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UMC Repository: Recent submissions

  • Longitudinal changes in DNA methylation associated with clozapine use in treatment-resistant schizophrenia from two international cohorts 
    Gillespie, Amy L.; Walker, Emma M.; Hannon, Eilis; McQueen, Grant A.; Sendt, Kyra Verena; Avila, Alessia; Lally, John; Okhuijsen-Pfeifer, Cynthia; van der Horst, Marte; Hasan, Alkomiet; Dempster, Emma L.; Burrage, Joe; Bogers, Jan; Cohen, Dan; Boks, Marco P.; Collier, David A.; Egerton, Alice; Luykx, Jurjen J.; Mill, Jonathan; MacCabe, James H. (Nature Publishing Group, 2024-09-27)
    The second-generation antipsychotic clozapine is used as a medication for treatment-resistant schizophrenia. It has previously been associated with epigenetic changes in pre-clinical rodent models and cross-sectional studies ...
  • The INTOXICATE study: methodology and preliminary results of a prospective observational study 
    INTOXICATE Study Investigators Group (Springer Science + Business Media, 2024-09-27)
    BACKGROUND: There is currently no practice-based, multicenter database of poisoned patients admitted to intensive care units (ICUs). The INTOXICATE study, endorsed by the ESICM and EAPCCT, aimed to determine the rate of ...
  • European Association of Cardiothoracic Surgeons future view on robotic cardiac surgery in Europe 
    Oosterlinck, Wouter; Gianoli, Monica; Palmen, Meindert; Folliguet, Thierry; Bonatti, Johannes; Agnino, Alfonso; Singh, Sandeep; Franke, Ulrich; Modi, Paul; Pereda, Daniel; Kempfert, Jörg; Navarra, Emiliano; Suwalski, Piotr; Vojacek, Jan; Casselman, Filip; Myers, Patrick; Sadaba, J Rafael; Melfi, Franca; Hazekamp, Mark; Bavaria, Joseph; Beyersdorf, Friedhelm; Milojevics, Milan; Falk, Volkmar; Cerny, Stepan (Elsevier, 2024-10-01)
  • The relevance of tumor target expression levels on IgA-mediated cytotoxicity in cancer immunotherapy 
    Chan, Chilam; Cabanes, Núria Casalé; Jansen, J H Marco; Guillaume, Joël; Nederend, Maaike; Passchier, Elsemieke M; Gómez-Mellado, Valentina E; Peipp, Matthias; Boes, Marianne; van Tetering, Geert; Leusen, Jeanette H W (Springer Science and Business Media Deutschland GmbH, 2024-10-03)
    Recent advances in cancer immunotherapy, particularly the success of immune checkpoint inhibitors, have reignited interest in targeted monoclonal antibodies for immunotherapy. Antibody therapies aim to minimize on-target, ...
  • Safety of COVID-19 Vaccines among People with History of Allergy: A European Active Surveillance Study 
    Luxi, Nicoletta; Ciccimarra, Francesco; Bellitto, Chiara; Raethke, Monika; van Hunsel, Florence; Lieber, Thomas; Mulder, Erik; L'Abbate, Luca; Marques, Francisco Batel; Furci, Fabiana; Farcas, Andreea; Giele-Eshuis, Janneke; Morton, Kathryn; Sonderlichová, Simona; Thurin, Nicolas H; Villalobos, Felipe; Riefolo, Fabio; Sturkenboom, Miriam C; Trifirò, Gianluca (Multidisciplinary Digital Publishing Institute, 2024-09-17)
    Background: Conventional vaccines rarely cause severe allergic reactions. However, the rapid development and approval of COVID-19 vaccines left limited initial data on their adverse reactions, particularly in individuals ...
  • Unravelling differential Hes1 dynamics during axis elongation of mouse embryos through single-cell tracking 
    Azhar, Yasmine el; Schulthess, Pascal; van Oostrom, Marek J.; Weterings, Sonja D.C.; Meijer, Wilke H.M.; Tsuchida-Straeten, Nobuko; Thomas, Wouter M.; Bauer, Marianne; Sonnen, Katharina F. (Company of Biologists Ltd, 2024-09)
    The intricate dynamics of Hes expression across diverse cell types in the developing vertebrate embryonic tail have remained elusive. To address this, we have developed an endogenously tagged Hes1-Achilles mouse line, ...
  • Global estimates on the number of people blind or visually impaired by age-related macular degeneration: a meta-analysis from 2000 to 2020 
    Vision Loss Expert Group of the Global Burden of Disease Study; the GBD 2019 Blindness and Vision Impairment Collaborators (Springer Nature, 2024-08)
    Background: We aimed to update estimates of global vision loss due to age-related macular degeneration (AMD). Methods: We did a systematic review and meta-analysis of population-based surveys of eye diseases from January, ...
  • Landscape of healthcare transition services in Canada: a multi-method environmental scan 
    Li, Lin; Soper, Alice Kelen; McCauley, Dayle; Gorter, Jan Willem; Doucet, Shelley; Greenaway, Jon; Luke, Alison (BioMed Central, 2024-09-27)
    BACKGROUND: Poorly supported transitions from pediatric to adult healthcare can lead to negative health outcomes for youth and their families. To better understand the current landscape of healthcare transition care across ...
  • Twenty-five years of observations from the International Registry of Acute Aortic Dissection (IRAD) and its impact on the cardiovascular scientific community 
    Trimarchi, Santi; Mandigers, Tim J.; Bissacco, Daniele; Nienaber, Christoph; Isselbacher, Eric M.; Evangelista, Arturo; Suzuki, Toru; Bossone, Eduardo; Pape, Linda A.; Januzzi, James L.; Harris, Kevin M.; O'Gara, Patrick T.; Gilon, Dan; Hutchison, Stuart; Patel, Himanshu J.; Woznicki, Elise M.; Montgomery, Daniel; Kline-Rogers, Eva; Eagle, Kim A. (Mosby Inc., 2024-10)
    Objective: The International Registry of Acute Aortic Dissection (IRAD) celebrated its 25th anniversary in January 2021. This study evaluated IRAD's role in promoting the understanding and management of acute aortic ...
  • The role of medical physics experts in clinical trials: A guideline from the European Federation of Organisations for Medical Physics 
    Abbott, Natalie Louise; Chauvie, Stephane; Marcu, Loredana; DeJean, Catherine; Melidis, Christos; Wientjes, Rens; Gasnier, Anne; Lisbona, Albert; Luzzara, Marco; Mazzoni, Lorenzo Nicola; O'Doherty, Jim; Koutsouveli, Efi; Appelt, Ane; Hansen, Christian Rønn (Associazione Italiana di Fisica Medica, 2024-10)
    The EFOMP working group on the Role of Medical Physics Experts (MPEs) in Clinical Trials was established in 2010, with experts from across Europe and different areas of medical physics. Their main aims were: (1) To develop ...
  • Targeting RNA Helicase DDX3X with a Small Molecule Inhibitor for Breast Cancer Bone Metastasis Treatment 
    Winnard, Paul T; Vesuna, Farhad; Bol, Guus M; Gabrielson, Kathleen L; Chenevix-Trench, Georgia; Ter Hoeve, Natalie D; van Diest, Paul J; Raman, Venu (Elsevier Ireland Ltd, 2024-11)
    Patients who present with breast cancer bone metastasis only have limited palliative treatment strategies and efficacious drug treatments are needed. In breast cancer patient data, high levels of the RNA helicase DDX3 are ...
  • Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts 
    Wani, Agaz H.; Katrinli, Seyma; Zhao, Xiang; Daskalakis, Nikolaos P.; Zannas, Anthony S.; Aiello, Allison E.; Baker, Dewleen G.; Boks, Marco P.; Brick, Leslie A.; Chen, Chia Yen; Dalvie, Shareefa; Fortier, Catherine; Geuze, Elbert; Hayes, Jasmeet P.; Kessler, Ronald C.; King, Anthony P.; Koen, Nastassja; Liberzon, Israel; Lori, Adriana; Luykx, Jurjen J.; Maihofer, Adam X.; Milberg, William; Miller, Mark W.; Mufford, Mary S.; Nugent, Nicole R.; Rauch, Sheila; Ressler, Kerry J.; Risbrough, Victoria B.; Rutten, Bart P.F.; Stein, Dan J.; Stein, Murray B.; Ursano, Robert J.; Verfaellie, Mieke H.; Vermetten, Eric; Vinkers, Christiaan H.; Ware, Erin B.; Wildman, Derek E.; Wolf, Erika J.; Nievergelt, Caroline M.; Logue, Mark W.; Smith, Alicia K.; Uddin, Monica (BioMed Central, 2024-09-27)
    BACKGROUND: Incorporating genomic data into risk prediction has become an increasingly popular approach for rapid identification of individuals most at risk for complex disorders such as PTSD. Our goal was to develop and ...
  • Leaving no patient behind! Expert recommendation in the use of innovative technologies for diagnosing rare diseases 
    van Karnebeek, Clara D.M.; O’Donnell-Luria, Anne; Baynam, Gareth; Baudot, Anaïs; Groza, Tudor; Jans, Judith J.M.; Lassmann, Timo; Letinturier, Mary Catherine V.; Montgomery, Stephen B.; Robinson, Peter N.; Sansen, Stefaan; Mehrian-Shai, Ruty; Steward, Charles; Kosaki, Kenjiro; Durao, Patricia; Sadikovic, Bekim (BioMed Central, 2024-12)
    Genetic diagnosis plays a crucial role in rare diseases, particularly with the increasing availability of emerging and accessible treatments. The International Rare Diseases Research Consortium (IRDiRC) has set its primary ...
  • Prognostic Value of Circulating Fibrosis Biomarkers in Dilated Cardiomyopathy (DCM): Insights into Clinical Outcomes 
    Kayvanpour, Elham; Sedaghat-Hamedani, Farbod; Li, Daniel Tian; Miersch, Tobias; Weis, Tanja; Hoefer, Imo; Frey, Norbert; Meder, Benjamin (Multidisciplinary Digital Publishing Institute (MDPI), 2024-09)
    Background: Dilated cardiomyopathy (DCM) involves myocardial remodeling, characterized by significant fibrosis and extracellular matrix expansion. These changes impair heart function, increasing the risk of heart failure ...
  • Supercooling preservation of vascularized composite allografts through CPA optimization, thermal tracking, and stepwise loading techniques 
    Filz von Reiterdank, I.; Dinicu, A. T.; Rosales, I.; Cetrulo, C. L.; Coert, J. H.; Mink van der Molen, A. B.; Uygun, K. (Nature Publishing Group, 2024-12)
    Vascularized composite allografts (VCAs) present unique challenges in transplant medicine, owing to their complex structure and vulnerability to ischemic injury. Innovative preservation techniques are crucial for extending ...
  • Guideline recommendations on minimal blood vessel diameters and arteriovenous fistula outcomes 
    van Vliet, Letty V.; Zonnebeld, Niek; Tordoir, Jan H.; Huberts, Wouter; Bouwman, Lee H.; Cuypers, Philippe W.; Heinen, Stefan G.; Huisman, Laurens C.; Lemson, Susan; Mees, Barend M.E.; Schlösser, Felix J.; de Smet, André A.; Toorop, Raechel J.; Delhaas, Tammo; Snoeijs, Maarten G. (Wichtig Publishing, 2024-09)
    Objective: Clinical guidelines provide recommendations on the minimal blood vessel diameters required for arteriovenous fistula creation but the evidence for these recommendations is limited. We compared vascular access ...
  • Effect of optical diagnosis training on recognition and treatment of submucosal invasive colorectal cancer in community hospitals: a prospective multicenter intervention study 
    (on behalf of the OPTICAL-STAR study team and the Dutch T1 CRC Working Group) (Georg Thieme Verlag, 2024-10)
    Background and study aims: Recognition of T1 colorectal cancer (CRC) is difficult, with sensitivities of 35-60% in Western countries. We evaluated the real-life effects of the implementation of the OPTICAL model, a recently ...
  • Health Care Industry Payments to Editorial Board Members of Major Neurosurgery Journals Between 2017 and 2022 
    Harlianto, Netanja I.; Harlianto, Zaneta N. (Lippincott Williams & Wilkins, 2024-10-01)
    BACKGROUND AND OBJECTIVES: Financial conflicts of interest between editorial board members and industry could lead to biases and impartial editorial decisions. We aimed to evaluate the frequency, amount, and characteristics ...
  • IGF-1 as screening tool for acromegaly and adult-onset growth hormone deficiency in the Netherlands 
    Postma, Mark R.; van Beek, André P.; van der Klauw, Melanie M.; Lentjes, Eef G.W.M.; Muller Kobold, Anneke C. (Wiley-Blackwell, 2024-03)
    Objective: Insulin-like growth factor 1 (IGF-1) measurements play a central role in the diagnosis and follow-up of acromegaly and growth hormone deficiency. However, improving health care outcomes for these patients involves ...
  • Early warning of potential epidemics: A pilot application of an early warning tool to data from the pulmonary clinic of the university hospital of Thessaly, Greece 
    Meletis, Eleftherios; Poulakida, Irene; Perlepe, Garyfallia; Katsea, Asimina; Pateras, Konstantinos; Boutlas, Stylianos; Papadamou, Georgia; Gourgoulianis, Konstantinos; Kostoulas, Polychronis (Elsevier, 2024-03)
    Background & methods: This paper describes a pilot application of the Epidemic Volatility Index (EVI) to data from the pulmonary clinic of the University Hospital of Thessaly, Greece, for monitoring respiratory infections, ...