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UMC Repository: Recent submissions

  • The Role of Social Deprivation and Cannabis Use in Explaining Variation in the Incidence of Psychotic Disorders: Findings From the EU-GEI Study 
    Brink, Vera; Andleeb, Humma; Gayer-Anderson, Charlotte; Arango, Celso; Arrojo, Manuel; Berardi, Domenico; Bernardo, Miquel; Bobes, Julio; Del-Ben, Cristina Marta; Ferraro, Laura; de Haan, Lieuwe; La Barbera, Daniele; La Cascia, Caterina; Lasalvia, Antonio; Llorca, Pierre-Michel; Menezes, Paolo Rossi; Pignon, Baptiste; Sanjuán, Julio; Santos, José Luis; Selten, Jean-Paul; Tarricone, Ilaria; Tortelli, Andrea; Tripoli, Giada; Velthorst, Eva; Rutten, Bart P F; van Os, Jim; Quattrone, Diego; Murray, Robin M; Jones, Peter B; Morgan, Craig; Di Forti, Marta; Jongsma, Hannah E; Kirkbride, James B (Oxford University Press, 2024-08-27)
    BACKGROUND AND HYPOTHESIS: Recent findings suggest the incidence of first-episode psychotic disorders (FEP) varies according to setting-level deprivation and cannabis use, but these factors have not been investigated ...
  • Western European Variation in the Organization of Esophageal Cancer Surgical Care 
    Visser, Maurits R.; Voeten, Daan M.; Gisbertz, Suzanne S.; Ruurda, Jelle P.; Achiam, Michael P.; Nilsson, Magnus; Markar, Sheraz R.; Pera, Manuel; Rosati, Riccardo; Piessen, Guillaume; Nafteux, Philippe; Gutschow, Christian A.; Grimminger, Peter P.; Räsänen, Jari V.; Reynolds, John V.; Johannessen, Hans Olaf; Vieira, Pedro; Weitzendorfer, Michael; Kechagias, Aristotelis; van Berge Henegouwen, Mark I.; van Hillegersberg, Richard (Wiley-Blackwell, 2024-09-01)
    Reasons for structural and outcome differences in esophageal cancer surgery in Western Europe remain unclear. This questionnaire study aimed to identify differences in the organization of esophageal cancer surgical care ...
  • The transition of general practice into an academic discipline: tracing the origins through the first four professors in general practice/family medicine 
    Straand, Jørund; Wit, Niek de (Informa Healthcare, 2024-09)
    Being the ‘mother’ of most clinical specialties, general practice is as old as medicine itself. However, as a recognized academic discipline within medical schools, general practice has a relatively short life span. A ...
  • A novel tool for arrhythmic risk stratification in desmoplakin gene variant carriers 
    Carrick, Richard T; Gasperetti, Alessio; Protonotarios, Alexandros; Murray, Brittney; Laredo, Mikael; van der Schaaf, Iris; Dooijes, Dennis; Syrris, Petros; Cannie, Douglas; Tichnell, Crystal; Gilotra, Nisha A; Cappelletto, Chiara; Medo, Kristen; Saguner, Ardan M; Duru, Firat; Hylind, Robyn J; Abrams, Dominic J; Lakdawala, Neal K; Cadrin-Tourigny, Julia; Targetti, Mattia; Olivotto, Iacopo; Graziosi, Maddalena; Cox, Moniek; Biagini, Elena; Charron, Philippe; Compagnucci, Paolo; Casella, Michela; Conte, Giulio; Tondo, Claudio; Yazdani, Momina; Ware, James S; Prasad, Sanjay K; Calò, Leonardo; Smith, Eric D; Helms, Adam S; Hespe, Sophie; Ingles, Jodie; Tandri, Harikrishna; Ader, Flavie; Peretto, Giovanni; Peters, Stacey; Horton, Ari; Yao, Jessica; Schulze-Bahr, Eric; Dittman, Sven; Carruth, Eric D; Young, Katelyn; Qureshi, Maria; Haggerty, Chris; Parikh, Victoria N; Taylor, Matthew; Mestroni, Luisa; Wilde, Arthur; Sinagra, Gianfranco; Merlo, Marco; Gandjbakhch, Estelle; van Tintelen, J Peter; Te Riele, Anneline S J M; Elliot, Perry; Calkins, Hugh; Wu, Katherine C; James, Cynthia A (Oxford University Press, 2024-08-21)
    Background and Pathogenic desmoplakin (DSP) gene variants are associated with the development of a distinct form of arrhythmogenic car-Aims diomyopathy known as DSP cardiomyopathy. Patients harbouring these variants are ...
  • Repeatability and reproducibility of the Forskolin-induced swelling (FIS) assay on intestinal organoids from people with Cystic Fibrosis 
    Bierlaagh, Marlou C.; Ramalho, Anabela S.; Silva, Iris A.L.; Vonk, Annelotte M.; van den Bor, Rutger M.; van Mourik, Peter; Pott, Johanna; Suen, Sylvia W.F.; Boj, Sylvia F.; Vries, Robert G.J.; Lammertyn, Elise; Vermeulen, François; Amaral, Margarida D.; de Boeck, Kris; van der Ent, Cornelis K.; Beekman, Jeffrey M. (Elsevier, 2024-07)
    Background: The forskolin-induced swelling (FIS) assay measures CFTR function on patient-derived intestinal organoids (PDIOs) and may guide treatment selection for individuals with Cystic Fibrosis (CF). The aim of this ...
  • Airway epithelial cell response to RSV is mostly impaired in goblet and multiciliated cells in asthma 
    Gay, Aurore C A; Banchero, Martin; Carpaij, Orestes; Kole, Tessa M; Apperloo, Leonie; van Gosliga, Djoke; Fajar, Putri Ayu; Koppelman, Gerard H; Bont, Louis; Hendriks, Rudi W; van den Berge, Maarten; Nawijn, Martijn C (BMJ Publishing Group, 2024-08-19)
    Background: In patients with asthma, respiratory syncytial virus (RSV) infections can cause disease exacerbation by infecting the epithelial layer of the airways, inducing subsequent immune response. The type I interferon ...
  • Complexity in Simplicity: Unraveling the Heterogeneous Nature of Malignant Rhabdoid Tumors 
    Paassen, Irene Evelyn Karla (Utrecht University, 2024-09-20)
    In this thesis we study the heterogeneity seen within the childhood cancer: malignant rhabdoid tumors (MRTs). These tumores are defined solely by loss of SMARCB1, a gene which is part of the swi/snf complex. Although we ...
  • New Insights in the Detection and Staging of Prostate Cancer 
    Heetman, Joris Gilles (Utrecht University, 2024-09-19)
    Prostate cancer (PCa) is a prevalent malignancy with a significant gap between its incidence and mortality rates, indicating that not all forms are life-threatening. The disease ranges from indolent to aggressive types, ...
  • Prenatal sonographic features can accurately determine parental origin in triploid pregnancies 
    Lugthart, Malou A.; Horenblas, Judith; Kleinrouweler, Emily C.; Engels, Melanie; Knegt, Alida C.; Huijsdens, Karin; van Leeuwen, Elisabeth; Pajkrt, Eva (John Wiley & Sons Inc., 2020-05-01)
    Objective: To describe the prenatal sonographic features and maternal biochemical markers in triploid pregnancies and to assess whether prenatal phenotype can determine genetic origin. Methods: We performed a retrospective ...
  • Correspondence on ‘Re-examining remission definitions in rheumatoid arthritis: considering the 28-joint disease activity score, C reactive protein level and patient global assessment’ 
    Ferreira, Ricardo J.O.; Welsing, Paco M.J.; Jacobs, Johannes W.G.; Gossec, Laure; Ndosi, Mwidimi; MacHado, Pedro M.; Van Der Heijde, Désirée; Da Silva, Jose A.P. (Elsevier, 2023-08)
  • Difference Makers: Chromosomal Instability versus Aneuploidy in Cancer 
    van Jaarsveld, Richard H; Kops, Geert J P L (Cell Press, 2016-10)
    Human cancers harbor great numbers of genomic alterations. One of the most common alterations is aneuploidy, an imbalance at the chromosome level. Some aneuploid cancer cell populations show varying chromosome copy number ...
  • Development and validation of a prognostic model to predict birth weight: individual participant data meta-analysis 
    International Prediction of Pregnancy Complications collaborative network (2024-08-14)
    OBJECTIVE: To predict birth weight at various potential gestational ages of delivery based on data routinely available at the first antenatal visit. DESIGN: Individual participant data meta-analysis. DATA SOURCES: Individual ...
  • Telemonitoring in Ophthalmology 
    Claessens, Janneau (Utrecht University, 2024-09-19)
    In this thesis, we explored the role of telemonitoring in ophthalmology. We have shown that a plethora of digital tools for vision self-assessments are available, yet also underlined the importance of research before ...
  • ECG-based techniques to enhance clinical practice in cardiac genetic disease management 
    Boonstra, Machteld; Kloosterman, Manon; van der Schaaf, Iris; Roudijk, Rob; van Dam, Peter; Loh, Peter (Churchill Livingstone, 2023-01-01)
    Introduction: Inherited cardiomyopathies are associated with a broad spectrum of potentially lethal phenotypes characterized by structural and electrical myocardial remodeling. Increased awareness and genetic cascade ...
  • The end of wide local excision (WLE) margins for melanoma ? 
    Zijlker, Lisanne P.; Eggermont, Alexander M.M.; van Akkooi, Alexander C.J. (Elsevier Limited, 2023-01)
    Clinical question: Is there nowadays any benefit of continuing the practice of routine wide local excision (WLE) for primary stage I/II cutaneous melanoma? Background: WLE aims to eradicate potential microsatellites around ...
  • A web-based decision aid for shared decision making in pelvic organ prolapse: the SHADE-POP trial 
    Drost, Larissa Esmeralda; Stegeman, Marjan; Gerritse, Maria B.E.; Franx, Arie; Vos, M. Caroline; Lamers, Romy E.D.; Ezendam, Nicole P.M.; Dam, Anika; Schrickx, Jan; van Wijk, Heidy F.; On behalf of the SHADE-POP study group (Springer Nature, 2023-01)
    Introduction and hypothesis: Among women worldwide, pelvic organ prolapse (POP) is a common problem. There are three different treatment options for POP: pelvic floor muscle therapy, pessary treatment and prolapse surgery. ...
  • Serial cardiac biomarkers, pulmonary artery pressures and traditional parameters of fluid status in relation to prognosis in patients with chronic heart failure: Design and rationale of the BioMEMS study 
    Allach, Youssra; Barry-Loncq de Jong, Mylene; Clephas, Pascal R D; van Gent, Marco W F; Brunner-La Rocca, Hans-Peter; Szymanski, Mariusz K; van Halm, Vokko P; Handoko, M Louis; Kok, Wouter E M; Asselbergs, Folkert W; van Kimmenade, Roland R J; Manintveld, Olivier C; van Mieghem, Nicolas M D A; Beeres, Saskia L M A; Rienstra, Michiel; Post, Marco C; van Heerebeek, Loek; Borleffs, C Jan Willem; Tukkie, Raymond; Mosterd, Arend; Linssen, Gerard C M; Spee, Ruud F; Emans, Mireille E; Smilde, Tom D J; van Ramshorst, Jan; Kirchhof, Charles J H J; Feenema-Aardema, Margriet W; da Fonseca, Carlos A; van den Heuvel, Mieke; Hazeleger, Ronald; van Eck, J W Martijn; Boersma, Eric; Kardys, Isabella; de Boer, Rudolf A; Brugts, Jasper J (Oxford University Press, 2024-08)
    AIMS: Heart failure (HF), a global pandemic affecting millions of individuals, calls for adequate predictive guidance for improved therapy. Congestion, a key factor in HF-related hospitalizations, further underscores the ...
  • Serial Quality of Life Assessment around Screening for Familial Intracranial Aneurysms: A Prospective Cohort Study 
    Mensing, Liselore A.; Atash, Keneshka; Rinkel, Gabriel J.E.; Ruigrok, Ynte M. (S. Karger AG, 2024-08-01)
    Introduction: Screening for intracranial aneurysms (IAs) is cost-effective in first-degree relatives of aneurysmal subarachnoid haemorrhage patients, but its psychosocial impact is largely unknown. Patients and Methods: A ...
  • Exercise training decreases lactylation and prevents myocardial ischemia–reperfusion injury by inhibiting YTHDF2 
    Xu, Gui E.; Yu, Pujiao; Hu, Yuxue; Wan, Wensi; Shen, Keting; Cui, Xinxin; Wang, Jiaqi; Wang, Tianhui; Cui, Caiyue; Chatterjee, Emeli; Li, Guoping; Cretoiu, Dragos; Sluijter, Joost P.G.; Xu, Jiahong; Wang, Lijun; Xiao, Junjie (Springer Science and Business Media Deutschland GmbH, 2024-08)
    Exercise improves cardiac function and metabolism. Although long-term exercise leads to circulating and micro-environmental metabolic changes, the effect of exercise on protein post-translational lactylation modifications ...
  • The time has come to question the infinite maintenance treatment for bipolar disorders 
    Dols, Annemiek; Kupka, Ralph W; Mathijssen, Henk; Regeer, Eline J (Blackwell Munksgaard, 2024-08)