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UMC Repository: Recent submissions

  • Smoking is Associated with Higher Disease-related Costs and Lower Health-related Quality of Life in Inflammatory Bowel Disease 
    Severs, M.; Mangen, M. J.J.; van der Valk, M. E.; Fidder, H. H.; Dijkstra, G.; van der Have, M.; Van Bodegraven, Ad A.; de Jong, J.; van der Woude, C Janneke; Romberg-Camps, Mariëlle J L; Clemens, C. H. M.; Jansen, J. M.; van de Meeberg, Paul C; Mahmmod, N.; Ponsioen, Cyriel Y; Vermeijden, Jacob R.; Van der Meulen-de Jong, Andrea E; Pierik, M.; Siersema, P. D.; Oldenburg, B.; COIN study group and the Dutch Initiative on Crohn and Colitis (Elsevier, 2017-03-01)
    Background and Aims: Smoking affects the course of inflammatory bowel disease [IBD]. We aimed to study the impact of smoking on IBD-specific costs and health-related quality-of-life [HrQoL] among adults with Crohn's disease ...
  • Paediatric Drug Development and Formulation Design—a European Perspective 
    van Riet-Nales, Diana A.; Kozarewicz, Piotr; Aylward, Brian; de Vries, Rutger; Egberts, Toine C G; Rademaker, Carin M A; Schobben, Alfred F A M (American Association of Pharmaceutical Scientists, 2017-02)
    The availability of licensed paediatric drugs is lagging behind those for adults, and there is a lack of safe formulations in suitable doses that children are able and willing to take. As a consequence, children are commonly ...
  • C9orf72 expansion differentially affects males with spinal onset amyotrophic lateral sclerosis 
    Rooney, James; Fogh, Isabella; Westeneng, Henk Jan; Vajda, Alice; McLaughlin, Russell; Heverin, Mark; Jones, Ashley; Van Eijk, Ruben; Calvo, Andrea; Mazzini, Letizia; Shaw, Christopher E; Morrison, Karen E; Shaw, Pamela J; Robberecht, Wim; Van Damme, Phillip; Al-Chalabi, Ammar; Van Den Berg, Leonard; Chiò, Adriano; Veldink, Jan; Hardiman, Orla (BMJ Publishing Group, 2017-04-01)
    Introduction: The C9orf72 repeat expansion has been reported as a negative prognostic factor in amyotrophic lateral sclerosis (ALS). We have examined the prognostic impact of the C9orf72 repeat expansion in European subgroups ...
  • Comparing fracture healing disorders and long-term functional outcome of polytrauma patients and patients with an isolated displaced midshaft clavicle fracture 
    Ferree, Steven; Hietbrink, Falco; van der Meijden, Olivier A J; Verleisdonk, Egbert Jan M M; Leenen, Luke P.H.; Houwert, Roderick M. (Mosby Inc., 2017-01-01)
    Background Although clavicle fractures are a common injury in polytrauma patients, the functional outcome of displaced midshaft clavicle fractures (DMCFs) in this population is unknown. Our hypothesis was that there would ...
  • The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction 
    Van Hout, Gerardus P.J.; Bosch, Lena; Ellenbroek, Guilielmus H.J.M.; De Haan, Judith J.; Van Solinge, Wouter W.; Cooper, Matthew A; Arslan, Fatih; De Jager, Saskia C.A.; Robertson, Avril A B; Pasterkamp, Gerard; Hoefer, Imo E. (Oxford University Press, 2017)
    Aims Myocardial infarction (MI) triggers an intense inflammatory response that is associated with infarct expansion and is detrimental for cardiac function. Interleukin (IL)-1b and IL-18 are key players in this response ...
  • Forebrain glutamatergic, but not GABAergic, neurons mediate anxiogenic effects of the glucocorticoid receptor 
    Hartmann, J.; Dedic, N.; Pöhlmann, M. L.; Häusl, A.; Karst, H.; Engelhardt, C.; Westerholz, S.; Wagner, K. V.; Labermaier, C.; Hoeijmakers, L.; Kertokarijo, M.; Chen, A.; Joëls, M.; Deussing, J. M.; Schmidt, M. V. (Springer Nature, 2017)
    Anxiety disorders constitute a major disease and social burden worldwide; however, many questions concerning the underlying molecular mechanisms still remain open. Besides the involvement of the major excitatory (glutamate) ...
  • Amide proton transfer (APT) imaging of brain tumors at 7 T: The role of tissue water T1 -Relaxation properties 
    Khlebnikov, V; Polders, Daniel; Hendrikse, J; Robe, Pierre A.; Voormolen, Eduard H; Luijten, Peter R; Klomp, DWJ; Hoogduin, Hans (John Wiley & Sons Inc., 2017-04)
    Purpose: To provide insight into the effect of water T 1 relaxation (T 1wat) on amide proton transfer (APT) contrast in tumors. Three different metrics of APT contrast—magnetization transfer ratio (MTR Rex), relaxation-compensated ...
  • Cost-effectiveness of implant-supported mandibular removable partial dentures 
    Jensen, Charlotte; Ross, JN; feenstra, Talitha; Raghoebar, G.M.; Speksnijder, CM; Meijer, Henny; Cune, Marco (Blackwell Munksgaard, 2017-05)
    Objectives: The aim of this study was to conduct a cost-effectiveness analysis comparing conventional removable partial dentures (RPDs) and implant-supported RPDs (ISRPDs) treatment in patients with an edentulous maxilla ...
  • FKBP5 modulates the hippocampal connectivity deficits in depression: a study in twins 
    Córdova-Palomera, Aldo; de Reus, Marcel A.; Fatjó-Vilas, Mar; Falcón, Carles; Bargalló, Nuria; van Den Heuvel, Martijn P.; Fañanás, Lourdes (Springer New York, 2017-02)
    The hippocampus is a key modulator of stress responses underlying depressive behavior. While FKBP5 has been found associated with a large number of stress-related outcomes and hippocampal features, its potential role in ...
  • Long-term outcome of transvenous pacemaker implantation in infants: A retrospective cohort study 
    Vos, Laura M.; Kammeraad, Janneke A.E.; Freund, Matthias W.; Blank, Andreas C.; Breur, Johannes M.P.J. (Oxford University Press, 2017-04-01)
    Aim Evaluation of long-term outcome of transvenous pacemaker (PM) implantation in infants. Methods and results A retrospective analysis of all transvenous PM implantations in infants <10kg between September 1997 and October ...
  • In the aftermath of trauma: Marks of stress-related psychopathology 
    Schür, RR (Utrecht University, 2017-08-31)
    In this thesis we investigated (traumatic) stress and psychopathology with a focus on the potential roles of the hypothalamus-pituitary-adrenal (HPA) axis, the GABA system, their association, and the general genetic ...
  • Mending broken hearts: Cardiac regeneration in zebrafish 
    Kruse, F.K. (Utrecht University, 2017-08-31)
    Cardiovascular disease is the leading global cause of death, accounting for more than 30% of all deaths. It claims more lives than all forms of cancer combined. Bearing these facts in mind, research in this field is direly ...
  • Portal vein ligation versus portal vein embolization for induction of hypertrophy of the future liver remnant: A systematic review and meta-analysis 
    Isfordink, C J; Samim, M; Braat, M N G J A; Almalki, A M; Hagendoorn, J; Borel Rinkes, I H M; Molenaar, I Q (Elsevier Limited, 2017-09)
    An important risk of major hepatic resection is postoperative liver failure, which is directly related to insufficient future liver remnant (FLR). Portal vein embolization (PVE) and portal vein ligation (PVL) can minimize ...
  • Sequencing of DICER1 in sarcomas identifies biallelic somatic DICER1 mutations in an adult-onset embryonal rhabdomyosarcoma 
    de Kock, Leanne; Rivera, Barbara; Revil, Timothée; Thorner, Paul; Goudie, Catherine; Bouron-Dal Soglio, Dorothée; Choong, Catherine S.; Priest, John R.; Van Diest, Paul J.; Tanboon, Jantima; Wagner, Anja; Ragoussis, Jiannis; Choong, Peter F.M.; Foulkes, William D (Springer Nature, 2017-06-06)
    Background:Sarcomas are rare and heterogeneous cancers. We assessed the contribution of DICER1 mutations to sarcoma development.Methods:The coding region of DICER1 was sequenced in 67 sarcomas using a custom Fluidigm Access ...
  • Neurodevelopment: Lineage-dependent spatial and functional organization of the mammalian enteric nervous system 
    Lasrado, Reena; Boesmans, Werend; Kleinjung, Jens; Pin, Carmen; Bell, Donald; Bhaw, Leena; McCallum, Sarah; Zong, Hui; Luo, Liqun; Clevers, Hans; Vanden Berghe, Pieter; Pachnis, Vassilis (American Association for the Advancement of Science, 2017-05-19)
    The enteric nervous system(ENS) is essential for digestive function and gut homeostasis. Here we show that the amorphous neuroglia networks of the mouse ENS are composed of overlapping clonal units founded by postmigratory ...
  • Small chromosomal regions position themselves autonomously according to their chromatin class 
    Van De Werken, Harmen J.G.; Haan, Josien C.; Feodorova, Yana; Bijos, Dominika; Weuts, An; Theunis, Koen; Holwerda, Sjoerd J.B.; Meuleman, Wouter; Pagie, Ludo; Thanisch, Katharina; Kumar, Parveen; Leonhardt, Heinrich; Marynen, Peter; van Steensel, Bas; Voet, Thierry; De Laat, Wouter; Solovei, Irina; Joffe, Boris (Cold Spring Harbor Laboratory Press, 2017-06-01)
    The spatial arrangement of chromatin is linked to the regulation of nuclear processes. One striking aspect of nuclear organization is the spatial segregation of heterochromatic and euchromatic domains. The mechanisms of ...
  • Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities 
    Nusse, Roel; Clevers, Hans (Elsevier, 2017-06-01)
    The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway ...
  • Upright, prone, and supine spinal morphology and alignment in adolescent idiopathic scoliosis 
    Brink, Rob C; Colo, Dino; Schlösser, Tom P C; Vincken, Koen L; van Stralen, Marijn; Hui, Steve C N; Shi, Lin; Chu, Winnie C W; Cheng, Jack C Y; Castelein, RM (BioMed Central, 2017-02-22)
    Background: Patients with adolescent idiopathic scoliosis (AIS) are usually investigated by serial imaging studies during the course of treatment, some imaging involves ionizing radiation, and the radiation doses are ...
  • Antenatal coffee and tea consumption and the effect on birth outcome and hypertensive pregnancy disorders 
    Van Der Hoeven, Timothy; Browne, Joyce L.; Uiterwaal, Cuno S.P.M.; Van Der Ent, Cornelis K.; Grobbee, Diederick E.; Dalmeijer, Geertje W. (Public Library of Science, 2017-05-01)
    Background and objective: Coffee and tea are commonly consumed during pregnancy. While several of their components, like caffeine, have strong pharmacological effects, the effect on the unborn fetus remains unclear. Caffeine ...
  • Growth condition dependency is the major cause of non-responsiveness upon genetic perturbation 
    Amini, Saman; Holstege, Frank C P; Kemmeren, Patrick (Public Library of Science, 2017-03-01)
    Investigating the role and interplay between individual proteins in biological processes is often performed by assessing the functional consequences of gene inactivation or removal. Depending on the sensitivity of the assay ...