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UMC Repository: Recent submissions

  • Non-dispensing pharmacist integrated in the primary care team: effect on the quality of physician’s prescribing, a non-randomised comparative study 
    Sloeserwij, Vivianne M.; Zwart, Dorien L.M.; Hazen, Ankie C.M.; Poldervaart, Judith M.; Leendertse, Anne J.; de Bont, Antoinette A.; Bouvy, Marcel L.; de Wit, Niek J.; de Gier, Han J. (Springer Netherlands, 2020-10-01)
    Background Especially in elderly with polypharmacy, medication can do harm. Clinical pharmacists integrated in primary care teams might improve quality of pharmaceutical care. Objective To assess the effect of non-dispensing ...
  • Meningen dokter en patiënt over onnodige vitaminebepalingen 
    Hofstede, Hetty; van der Burg, Rosalie; Mulder, Bob; Bohnen, Arthur; Bindels, Patrick; de Wit, Niek; van Vugt, S. F.; de Schepper, E. I.T. (Bohn Stafleu van Loghum, 2020-11-01)
  • High variability in implementation of selective-prevention services for cardiometabolic diseases in five european primary care settings 
    Lionis, Christos; Anastasaki, Marilena; Bertsias, Antonios; Angelaki, Agapi; Carlsson, Axel C.; Gudjonsdottir, Hrafnhildur; Wändell, Per; Sonderlund, Anders Larrabee; Thilsing, Trine; Søndergaard, Jens; Seifert, Bohumil; Kral, Norbert; De Wit, Niek J.; Hollander, Monika; Korevaar, Joke; Schellevis, François (Multidisciplinary Digital Publishing Institute (MDPI), 2020-12-04)
    (1) Background: Cardiometabolic diseases are the most common cause of death worldwide. As part of a collaborative European study, this paper aims to explore the implementation of primary care selective-prevention services ...
  • Prevalence and Prognostic Impact of Pathogenic Variants in Patients With Dilated Cardiomyopathy Referred for Ventricular Tachycardia Ablation 
    Ebert, Micaela; Wijnmaalen, Adrianus P.; de Riva, Marta; Trines, Serge A.; Androulakis, Alexander F.A.; Glashan, Claire A.; Schalij, Martin J.; Peter van Tintelen, J.; Jongbloed, Jan D.H.; Zeppenfeld, Katja (Elsevier, 2020-09)
    Objectives: This study aimed to assess the frequency of (likely) pathogenic variants (LP/Pv) among dilated cardiomyopathy (DCM) ventricular tachycardia (VT) patients referred for CA and their impact on procedural outcome ...
  • World Endoscopy Organization Consensus Statements on Post-Colonoscopy and Post-Imaging Colorectal Cancer 
    Rutter, Matthew D.; Beintaris, Iosif; Valori, Roland; Chiu, Han Mo; Corley, Douglas A.; Cuatrecasas, Miriam; Dekker, Evelien; Forsberg, Anna; Gore-Booth, Jola; Haug, Ulrike; Kaminski, Michal F.; Matsuda, Takahisa; Meijer, Gerrit A.; Morris, Eva; Plumb, Andrew A.; Rabeneck, Linda; Robertson, Douglas J.; Schoen, Robert E.; Singh, Harminder; Tinmouth, Jill; Young, Graeme P.; Sanduleanu, Silvia (W.B. Saunders, 2018-09)
    Background & Aims: Colonoscopy examination does not always detect colorectal cancer (CRC)— some patients develop CRC after negative findings from an examination. When this occurs before the next recommended examination, ...
  • Luminal A versus luminal B breast cancer: MammaTyper mRNA versus immunohistochemical subtyping with an emphasis on standardised Ki67 labelling-based or mitotic activity index-based proliferation assessment 
    Finsterbusch, Kai; Decker, Thomas; van Diest, Paul J.; Focke, Cornelia M. (Wiley-Blackwell, 2020-04-01)
    Aims: Proliferation assessment by the use of Ki67 is a crucial component in intrinsic subtyping of luminal breast cancers (BCs), but suffers from variability between laboratories, observers, and methods. MammaTyper is a ...
  • Nanobody-targeted photodynamic therapy induces significant tumor regression of trastuzumab-resistant HER2-positive breast cancer, after a single treatment session 
    Deken, Marion M.; Kijanka, Marta M.; Beltrán Hernández, Irati; Slooter, Maxime D.; de Bruijn, Henriette S.; van Diest, Paul J.; van Bergen en Henegouwen, Paul M.P.; Lowik, Clemens W.G.M.; Robinson, Dominic J.; Vahrmeijer, Alexander L.; Oliveira, Sabrina (Elsevier, 2020-07-10)
    Rationale: A substantial number of breast cancer patients with an overexpression of the human epidermal growth factor receptor 2 (HER2) have residual disease after neoadjuvant therapy or become resistant to trastuzumab. ...
  • USP6-Associated Neoplasms: A Rapidly Expanding Family of Lesions 
    Hiemcke-Jiwa, Laura S.; van Gorp, Joost M.; Fisher, Cyril; Creytens, David; van Diest, Paul J.; Flucke, Uta (SAGE Publications Inc., 2020-12-01)
    Nearly 20 years ago, the first description of a translocation involving chromosome 17 on which USP6 resides was described. Since then, not only the culprit gene but also many fusion partners, leading to transcriptional ...
  • Breast Cancer and Major Deviations of Genetic and Gender-related Structures and Function 
    Coelingh Bennink, Herjan J.T.; Egberts, Jan F.M.; Mol, Jan A.; Roes, Kit C.B.; van Diest, Paul J. (Endocrine Society, 2020-09-01)
    We have searched the literature for information on the risk of breast cancer (BC) in relation to gender, breast development, and gonadal function in the following 8 populations: 1) females with the Turner syndrome (45, ...
  • The 2019 World Health Organization classification of tumours of the breast 
    Tan, Puay Hoon; Ellis, Ian; Allison, Kimberly; Brogi, Edi; Fox, Stephen B.; Lakhani, Sunil; Lazar, Alexander J.; Morris, Elizabeth A.; Sahin, Aysegul; Salgado, Roberto; Sapino, Anna; Sasano, Hironobu; Schnitt, Stuart; Sotiriou, Christos; van Diest, Paul; White, Valerie A.; Lokuhetty, Dilani; Cree, Ian A. (Wiley-Blackwell, 2020-08-01)
  • Prognostic value of histopathological DCIS features in a large-scale international interrater reliability study 
    Grand Challenge PRECISION consortium (Springer New York, 2020-10-01)
    Purpose: For optimal management of ductal carcinoma in situ (DCIS), reproducible histopathological assessment is essential to distinguish low-risk from high-risk DCIS. Therefore, we analyzed interrater reliability of ...
  • Long-term safety and sustained efficacy for up to 5 years of treatment with recombinant factor IX Fc fusion protein in subjects with haemophilia B: Results from the B-YOND extension study 
    Pasi, K. John; Fischer, Kathelijn; Ragni, Margaret; Kulkarni, Roshni; Ozelo, Margareth C.; Mahlangu, Johnny; Shapiro, Amy; P’Ng, Stephanie; Chambost, Hervé; Nolan, Beatrice; Bennett, Carolyn; Matsushita, Tadashi; Winding, Bent; Fruebis, Joachim; Yuan, Huixing; Rudin, Dan; Oldenburg, Johannes (Wiley-Blackwell, 2020-11)
    Introduction: Recombinant factor IX Fc fusion protein (rFIXFc) has demonstrated efficacy for treatment of haemophilia B in the Phase 3 B-LONG and Kids B-LONG studies. However, long-term rFIXFc safety and efficacy data have ...
  • Immunological Outcomes of Allergen-Specific Immunotherapy in Food Allergy 
    Core Outcome Measures for Food Allergy (COMFA) consortium (Frontiers Media S. A., 2020-11-03)
    IgE-mediated food allergies are caused by adverse immunologic responses to food proteins. Allergic reactions may present locally in different tissues such as skin, gastrointestinal and respiratory tract and may result is ...
  • Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 
    Zhang, Qian; Bastard, Paul; Liu, Zhiyong; Le Pen, Jérémie; Moncada-Velez, Marcela; Chen, Jie; Ogishi, Masato; Sabli, Ira K D; Hodeib, Stephanie; Korol, Cecilia; Rosain, Jérémie; Bilguvar, Kaya; Ye, Junqiang; Bolze, Alexandre; Bigio, Benedetta; Yang, Rui; Arias, Andrés Augusto; Zhou, Qinhua; Zhang, Yu; Onodi, Fanny; Korniotis, Sarantis; Karpf, Léa; Philippot, Quentin; Chbihi, Marwa; Bonnet-Madin, Lucie; Dorgham, Karim; Smith, Nikaïa; Schneider, William M; Razooky, Brandon S; Hoffmann, Hans-Heinrich; Michailidis, Eleftherios; Moens, Leen; Han, Ji Eun; Lorenzo, Lazaro; Bizien, Lucy; Meade, Philip; Neehus, Anna-Lena; Ugurbil, Aileen Camille; Corneau, Aurélien; Kerner, Gaspard; Zhang, Peng; Rapaport, Franck; Seeleuthner, Yoann; Manry, Jeremy; Masson, Cecile; Schmitt, Yohann; Schlüter, Agatha; Le Voyer, Tom; Khan, Taushif; Spaan, András N; COVID-STORM Clinicians; Bruijning-Verhagen, P. (American Association for the Advancement of Science, 2020-10-23)
    Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants ...
  • Autoantibodies against type I IFNs in patients with life-threatening COVID-19 
    Bastard, Paul; Rosen, Lindsey B; Zhang, Qian; Michailidis, Eleftherios; Hoffmann, Hans-Heinrich; Zhang, Yu; Dorgham, Karim; Philippot, Quentin; Rosain, Jérémie; Béziat, Vivien; Manry, Jérémy; Shaw, Elana; Haljasmägi, Liis; Peterson, Pärt; Lorenzo, Lazaro; Bizien, Lucy; Trouillet-Assant, Sophie; Dobbs, Kerry; de Jesus, Adriana Almeida; Belot, Alexandre; Kallaste, Anne; Catherinot, Emilie; Tandjaoui-Lambiotte, Yacine; Le Pen, Jeremie; Kerner, Gaspard; Bigio, Benedetta; Seeleuthner, Yoann; Yang, Rui; Bolze, Alexandre; Spaan, András N; Delmonte, Ottavia M; Abers, Michael S; Aiuti, Alessandro; Casari, Giorgio; Lampasona, Vito; Piemonti, Lorenzo; Ciceri, Fabio; Bilguvar, Kaya; Lifton, Richard P; Vasse, Marc; Smadja, David M; Migaud, Mélanie; Hadjadj, Jérome; Terrier, Benjamin; Duffy, Darragh; Quintana-Murci, Lluis; van de Beek, Diederik; Roussel, Lucie; Vinh, Donald C; Tangye, Stuart G; HGID Lab; Bruijning-Verhagen, P. (American Association for the Advancement of Science, 2020-10-23)
    Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease ...
  • Antibodies against ARHGDIB and ARHGDIB gene expression associate with kidney allograft outcome 
    Senev, Aleksandar; Senev, Aleksandar; Otten, Henny G.; Kamburova, Elena G.; Callemeyn, Jasper; Lerut, Evelyne; Van Sandt, Vicky; Kuypers, Dirk; Kuypers, Dirk; Emonds, Marie Paule; Emonds, Marie Paule; Naesens, Maarten; Naesens, Maarten (Lippincott Williams & Wilkins, 2020-07)
    Background. The impact of donor-specific anti-HLA antibodies (DSA) on antibody-mediated rejection (AMR) and kidney allograft failure is well established. However, the relevance of non-HLA antibodies remains unclear. Methods. ...
  • CD38-targeted therapy with daratumumab reduces autoantibody levels in multiple myeloma patients 
    Frerichs, Kristine A.; Verkleij, Christie P.M.; Bosman, Patricia W.C.; Zweegman, Sonja; Otten, Henny; van de Donk, Niels W.C.J. (Elsevier, 2019-12)
    Autoantibody-producing plasma cells are frequently resistant to conventional immunosuppressive treatments and B-cell depletion therapy. As a result of this resistance, autoreactive plasma cells survive conventional therapy, ...
  • A Review on the Function and Regulation of ARHGDIB/RhoGDI2 Expression including the Hypothetical Role of ARHGDIB/RhoGDI2 Autoantibodies in Kidney Transplantation 
    Kardol-Hoefnagel, Tineke; Van Logtestijn, Sofie A.L.M.; Otten, Henny G. (Wolters Kluwer Health, 2020-05)
    Challenging and still unsolved problems in kidney transplantation are risk stratification and the treatment of humoral rejection. Antibody-mediated rejection is an important cause of early and chronic rejection. The impact ...
  • Phenome-wide and genome-wide analyses of quality of life in schizophrenia 
    GROUP Investigators (Cambridge University Press, 2020-12-09)
    BACKGROUND: Schizophrenia negatively affects quality of life (QoL). A handful of variables from small studies have been reported to influence QoL in patients with schizophrenia, but a study comprehensively dissecting the ...
  • The Young Community of the European Association of Preventive Cardiology: The future in motion 
    D’Ascenzi, Flavio; Adami, Paolo Emilio; Eichler, Sarah; Castelletti, Silvia; Wagenaar, Kim P.; Pelliccia, Antonio; Dendale, Paul; Grobbee, Diederick E. (Oxford University Press, 2018-04-01)