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Now showing items 6901-6920 of 40729

The detection of a strong episignature for Chung-Jansen syndrome, partially overlapping with Börjeson-Forssman-Lehmann and White-Kernohan syndromes

Vos, Niels; Haghshenas, Sadegheh; van der Laan, Liselot; Russel, Perle K M; Rooney, Kathleen; Levy, Michael A; Relator, Raissa; Kerkhof, Jennifer; McConkey, Haley; Maas, Saskia M; Vissers, Lisenka E L M; de Vries, Bert B A; Pfundt, Rolph; Elting, Mariet W; van Hagen, Johanna M; Verbeek, Nienke E; Jongmans, Marjolijn C J; Lakeman, Phillis; Rumping, Lynne; Bosch, Danielle G M; Vitobello, Antonio; Thauvin-Robinet, Christel; Faivre, Laurence; Nambot, Sophie; Garde, Aurore; Willems, Marjolaine; Genevieve, David; Nicolas, Gaël; Busa, Tiffany; Toutain, Annick; Gérard, Marion; Bizaoui, Varoona; Isidor, Bertrand; Merla, Giuseppe; Accadia, Maria; Schwartz, Charles E; Ounap, Katrin; Hoffer, Mariëtte J V; Nezarati, Marjan M; van den Boogaard, Marie-José H; Tedder, Matthew L; Rogers, Curtis; Brusco, Alfredo; Ferrero, Giovanni B; Spodenkiewicz, Marta; Sidlow, Richard; Mussa, Alessandro; Trajkova, Slavica; McCann, Emma; Mroczkowski, Henry J; Jansen, Sandra; Donker-Kaat, Laura; Duijkers, Floor A M; Stuurman, Kyra E; Mannens, Marcel M A M; Alders, Mariëlle; Henneman, Peter; White, Susan M; Sadikovic, Bekim; van Haelst, Mieke M (Springer-Verlag, 2024-06)

Chung-Jansen syndrome is a neurodevelopmental disorder characterized by intellectual disability, behavioral problems, obesity and dysmorphic features. It is caused by pathogenic variants in the PHIP gene that encodes for ...
Combining Cellular Immunization and Phage Display Screening Results in Novel, FcγRI-Specific Antibodies

Krohn, Steffen; Holtrop, Tosca; Brandsma, Arianne M; Moerer, Petra; Nederend, Maaike; Darzentas, Nikos; Brüggemann, Monika; Klausz, Katja; Leusen, Jeanette H W; Peipp, Matthias (Multidisciplinary Digital Publishing Institute (MDPI), 2024-04-12)

Antibodies that specifically bind to individual human fragment crystallizable γ receptors (FcγRs) are of interest as research tools in studying immune cell functions, as well as components in bispecific antibodies for ...
Advancing hypertensive disorders of pregnancy management: insights from the 5th preeclampsia scientific symposium in Ghana

APEC-Ghana (BioMed Central Ltd., 2024-06-13)

The 5th Preeclampsia Scientific Symposium (PSS2023) organized by Action on Preeclampsia (APEC) Ghana was themed: 'Realign, Refocus: Improving outcomes of Hypertensive Disorders of Pregnancy through Shared Decision Making, ...
Using Team-Based Learning to Teach Pharmacology within the Medical Curriculum

Luitjes, Nora L D; van der Velden, Gisela J; Pandit, Rahul (MDPI AG, 2024-06-12)

The primary goal of pharmacology teaching is to prepare medical students to prescribe medications both safely and efficiently. At the Utrecht University Medical School, pharmacology is integrated into the three-year ...
Navigating the challenges: a case report on managing a complicated postpartum course in type 3 von Willebrand disease with alloantibodies

van der Zwet, Konrad; van Galen, Karin P M; Evers, Annemiek C C; Fischer, Kathelijn; Schutgens, Roger E G; van Vulpen, Lize F D (Elsevier, 2024-03)

BACKGROUND: Von Willebrand disease (VWD) type 3 is characterized by a complete deficiency of von Willebrand factor (VWF), resulting in a severe bleeding phenotype. Treatment often requires administration of VWF concentrates/factor ...
Treatment-associated imaging changes in newly diagnosed MGMT promoter-methylated glioblastoma undergoing chemoradiation with or without cilengitide

Flies, Christina Maria; Friedrich, Michel; Lohmann, Philipp; van Garderen, Karin Alida; Smits, Marion; Tonn, Joerg-Christian; Weller, Michael; Galldiks, Norbert; Snijders, Tom Jan (Oxford University Press, 2024-05-01)

BACKGROUND: Radiological progression may originate from progressive disease (PD) or pseudoprogression/treatment-associated changes. We assessed radiological progression in O6-methylguanine-DNA methyltransferase (MGMT) ...
Influenza Infection and Acute Myocardial Infarction

de Boer, Annemarijn R; Riezebos-Brilman, Annelies; van Hout, Denise; van Mourik, Maaike S M; Rümke, Lidewij W; de Hoog, Marieke L A; Vaartjes, Ilonca; Bruijning-Verhagen, Patricia C J L (Massachussetts Medical Society, 2024-07)

BACKGROUND: Acute respiratory infections can trigger acute myocardial infarction. We aimed to quantify the association between laboratory-confirmed influenza infection and acute myocardial infarction, particularly in ...
Experimental Data on PIRCHE and T-Cell Reactivity: HLA-DPB1-Derived Peptides Identified by PIRCHE-I Show Binding to HLA-A*02:01 in vitro and T-Cell Activation in vivo

Peereboom, Emma T.M.; Maranus, Anna E.; Timmerman, Laura M.; Geneugelijk, Kirsten; Spierings, Eric (S. Karger AG, 2024-04-02)

Introduction: Human leukocyte antigen (HLA)-DPB1 mismatches during hematopoietic stem cell transplantation (HSCT) with an unrelated donor result in an increased risk for the development of graft-versus-host disease (GvHD). ...
PIRCHE-II Risk and Acceptable Mismatch Profile Analysis in Solid Organ Transplantation

Niemann, Matthias; Matern, Benedict M; Spierings, Eric (Humana Press, 2024)

To optimize outcomes in solid organ transplantation, the HLA genes are regularly compared and matched between the donor and recipient. However, in many cases a transplant cannot be fully matched, due to widespread variation ...
Inter-laboratory multiplex bead-based surface protein profiling of MSC-derived EV preparations identifies MSC-EV surface marker signatures

Nguyen, Vivian V.T.; Welsh, Joshua A.; Tertel, Tobias; Choo, Andre; van de Wakker, Simonides I.; Defourny, Kyra A.Y.; Giebel, Bernd; Vader, Pieter; Padmanabhan, Jayanthi; Lim, Sai Kiang; Nolte-'t Hoen, Esther N.M.; Verhaar, Marianne C.; Bostancioglu, R. Beklem; Zickler, Antje M.; Hong, Jia Mei; Jones, Jennifer C.; EL Andaloussi, Samir; van Balkom, Bas W.M.; Görgens, André (John Wiley & Sons Inc., 2024-06)

Mesenchymal stromal cells (MSCs) are promising regenerative therapeutics that primarily exert their effects through secreted extracellular vesicles (EVs). These EVs – being small and non-living – are easier to handle and ...
European survey of newborn bloodspot screening for CF: opportunity to address challenges and improve performance

Munck, Anne; Berger, Daria O; Southern, Kevin W; Carducci, Carla; de Winter-de Groot, Karin M; Gartner, Silvia; Kashirskaya, Nataliya; Linnane, Barry; Proesmans, Marijke; Sands, Dorota; Sommerburg, Olaf; Castellani, Carlo; Barben, Jürg; European CF Society Neonatal Screening Working Group (ECFS NSWG) (Elsevier, 2023-05)

BACKGROUND: The aim of this study was to record the current status of newborn bloodspot screening (NBS) for CF across Europe and assess performance. METHODS: Survey of representatives of NBS for CF programmes across Europe. ...
The More Things Change . .

Kahn, René S. (2024-06-01)
Ocular surface disease in moderate-to-severe atopic dermatitis patients and the effect of biological therapy

Achten, Roselie; Thijs, Judith; van der Wal, Marlot; van Luijk, Chantal; Bakker, Daphne; Knol, Edward; van Luin, Matthijs; El Amrani, Mohsin; Delemarre, Eveline; Elfiky, Ahmed M I; de Boer, Joke; van Wijk, Femke; de Graaf, Marlies; de Bruin-Weller, Marjolein (Wiley-Blackwell, 2024-04)

Atopic dermatitis (AD) is a chronic inflammatory skin disease for which new targeted therapies are currently available. Due to the increased rates of ocular surface disease (OSD) reported during treatment with these new ...
Addition of FFRct in the diagnostic pathway of patients with stable chest pain to reduce unnecessary invasive coronary angiography (FUSION): Rationale and design for the multicentre, randomised, controlled FUSION trial

Sharma, S P; Hirsch, A; Hunink, M G M; Cramer, M J M; Mohamed Hoesein, F A A; Geluk, C A; Kramer, G; Gratama, J W C; Braam, R L; van der Zee, P M; Yassi, W; Wolters, S L; Gürlek, C; Pundziute, G; Vliegenthart, R; Budde, R P J (Bohn Stafleu van Loghum, 2023-02)

Background: Coronary computed tomography angiography (CCTA) is widely used in the diagnostic work-up of patients with stable chest pain. CCTA has an excellent negative predictive value, but a moderate positive predictive ...
Transmural collaborative care model for the review of antipsychotics: a feasibility study of a complex intervention

Jakobs, Kirsti M.; van den Brule-Barnhoorn, Karlijn J.; van Lieshout, Jan; Janzing, Joost G.E.; Cahn, Wiepke; van den Muijsenbergh, Maria; Biermans, Marion C.J.; Bischoff, Erik W.M.A. (Nature Publishing Group, 2024-05-29)

General practitioners (GPs) are often unaware of antipsychotic (AP)-induced cardiovascular risk (CVR) and therefore patients using atypical APs are not systematically monitored. We evaluated the feasibility of a complex ...
Standardized Assessment of Automatic Segmentation of White Matter Hyperintensities and Results of the WMH Segmentation Challenge

Kuijf, Hugo J; Biesbroek, J Matthijs; de Bresser, Jeroen; Heinen, Rutger; Andermatt, Simon; Bento, Mariana; Berseth, Matt; Belyaev, Mikhail; Cardoso, M Jorge; Casamitjana, Adria; Collins, D Louis; Dadar, Mahsa; Georgiou, Achilleas; Ghafoorian, Mohsen; Jin, Dakai; Khademi, April; Knight, Jesse; Li, Hongwei; Llado, Xavier; Luna, Miguel; Mahmood, Qaiser; McKinley, Richard; Mehrtash, Alireza; Ourselin, Sebastien; Park, Bo-Yong; Park, Hyunjin; Park, Sang Hyun; Pezold, Simon; Puybareau, Elodie; Rittner, Leticia; Sudre, Carole H; Valverde, Sergi; Vilaplana, Veronica; Wiest, Roland; Xu, Yongchao; Xu, Ziyue; Zeng, Guodong; Zhang, Jianguo; Zheng, Guoyan; Chen, Christopher; van der Flier, Wiesje; Barkhof, Frederik; Viergever, Max A; Biessels, Geert Jan (Institute of Electrical and Electronics Engineers Inc., 2019-11)

Quantification of cerebral white matter hyperintensities (WMH) of presumed vascular origin is of key importance in many neurological research studies. Currently, measurements are often still obtained from manual segmentations ...
Neuropsychological assessment in vascular cognitive impairment: A call to lay the quest for the best test to rest

Biessels, G. J. (Elsevier, 2024-01)
Fertility-Preserving Treatments and Patient- and Parental Satisfaction on Fertility Counseling in a Cohort of Newly Diagnosed Boys and Girls with Childhood Hodgkin Lymphoma

EuroNet-PHL-C2 Study Group (Multidisciplinary Digital Publishing Institute (MDPI), 2024-06)

PURPOSE: The purpose of this study is to evaluate the use of fertility-preserving (FP) treatments and fertility counseling that was offered in a cohort of newly diagnosed children with classical Hodgkin lymphoma (cHL). ...
Representation of Women in Stroke Clinical Trials: A Review of 281 Trials Involving More Than 500,000 Participants

Carcel, Cheryl; Harris, Katie; Peters, Sanne A E; Sandset, Else Charlotte; Balicki, Grace; Bushnell, Cheryl D; Howard, Virginia J; Reeves, Mathew J; Anderson, Craig S; Kelly, Peter J; Woodward, Mark (Lippincott Williams & Wilkins, 2021-11-02)

Background and ObjectivesWomen have been underrepresented in cardiovascular disease clinical trials but there is less certainty over the level of disparity specifically in stroke. We examined the participation of women in ...
Dolutegravir/Lamivudine Is Noninferior to Continuing Dolutegravir- and Non-Dolutegravir-Based Triple-Drug Antiretroviral Therapy in Virologically Suppressed People With Human Immunodeficiency Virus: DUALING Prospective Nationwide Matched Cohort Study

the AIDS Therapy Evaluation in the Netherlands (ATHENA) Observational HIV Cohort (Oxford University Press, 2024-04-01)

Background. Confirming the efficacy of dolutegravir/lamivudine in clinical practice solidifies recommendations on its use. Methods. Prospective cohort study (DUALING) in 24 human immunodeficiency virus (HIV) treatment ...

Now showing items 6901-6920 of 40729