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UMC Repository: Recent submissions

  • The preventive effect of the bounding exercise programme on hamstring injuries in amateur soccer players: The design of a randomized controlled trial 
    Van De Hoef, S.; Huisstede, B. M.A.; Brink, M. S.; de Vries, N.; Goedhart, Edwin A.; Backx, F. J.G. (BioMed Central, 2017-08-22)
    Background: Hamstring injuries are the most common muscle injury in amateur and professional soccer. Most hamstring injuries occur in the late swing phase, when the hamstring undergoes a stretch-shortening cycle and the ...
  • Measured adiposity in relation to head and neck cancer risk in the European prospective investigation into cancer and nutrition 
    Ward, Heather A.; Wark, Petra A.; Muller, David C.; Steffen, Annika; Johansson, Mattias; Norat, Teresa; Gunter, Marc J.; Overvad, Kim; Dahm, Christina C.; Halkjær, Jytte; Tjønneland, Anne; Boutron-Ruault, Marie Christine; Fagherazzi, Guy; Mesrine, Sylvie; Brennan, Paul; Freisling, Heinz; Li, Kuanrong; Kaaks, Rudolf; Trichopoulou, Antonia; Lagiou, Pagona; Panico, Salavatore; Grioni, Sara; Tumino, Rosario; Vineis, Paolo; Palli, Domenico; Peeters, Petra H.M.; Bueno-De-Mesquita, H. Bas; Weiderpass, Elisabete; Agudo, Antonio; Quiros, Jose Ramon; Larranaga, Nerea; Ardanaz, Eva; Huerta, Jose María; Sanchez, María Jose; Laurell, Goran; Johansson, Ingegerd; Westin, Ulla; Wallstrom, Peter; Bradbury, Kathryn E.; Wareham, Nicholas J.; Khaw, Kay Tee; Pearson, Clare; Boeing, Heiner; Riboli, Elio (American Association for Cancer Research Inc., 2017-06-01)
    Background: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer. However, most studies have used self-reported anthropometry which is prone to error. ...
  • Consumption of fish is not associated with risk of differentiated thyroid carcinoma in the European prospective investigation into cancer and nutrition (EPIC) study 
    Zamora-Ros, Raul; Castañeda, Jazmín; Rinaldi, Sabina; Cayssials, Valerie; Slimani, Nadia; Weiderpass, Elisabete; Tsilidis, Konstantinos K.; Boutron-Ruault, Marie Christine; Overvad, Kim; Eriksen, Anne K.; Tjønneland, Anne; Kühn, Tilman; Katzke, Verena; Boeing, Heiner; Trichopoulou, Antonia; La Vecchia, Carlo; Kotanidou, Anastasia; Palli, Domenico; Grioni, Sara; Mattiello, Amalia; Tumino, Rosario; Sciannameo, Veronica; Lund, Eiliv; Merino, Susana; Salamanca-Fernández, Elena; Amiano, Pilar; Huerta, José María; Barricarte, Aurelio; Ericson, Ulrika; Almquist, Martin; Hennings, Joakim; Sandström, Maria; Bueno-de-Mesquita, H. Bas; Peeters, Petra H.; Khaw, Kay Tee; Wareham, Nicholas J.; Schmidt, Julie A.; Cross, Amanda J.; Riboli, Elio; Scalbert, Augustin; Romieu, Isabelle; Agudo, Antonio; Franceschi, Silvia (Elsevier, 2017-07-01)
    Background: Differentiated thyroid cancer (TC) is the most common endocrine cancer. Fish can be an important source of iodine and other micronutrients and contaminants that may affect the thyroid gland and TC risk. Objective: ...
  • Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study 
    Duell, Eric J.; Lujan-Barroso, Leila; Sala, Núria; Deitz McElyea, Samantha; Overvad, Kim; Tjonneland, Anne; Olsen, Anja; Weiderpass, Elisabete; Busund, Lill Tove; Moi, Line; Muller, David C.; Vineis, Paolo; Aune, Dagfinn; Matullo, Giuseppe; Naccarati, Alessio; Panico, Salvatore; Tagliabue, Giovanna; Tumino, Rosario; Palli, Domenico; Kaaks, Rudolf; Katzke, Verena A.; Boeing, Heiner; Bueno-de-Mesquita, H. Bas; Peeters, Petra H.; Trichopoulou, Antonia; Lagiou, Pagona; Kotanidou, Anastasia; Travis, Ruth C.; Wareham, Nick; Khaw, Kay Tee; Ramon Quiros, Jose; Rodríguez-Barranco, Miguel; Dorronsoro, Miren; Chirlaque, María Dolores; Ardanaz, Eva; Severi, Gianluca; Boutron-Ruault, Marie Christine; Rebours, Vinciane; Brennan, Paul; Gunter, Marc J.; Scelo, Ghislaine; Cote, Greg; Sherman, Stuart; Korc, Murray (John Wiley & Sons Inc., 2017-09-01)
    Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into ...
  • Hepcidin levels and gastric cancer risk in the EPIC-EurGast study 
    Jakszyn, Paula; Fonseca-Nunes, Ana; Lujan-Barroso, Leila; Aranda, Núria; Tous, Mónica; Arija, Victoria; Cross, Amanda J.; Bueno-de-Mesquita, H. Bas; Weiderpass, Elisabete; Kühn, Tilman; Kaaks, Rudolf; Sjöberg, Klas; Ohlsson, Bodil; Tumino, Rosario; Palli, Domenico; Ricceri, Fulvio; Fasanelli, Francesca; Krogh, Vittorio; Mattiello, Amalia; Jenab, Mazda; Gunter, Marc J.; Perez-Cornago, Aurora; Khaw, Kay Tee; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Trichopoulou, Antonia; Peppa, Eleni; Vasilopoulou, Effie; Boeing, Heiner; Sánchez-Cantalejo, Emilio; Huerta, José María; Dorronsoro, Miren; Barricarte, Aurelio; Quirós, José Maria; Peeters, Petra H.; Agudo, Antonio (John Wiley & Sons Inc., 2017-09-01)
    Hepcidin is the main regulator of iron homeostasis and dysregulation of proteins involved in iron metabolism has been associated with tumorogenesis. However, to date, no epidemiological study has researched the association ...
  • Analysis of 24-h rhythm in ventricular repolarization identifies QT diurnality as a novel clinical parameter associated with previous ventricular arrhythmias in heart failure patients 
    du Pre, Bastiaan C.; van Laake, Linda W.; Meine, Matthias; van der Heijden, Jeroen F.; Doevendans, Pieter A.; vos, Marc A.; van Veen, Toon A.B. (Frontiers Research Foundation, 2017-08-15)
    Introduction: Cardiac repolarization abnormalities are among the major causes of ventricular arrhythmias and sudden cardiac death. In humans, cardiac repolarization duration has a 24-h rhythm. Animal studies show that this ...
  • Eigentumors for prediction of treatment failure in patients with early-stage breast cancer using dynamic contrast-enhanced MRI : a feasibility study 
    Chan, HM; van der Velden, Bas H M; Loo, Claudette E.; Gilhuijs, Kenneth G A (2017)
    We present a radiomics model to discriminate between patients at low risk and those at high risk of treatment failure at long-term follow-up based on eigentumors: principal components computed from volumes encompassing ...
  • Diffusion weighted MRI with minimal distortion in head-and-neck radiotherapy using a turbo spin echo acquisition method 
    Schakel, Tim; Hoogduin, JM; Terhaard, Chris H J; Philippens, Marielle E P (John Wiley & Sons Inc., 2017)
    PURPOSE: Diffusion weighted (DW) MRI, showing high contrast between tumor and background tissue, is a promising technique in radiotherapy for tumor delineation. However, its use for head-and-neck patients is hampered by ...
  • Multi-faceted implementation strategy to increase use of a clinical guideline for the diagnosis of deep venous thrombosis in primary care 
    Kingma, Anna E C; van Stel, Henk F; Oudega, Ruud; Moons, Karel G M; Geersing, Geert-Jan (Oxford University Press, 2017-08-01)
    BACKGROUND: A clinical decision rule (CDR), combined with a negative D-dimer test, can safely rule out deep venous thrombosis (DVT) in primary care. This strategy is recommended by guidelines, yet uptake by GPs is low. ...
  • Translating iterative reconstruction for CT to the clinic 
    den Harder, A.M. (Utrecht University, 2017-10-24)
    Introduction: Increasing numbers of CT examinations has raised concerns about the possible risk of carcinogenesis due to radiation exposure. Therefore, CT examinations should only be performed when there is a proper ...
  • Risk management of patients with atrial fibrillation in general practice 
    van Doorn, S. (Utrecht University, 2017-09-28)
    Atrial fibrillation (AF) is the most common cardiac arrhythmia and poses patients at many risks. In this thesis we address the management of these risks in general practice including the prediction and prevention of ischaemic ...
  • Laparoscopic antireflux surgery and hiatal hernia repair: techniques and outcome 
    Oor, J.E. (Utrecht University, 2017-09-14)
    Gastroesophageal reflux disease (GERD) is the most prevalent benign disorder of the upper gastrointestinal tract. For patients who suffer from PPI-refractory GERD, severe regurgitation or for those who are unwilling to ...
  • The pressure-loaded right ventricle 
    Driessen, M.M.P. (Utrecht University, 2017-09-28)
    Heart failure due to primary failure of the right ventricle is a common cause of morbidity and mortality in patients with pulmonary hypertension and congenital heart disease. Imaging techniques to monitor function of the ...
  • Neuronal subset-specific migration and axonal wiring mechanisms in the developing midbrain dopamine system 
    Brignani, Sara; Pasterkamp, R. J. (Frontiers Research Foundation, 2017-07-10)
    The midbrain dopamine (mDA) system is involved in the control of cognitive and motor behaviors, and is associated with several psychiatric and neurodegenerative diseases. mDA neurons receive diverse afferent inputs and ...
  • Remarkable improvement in mitral valve regurgitation in paediatric eosinophilic granuloma with polyangiitis 
    Van Der Aa, Niek E.; Grotenhuis, Heynric B.; Breur, Hans J M (Cambridge University Press, 2017-10-01)
    We report the case of a 12-year-old boy who presented with acute heart failure due to newly developed mitral valve regurgitation. The boy's history combined with raised levels of inflammatory markers was suggestive of ...
  • Electroencephalographic fractal dimension in healthy ageing and Alzheimer's disease 
    Smits, Fenne Margreeth; Porcaro, Camillo; Cottone, Carlo; Cancelli, Andrea; Rossini, Paolo Maria; Tecchio, Franca (Public Library of Science, 2016-02-01)
    Brain activity is complex; a reflection of its structural and functional organization. Among other measures of complexity, the fractal dimension is emerging as being sensitive to neuronal damage secondary to neurological ...
  • An in vitro model of hemogenic endothelium commitment and hematopoietic production 
    Yvernogeau, Laurent; Gautier, Rodolphe; Khoury, Hanane; Menegatti, Sara; Schmidt, Melanie; Gilles, Jean Francois; Jaffredo, Thierry (Company of Biologists Ltd, 2016-04-15)
    Adult-type hematopoietic stem and progenitor cells are formed during ontogeny from a specialized subset of endothelium, termed the hemogenic endothelium, via an endothelial-to-hematopoietic transition (EHT) that occurs in ...
  • Behandeling van dementie 
    Blom, Kim; Van Den Elsen, Geke A.H.; Koek, H. L.; Sanders, Joost B.; Kruithof, Henk C.; Claassen, Jurgen A H R (Bohn Stafleu van Loghum, 2017)
    • Treatment options for patients with dementia are limited. This article provides an overview of possible interventions, both pharmaceutical and nonpharmaceutical, for Alzheimer's disease, vascular dementia and mixed ...
  • Quality of life as indicator of poor outcome in hemodialysis: relation with mortality in different age groups 
    van Loon, I N; Bots, M L; Boereboom, Frans T J; Grooteman, Muriel P C; Blankestijn, P J; van den Dorpel, Marinus A.; Nubé, Menso J.; ter Wee, Pieter M.; Verhaar, M C; Hamaker, M. E. (BioMed Central, 2017-07-06)
    Background: Physical, cognitive and psychosocial functioning are frequently impaired in dialysis patients and impairment in these domains relates to poor outcome. The aim of this analysis was to compare the prevalence of ...
  • Does renal denervation lower sympathetic activity? 
    Blankestijn, Peter J (Oxford University Press, 2017-08-01)