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Comparing Pharmacological Modulation of Sensory Gating in Healthy Humans and Rats: The Effects of Reboxetine and Haloperidol

Witten, Louise; Bastlund, Jesper Frank; Glenthøj, Birte Y.; Bundgaard, Christoffer; Steiniger-Brach, Björn; Mørk, Arne; Oranje, Bob (Springer Nature, 2016)

Sensory gating is the brain’s ability to filter out irrelevant information before it reaches high levels of conscious processing. In the current study we aimed to investigate the involvement of the noradrenergic and ...
Individualized versus conventional ovarian stimulation for in vitro fertilization: a multicenter, randomized, controlled, assessor-blinded, phase 3 noninferiority trial

Nyboe Andersen, Anders; Nelson, Scott M; Fauser, Bart C J M; García-Velasco, Juan Antonio; Klein, Bjarke M; Arce, Joan-Carles; ESTHER-1 study group (Elsevier, 2017-02)

Objective To compare the efficacy and safety of follitropin delta, a new human recombinant FSH with individualized dosing based on serum antimüllerian hormone (AMH) and body weight, with conventional follitropin alfa dosing ...
Amplification and protein overexpression of cyclin D1: Predictor of occult nodal metastasis in early oral cancer

Noorlag, Rob; Boeve, Koos; Witjes, Max J H; Koole, Ronald; Peeters, Ton L M; Schuuring, Ed; Willems, Stefan M.; van Es, Robert J J (John Wiley & Sons Inc., 2017-02)

Background: Accurate nodal staging is pivotal for treatment planning in early (stage I-II) oral cancer. Unfortunately, current imaging modalities lack sensitivity to detect occult nodal metastases. Chromosomal region 11q13, ...
Novel genetic causes for cerebral visual impairment

Bosch, Daniëlle Gm; Boonstra, F Nienke; de Leeuw, Nicole; Pfundt, Rolph; Nillesen, Willy M; de Ligt, Joep; Gilissen, Christian; Jhangiani, Shalini; Lupski, James R; Cremers, Frans Pm; de Vries, Bert Ba (Springer Nature, 2016)

Cerebral visual impairment (CVI) is a major cause of low vision in children due to impairment in projection and/or interpretation of the visual input in the brain. Although acquired causes for CVI are well known, genetic ...
IκBNS enhances follicular helper T-cell differentiation and function downstream of ASCl2

Hosokawa, Junichi; Suzuki, Kotaro; Meguro, Kazuyuki; Tanaka, Shigeru; Maezawa, Yuko; Suto, Akira; Fujimura, Lisa; Sakamoto, Akemi; Clevers, Hans; Ohara, Osamu; Nakajima, Hiroshi (Mosby Inc., 2017-07)
Structural Brain Connectome and Cognitive Impairment in Parkinson Disease

Galantucci, Sebastiano; Agosta, Federica; Stefanova, Elka; Basaia, Silvia; van den Heuvel, Martijn P; Stojković, Tanja; Canu, Elisa; Stanković, Iva; Spica, Vladana; Copetti, Massimiliano; Gagliardi, Delia; Kostić, Vladimir S; Filippi, Massimo (Radiological Society of North America Inc., 2017-05)

Purpose To investigate the structural brain connectome in patients with Parkinson disease (PD) and mild cognitive impairment (MCI) and in patients with PD without MCI. Materials and Methods This prospective study was ...
Maintaining physiological testosterone levels by adding dehydroepiandrosterone to combined oral contraceptives: I. Endocrine effects

Coelingh Bennink, Herjan J T; Zimmerman, Yvette; Laan, Ellen; Termeer, Hanneke M M; Appels, Nicole; Albert, Adelin; Fauser, Bart C J M; Thijssen, Jos H H; van Lunsen, Rik H W (Elsevier, 2017-11)

Objective: To determine whether adding dehydroepiandrosterone to combined oral contraceptives (COCs) maintains physiological levels of free testosterone. Study design: A randomized, double-blind, placebo-controlled, two-way ...
Platelet secretory behaviour: As diverse as the granules ... or not?

Heijnen, H.; van der Sluijs, P. (Wiley-Blackwell, 2015-12)

Platelets play a central role in the arrest of bleeding after damage to a blood vessel and in the development of thrombosis. Platelets rapidly respond after interaction with sub-endothelial components and release cargo ...
Dosing and therapeutic drug monitoring of voriconazole in bottlenose dolphins (Tursiops truncatus)

Ferrier, KRM; van Elk, C E; Bunskoek, P E; van den Broek, MPH (Informa Healthcare, 2017-02)

Bottlenose dolphins (Tursiops truncatus) can suffer from fungal infections, which can be treated with voriconazole. In common practice, the voriconazole doses are extrapolated from human doses by adjusting for body weight ...
High-Throughput Screening Assay Identifies Small Molecules Capable of Modulating the BMP-2 and TGF-β1 Signaling Pathway

Ghebes, Corina-Adriana; van Lente, Jéré; Post, Janine Nicole; Saris, Daniel B F; Fernandes, Hugo (SAGE Publications Inc., 2017-01)

Modulating the bone morphogenetic protein 2 (BMP-2) and transforming growth factor-β1 (TGF-β1) signaling pathways is essential during tendon/ligament (T/L) healing. Unfortunately, growth factor delivery in situ is far from ...
Ketones and inborn errors of metabolism: old friends revisited

Wüst, Rob C I; Visser, Gepke; Wanders, Ronald J A; Houtkooper, Riekelt H. (Springer Netherlands, 2017-01)
Technology use by older adults in the Netherlands and its associations with demographics and health outcomes

Vorrink, Sigrid N W; Antonietti, Angelo M G E F; Kort, Helianthe S M; Troosters, Thierry; Zanen, Pieter; Lammers, Jan-Willem J (Taylor and Francis Ltd., 2017)

Information and communications technology (ICT) has the potential to contribute to the quality of life of older adults. The aim of this study was to analyze the use of a broad array of ICT devices and services among Dutch ...
Gene discovery in amyotrophic lateral sclerosis: implications for clinical management

Al-Chalabi, Ammar; van den Berg, Leonard H; Veldink, Jan (Nature Research, 2017-02)

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease predominantly affecting upper and lower motor neurons. The disease leads to relentlessly progressive weakness of voluntary muscles, with death typically ...
Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation

van Heesbeen, Roy G H P; Raaijmakers, Jonne A; Tanenbaum, Marvin E; Halim, Vincentius A; Lelieveld, Daphne; Lieftink, Cor; Heck, Albert J R; Egan, David A; Medema, René H (Springer Science and Business Media Deutschland GmbH, 2017)

Inhibition of the microtubule (MT) motor protein Eg5 results in a mitotic arrest due to the formation of monopolar spindles, making Eg5 an attractive target for anti-cancer therapies. However, Eg5-independent pathways for ...
Long-term Recurrence-free Survival After Standard Endoscopic Resection Versus Surgical Resection of Submucosal Invasive Colorectal Cancer: A Population-based Study

Belderbos, Tim D G; van Erning, Felice N; de Hingh, Ignace H J T; van Oijen, Martijn G H; Lemmens, Valery E P P; Siersema, Peter D (W.B. Saunders, 2017-03)

BACKGROUND & AIMS: There is controversy over the optimal management for T1 colorectal cancer (T1 CRC). This study compared initial endoscopic resection with or without additional surgery, or initial surgery for T1 CRC, and ...
Resolving artefacts in voltage-clamp experiments with computational modelling: an application to fast sodium current recordings

Lei, Chon Lok; Clark, Alexander P; Clerx, Michael; Wei, Siyu; Bloothooft, Meye; de Boer, Teun P; Christini, David J; Krogh-Madsen, Trine; Mirams, Gary R (BioRxivCold Spring Harbor Laboratory Press, 2024-07-24)

Cellular electrophysiology is the foundation of many fields, from basic science in neurology, cardiology, oncology to safety critical applications for drug safety testing, clinical phenotyping, etc. Patch-clamp voltage ...
Towards global prevention of severe pediatric RSV infection

Löwensteyn, Yvette (Utrecht University, 2024-09-05)

Respiratory syncytial virus (RSV) is the major cause of respiratory infections in young children. Globally, RSV infection presents a significant health problem with over 100,000 deaths annually among children <5 years. The ...
Use of thiazolidinediones and the risk of elective hip or knee replacement: A population based case-control study

Nielen, Johannes T H; de Vries, Frank; Dagnelie, Pieter C.; van den Bemt, Bart J F; Emans, Pieter J.; Lalmohamed, Arief; de Boer, Anthonius; Boonen, Annelies (Wiley-Blackwell, 2016-02)

Aims: Osteoarthritis (OA) is the most common musculoskeletal condition in the elderly population. However, no disease modifying drug exists for this disease. In vivo animal studies have suggested that thiazolidinediones ...
SIRV: Spatial inference of RNA velocity at the single-cell resolution

Abdelaal, Tamim; Grossouw, Laurens M; Pasterkamp, R Jeroen; Lelieveldt, Boudewijn P F; Reinders, Marcel J T; Mahfouz, Ahmed (Oxford University Press, 2024-09-01)

RNA Velocity allows the inference of cellular differentiation trajectories from single-cell RNA sequencing (scRNA-seq) data. It would be highly interesting to study these differentiation dynamics in the spatial context of ...
On the shoulders of Hubrecht: From embryos to stem cells

Rabouille, Catherine; Deschamps, Jacqueline (Academic Press Inc., 2017-08-15)

One hundred years of the Hubrecht Institute were celebrated in May 2016 with the organization of a one-day symposium From embryos to stem cells on the Uithof Campus, Utrecht, the Netherlands. Nine distinguished speakers ...

Now showing items 5281-5300 of 40729