies. Predictions from these animal models are only as effective as their ability to predict human results. To narrow ...
  • Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy 
    Wienke, Judith; Visser, Lindy L; Kholosy, Waleed M; Keller, Kaylee M; Barisa, Marta; Poon, Evon; Munnings-Tomes, Sophie; Himsworth, Courtney; Calton, Elizabeth; Rodriguez, Ana; Bernardi, Ronald; van den Ham, Femke; van Hooff, Sander R; Matser, Yvette A H; Tas, Michelle L; Langenberg, Karin P S; Lijnzaad, Philip; Borst, Anne L; Zappa, Elisa; Bergsma, Francisca J; Strijker, Josephine G M; Verhoeven, Bronte M; Mei, Shenglin; Kramdi, Amira; Restuadi, Restuadi; Sanchez-Bernabeu, Alvaro; Cornel, Annelisa M; Holstege, Frank C P; Gray, Juliet C; Tytgat, Godelieve A M; Scheijde-Vermeulen, Marijn A; Wijnen, Marc H W A; Dierselhuis, Miranda P; Straathof, Karin; Behjati, Sam; Wu, Wei; Heck, Albert J R; Koster, Jan; Nierkens, Stefan; Janoueix-Lerosey, Isabelle; de Krijger, Ronald R; Baryawno, Ninib; Chesler, Louis; Anderson, John; Caron, Hubert N; Margaritis, Thanasis; van Noesel, Max M; Molenaar, Jan J (Cell Press, 2024-02-12)
    Pediatric patients with high-risk neuroblastoma have poor survival rates and urgently need more effective treatment options with less side effects. Since novel and improved immunotherapies may fill this need, we dissect ...
  • FOXO transcription factors as mediators of stress adaptation 
    Rodriguez-Colman, Maria J.; Dansen, Tobias B.; Burgering, Boudewijn M.T. (Nature Research, 2024-01)
    The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6) transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16, which gained notoriety for its capability to double ...
  • The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets 
    Sleeboom, Jelle J.F.; van Tienderen, Gilles S.; Schenke-Layland, Katja; van der Laan, Luc J.W.; Khalil, Antoine A.; Verstegen, Monique M.A. (American Association for the Advancement of Science, 2024-01-03)
    The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a critical role in cancer. Although research often concentrates on the tumor’s cellular aspect, attention is growing for the importance ...