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UMC Repository: Recent submissions

  • Move to Eat: Towards personalization of supportive care for patients with head and neck cancer undergoing chemoradiotherapy 
    Kok, Annemieke (Utrecht University, 2024-12-10)
    The diagnosis and treatment of head and neck cancer (HNC)significantly impact patients' lives. Tumor-related symptoms and toxicity of chemoradiotherapy (CRT) treatment often reduce oral food intake, leading to unintended ...
  • Applied deep learning to nanopore sequencing: Genomics, epigenomics, and diagnostics 
    Pages Gallego, Marc (Utrecht University, 2025-01-13)
    Machine learning, particularly neural networks and deep learning, has significantly advanced bioinformatics by enabling the analysis of complex biological data. Nanopore sequencing, a third generation sequencing technology, ...
  • Uncovering the etiological mechanisms of mechanical cardiac device-induced thrombosis 
    Liesdek, Omayra (Utrecht University, 2024-12-05)
    While life-saving, continuous-flow left ventricular assist devices (CF-LVADs) are associated with significant risks of thrombosis, necessitating lifelong antithrombotic therapy. Pump thrombosis and thromboembolic complications ...
  • GFAP and vimentin during human brain development: A focus on Alexander Disease 
    Dykstra, Werner (Utrecht University, 2025-02-11)
    This dissertation focuses on GFAP and Alexander disease. GFAP (glial fibrillary acidic protein) is a cytoskeletal protein of the intermediate filament type that supports cell structure and stability. Mutations in the GFAP ...
  • A critical evaluation on additional treatment in children with refractory incontinence 
    van Geen, Frank (Utrecht University, 2025-02-04)
    Daytime urinary incontinence (DUI) is a common condition affecting 21.7% of school-aged children. Regardless of the subtype, standard urotherapy is considered the initial treatment for all children with functional DUI. ...
  • Effectiveness and safety of dupilumab and JAK-inhibitors in daily practice: Optimizing Treatment for Atopic Dermatitis 
    Boesjes, Celeste (Utrecht University, 2024-12-17)
    Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases worldwide. Until recently, adequate systemic treatment options for patients with moderate-to-severe AD were limited. Due to the increased ...
  • Catching Houdini - targeting TP53-deficient ALL 
    Cox, Willem P.J. (Utrecht University, 2025-01-23)
    With over 90% being cures, the treatment of acute lymphoblastic leukemia (ALL) in children is a success story. Improving this cure rate even more starts with the identification of those patients at risk and defining novel ...
  • On the road to optimizing long-term survival: Subsequent neoplasms in childhood cancer survivors across five decades 
    Westerveld, Aimee S R (Utrecht University, 2024-12-10)
    To investigate the risk of developing subsequent neoplasms, we used data from the Dutch Childhood Cancer Survivor Study (DCCSS) LATER cohort (1963-2014), including a total of 11,548 survivors. Data on subsequent neoplasms ...
  • A Three-Dimensional Exploration of the Facial Musculature: Unraveling facial dynamics 
    Schutte, Hilde (Utrecht University, 2024-12-05)
    In this thesis, the convergence of facial aesthetics and facial surgery was elaborated. It created 3D average facial models, explored upon facial expressions, and created methods for imaging and assessment of facial ...
  • Opportunities for effective communication in musculoskeletal care 
    van Hoorn, Bastiaan (Utrecht University, 2024-12-06)
    Effective communication, based on patient engagement and trust, facilitates patient-physician decision-making and leads to more satisfied patients, better treatment adherence, alleviated symptoms and concerns, and faster ...
  • Genomics-guided Oncology: Advancing Efficacy and Access 
    Zeverijn, Laurien J (Utrecht University, 2024-11-28)
    The approach to cancer treatment that bases treatment decisions on patient- or tumor-specific characteristics has changed our perspective on the combat and prognosis of cancer. Rapid developments in quality and availability ...
  • Fostering students’ interprofessional feedback dialogues in health professions education 
    Tielemans, Claudia Jeanne Maria (Utrecht University, 2024-12-03)
    Interprofessional feedback helps health profession trainees collaborate and learn in the complex, ever-changing clinical workplace. Fostering interprofessional feedback processes is thus a key aim of interprofessional ...
  • Rebuilding a repertoire; reconstitution of γδ T cells after allogeneic stem cell transplantation 
    Janssen, Anke (Utrecht University, 2024-12-03)
    γδ T cells are among the first immune cells to recover after allogeneic stem cell transplantation (SCT). SCT still remains the only curative treatment for various hematological malignancies, but is often complicated by ...
  • Accelerated computational models for multi-parametric MRI reconstruction 
    Liu, Hongyan (Utrecht University, 2024-12-02)
    This thesis focuses on advancing Magnetic Resonance Spin Tomography in Time-Domain (MR-STAT), a novel quantitative MRI (qMRI) technique. Comparing to conventional contrast-weighted MR techniques which produce contrast-weighted, ...
  • Neurobehavioral Monitoring: A Multimodal Perspective 
    Arasteh Emamzadeh Hashemi, Emad (Utrecht University, 2024-11-25)
    ptimal care for newborns in the neonatal intensive care unit (NICU), especially for premature infants, requires innovative methods to monitor vital functions and behavior. Although current monitoring techniques are proven ...
  • De-escalating breast surgery: intraductal techniques and refining lumpectomy 
    Makineli, Seher (Utrecht University, 2024-11-21)
    This thesis explores innovative approaches to improve the diagnosis and treatment of breast diseases, focusing on two areas: the management of pathological nipple discharge (PND) and the optimization of breast-conserving ...
  • Advanced Imaging Techniques for Knee and Ankle Pathologies: Applications of deep learning and statistical shape modelling 
    Arbabi, Saeed (Utrecht University, 2024-11-21)
    This thesis presents innovative applications of deep learning and statistical shape modeling (SSM) in musculoskeletal imaging, with a focus on knee and ankle pathologies, such as osteoarthritis, enthesitis, and impingement. ...
  • Optimising colorectal cancer surveillance in inflammatory bowel disease 
    Wijnands, Anouk Maria (Utrecht University, 2024-11-08)
    Inflammatory bowel disease (IBD), comprising ulcerative colitis and Crohn’s disease, is a chronic inflammatory condition of the gastrointestinal tract. Compared with the general population, patients with colonic IBD are ...
  • Genotype-phenotype correlations in RHOBTB2-associated neurodevelopmental disorders 
    Langhammer, Franziska; Maroofian, Reza; Badar, Rueda; Gregor, Anne; Rochman, Michelle; Ratliff, Jeffrey B; Koopmans, Marije; Herget, Theresia; Hempel, Maja; Kortüm, Fanny; Heron, Delphine; Mignot, Cyril; Keren, Boris; Brooks, Susan; Botti, Christina; Ben-Zeev, Bruria; Argilli, Emanuela; Sherr, Elliot H; Gowda, Vykuntaraju K; Srinivasan, Varunvenkat M; Bakhtiari, Somayeh; Kruer, Michael C; Salih, Mustafa A; Kuechler, Alma; Muller, Eric A; Blocker, Karli; Kuismin, Outi; Park, Kristen L; Kochhar, Aaina; Brown, Kathleen; Ramanathan, Subhadra; Clark, Robin D; Elgizouli, Magdeldin; Melikishvili, Gia; Tabatadze, Nazhi; Stark, Zornitza; Mirzaa, Ghayda M; Ong, Jinfon; Grasshoff, Ute; Bevot, Andrea; von Wintzingerode, Lydia; Jamra, Rami A; Hennig, Yvonne; Goldenberg, Paula; Al Alam, Chadi; Charif, Majida; Boulouiz, Redouane; Bellaoui, Mohammed; Amrani, Rim; Al Mutairi, Fuad; Tamim, Abdullah M; Abdulwahab, Firdous; Alkuraya, Fowzan S; Khouj, Ebtissal M; Alvi, Javeria R; Sultan, Tipu; Hashemi, Narges; Karimiani, Ehsan G; Ashrafzadeh, Farah; Imannezhad, Shima; Efthymiou, Stephanie; Houlden, Henry; Sticht, Heinrich; Zweier, Christiane (Lippincott Williams & Wilkins, 2023-08)
    PURPOSE: Missense variants clustering in the BTB domain region of RHOBTB2 cause a developmental and epileptic encephalopathy with early-onset seizures and severe intellectual disability. METHODS: By international collaboration, ...
  • Federated systems for automated infection surveillance: a perspective 
    van Rooden, Stephanie M.; van der Werff, Suzanne D.; van Mourik, Maaike S.M.; Lomholt, Frederikke; Møller, Karina Lauenborg; Valk, Sarah; Dos Santos Ribeiro, Carolina; Wong, Albert; Haitjema, Saskia; Behnke, Michael; Rinaldi, Eugenia (BioMed Central Ltd., 2024-09-27)
    Automation of surveillance of infectious diseases-where algorithms are applied to routine care data to replace manual decisions-likely reduces workload and improves quality of surveillance. However, various barriers limit ...