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Now showing items 7561-7580 of 40729

Next generation sequencing of high-grade adult-type diffuse glioma in the Netherlands: interlaboratory variation in the primary diagnostic and recurrent setting

van Opijnen, Mark P; Broekman, Marike L D; Cuppen, Edwin; Dubbink, Hendrikus J; Ter Elst, Arja; van Eijk, Ronald; Mühlebner, Angelika; Jansen, Casper; van der Geize, Robert; Speel, Ernst-Jan M; Groenen, Patricia J T A; de Vos, Filip Y F; Wesseling, Pieter; de Leng, Wendy W J; Maas, Sybren L N (Kluwer Academic Publishers, 2024-02)

PURPOSE: Next generation sequencing (NGS) is an important tool used in clinical practice to obtain the required molecular information for accurate diagnostics of high-grade adult-type diffuse glioma (HGG). Since individual ...
Mitochondrial H2O2 release does not directly cause damage to chromosomal DNA.

van Soest, Daan M K; Polderman, Paulien E; den Toom, Wytze T F; Keijer, Janneke P; van Roosmalen, Markus J; Leyten, Tim M F; Lehmann, Johannes; Zwakenberg, Susan; De Henau, Sasha; van Boxtel, Ruben; Burgering, Boudewijn M T; Dansen, Tobias B (Nature Publishing Group, 2024-03-28)

Reactive Oxygen Species (ROS) derived from mitochondrial respiration are frequently cited as a major source of chromosomal DNA mutations that contribute to cancer development and aging. However, experimental evidence showing ...
A critical appreciation of pathway analysis in atherosclerotic disease. Cellular phenotypic plasticity as an illustrative example

Wesseling, M; Diez-Benavente, E; Mokry, M; den Ruijter, H M; Pasterkamp, G (Elsevier, 2024-03)

The rapid advancements in genome-scale (omics) techniques has created significant opportunities to investigate complex disease mechanisms in tissues and cells. Nevertheless, interpreting -omics data can be challenging, and ...
Predicting Recurrence-Free and Overall Survival for Patients With Stage II Melanoma: The MIA Calculator

Varey, Alexander H R; Li, Isabel; El Sharouni, Mary-Ann; Simon, Julie; Dedeilia, Aikaterini; Ch'ng, Sydney; Saw, Robyn P M; Spillane, Andrew J; Shannon, Kerwin F; Pennington, Thomas E; Rtshiladze, Michael; Stretch, Jonathan R; Nieweg, Omgo E; van Akkooi, Alexander; Sullivan, Ryan J; Boland, Genevieve M; Gershenwald, Jeffrey E; van Diest, Paul J; Scolyer, Richard A; Long, Georgina V; Thompson, John F; Lo, Serigne N (Lippincott Williams & Wilkins, 2024-04-01)

PURPOSE Improvements in recurrence-free survival (RFS) were demonstrated in two recent randomized trials for patients with sentinel node (SN)–negative stage IIB or IIC melanoma receiving adjuvant systemic therapy ...
A farnesyl-dependent structural role for CENP-E in expansion of the fibrous corona

Wu, Jingchao; Raas, Maximilian W.D.; Alcaraz, Paula Sobrevals; Vos, Harmjan R.; Tromer, Eelco C.; Snel, Berend; Kops, Geert J.P.L. (Rockefeller University Press, 2024-01-01)

Correct chromosome segregation during cell division depends on proper connections between spindle microtubules and kinetochores. During prometaphase, kinetochores are temporarily covered with a dense protein meshwork known ...
Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging: Erratum

de Bruijn, Henriette S; Mashayekhi, Vida; Schreurs, Tom J L; van Driel, Pieter B A A; Strijkers, Gustav J; van Diest, Paul J; Lowik, Clemens W G M; Seynhaeve, Ann L B; Ten Hagen, Timo L M; Prompers, Jeanine J; van Bergen En Henegouwen, Paul M P; Robinson, Dominic J; Oliveira, Sabrina (Ivyspring International Publisher, 2024)

Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging (Theranostics (2020) 10:5 (2436-2452) ...
Use of the oxygen gradient ektacytometry in the dose titration of hydroxyurea therapy in children with sickle cell disease

SCORE Consortium (Wiley-Blackwell, 2024-04)
Pros and cons of artificial intelligence implementation in diagnostic pathology

van Diest, Paul J; Flach, Rachel N; van Dooijeweert, Carmen; Makineli, Seher; Breimer, Gerben E; Stathonikos, Nikolas; Pham, Paul; Nguyen, Tri Q; Veta, Mitko (Wiley-Blackwell, 2024-05)

The rapid introduction of digital pathology has greatly facilitated development of artificial intelligence (AI) models in pathology that have shown great promise in assisting morphological diagnostics and quantitation of ...
Trends in body mass index in the pre-dolutegravir period in South Africa

Ginkel, Florian van; Barth, Roos; Tempelman, Hugo; Klipstein-Grobusch, Kerstin; Grobbee, Diederick; Scheuermaier, Karine; Venter, Francois; Vos-Seda, Alinda (AOSIS (Pty) Ltd, 2024-04-23)

Background: Antiretroviral therapy (ART) is associated with weight gain, but this has been shown to be more marked with dolutegravir and other integrase strand transfer inhibitors. Objectives: We studied weight gain in ...
Non-dispensing pharmacists integrated into general practices as a new interprofessional model: a qualitative evaluation of general practitioners’ experiences and views

Hazen, A. C.M.; Sloeserwij, V. M.; de Groot, E.; de Gier, J. J.; de Wit, N. J.; de Bont, A. A.; Zwart, D. L.M. (BioMed Central, 2024-04-23)

Background: A new interprofessional model incorporating non-dispensing pharmacists in general practice teams can improve the quality of pharmaceutical care. However, results of the model are dependent on the context. ...
COVID-19 and pregnancy: A European study on pre- and post-infection medication use

Hurley, Eimir; Geisler, Benjamin P; Lupattelli, Angela; Poblador-Plou, Beatriz; Lassalle, Régis; Jové, Jérémy; Bernard, Marie-Agnes; Sakr, Dunia; Sanfélix-Gimeno, Gabriel; Sánchez-Saez, Francisco; Rodríguez-Bernal, Clara L; Sabaté, Mònica; Ballarín, Elena; Aguilera, Cristina; Jordan, Sue; Thayer, Daniel; Farr, Ian; Ahmed, Saira; Bartolini, Claudia; Limoncella, Giorgio; Paoletti, Olga; Gini, Rosa; Maglanoc, Luigi A; Dudukina, Elena; Ehrenstein, Vera; Alsina, Ema; Vaz, Tiago A; Riera-Arnau, Judit; Sturkenboom, Miriam C J M; Nordeng, Hedvig M E (Springer-Verlag, 2024-05)

PURPOSE: The COVID-19 pandemic has impacted medication needs and prescribing practices, including those affecting pregnant women. Our goal was to investigate patterns of medication use among pregnant women with COVID-19, ...
Automated, Point-of-Care mobile flow cytometry: Bringing the laboratory to the sample

Jukema, B. N.; Pelgrim, T. C.; Spoelder, M.; Bongers, C. C.W.G.; Hopman, M. T.E.; Smit, K.; Rijk, M. H.; Venekamp, R. P.; Vrisekoop, N.; Koenderman, L. (Elsevier, 2024-04-30)

Background: Innate effector cells are very responsive to infectious and inflammatory cues found in damaged and inflamed tissues. Their activation is a potential target to assess the state of the immune system. Unfortunately, ...
Effect of Physical Exercise on MRI-Assessed Brain Perfusion in Chemotherapy-Treated Breast Cancer Patients: A Randomized Controlled Trial

PAM study group (John Wiley & Sons Inc., 2024-05)

BACKGROUND: Exercise is a promising intervention to alleviate cognitive problems in breast cancer patients, but studies on mechanisms underlying these effects are lacking. PURPOSE: Investigating whether an exercise ...
Specific and off-target immune responses following COVID-19 vaccination with ChAdOx1-S and BNT162b2 vaccines—an exploratory sub-study of the BRACE trial

BRACE trial (Elsevier, 2024-05)

Background: The COVID-19 pandemic led to the rapid development and deployment of several highly effective vaccines against SARS-CoV-2. Recent studies suggest that these vaccines may also have off-target effects on the ...
Frequency and timing of adverse reactions to COVID-19 vaccines; A multi-country cohort event monitoring study

Raethke, Monika; van Hunsel, Florence; Luxi, Nicoletta; Lieber, Thomas; Bellitto, Chiara; Mulder, Erik; Ciccimarra, Francesco; Riefolo, Fabio; Thurin, Nicolas H; Roy, Debabrata; Morton, Kathryn; Villalobos, Felipe; Batel Marques, Francisco; Farcas, Andreea; Sonderlichová, Simona; Belitser, Svetlana; Klungel, Olaf; Trifirò, Gianluca; Sturkenboom, Miriam C (Elsevier, 2024-04-02)

INTRODUCTION: During the COVID-19 pandemic, EMA set-up a large-scale cohort event monitoring (CEM) system to estimate incidence rates of patient-reported adverse drug reactions (ADRs) of different COVID-19 vaccines across ...
Education pathways and key tasks for research nurses in Europe, results from a VACCELERATE online survey

Salmanton-García, Jon; Stewart, Fiona A.; Wipfler, Pauline; Hofstraat, Sanne H.I.; Bruijning-Verhagen, Patricia; Cornely, Oliver A. (Elsevier, 2024-05)

Aim: This article aims to provide a comprehensive overview of the educational pathways and responsibilities of research nurses in Europe, particularly focusing on their essential role in conducting research in clinical ...
The Utility of Risk Factors to Define Complicated Staphylococcus aureus Bacteremia in a Setting With Low Methicillin-Resistant S. aureus Prevalence

van der Vaart, Thomas W; Prins, Jan M; Goorhuis, Abraham; Lemkes, Bregtje A; Sigaloff, Kim C E; Spoorenberg, Veroniek; Stijnis, Cornelis; Bonten, Marc J M; van der Meer, Jan T M (Oxford University Press, 2024-04-15)

Introduction. Recommended duration of antibiotic treatment of Staphylococcus aureus bacteremia (SAB) is frequently based on distinguishing uncomplicated and complicated SAB, and several risk factors at the onset of infection ...
Corrigendum: Diabetes—Tuberculosis Care in Eswatini: A Qualitative Study of Opportunities and Recommendations for Effective Services Integration

Williams, Victor; Vos-Seda, Alinda G; Haumba, Samson; Mdluli-Dlamini, Lindiwe; Calnan, Marianne; Grobbee, Diederick E; Otwombe, Kennedy; Klipstein-Grobusch, Kerstin (Frontiers Media S. A., 2024-01-24)

[This corrects the article DOI: 10.3389/ijph.2023.1605551.].
Development and validation of a risk prediction model for hospital admission in COVID-19 patients presenting to primary care

Wynants, Laure; Broers, Natascha Jh; Platteel, Tamara N; Venekamp, Roderick P; Barten, Dennis G; Leers, Mathie Pg; Verheij, Theo Jm; Stassen, Patricia M; Cals, Jochen Wl; de Bont, Eefje Gpm (Informa Healthcare, 2024-04-29)

BACKGROUND: There is a paucity of prognostic models for COVID-19 that are usable for in-office patient assessment in general practice (GP). OBJECTIVES: To develop and validate a risk prediction model for hospital admission ...
Antibody responses and B cell immunity after pertussis booster vaccination: immunity in young and old in times of endemic pertussis

Versteegen, Pauline (Utrecht University, 2024-05-28)

Pertussis, commonly known as whooping cough, is caused by the Bordetella pertussis bacterium and is a respiratory tract infection with potentially severe complications, especially in unvaccinated infants. Vaccination against ...

Now showing items 7561-7580 of 40729