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Now showing items 3721-3740 of 40729

The Launch of the European Patients' Academy on Therapeutic Innovation in the Netherlands: A Qualitative Multi-Stakeholder Analysis

van Rensen, Annemiek; Voogdt-Pruis, Helene R; Vroonland, Eva (Frontiers Media S. A., 2020-09-11)

Background: Involving patients' representatives in the research and development of medicinal products (medicines R&D) leads to better medical treatment. In 2014, the European Patients' Academy on Therapeutic Innovation ...
Breeding brains? Patients' and laymen's perspectives on cerebral organoids

Haselager, Dolly R.; Boers, Sarah N.; Jongsma, Karin R.; Vinkers, Christiaan H.; Broekman, Marike L.; Bredenoord, Annelien L. (Taylor and Francis Ltd., 2020-12)

Aim: To explore the perspectives of patients and laymen with regard to the development, use and storage of cerebral organoids, in order to contribute to the ethical debate about this technology. Materials & methods: In ...
Coronary artery disease prediction in women and men using chest pain characteristics and risk factors: an observational study in outpatient clinics

Groepenhoff, Floor; Eikendal, Anouk L M; Onland-Moret, N Charlotte; Bots, Sophie Heleen; Menken, Roxana; Tulevski, Igor I; Somsen, Aernout G; Hofstra, Leonard; den Ruijter, Hester M (BMJ Publishing Group, 2020-04-26)

OBJECTIVES: To assess the diagnostic value of non-acute chest pain characteristics for coronary artery disease in women and men referred to outpatient cardiology clinics. DESIGN AND SETTING: This is an observational study ...
Diagnosis of SARS-CoV-2 infection and COVID-19: accuracy of signs and symptoms; molecular, antigen, and antibody tests; and routine laboratory markers

Deeks, Jonathan J.; Dinnes, Jacqueline; Takwoingi, Yemisi; Davenport, Clare; Leeflang, Mariska M.G.; Spijker, René; Hooft, Lotty; Van den Bruel, Ann; Emperador, Devy; Dittrich, Sabine (John Wiley & Sons Inc., 2020-04-27)

Objectives: This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows:. To assess the diagnostic accuracy of laboratory real-time polymerase chain reaction (RT-PCR) and other laboratory molecular ...
Preferred reporting items for systematic review and meta-analysis of diagnostic test accuracy studies (PRISMA-DTA): Explanation, elaboration, and checklist

Salameh, Jean Paul; Bossuyt, Patrick M.; McGrath, Trevor A.; Thombs, Brett D.; Hyde, Christopher J.; MacAskill, Petra; Deeks, Jonathan J.; Leeflang, Mariska; Korevaar, Daniël A.; Whiting, Penny; Takwoingi, Yemisi; Reitsma, Johannes B.; Cohen, Jérémie F.; Frank, Robert A.; Hunt, Harriet A.; Hooft, Lotty; Rutjes, Anne W.S.; Willis, Brian H.; Gatsonis, Constantine; Levis, Brooke; Moher, David; McInnes, Matthew D.F. (BMJ Publishing Group, 2020-08-14)

Systematic reviews of diagnostic test accuracy (DTA) studies are fundamental to the decision making process in evidence based medicine. Although such studies are regarded as high level evidence, these reviews are not always ...
World Heart Federation Briefing on Prevention: Coronavirus Disease 2019 (COVID-19) in Low-Income Countries

Thienemann, Friedrich; Pinto, Fausto; Grobbee, Diederick E; Boehm, Michael; Bazargani, Nooshin; Ge, Junbo; Sliwa, Karen (Elsevier Science & Technology, 2020-04-09)

In December 2019, the novel coronavirus Coronavirus Disease 2019 (COVID-19) outbreak started in Wuhan, the capital of Hubei province in China. Since then it has spread to many other regions, including low-income countries.
Extracellular vesicle Cystatin C and CD14 are associated with both renal dysfunction and heart failure

Verbree-Willemsen, Laura; Zhang, Ya-Nan; Ibrahim, Irwani; Ooi, Shirley B S; Wang, Jiong-Wei; Mazlan, Muhammad I; Kuan, Win S; Chan, Siew-Pang; Peelen, Linda M; Grobbee, Diederick E; Richards, A Mark; Lam, Carolyn S P; de Kleijn, Dominique P V (John Wiley & Sons Inc., 2020-10-01)

Aims: Extracellular vesicles (EVs) are small double-membrane plasma vesicles that play key roles in cellular crosstalk and mechanisms such as inflammation. The role of EVs in combined organ failure such as cardiorenal ...
Implementing Fixed Dose Combination Medications for the Prevention and Control of Cardiovascular Diseases

Webster, Ruth; Murphy, Adrianna; Bygrave, Helen; Ansbro, Éimhín; Grobbee, Diederick E; Perel, Pablo (Elsevier Science & Technology, 2020-08-19)

Highlights: - Despite clinical evidence of its effectiveness in secondary prevention of cardiovascular disease, uptake of fixed dose combination therapy (FDCs) for CVD has been poor.- A symposium was held bringing together ...
Alcohol consumption patterns across Europe and adherence to the European guidelines in coronary patients: Findings from the ESC-EORP EUROASPIRE V survey

van de Luitgaarden, Inge A T; Schrieks, Ilse C; De Bacquer, Dirk; van Oort, Sabine; Mirrakhimov, Erkin M; Pogosova, Nana; Davletov, Kairat; Dolzhenko, Maryna; van Ballegooijen, Adriana J; Kotseva, Kornelia; Grobbee, Diederick E; Beulens, Joline W J; EUROASPIRE V investigators group (Elsevier, 2020-11)

BACKGROUND AND AIMS: Alcohol consumption is an important risk factor for cardiovascular morbidity and mortality worldwide. The highest levels of alcohol consumption are observed in Europe, where alcohol as contributing ...
Association of Cardiovascular Risk Factors and Lifestyle Behaviors With Hypertension: A Mendelian Randomization Study

van Oort, Sabine; Beulens, Joline W J; van Ballegooijen, Adriana J; Grobbee, Diederick E; Larsson, Susanna C (Lippincott Williams & Wilkins, 2020-12)

Hypertension is a major risk factor for cardiovascular disease and mortality. To identify targets for the prevention of hypertension and its associated disease burden, we used the 2-sample Mendelian randomization method ...
The ESC Global Affairs Committee (2018–20): Tackling cardiovascular disease worldwide

Grobbee, Diederick E. (Oxford University Press, 2020-12-01)
Age-specific vaccination coverage estimates for influenza, human papillomavirus and measles containing vaccines from seven population-based healthcare databases from four EU countries - The ADVANCE project

Braeye, Toon; Emborg, Hanne-Dorthe; Llorente-García, Ana; Huerta, Consuelo; Martín-Merino, Elisa; Duarte-Salles, Talita; Danieli, Giorgia; Tramontan, Lara; Weibel, Daniel; McGee, Chris; Villa, Marco; Gini, Rosa; Lehtinen, Matti; Titievsky, Lina; Sturkenboom, Miriam (Elsevier, 2020-04-03)

BACKGROUND: The Accelerated Development of VAccine beNefit-risk Collaboration in Europe (ADVANCE) is a public-private collaboration aiming to develop and test a system for rapid benefit-risk monitoring of vaccines using ...
Multinational cohort study of mortality in patients with asthma and severe asthma

Engelkes, Marjolein; de Ridder, Maria Aj; Svensson, Elisabeth; Berencsi, Klara; Prieto-Alhambra, Daniel; Lapi, Francesco; Giaquinto, Carlo; Picelli, Gino; Boudiaf, Nada; Albers, Frank C; Cockle, Sarah M; Bradford, Eric S; Suruki, Robert Y; Brusselle, Guy Go; Rijnbeek, Peter R; Sturkenboom, Miriam Cjm; Verhamme, Katia Mc (W.B. Saunders Ltd, 2020-04-01)

BACKGROUND: Data on the risk of death following an asthma exacerbation are scarce. With this multinational cohort study, we assessed all-cause mortality rates, mortality rates following an exacerbation, and patient ...
Different Strategies to Execute Multi-Database Studies for Medicines Surveillance in Real-World Setting: A Reflection on the European Model

Working Group 3 of ENCePP (Inventory of EU data sources and methodological approaches for multisource studies) (Wiley-Blackwell, 2020-08-01)

Although postmarketing studies conducted in population-based databases often contain information on patients in the order of millions, they can still be underpowered if outcomes or exposure of interest is rare, or the ...
'Use of antipsychotics in children and adolescents: a picture from the ARITMO population-based European cohort study'

Kaguelidou, Florentia; Holstiege, Jakob; Schink, Tania; Bezemer, Irene; Poluzzi, Elisabetta; Mazzaglia, Giampiero; Pedersen, Lars; Sturkenboom, Miriam; Trifirò, Gianluca (Cambridge University Press, 2020-04-20)

AimsPrevalence of the use of antipsychotics (APs) in the paediatric population is globally increasing. The aim of this study was to describe multinational trends and patterns in AP use in children and adolescents in ...
Comparative cardiovascular safety of strontium ranelate and bisphosphonates: a multi-database study in 5 EU countries by the EU-ADR Alliance

Ali, M S; Berencsi, K; Marinier, K; Deltour, N; Perez-Guthann, S; Pedersen, L; Rijnbeek, P; Lapi, F; Simonetti, M; Reyes, C; Van der Lei, J; Sturkenboom, M; Prieto-Alhambra, D (Springer Science and Business Media Deutschland GmbH, 2020-12)

Summary: Strontium ranelate use, compared with oral bisphosphonates, is not associated with increased risk of AMI in patients with no contraindications for SR use. However, current strontium ranelate (compared with current ...
Blockchain technology applications to postmarket surveillance of medical devices

Pane, Josep; Verhamme, Katia M C; Shrum, Lacey; Rebollo, Irene; Sturkenboom, Miriam C J M (Taylor and Francis Ltd., 2020-10-02)

INTRODUCTION: The amount of mandatory data that needs to be analyzed as part of a medical device postmarket surveillance (PMS) system has grown exponentially in recent times. This is a consequence of increasingly demanding ...
Age-related natural fertility outcomes in women over 35 years: a systematic review and individual participant data meta-analysis

Chua, S J; Danhof, N A; Mochtar, M H; van Wely, M; McLernon, D J; Custers, I; Lee, E; Dreyer, K; Cahill, D J; Gillett, W R; Righarts, A; Strandell, A; Rantsi, T; Schmidt, L; Eijkemans, M J C; Mol, B W J; van Eekelen, R (Oxford University Press, 2020-08-01)

STUDY QUESTION: What is the rate of natural conception leading to ongoing pregnancy or livebirth over 6-12 months for infertile women of age ≥35 years? SUMMARY ANSWER: Natural conception rates were still clinically relevant ...
A framework for assessing neuropsychiatric phenotypes by using smartphone-based location data

Jongs, Niels; Jagesar, Raj; van Haren, Neeltje E M; Penninx, Brenda W J H; Reus, Lianne; Visser, Pieter J; van der Wee, Nic J A; Koning, Ina M; Arango, Celso; Sommer, Iris E C; Eijkemans, Marinus J C; Vorstman, Jacob A; Kas, Martien J (Nature Publishing Group, 2020-12-01)

The use of smartphone-based location data to quantify behavior longitudinally and passively is rapidly gaining traction in neuropsychiatric research. However, a standardized and validated preprocessing framework for deriving ...
Cost-effectiveness of medically assisted reproduction or expectant management for unexplained subfertility: when to start treatment?

van Eekelen, R; Eijkemans, M J; Mochtar, M; Mol, F; Mol, B W; Groen, H; van Wely, M (Oxford University Press, 2020-09-02)

STUDY QUESTION: Over a time period of 3 years, which order of expectant management (EM), IUI with ovarian stimulation (IUI-OS) and IVF is the most cost-effective for couples with unexplained subfertility with the female ...

Now showing items 3721-3740 of 40729