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Ensuring safety in cannabinoid prescriptions: A call for critical assessment

Bueno, Laura; Batalla, Albert; Balcells, Mercè; López-Pelayo, Hugo (Elsevier, 2024-10)
Clinical Application and Further Development of Augmented Reality Guidance for the Surgical Localization of Pediatric Chest Wall Tumors

van der Woude, Rémi; Fitski, Matthijs; van der Zee, Jasper M.; van de Ven, Cornelis P.; Bökkerink, Guus M.J.; Wijnen, Marc H.W.A.; Meulstee, Jene W.; van Doormaal, Tristan P.C.; Siepel, Françoise J.; van der Steeg, Alida F.W. (W.B. Saunders, 2024-08)

Background: Surgical treatment of pediatric chest wall tumors requires accurate surgical planning and tumor localization to achieve radical resections while sparing as much healthy tissue as possible. Augmented Reality ...
Associations of very low Lipoprotein(a) levels with risks of new-onset diabetes and non-alcoholic liver disease

Yeung, Ming Wai; Said, M. Abdullah; van de Vegte, Yordi J.; Verweij, Niek; Dullaart, Robin P.F.; van der Harst, Pim (Elsevier Ireland Ltd, 2024-09)

Background and aims: We aimed to study the association of very low serum Lipoprotein(a) [Lp(a)] concentrations with new-onset type 2 diabetes (T2D) and non-alcoholic liver disease (NAFLD) in the context of statin usage in ...
Sarcoma Size and Limb Dimensions Predict Complications, Recurrence, and Death in Patients with Soft Tissue Sarcoma in the Thigh: A Multidimensional Analysis

Elmorsi, Rami; Camacho, Luis; Krijgh, David D.; Tilney, Gordon S.; Lyu, Heather; Traweek, Raymond S.; Witt, Russell G.; Roubaud, Margaret S.; Roland, Christina L.; Mericli, Alexander F. (Springer New York, 2024-08)

Background: Limb-sparing resections of thigh soft tissue sarcomas (STSs) can result in adverse outcomes. Identifying preoperative predictors for wound healing complications, tumor recurrence, and mortality is crucial for ...
Co-expression in tissue-specific gene networks links genes in cancer-susceptibility loci to known somatic driver genes

Urzúa-Traslaviña, Carlos G.; van Lieshout, Tijs; Boulogne, Floranne; Domanegg, Kevin; Zidan, Mahmoud; Bakker, Olivier B.; Claringbould, Annique; de Ridder, Jeroen; Zwart, Wilbert; Westra, Harm Jan; Deelen, Patrick; Franke, Lude (BioMed Central, 2024-07-15)

Background: The genetic background of cancer remains complex and challenging to integrate. Many somatic mutations within genes are known to cause and drive cancer, while genome-wide association studies (GWAS) of cancer ...
Oncogenic and immunological targets for matched therapy of pediatric blood cancer patients: Dutch iTHER study experience

Boer, Judith M.; Ilan, Uri; Boeree, Aurélie; Langenberg, Karin P.S.; Koster, Jan; Koudijs, Marco J.; Hehir-Kwa, Jayne Y.; Rossi, Corinne; Nierkens, Stefan; Molenaar, Jan J.; Goemans, Bianca F.; den Boer, Monique L.; Zwaan, C. Michel (Wolters Kluwer Health, 2024-07)

Over the past 10 years, institutional and national molecular tumor boards have been implemented for relapsed or refractory pediatric cancer to prioritize targeted drugs for individualized treatment based on actionable ...
Shared effects of electroconvulsive shocks and ketamine on neuroplasticity: A systematic review of animal models of depression

De Jager, Jesca E.; Boesjes, Rutger; Roelandt, Gijs H.J.; Koliaki, Ilektra; Sommer, Iris E.C.; Schoevers, Robert A.; Nuninga, Jasper O. (Elsevier Limited, 2024-09)

Electroconvulsive shocks (ECS) and ketamine are antidepressant treatments with a relatively fast onset of therapeutic effects compared to conventional medication and psychotherapy. While the exact neurobiological mechanisms ...
Investigating the use of comprehensive motion monitoring for intrafraction 3D drift assessment of hypofractionated prostate cancer patients on a 1.5T magnetic resonance imaging radiotherapy system

Tsekas, Georgios; Zachiu, Cornel; Bol, Gijsbert H.; van den Dobbelsteen, Madelon; Meijers, Lieke T.C.; van Lier, Astrid L.H.M.W.; de Boer, Johannes C.J.; Raaymakers, Bas W. (Elsevier, 2024-07)

This work investigates the use of a multi-2D cine magnetic resonance imaging-based comprehensive motion monitoring (CMM) system for the assessment of prostate intrafraction 3D drifts. The data of six healthy volunteers ...
Mutations in the tail and rod domains of the neurofilament heavy-chain gene increase the risk of ALS

Marriott, Heather; Spargo, Thomas P; Al Khleifat, Ahmad; Andersen, Peter M; Başak, Nazli A; Cooper-Knock, Johnathan; Corcia, Philippe; Couratier, Philippe; de Carvalho, Mamede; Drory, Vivian; Gotkine, Marc; Landers, John E; McLaughlin, Russell; Pardina, Jesús S Mora; Morrison, Karen E; Pinto, Susana; Shaw, Christopher E; Shaw, Pamela J; Silani, Vincenzo; Ticozzi, Nicola; van Damme, Philip; van den Berg, Leonard H; Vourc'h, Patrick; Weber, Markus; Veldink, Jan H; Dobson, Richard J; Schwab, Patrick; Al-Chalabi, Ammar; Iacoangeli, Alfredo; Project MinE ALS Sequencing Consortium (John Wiley & Sons Inc., 2024-07)

Objective: Neurofilament heavy-chain gene (NEFH) variants are associated with multiple neurodegenerative diseases, however, their relationship with ALS has not been robustly explored. Still, NEFH is commonly included in ...
Barriers and facilitators for healthcare professionals to the implementation of Multidisciplinary Timely Undertaken Advance Care Planning conversations at the outpatient clinic (the MUTUAL intervention): a sequential exploratory mixed-methods study

van Lummel, Eline V T J; Meijer, Yoeki; Tjan, Dave H T; van Delden, Johannes J M (BioMed Central Ltd., 2023-03-15)

BACKGROUND: Advance Care Planning (ACP) enables patients to define and discuss their goals and preferences for future medical treatment and care. However, the structural implementation of ACP interventions remains challenging. ...
Self-efficacy of advanced cancer patients for participation in treatment-related decision-making in six European countries: the ACTION study

Yildiz, Berivan; Korfage, Ida J; Deliens, Luc; Preston, Nancy J; Miccinesi, Guido; Kodba-Ceh, Hana; Pollock, Kristian; Johnsen, Anna Thit; van Delden, Johannes J M; Rietjens, Judith A C; van der Heide, Agnes (Springer-Verlag, 2023-08-08)

PURPOSE: Many patients prefer an active role in making decisions about their care and treatment, but participating in such decision-making is challenging. The aim of this study was to explore whether patient-reported ...
Should we all die asleep?: The problem of the normalization of palliative sedation

van Delden, Johannes J M; Heijltjes, Madelon T; Harwood, Rowan H (Oxford University Press, 2023-08-01)

Palliative sedation is a medical intervention to manage distress in dying patients, by reducing consciousness when symptom-directed therapies fail. Continuous deep sedation is ethically sensitive because it may shorten ...
Commentary: Can an effective end-of-life intervention for advanced dementia be viewed as moral?

Scheeres-Feitsma, Trijntje M; Schaafsma, Petruschka; van der Steen, Jenny T; van Delden, Johannes J M (John Wiley & Sons Inc., 2024-03)

We comment on Dr. Terman's considerations on the moral justification of ceasing assisted feeding and hydration for people with advanced dementia. The core idea of his paper is that an advance directive can solve future ...
Balancing ethical norms and duties for the introduction of new medicines through conditional marketing authorization: a research agenda

Maksimova, Mariia V.; van Thiel, Ghislaine J.M.W.; Tromp, Yke; Lechner, Rosan; van Delden, Johannes J.M.; Bloem, Lourens T. (Frontiers Media S. A., 2024-06-24)

The European Medicines Agency’s conditional marketing authorization (CMA) aims to expedite patient access to medicines for unmet medical needs by shifting a part of the drug development process post-authorization. We ...
Juvenile idiopathic arthritis

Del Giudice, Emanuela; Swart, Joost F.; Wulffraat, N. M. (Springer International Publishing, 2017-08-24)

In the last years, the interest in the concept of comorbidity and its societal as well as individual impact has increased. Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease starting in childhood which ...
Serology, anterior chamber and vitreous diagnostics

de Groot-Mijnes, Jolanda D F; Rothova, Aniki; Kijlstra, Aize (Springer Berlin Heidelberg, 2016-01-01)

Anterior chamber (AC) fluid analysis represents a valuable diagnostic tool, used predominantly to identify the infectious agents causing uveitis and for the diagnosis of masquerade syndromes, especially malignancies. In ...
Platelet morphology and ultrastructure

Heijnen, Harry F.G.; Korporaal, Suzanne J.A. (Springer International Publishing, 2017-03-08)

Platelets are key players in hemostasis, the process that is essential in the prevention of blood loss in response to injury of a blood vessel. When platelets encounter breaches in the vascular wall, they rapidly adhere ...
Protocol to create isogenic disease models from adult stem cell-derived organoids using next-generation CRISPR tools

Celotti, Martina; Derks, Lucca L.M.; van Es, Johan; van Boxtel, Ruben; Clevers, Hans; Geurts, Maarten H. (Cell Press, 2024-09-20)

Isogenic disease models, such as genetically engineered organoids, provide insight into the impact of genetic variants on organ function. Here, we present a protocol to create isogenic disease models from adult stem ...
Tunable resistive pulse sensing for the characterization of extracellular vesicles

Maas, Sybren L.N.; Broekman, Marike L.D.; de Vrij, Jeroen (Humana Press Inc., 2017-01-01)

Accurate characterization of extracellular vesicles (EVs), including exosomes and microvesicles, is essential to obtain further knowledge on the biological relevance of EVs. Tunable resistive pulse sensing (tRPS) has shown ...
Stereotactic Body Radiotherapy in Recurrent and Oligometastatic Head and Neck Tumours

Tham, Jodie L.M.; Ng, Sweet Ping; Khor, Richard; Wada, Morikatsu; Gan, Hui; Thai, Alesha A.; Corry, June; Bahig, Houda; Mäkitie, Antti A.; Nuyts, Sandra; De Bree, Remco; Strojan, Primož; Ng, Wai Tong; Eisbruch, Avraham; Chow, James C.H.; Ferlito, Alfio (Multidisciplinary Digital Publishing Institute (MDPI), 2024-06)

The treatment of head and neck cancers (HNCs) encompasses a complex paradigm involving a combination of surgery, radiotherapy, and systemic treatment. Locoregional recurrence is a common cause of treatment failure, and few ...

Now showing items 5981-6000 of 40729