Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

Now showing items 4481-4500 of 40729

Reduced ovarian cholesterol and steroid biosynthesis along with increased inflammation are associated with high DEHP metabolite levels in human ovarian follicular fluids

Varik, Inge; Zou, Runyu; Bellavia, Andrea; Rosenberg, Kristine; Sjunnesson, Ylva; Hallberg, Ida; Holte, Jan; Lenters, Virissa; Van Duursen, Majorie; Pedersen, Mikael; Svingen, Terje; Vermeulen, Roel; Salumets, Andres; Damdimopoulou, Pauliina; Velthut-Meikas, Agne (Elsevier Limited, 2024-09)

The plasticizer di(2-ethylhexyl) phthalate (DEHP) is known to have endocrine-disrupting properties mediated by its many metabolites that form upon exposure in biological systems. In a previous study, we reported an inverse ...
Klebsiella LPS O1-antigen prevents complement-mediated killing by inhibiting C9 polymerization

Masson, Frerich M; Káradóttir, Salvör; van der Lans, Sjors P A; Doorduijn, Dennis J; de Haas, Carla J C; Rooijakkers, Suzan H M; Bardoel, Bart W (Nature Publishing Group, 2024-09-05)

The Gram-negative bacterium Klebsiella pneumoniae is an important human pathogen. Its treatment has been complicated by the emergence of multi-drug resistant strains. The human complement system is an important part of our ...
Design of TOLERANT: phase I/II safety assessment of intranodal administration of HSP70/mB29a self-peptide antigen-loaded autologous tolerogenic dendritic cells in patients with rheumatoid arthritis

Stoppelenburg, Arie Jan; Schreibelt, Gerty; Koeneman, Bouke; Welsing, Paco; Breman, Evert-Jan; Lammers, Laureen; de Goede, Anna; Duiveman-de Boer, Tjitske; van Eden, Willem; Leufkens, Paul; de Vries, I Jolanda M; Broere, Femke; van Laar, Jacob M (BMJ Publishing Group, 2024-09-12)

Introduction In rheumatoid arthritis (RA), immunosuppressive therapies may achieve symptomatic relief, but do not induce long-term, drug-free remission. Meanwhile, the lifelong use of immunosuppressive drugs confers increased ...
Scale-Up of Integrated Care Interventions for Chronic Diseases in Diverse Settings

Ku, Grace Marie; Klemenc-Ketiš, Zalika; Poplas-Susič, Antonija; Remmens, Roy; Van Damme, Wim; Wouters, Edwin; Van Olmen, Josefien; Klipstein-Grobusch, Kerstin (Igitur, Utrecht Publishing and Archiving Services, 2024-09-10)
The effect on relapse rate and psychiatric symptomatology: Switching a combination of first- and second-generation antipsychotic polypharmacy to antipsychotic monotherapy in long-term inpatients with schizophrenia and related disorders. A pragmatic randomized open-label trial (SwAP trial)

Shakir, Mushde; Willems, Anne E.; van Harten, Peter N.; van Lutterveld, Remko; Tenback, Diederik E. (Elsevier, 2022-05)

Background: There is little evidence to support the use of antipsychotic polypharmacy, and there are concerns about safety and side effects. Nonetheless, it is commonly used in the treatment of long-term inpatients with ...
Acute kidney injury in Staphylococcus aureus bacteraemia: a recurrent events analysis

Buis, David T P; van der Vaart, Thomas W; Mohan, Asna; Prins, Jan M; van der Meer, Jan T M; Bonten, Marc J M; Jakulj, Lily; van Werkhoven, Cornelis H; Sigaloff, Kim C E (Elsevier, 2024-10)

OBJECTIVES: To estimate risk factors for acute kidney injury (AKI) and the effect of AKI on mortality in Staphylococcus aureus bacteraemia, while taking into account recurrent AKI episodes, competing risks, time-varying ...
Advancing collaboration in health professions education in the general practice domain, developing a national research agenda

de Groot, Esther; der Vossen, Marianne Mak van; Slootweg, Irene; Çorum, Meryem; Kramer, Anneke; Muris, Jean; Scherpbier, Nynke; Thoonen, Bart; Damoiseaux, Roger (Springer Netherlands, 2024-09)

Background: Health professions education (HPE) research in the General Practice domain (GP-HPE) is vital for high-quality healthcare. Collaboration among GP-HPE researchers is crucial but challenging. Formulating a research ...
Chemotherapy-Induced Peripheral Neuropathy in Patients With Gastroesophageal Cancer

van Velzen, Merel J M; Pape, Marieke; Sprangers, Mirjam A G; van Kleef, Jessy Joy; Mostert, Bianca; Beerepoot, Laurens V; Slingerland, Marije; Gootjes, Elske C; Hoekstra, Ronald; van de Poll-Franse, Lonneke V; Haj Mohammad, Nadia; van Laarhoven, Hanneke W M (Harborside Press, 2024-07-08)

BACKGROUND: Chemotherapy for various stages of gastroesophageal cancer (GEC) is often neurotoxic. Chemotherapy-induced peripheral neuropathy (CIPN) impairs health-related quality of life (HRQoL). This study investigates ...
Editor's Choice – Prognostic Factors and Models to Predict Mortality Outcomes in Patients with Peripheral Arterial Disease: A Systematic Review

Porras, Cindy P; Teraa, Martin; Damen, Johanna A A; Hazenberg, Constantijn E V B; Bots, Michiel L; Verhaar, Marianne C; Vernooij, Robin W M (W.B. Saunders Ltd, 2024-09)

Objective: Predicting adverse outcomes in patients with peripheral arterial disease (PAD) is a complex task owing to the heterogeneity in patient and disease characteristics. This systematic review aimed to identify ...
Drug classes affecting intracranial aneurysm risk: Genetic correlation and Mendelian randomization

Ruigrok, Ynte M.; Veldink, Jan H.; Bakker, Mark K. (SAGE Publications Inc., 2024-09)

Introduction: There is no non-invasive treatment to prevent aneurysmal subarachnoid hemorrhage (ASAH) caused by intracranial aneurysm (IA) rupture. We aimed to identify drug classes that may affect liability to IA using a ...
Current Perspectives on the Clinical Research and Medicalization of Psychedelic Drugs for Addiction Treatments: Safety, Efficacy, Limitations and Challenges

Gomez-Escolar, Anton; Folch-Sanchez, Daniel; Stefaniuk, Joanna; Swithenbank, Zoe; Nisa, Andreia; Braddick, Fleur; Idrees Chaudhary, Nazish; van der Meer, Pim B; Batalla, Albert (Adis, 2024-10)

Mental health disorders and substance use disorders (SUDs) in particular, contribute greatly to the global burden of disease. Psychedelics, including entactogens and dissociative substances, are currently being explored ...
The Specificity of Left Ventricular Bite-Like Fibrofatty Replacement for Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy

Umair, Muhammad; Asatryan, Babken; Aliyari Ghasabeh, Mounes; Bosman, Laurens P.; Murray, Brittney; Tichnell, Crystal; te Riele, Anneline S.J.M.; Velthuis, Birgitta K.; James, Cynthia A.; Zimmerman, Stefan L. (Elsevier, 2024-09)
IGF2BP3 participates in the pathogenesis of recurrent spontaneous abortion by regulating ferroptosis

Dai, Fangfang; Zhang, Yuwei; Deng, Zhimin; Zhang, Jie; Wang, Ruiqi; Chen, Jing; Yang, Dongyong; Mao, Sisi; Liu, Hua; Cheng, Yanxiang; Hu, Min (Elsevier Ireland Ltd, 2024-09)

The aberrant invasive capability of trophoblast cells is widely acknowledged as a primary mechanism underlying RSA. Recently, IGF2BP3 has been implicated in various cancers due to its influence on cellular invasion and ...
Interindividual variation in ovarian reserve after gonadotoxic treatment in female childhood cancer survivors - a genome-wide association study: results from PanCareLIFE

van der Perk, M E Madeleine; Broer, Linda; Yasui, Yutaka; Laven, Joop S E; Robison, Leslie L; Tissing, Wim J E; Versluys, Birgitta; Bresters, Dorine; Kaspers, Gertjan J L; Lambalk, Cornelis B; Overbeek, Annelies; Loonen, Jacqueline J; Beerendonk, Catharina C M; Byrne, Julianne; Berger, Claire; Clemens, Eva; van Dulmen-den Broeder, Eline; Dirksen, Uta; van der Pal, Helena J; de Vries, Andrica C H; Winther, Jeanette Falck; Ranft, Andreas; Fosså, Sophie D; Grabow, Desiree; Muraca, Monica; Kaiser, Melanie; Kepák, Tomáš; Kruseova, Jarmila; Modan-Moses, Dalit; Spix, Claudia; Zolk, Oliver; Kaatsch, Peter; Kremer, Leontien C M; Brooke, Russell J; Wang, Fan; Baedke, Jessica L; Uitterlinden, André G; Bos, Annelies M E; van Leeuwen, Flora E; Ness, Kirsten K; Hudson, Melissa M; van der Kooi, Anne-Lotte L F; van den Heuvel-Eibrink, Marry M; PanCareLIFE Consortium (Elsevier, 2024-09)

Objective: To discover new variants associated with low ovarian reserve after gonadotoxic treatment among adult female childhood cancer survivors using a genome-wide association study approach. Design: Genome-wide association ...
Standardizing designed and emergent quantitative features in microphysiological systems

Nahon, Dennis M.; Moerkens, Renée; Aydogmus, Hande; Lendemeijer, Bas; Martínez-Silgado, Adriana; Stein, Jeroen M.; Dostanić, Milica; Frimat, Jean Philippe; Gontan, Cristina; de Graaf, Mees N.S.; Hu, Michel; Kasi, Dhanesh G.; Koch, Lena S.; Le, Kieu T.T.; Lim, Sangho; Middelkamp, Heleen H.T.; Mooiweer, Joram; Motreuil-Ragot, Paul; Niggl, Eva; Pleguezuelos-Manzano, Cayetano; Puschhof, Jens; Revyn, Nele; Rivera-Arbelaez, José M.; Slager, Jelle; Windt, Laura M.; Zakharova, Mariia; van Meer, Berend J.; Orlova, Valeria V.; de Vrij, Femke M.S.; Withoff, Sebo; Mastrangeli, Massimo; van der Meer, Andries D.; Mummery, Christine L. (Nature Publishing Group, 2024-08)

Microphysiological systems (MPSs) are cellular models that replicate aspects of organ and tissue functions in vitro. In contrast with conventional cell cultures, MPSs often provide physiological mechanical cues to cells, ...
Patient profiling in heart failure for tailoring medical therapy. A consensus document of the Heart Failure Association of the European Society of Cardiology

Rosano, Giuseppe M C; Moura, Brenda; Metra, Marco; Böhm, Michael; Bauersachs, Johann; Ben Gal, Tuvia; Adamopoulos, Stamatis; Abdelhamid, Magdy; Bistola, Vasiliki; Čelutkienė, Jelena; Chioncel, Ovidiu; Farmakis, Dimitrios; Ferrari, Roberto; Filippatos, Gerasimos; Hill, Loreena; Jankowska, Ewa A; Jaarsma, Tiny; Jhund, Pardeep; Lainscak, Mitja; Lopatin, Yuri; Lund, Lars H; Milicic, Davor; Mullens, Wilfried; Pinto, Fausto; Ponikowski, Piotr; Savarese, Gianluigi; Thum, Thomas; Volterrani, Maurizio; Anker, Stefan D; Seferovic, Petar M; Coats, Andrew J S (Oxford University Press, 2021-06)

Despite guideline recommendations and available evidence, implementation of treatment in heart failure (HF) is poor. The majority of patients are not prescribed drugs at target doses that have been proven to positively ...
Incidence and prevalence of epilepsy and associated factors in a health district in North-West Cameroon: A population survey

Angwafor, Samuel A.; Bell, Gail S.; Ngarka, Leonard; Otte, Willem; Tabah, Earnest N.; Nfor, Leonard N.; Njamnshi, Theophilus N.; Njamnshi, Alfred K.; Sander, Josemir W. (Academic Press Inc., 2021-08)

This population-based cross-sectional survey with a follow-up case-control study assessed the prevalence, incidence, and risk factors for epilepsy in a rural health district in the North-West Region of Cameroon. Community-based ...
Epilepsy in a health district in North-West Cameroon: Clinical characteristics and treatment gap

Angwafor, Samuel A.; Bell, Gail S.; Ngarka, Leonard; Otte, Willem M.; Tabah, Earnest N.; Nfor, Leonard N.; Njamnshi, Theophilus N.; Sander, Josemir W.; Njamnshi, Alfred K. (Academic Press Inc., 2021-08)

Introduction: Epilepsy is a common yet misunderstood condition in Cameroon, including in the Batibo Health district. Methods: This cross-sectional study describes epilepsy clinical characteristics, the treatment gap, and ...
Bayesian model-averaged meta-analysis in medicine

Bartoš, František; Gronau, Quentin F.; Timmers, Bram; Otte, Willem M.; Ly, Alexander; Wagenmakers, Eric Jan (John Wiley & Sons Inc., 2021-12-30)

We outline a Bayesian model-averaged (BMA) meta-analysis for standardized mean differences in order to quantify evidence for both treatment effectiveness (Formula presented.) and across-study heterogeneity (Formula ...
Postoperative headache after surgical treatment of cerebellopontine angle tumors: a systematic review

Pogoda, Louis; Nijdam, Jelle S.; Smeeing, Diederik P.J.; Voormolen, Eduard H.J.; Ziylan, Fuat; Thomeer, Hans G.X.M. (Springer-Verlag, 2021-10)

Purpose: Postoperative headache (POH) is a complication that occurs after surgical resection of cerebellopontine angle (CPA) tumors. The two most common surgical approaches are the translabyrinthine (TL), and retrosigmoid ...

Now showing items 4481-4500 of 40729