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Now showing items 4901-4920 of 40729

Self-organizing models of human trunk organogenesis recapitulate spinal cord and spine co-morphogenesis

Gribaudo, Simona; Robert, Rémi; van Sambeek, Björn; Mirdass, Camil; Lyubimova, Anna; Bouhali, Kamal; Ferent, Julien; Morin, Xavier; van Oudenaarden, Alexander; Nedelec, Stéphane (Nature Research, 2024-08)

Integrated in vitro models of human organogenesis are needed to elucidate the multi-systemic events underlying development and disease. Here we report the generation of human trunk-like structures that model the co-morphogenesis, ...
Absence of an increased wall thickness does not rule out cardiac amyloidosis

Muller, Steven A; Achten, Anouk; van der Meer, Manon G; Zwetsloot, Peter-Paul; Sanders-van Wijk, Sandra; van der Harst, Pim; van Tintelen, J Peter; Te Riele, Anneline S J M; van Empel, Vanessa; Knackstedt, Christian; Oerlemans, Marish I F J (Informa Healthcare, 2024-09)
Role of inflammatory signaling pathways involving the CD40–CD40L–TRAF cascade in diabetes and hypertension—insights from animal and human studies

Strohm, Lea; Daiber, Andreas; Ubbens, Henning; Krishnankutty, Roopesh; Oelze, Matthias; Kuntic, Marin; Hahad, Omar; Klein, Veronique; Hoefer, Imo E.; von Kriegsheim, Alex; Kleinert, Hartmut; Atzler, Dorothee; Lurz, Philipp; Weber, Christian; Wild, Philipp S.; Münzel, Thomas; Knosalla, Christoph; Lutgens, Esther; Daub, Steffen (Springer Science and Business Media Deutschland GmbH, 2024-08)

CD40L–CD40–TRAF signaling plays a role in atherosclerosis progression and affects the pathogenesis of coronary heart disease (CHD). We tested the hypothesis that CD40L–CD40–TRAF signaling is a potential therapeutic target ...
Individualized 3D-printed applicators for magnetic resonance imaging-guided brachytherapy in nasal vestibule cancer

de Ridder, Mischa; Smolić, Milena; Kastelijns, Maarten; Kloosterman, Samantha; van der Vegt, Stefan; Rijken, Johannes; Schulz-Jurgenliemk, Ina-Maria; Dehnad, Homan; Kroon-van Loon, PS; Moerland, Rien (Elsevier, 2024-07)

Background and purpose Brachytherapy is treatment of choice for early stage nasal vestibule cancer. Over the years improvements were achieved by means of image guided target definition, interstitial implant techniques and ...
Peripheral Interventions in Patients with Pseudoxanthoma Elasticum (PXE)

Verwer, Maarten C.; Hazenberg, Constantijn E.V.B.; Spiering, Wilko; de Borst, Gert J. (W.B. Saunders Ltd, 2023-01)

Objective: Pseudoxanthoma elasticum (PXE) is an autosomal recessive metabolic disorder that may be associated with a high prevalence of peripheral artery disease (PAD) and related symptoms. However, the evidence supporting ...
2022 EULAR recommendations for screening and prophylaxis of chronic and opportunistic infections in adults with autoimmune inflammatory rheumatic diseases

Fragoulis, George E.; Nikiphorou, Elena; Dey, Mrinalini; Zhao, Sizheng Steven; Courvoisier, Delphine Sophie; Arnaud, Laurent; Atzeni, Fabiola; Behrens, Georg M.N.; Bijlsma, Johannes W.J.; Böhm, Peter; Constantinou, Costas A.; Garcia-Diaz, Silvia; Kapetanovic, Meliha Crnkic; Lauper, Kim; Luís, Mariana; Morel, Jacques; Nagy, György; Polverino, Eva; Van Rompay, Jef; Sebastiani, Marco; Strangfeld, Anja; De Thurah, Annette; Galloway, James; Hyrich, Kimme L. (Elsevier, 2023-06-01)

Objectives To develop EULAR recommendations for screening and prophylaxis of chronic and opportunistic infections in patients with autoimmune inflammatory rheumatic diseases (AIIRD). Methods An international Task Force ...
Disease burden in primary sclerosing cholangitis in the Netherlands: A long-term follow-up study

van Munster, Kim N.; Mol, Bregje; Goet, Jorn C.; van Munster, Sanne N.; Weersma, Rinse K.; de Vries, Annemarie C.; van der Meer, Adriaan J.; Inderson, Akin; Drenth, Joost P.; van Erpecum, Karel J.; Boonstra, Kirsten; Beuers, Ulrich; Dijkgraaf, Marcel G.W.; Ponsioen, Cyriel Y.; the EpiPSC2 Study Group (Wiley-Blackwell, 2023-03)

Background & Aims: Primary sclerosing cholangitis (PSC) is a progressive, cholestatic liver disease which greatly impacts the lives of individuals. Burden of disease due to shortened life expectancy and impaired quality ...
Treatment and outcome in combined scapula and rib fractures: a retrospective study

Hoepelman, Ruben Joost; Beeres, Frank Joseph Paulus; van Veelen, Nicole; Houwert, Roderick Marijn; Babst, Reto; Link, Björn Christian; van de Wall, Bryan Joost Marinus (Springer-Verlag, 2023-08)

Purpose: The primary aim was to describe the population characteristics of patients with combined scapula and rib fractures and outcomes associated with different treatment strategies. Methods: All adult (≥ 18 years) ...
Natural experiments for orthopaedic trauma research: An introduction

NEXT Study Group (Elsevier, 2023-02)

Natural experiments are observational studies of medical treatments in which treatment allocation is determined by factors outside the control of the investigators, arguably resembling experimental randomisation. Natural ...
Spectrum of epilepsy with eyelid myoclonia: Delineation of disease subtypes from a large multicenter study

Cerulli Irelli, Emanuele; Cocchi, Enrico; Ramantani, Georgia; Riva, Antonella; Caraballo, Roberto Horacio; Morano, Alessandra; Giuliano, Loretta; Yilmaz, Tülay; Panagiotakaki, Eleni; Operto, Francesca F.; Giraldez, Beatriz Gonzalez; Balestrini, Simona; Silvennoinen, Katri; Casciato, Sara; Comajuan, Marion; Fortunato, Francesco; Giallonardo, Anna Teresa; Gamirova, Rimma; Coppola, Antonietta; Di Gennaro, Giancarlo; Labate, Angelo; Sofia, Vito; Kluger, Gerhard Josef; Gambardella, Antonio; Kasteleijn-NolstTrenite, Dorothee G.A.; Baykan, Betul; Sisodiya, Sanjay M.; Arzimanoglou, Alexis; Striano, Pasquale; Di Bonaventura, Carlo; the EMA Study Group (Wiley-Blackwell, 2023-01)

Objective: Epilepsy with eyelid myoclonia (EEM) has been associated with marked clinical heterogeneity. Early epilepsy onset has been recently linked to lower chances of achieving sustained remission and to a less favorable ...
A disease-specific patient reported outcome instrument for spine trauma is developed, validated and available! Re: Andrzejowski et al. Measuring functional outcomes in major trauma: can we do better?

Sadiqi, Said; Oner, F. Cumhur (Springer International Publishing AG, 2023-06)
Preclinical model for lumbar interbody fusion in small ruminants: Rationale and guideline

Duits, Anneli; Salvatori, Daniela; Schouten, Jacobine; van Urk, Paul; Gaalen, Steven van; Ottink, Karsten; Öner, Cuhmur; Kruyt, Moyo (Elsevier (Singapore) Pte Ltd, 2023-01)

Lumbar interbody fusion (IF) is a common procedure to obtain fusion of the spine by replacement of the intervertebral disc with a cage. Optimization of spinal cages is ongoing to reduce complications such as a pseudoarthrosis ...
Extracellular Vesicle Isolation and Characterization for Applications in Cartilage Tissue Engineering and Osteoarthritis Therapy

Otahal, Alexander; De Luna, Andrea; Mobasheri, Ali; Nehrer, Stefan (Humana Press Inc., 2023)

Extracellular vesicles (EVs) have the capacity for use in cartilage tissue engineering by stimulating tissue repair and microenvironmental reprogramming. This makes them ideal candidates for treating focal cartilage defects ...
The association between social jetlag and parameters of metabolic syndrome and type 2 diabetes: a systematic review and meta-analysis

Bouman, Emma J.; Beulens, Joline W.J.; Groeneveld, Lenka; de Kruijk, Rozemarijn S.; Schoonmade, Linda J.; Remmelzwaal, Sharon; Elders, Petra J.M.; Rutters, Femke (Wiley-Blackwell, 2023-06)

This study aims to determine the association between social jetlag and parameters of metabolic syndrome and type 2 diabetes (T2D) in a systematic review and meta-analysis. A systematic literature search was conducted in ...
Kidney function measures and cardiovascular outcomes in people with diabetes: the Hoorn Diabetes Care System cohort

Dal Canto, Elisa; Elders, Petra J.M.; van der Heijden, Amber A.; van Ballegooijen, Adriana J.; Lissenberg-Witte, Birgit I.; Rutters, Femke; Beulens, Joline W.J. (Springer-Verlag, 2023-03)

Aims/hypothesis: Both manifestations of kidney disease in diabetes, reduced eGFR (ml/min per 1.73 m2) and increased urinary albumin/creatinine ratio (UACR, mg/mmol), may increase the risk of specific CVD subtypes in adults ...
Health-Related Quality of Life Following Allogeneic Hematopoietic Cell Transplantation with Omidubicel versus Umbilical Cord Blood

Lin, Chenyu; Sajeev, Gautam; Stiff, Patrick J.; Brunstein, Claudio G.; Cutler, Corey; Sanz, Guillermo; Lindemans, Caroline A.; Rezvani, Andrew R.; Hanna, Rabi; Koh, Liang Piu; Maziarz, Richard T.; Hwang, William Y.K.; Song, Yan; Liu, Qing; Manghani, Rocio; Sivaraman, Smitha; Signorovitch, James; Horwitz, Mitchell E.; Sung, Anthony D. (Elsevier, 2023-01)

Omidubicel is an advanced cell therapy derived from umbilical cord blood (UCB) for use in allogeneic hematopoietic cell transplantation (HCT). A recent randomized phase 3 clinical trial demonstrated faster engraftment, ...
A qualitative evaluation of the revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R) by the patient community: a web-based cross-sectional survey

Boyce, Danielle; Robinson, Michael; Cedarbaum, Jesse M.; Shank, Lisa M.; McDermott, Christopher J.; van Eijk, Ruben P.A. (Informa Healthcare, 2023-05)

Objective: The revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) is the most commonly used outcome measure in ALS studies. The aim of this study was to identify potential limitations of the ALSFRS-R ...
Exploring preferences of at-risk individuals for preventive treatments for rheumatoid arthritis

Simons, G.; Schölin Bywall, K.; Englbrecht, M.; Johansson, E. C.; DiSantostefano, R. L.; Radawski, C.; Veldwijk, J.; Raza, K.; Falahee, M. (Informa Healthcare, 2023-09)

Objective: Some immunomodulatory drugs have been shown to delay the onset of, or lower the risk of developing, rheumatoid arthritis (RA), if given to individuals at risk. Several trials are ongoing in this area; however, ...
Parkinsonism in Genetic Neurodevelopmental Disorders: A Systematic Review

von Scheibler, Emma N.M.M.; van Eeghen, Agnies M.; de Koning, Tom J.; Kuijf, Mark L.; Zinkstok, Janneke R.; Müller, Annelieke R.; van Amelsvoort, Thérèse A.M.J.; Boot, Erik (John Wiley & Sons Inc., 2023-01)

Background: With advances in clinical genetic testing, associations between genetic neurodevelopmental disorders and parkinsonism are increasingly recognized. In this review, we aimed to provide a comprehensive overview ...
Patch angioplasty during carotid endarterectomy using different materials has similar clinical outcomes

Liesker, David J.; Gareb, Barzi; Looman, Rick S.; Donners, Simone J.A.; de Borst, Gert J.; Zeebregts, Clark J.; Saleem, Ben R. (Mosby Inc., 2023-02)

Objective: Patch angioplasty during carotid endarterectomy (CEA) is commonly used to treat carotid artery stenosis. However, the choice of which patch to use remains a matter of debate. Autologous venous material has ...

Now showing items 4901-4920 of 40729