Human parainfluenza virus type 3 (HPIV-3) can cause severe respiratory tract infections. There are no convenient small-animal infection models. Here, we show viral replication in the upper and lower airways of AG129 mice ...

Background: Sporadic inclusion body myositis (sIBM) is the predominant idiopathic inflammatory myopathy (IIM) in older people. Limitations of classical clinical assessments have been discussed as possible explanations for ...

Stratified medicine holds great promise to tailor treatment to the needs of individual patients. While genetics holds great potential to aid patient stratification, it remains a major challenge to operationalize complex ...

Importance: Mega-trials can provide large-scale evidence on important questions. Objective: To explore how the results of mega-trials compare with the meta-analysis results of trials with smaller sample sizes. Data Sources: ...

Integrating multi-omics data into predictive models has the potential to enhance accuracy, which is essential for precision medicine. In this study, we developed interpretable predictive models for multi-omics data by ...

Objective: To evaluate prognostic differences between minimally invasive esophagectomy (MIE) and open esophagectomy (OE) in patients with surgery after a prolonged interval (>12 wk) following chemoradiotherapy (CRT). ...

BACKGROUND: Carbapenem-resistant Enterobacterales (CRE) bloodstream infections (BSIs) are a major threat to patients. To date, data on risk factors have been limited, with low internal and external validity. In this ...

This thesis addresses the challenges in prostate cancer (PCa) diagnosis, focusing on Gleason grading in prostate needle biopsies, which plays a crucial role in risk stratification and subsequent treatment strategy. The ...

Pediatric cancer is rare and encompasses many cancer entities. It is the lead cause of childhood mortality, even though there has been an increase in overall survival over the years. This increase in survival was in part ...