Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

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Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
 
Nusse, Roel; Clevers, Hans
(2017) Cell, volume 169, issue 6, pp. 985 - 999
(Article)
Abstract
The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin ... read more
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Keywords: cancer, development, stem cells, therapy, Wnt, General Biochemistry,Genetics and Molecular Biology, Journal Article, Review
DOI: https://doi.org/10.1016/j.cell.2017.05.016
ISSN: 0092-8674
Publisher: Cell Press
Note: Funding Information: We thank Dr. Vivian Li for contributions to the figures. The authors are supported by the Howard Hughes Medical Institute (R.N.), the European Union, and the Cancer Genomics.nl program (H.C.). Publisher Copyright: © 2017 Elsevier Inc.
(Peer reviewed)