Measured adiposity in relation to head and neck cancer risk in the European prospective investigation into cancer and nutrition
Ward, Heather A.; Wark, Petra A.; Muller, David C.; Steffen, Annika; Johansson, Mattias; Norat, Teresa; Gunter, Marc J.; Overvad, Kim; Dahm, Christina C.; Halkjær, Jytte; Tjønneland, Anne; Boutron-Ruault, Marie Christine; Fagherazzi, Guy; Mesrine, Sylvie; Brennan, Paul; Freisling, Heinz; Li, Kuanrong; Kaaks, Rudolf; Trichopoulou, Antonia; Lagiou, Pagona; Panico, Salavatore; Grioni, Sara; Tumino, Rosario; Vineis, Paolo; Palli, Domenico; Peeters, Petra H.M.; Bueno-De-Mesquita, H. Bas; Weiderpass, Elisabete; Agudo, Antonio; Quiros, Jose Ramon; Larranaga, Nerea; Ardanaz, Eva; Huerta, Jose María; Sanchez, María Jose; Laurell, Goran; Johansson, Ingegerd; Westin, Ulla; Wallstrom, Peter; Bradbury, Kathryn E.; Wareham, Nicholas J.; Khaw, Kay Tee; Pearson, Clare; Boeing, Heiner; Riboli, Elio
(2017) Cancer Epidemiology Biomarkers & Prevention, volume 26, issue 6, pp. 895 - 904
(Article)
Abstract
Background: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer. However, most studies have used self-reported anthropometry which is prone to error. Methods: Among 363,094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there
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were 837 incident cases of head and neck cancer. Head and neck cancer risk was examined in relation to body mass index (BMI) [lean: <22.5 kg/m2, normal weight (reference): 22.5-24.9 kg/m2, overweight 25-29.9 kg/m2, obese: 30 kg/m2], waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) using Cox proportional hazards models. Results: Among men, a BMI < 22.5 kg/m2 was associated with higher head and neck cancer risk [HR 1.62; 95%confidence interval (CI), 1.23-2.12)];BMIwasnot associated with headandneck cancer among women. WC and WHR were associated with greater risk of head and neck cancer among women (WC per 5 cm:HR, 1.08; 95% CI, 1.02-1.15; WHR per 0.1 unit: HR, 1.64; 95% CI, 1.38-1.93). After stratification by smoking status, the association for WHR was present only among smokers (Pinteraction=0.004). Among men,WC and WHR were associated with head and neck cancer only upon additional adjustment for BMI (WC per 5 cm: HR 1.16; 95% CI, 1.07-1.26; WHR per 0.1 unit: HR, 1.42; 95% CI, 1.21-1.65). Conclusions: Central adiposity, particularly among women, may have a stronger association with head and neck cancer risk than previously estimated. Impact: Strategies to reduce obesity may beneficially impact head and neck cancer incidence.
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Keywords: Epidemiology, Oncology, Journal Article
ISSN: 1055-9965
Publisher: American Association for Cancer Research Inc.
Note: Publisher Copyright: © 2017 American Association for Cancer Research. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.
(Peer reviewed)