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The effect of propofol on effective brain networks

van Blooijs, D.; Blok, S.; Huiskamp, G. J.M.; van Eijsden, P.; Meijer, H. G.E.; Leijten, F. S.S. (Elsevier Ireland Ltd, 2024-05)

Objective: We compared the effective networks derived from Single Pulse Electrical Stimulation (SPES) in intracranial electrocorticography (ECoG) of awake epilepsy patients and while under general propofol-anesthesia to ...
Natural variability of TRAIL, IP-10, and CRP in healthy adults - The "HERACLES" study

Langedijk, Annefleur C; Rengerink, Katrien Oude; Harding, Eline; Wensing, Annemarie; van Slooten, Rianne; Israeli, Yael; Rosenberg, Michal; Gottlieb, Tanya; Eden, Eran; Bont, Louis J (Academic Press Inc., 2024-04)

A novel host-protein score (called MMBV) helps to distinguish bacterial from viral infection by combining the blood concentrations of three biomarkers: tumour necrosis factor related apoptosis inducing ligand (TRAIL), ...
A Prediction Model for Successful Increase of Adalimumab Dose Intervals in Patients with Crohn's Disease: Secondary Analysis of the Pragmatic Open-Label Randomised Controlled Non-inferiority LADI Trial

LADI study group, the Dutch Initiative on Crohn, Colitis (ICC) (Springer New York, 2024-06)

BACKGROUND: In the pragmatic open-label randomised controlled non-inferiority LADI trial we showed that increasing adalimumab (ADA) dose intervals was non-inferior to conventional dosing for persistent flares in patients ...
Men with metastatic prostate cancer carrying a pathogenic germline variant in breast cancer genes: disclosure of genetic test results to relatives

Vlaming, Michiel; Ausems, Margreet G.E.M.; Schijven, Gina; van Oort, Inge M.; Kets, C. Marleen; Komdeur, Fenne L.; van der Kolk, Lizet E.; Oldenburg, Rogier A.; Sijmons, Rolf H.; Kiemeney, Lambertus A.L.M.; Bleiker, Eveline M.A. (Springer Netherlands, 2024-06)

Some patients with metastatic prostate cancer carry a pathogenic germline variant (PV) in a gene, that is mainly associated with an increased risk of breast cancer in women. If they test positive for such a PV, prostate ...
Primary care usage at the end of life: a retrospective cohort study of cancer patients using linked primary and hospital care data

Grant, M.; McCarthy, D.; Kearney, C.; Collins, A.; Sundararajan, V.; Rhee, J.; Philip, J.; Emery, J. (Springer-Verlag, 2024-04-08)

Purpose: Health service use is most intensive in the final year of a person’s life, with 80% of this expenditure occurring in hospital. Close involvement of primary care services has been promoted to enhance quality ...
Cognition in older age bipolar disorder: An analysis of archival data across the globe

GAGE-BD Investigators (Elsevier, 2024-06-15)

BACKGROUND: Cognitive deficits in bipolar disorder (BD) impact functioning and are main contributors to disability in older age BD (OABD). We investigated the difference between OABD and age-comparable healthy comparison ...
Prescribed Drug Use and Aneurysmal Subarachnoid Hemorrhage Incidence: A Drug-Wide Association Study

Kanning, Jos P; Abtahi, Shahab; Schnier, Christian; Klungel, Olaf H; Geerlings, Mirjam I; Ruigrok, Ynte M (Lippincott Williams & Wilkins, 2024-06-25)

BACKGROUND AND OBJECTIVES: Current benefits of invasive intracranial aneurysm treatment to prevent aneurysmal subarachnoid hemorrhage (aSAH) rarely outweigh treatment risks. Most intracranial aneurysms thus remain untreated. ...
Characterization of discordance between mismatch repair deficiency and microsatellite instability testing may prevent inappropriate treatment with immunotherapy

Geurts, Birgit S; Zeverijn, Laurien J; van Berge Henegouwen, Jade M; van der Wijngaart, Hanneke; Hoes, Louisa R; de Wit, Gijs F; Spiekman, Ilse Ac; Battaglia, Thomas W; van Beek, Daphne M; Roepman, Paul; Jansen, Anne Ml; de Leng, Wendy Wj; Broeks, Annegien; Labots, Mariette; van Herpen, Carla Ml; Gelderblom, Hans; Verheul, Henk Mw; Snaebjornsson, Petur; Voest, Emile E (John Wiley & Sons Inc., 2024-07)

In the Drug Rediscovery Protocol (DRUP), patients with cancer are treated based on their tumor molecular profile with approved targeted and immunotherapies outside the labeled indication. Importantly, patients undergo a ...
Human liver organoids: From generation to applications

Afonso, Marta B; Marques, Vanda; van Mil, Saskia W C; Rodrigues, Cecilia M P (John Wiley & Sons Inc., 2024-06-01)

In the last decade, research into human hepatology has been revolutionized by the development of mini human livers in a dish. These liver organoids are formed by self-organizing stem cells and resemble their native ...
The 4th NextGen Therapies for SJIA and MAS: part 1 the elephant in the room: diagnostic/classification criteria for systemic juvenile idiopathic arthritis and adult-onset still's disease

Nigrovic, Peter A; de Benedetti, Fabrizio; Kimura, Yukiko; Lovell, Daniel J; Vastert, Sebastiaan J (BioMed Central Ltd., 2023-12)

Currently, the criteria used to classify patients with SJIA are different from those used for AOSD. However, it has been recognized that the existing terms are too narrow, subdividing the Still's population unnecessarily ...
Impaired GABAergic regulation and developmental immaturity in interneurons derived from the medial ganglionic eminence in the tuberous sclerosis complex

Scheper, Mirte; Sørensen, Frederik N F; Ruffolo, Gabriele; Gaeta, Alessandro; Lissner, Lilian J; Anink, Jasper J; Korshunova, Irina; Jansen, Floor E; Riney, Kate; van Hecke, Wim; Mühlebner, Angelika; Khodosevich, Konstantin; Schubert, Dirk; Palma, Eleonora; Mills, James D; Aronica, Eleonora (Springer, 2024-06)

GABAergic interneurons play a critical role in maintaining neural circuit balance, excitation-inhibition regulation, and cognitive function modulation. In tuberous sclerosis complex (TSC), GABAergic neuron dysfunction ...
Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a systematic review and meta-analysis of aggregated and individual participant data

Respiratory Virus Global Epidemiology Network (Elsevier, 2024-03-30)

BACKGROUND: Infants and young children born prematurely are at high risk of severe acute lower respiratory infection (ALRI) caused by respiratory syncytial virus (RSV). In this study, we aimed to assess the global disease ...
What, how and when do families communicate about ALS?: A qualitative exploration of parents' and children's perceptions

Sommers-Spijkerman, Marion; Stukker, Anna; Kavanaugh, Melinda S.; Ketelaar, Marjolijn; Visser-Meily, Johanna M.A.; Beelen, Anita (Informa Healthcare, 2024-05)

Objectives: In families with a parent diagnosed with amyotrophic lateral sclerosis (ALS), children's adaptation depends among others on how their parents communicate with them about the disease and its trajectory. The aim ...
Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2

Cremer, Tom; Hoelen, Hanneke; van de Weijer, Michael L; Janssen, George M; Costa, Ana I; van Veelen, Peter A; Lebbink, Robert Jan; Wiertz, Emmanuel J H J (Public Library of Science, 2024-05)

Type 1 diabetes (T1D) is characterized by HLA class I-mediated presentation of autoantigens on the surface of pancreatic β-cells. Recognition of these autoantigens by CD8+ T cells results in the destruction of pancreatic ...
Combined spatial Keratin expression profiles at the invasive front represent a prognostic classifier for head and neck cancer

Haughton, Peter D.; Haakma, Wisse E.; van Kempen, Sven; de Ruiter, Emma J.; Willems, Stefan M.; Derksen, Patrick W.B. (2024-06)

Keratin proteins are intermediate filaments that provide mechanical support and guide a plethora of important functions in epithelial cells. Although Keratins can be effectively used to characterize and differentiate cell ...
Etiological involvement of KCND1 variants in an X-linked neurodevelopmental disorder with variable expressivity

Kalm, Tassja; Schob, Claudia; Völler, Hanna; Gardeitchik, Thatjana; Gilissen, Christian; Pfundt, Rolph; Klöckner, Chiara; Platzer, Konrad; Klabunde-Cherwon, Annick; Ries, Markus; Syrbe, Steffen; Beccaria, Francesca; Madia, Francesca; Scala, Marcello; Zara, Federico; Hofstede, Floris; Simon, Marleen E H; van Jaarsveld, Richard H; Oegema, Renske; van Gassen, Koen L I; Holwerda, Sjoerd J B; Barakat, Tahsin Stefan; Bouman, Arjan; van Slegtenhorst, Marjon; Álvarez, Sara; Fernández-Jaén, Alberto; Porta, Javier; Accogli, Andrea; Mancardi, Margherita Maria; Striano, Pasquale; Iacomino, Michele; Chae, Jong-Hee; Jang, SeSong; Kim, Soo Y; Chitayat, David; Mercimek-Andrews, Saadet; Depienne, Christel; Kampmeier, Antje; Kuechler, Alma; Surowy, Harald; Bertini, Enrico Silvio; Radio, Francesca Clementina; Mancini, Cecilia; Pizzi, Simone; Tartaglia, Marco; Gauthier, Lucas; Genevieve, David; Tharreau, Mylène; Azoulay, Noy; Zaks-Hoffer, Gal; Gilad, Nesia K; Orenstein, Naama; Bernard, Geneviève; Thiffault, Isabelle; Denecke, Jonas; Herget, Theresia; Kortüm, Fanny; Kubisch, Christian; Bähring, Robert; Kindler, Stefan (Cell Press, 2024-06-06)

Utilizing trio whole-exome sequencing and a gene matching approach, we identified a cohort of 18 male individuals from 17 families with hemizygous variants in KCND1, including two de novo missense variants, three maternally ...
Both clinical trial register and electronic bibliographic database searches were needed to identify randomized clinical trials for systematic reviews: an evaluation study

Kaul, Tabea; Colombijn, Julia Mt; Vernooij, Robin Wm; Spijker, Rene; Idema, Demy L; Huis In 't Veld, Linde F; Damen, Johanna Aa; Hooft, Lotty (Elsevier, 2024-05)

OBJECTIVES: To determine whether clinical trial register (CTR) searches can accurately identify a greater number of completed randomized clinical trials (RCTs) than electronic bibliographic database (EBD) searches for ...
Continuous glucose monitoring in adults with type 2 diabetes: a systematic review and meta-analysis

Jancev, Milena; Vissers, Tessa A.C.M.; Visseren, Frank L.J.; van Bon, Arianne C.; Serné, Erik H.; DeVries, J. Hans; de Valk, Harold W.; van Sloten, Thomas T. (Springer-Verlag, 2024-05)

Aims/hypothesis: Continuous glucose monitoring (CGM) is increasingly used in the treatment of type 2 diabetes, but the effects on glycaemic control are unclear. The aim of this systematic review and meta-analysis is to ...
Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

Mocci, Giuseppe; Sukhavasi, Katyayani; Örd, Tiit; Bankier, Sean; Singha, Prosanta; Arasu, Uma Thanigai; Agbabiaje, Olayinka Oluwasegun; Mäkinen, Petri; Ma, Lijiang; Hodonsky, Chani J.; Aherrahrou, Redouane; Muhl, Lars; Liu, Jianping; Gustafsson, Sonja; Byandelger, Byambajav; Wang, Ying; Koplev, Simon; Lendahl, Urban; Owens, Gary K.; Leeper, Nicholas J.; Pasterkamp, Gerard; Vanlandewijck, Michael; Michoel, Tom; Ruusalepp, Arno; Hao, Ke; Ylä-Herttuala, Seppo; Väli, Marika; Järve, Heli; Mokry, Michal; Civelek, Mete; Miller, Clint J.; Kovacic, Jason C.; Kaikkonen, Minna U.; Betsholtz, Christer; Björkegren, Johan L.M. (Lippincott Williams & Wilkins, 2024-05-24)

BACKGROUND: While our understanding of the single-cell gene expression patterns underlying the transformation of vascular cell types during the progression of atherosclerosis is rapidly improving, the clinical and ...
Geriatric Assessment in CKD Care: An Implementation Study

Voorend, Carlijn; Berkhout-Byrne, Noeleen C.; van Bodegom-Vos, Leti; Diepenbroek, Adry; Franssen, Casper; Joosten, Hanneke; Mooijaart, Simon; Bos, Willem Jan; van Buren, Marjolijn; POLDER Study Group (Elsevier, 2024-05)

Rationale & Objective: Older people with progressive chronic kidney disease (CKD) have complex health care needs. Geriatric evaluation preceding decision making for kidney replacement is recommended in guidelines, but ...

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