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UMC Repository: Recent submissions

  • CCN2 reduction mediates protective effects of BMP7 treatment in obstructive nephropathy 
    Falke, Lucas L.; Leeuwis, Jan Willem; Lyons, Karen M.; Mummery, Christine L.; Nguyen, Tri Q.; Goldschmeding, Roel (Springer Netherlands, 2017-03-01)
    Treatment with rhBMP7 exerts profound protective effects in a wide variety of experimental models of renal disease. However, little is known about how these protective effects are mediated, and which cells in the kidney ...
  • Biofabrication: Reappraising the definition of an evolving field 
    Groll, Jürgen; Boland, Thomas; Blunk, Torsten; Burdick, Jason A.; Cho, Dong Woo; Dalton, Paul D.; Derby, Brian; Forgacs, Gabor; Li, Qing; Mironov, Vladimir A.; Moroni, Lorenzo; Nakamura, Makoto; Shu, Wenmiao; Takeuchi, Shoji; Vozzi, Giovanni; Woodfield, Tim B.F.; Xu, Tao; Yoo, James J.; Malda, Jos (IOP Publishing Ltd., 2016-01-08)
    Biofabrication is an evolving research field that has recently received significant attention. In particular, the adoption of Biofabrication concepts within the field of Tissue Engineering and Regenerative Medicine has ...
  • Extracellular vesicles: New tool for joint repair and regeneration 
    Malda, Jos; Boere, Janneke; van de Lest, Chris H A; van Weeren, P. René; Wauben, Marca H M (Nature Research, 2016-04-01)
    Cell-derived extracellular vesicles (EVs), present in synovial fluid and cartilage extracellular matrix (ECM), are involved in joint development and in the regulation of joint homeostasis. Although the exact function of ...
  • A Step Towards Clinical Translation of Biofabrication 
    Malda, Jos; Groll, Jürgen (Elsevier Limited, 2016-05-01)
  • Cartilage defect repair in horses: Current strategies and recent developments in regenerative medicine of the equine joint with emphasis on the surgical approach 
    Cokelaere, Stefan; Malda, Jos; van Weeren, P. René (Bailliere Tindall Ltd, 2016-08-01)
    Chondral and osteochondral lesions due to injury or other pathology are highly prevalent conditions in horses (and humans) and commonly result in the development of osteoarthritis and progression of joint deterioration. ...
  • Additive Biomanufacturing: An Advanced Approach for Periodontal Tissue Regeneration 
    Carter, Sarah Sophia D.; Costa, Pedro F.; Vaquette, Cedryck; Ivanovski, Saso; Hutmacher, Dietmar W.; Malda, Jos (Springer Netherlands, 2017-01-01)
    Periodontitis is defined as a chronic inflammatory condition, characterized by destruction of the periodontium, composed of hard (i.e. alveolar bone and cementum) and soft tissues (i.e. gingiva and periodontal ligament) ...
  • Additive Manufacturing of Biomaterials, Tissues, and Organs 
    Zadpoor, Amir A; Malda, Jos (Springer Netherlands, 2017-01-01)
    The introduction of additive manufacturing (AM), often referred to as three-dimensional (3D) printing, has initiated what some believe to be a manufacturing revolution, and has expedited the development of the field ...
  • Converging biofabrication and organoid technologies: The next frontier in hepatic and intestinal tissue engineering? 
    Schneeberger, Kerstin; Spee, Bart; Costa, Pedro; Sachs, Norman; Clevers, Hans; Malda, Jos (IOP Publishing Ltd., 2017-03-01)
    Adult tissue stem cells can form self-organizing 3D organoids in vitro. Organoids resemble small units of their organ of origin and have great potential for tissue engineering, as well as models of disease. However, current ...
  • Internet Program for Physical Activity and Exercise Capacity in Children With Juvenile Idiopathic Arthritis: A Multicenter Randomized Controlled Trial 
    Armbrust, Wineke; Bos, G J F Joyce; Wulffraat, Nico M.; van Brussel, Marco; Cappon, Jeannette; Dijkstra, Pieter U; Geertzen, Jan H B; Legger, G. Elizabeth; van Rossum, Marion A. J. J.; Sauer, Pieter J. J.; Lelieveld, Otto T. H. M. (John Wiley & Sons Inc., 2017-07)
    Objective To determine the effects of Rheumates@Work, an internet-based program supplemented with 4 group sessions, aimed at improving physical activity, exercise capacity, health-related quality of life (HRQoL), and ...
  • No benefits of hypothermia in patients treated with hemicraniectomy for large ischemic stroke 
    Schneider, Hauke; Krüger, Philipp; Algra, Ale; Hofmeijer, Jeannette; van der Worp, H. Bart; Jüttler, Eric; Vahedi, Katayoun; Schackert, Gabriele; Reichmann, Heinz; Puetz, Volker (SAGE Publications Ltd, 2017-10-01)
    Background: Space-occupying middle cerebral artery brain infarcts are associated with the development of brain edema, which may lead to cerebral herniation and death despite early hemicraniectomy. Aims: To evaluate the ...
  • Atopic dermatitis characteristics and medication-use patterns in school-age children with AD and asthma symptoms 
    Lee, M.; Arabkhazaeli, Ali; van Erp, F. C.; Raaijmakers, Antonia J A; van der Ent, C. K.; Bruijnzeel-Koomen, C. A.F.M.; de Bruin-Weller, M. S.; Vijverberg, S. J.H.; Maitland-van der Zee, Anke H. (Wiley-Blackwell, 2017-07-01)
    Background: Atopic dermatitis (AD) and asthma often coexist. Both diseases can have a major impact on the lives of children with AD and their caregivers. Aim: To investigate the association of patient characteristics, ...
  • Proportional thresholding in resting-state fMRI functional connectivity networks and consequences for patient-control connectome studies: Issues and recommendations 
    van den Heuvel, Martijn P.; de Lange, Siemon C.; Zalesky, Andrew; Seguin, Caio; Yeo, B T Thomas; Schmidt, Ruben (Academic Press Inc., 2017-05-15)
    Graph theoretical analysis has become an important tool in the examination of brain dysconnectivity in neurological and psychiatric brain disorders. A common analysis step in the construction of the functional graph or ...
  • Whole-brain structural connectivity in dyskinetic cerebral palsy and its association with motor and cognitive function 
    Ballester-Plané, Júlia; Schmidt, Ruben; Laporta-Hoyos, Olga; Junqué, Carme; Vázquez, Élida; Delgado, Ignacio; Zubiaurre-Elorza, Leire; Macaya, Alfons; Póo, Pilar; Toro, Esther; de Reus, Marcel A.; van den Heuvel, Martijn P.; Pueyo, Roser (Wiley-Liss Inc., 2017-09-01)
    Dyskinetic cerebral palsy (CP) has long been associated with basal ganglia and thalamus lesions. Recent evidence further points at white matter (WM) damage. This study aims to identify altered WM pathways in dyskinetic CP ...
  • Association of short antenatal corticosteroid administration-to-birth intervals with survival and morbidity among very preterm infants results from the EPICE cohort 
    Norman, Mikael; Piedvache, Aurelie; Børch, Klaus; Huusom, Lene Drasbek; Bonamy, Anna Karin Edstedt; Howell, Elizabeth A.; Jarreau, Pierre Henri; Maier, Rolf F.; Pryds, Ole; Toome, Liis; Varendi, Heili; Weber, Tom; Wilson, Emilija; van Heijst, Arno; Cuttini, Marina; Mazela, Jan; Barros, Henrique; Van Reempts, Patrick; Draper, Elizabeth S.; Zeitlin, Jennifer; Martens, Evelyne; Martens, Guy; Hasselager, Asbjoern; Ancel, Pierre Yves; Blondel, Béatrice; Bonet, Mercedes; Burguet, Antoine; Truffert, Patrick; Misselwitz, Bjoern; Schmidt, Stephan; Gortner, Ludvig; Baronciani, Dante; Gargano, Giancarlo; Agostino, Rocco; DiLallo, Domenico; Franco, Francesco; Carnielli, Virgilio; Croci, Ileana; Koopman-Esseboom, Corrine; Nijman, Joppe; Gadzinowski, Janusz; Graça, Luís Mendes; Do Céu Machado, Maria; Rodrigues, Carina; Ribeiro-Rodrigues, Teresa; Boyle, Elaine M.; Manktelow, Brad N.; Fenton, Alan C.; Effective Perinatal Intensive Care in Europe (EPICE) Research Group (American Medical Association, 2017-07-01)
    IMPORTANCE Administration-to-birth intervals of antenatal corticosteroids (ANS) vary. The significance of this variation is unclear. Specifically, to our knowledge, the shortest effective administration-to-birth interval ...
  • Variation in term birthweight across European countries affects the prevalence of small for gestational age among very preterm infants 
    Zeitlin, Jennifer; Bonamy, Anna Karin Edstedt; Piedvache, Aurelie; Cuttini, Marina; Barros, Henrique; Van Reempts, Patrick; Mazela, Jan; Jarreau, Pierre Henri; Gortner, Ludwig; Draper, Elizabeth S.; Maier, Rolf F.; Martens, E.; Martens, Guy; Boerch, Klaus; Hasselager, Asbjoern; Huusom, Lene; Pryds, Ole; Weber, Tom; Toome, Liis; Varendi, Heili; Ancel, Pierre Yves; Blondel, Beatrice; Burguet, Antoine; Truffert, P.; Misselwitz, Bjoern; Schmidt, S.; Baronciani, Dante; Gargano, G.; Agostino, Rocco; DiLallo, D.; Franco, Francesco; Carnielli, Virgilio; Koopman-Esseboom, C.; van Heijst, A.; Nijman, J.; Gadzinowski, Janusz; Graça, Luis M.; Ceu Machado, Maria; Carrapato, M. R.G.; Ribeiro-Rodrigues, Teresa; Norman, Mikael; Wilson, E.; Boyle, Elaine M.; Manktelow, B. N.; Fenton, A. C.; Milligan, David W A; Marques-Bonet, T.; the EPICE Research Group (Wiley-Blackwell, 2017-09-01)
    Aim: This study assessed the prevalence of small for gestational age (SGA) among very preterm (VPT) infants using national and European intrauterine references. Methods: We generated country-specific and common European ...
  • Changes in management policies for extremely preterm births and neonatal outcomes from 2003 to 2012: two population-based studies in ten European regions 
    Marques-Bonet, T.; Cuttini, Marina; Piedvache, A.; Boyle, Elaine M.; Jarreau, Pierre Henri; Kollée, Louis A A; Maier, Rolf F.; Milligan, David W A; van Reempts, P.; Weber, Tom; Barros, Henrique; Gadzinowki, J.; Draper, E. S.; Zeitlin, Jennifer; Martens, E.; Martens, Guy; Boerch, Klaus; Hasselager, Asbjoern; Huusom, Lene; Pryds, Ole; Ancel, Pierre Yves; Blondel, Beatrice; Bréart, G.; Gortner, Ludwig; Kuenzel, W.; Misselwitz, Bjoern; Schmidt, S.; Agostino, Rocco; DiLallo, D.; Franco, Francesco; Paesano, R.; Hukkelhoven, C.; Hulscher, M.; Koopman-Esseboom, C.; van Heijst, A.; Breborowicz, G.; Gadzinowski, Janusz; Mazela, Jan; Carrapato, M.; Ribeiro-Rodrigues, Teresa; Konje, J.; Manktelow, B. N.; Fenton, A. C.; Sturgiss, S.; the MOSAIC and EPICE research groups (Wiley-Blackwell, 2017-09-01)
    Objective: To investigate changes in maternity and neonatal unit policies towards extremely preterm infants (EPTIs) between 2003 and 2012, and concurrent trends in their mortality and morbidity in ten European regions. ...
  • Development of Refractive Errors—What Can We Learn From Inherited Retinal Dystrophies? 
    Hendriks, Michelle; Verhoeven, Virginie J M; Buitendijk, Gabriëlle H.S.; Polling, Jan Roelof; Meester-Smoor, Magda A.; Hofman, Albert; van Huet, Ramon A C; Klevering, B Jeroen; Bax, Nathalie M.; Lambertus, Stanley; Klaver, Caroline C W; Hoyng, Carel B.; Oomen, Clasien J; van Zelst-Stams, Wendy A. G.; Cremers, Frans Pm; Plomp, Astrid S; van Schooneveld, Mary J.; van Genderen, Mies M.; Schuil, José; Boonstra, F Nienke; Schlingemann, Reinier O; Bergen, Arthur A.; Pierrache, Laurence; Meester-Smoor, Magda; van den Born, L Ingeborgh; Boon, Camiel J.F.; Pott, Jan W.R.; van Leeuwen, Redmer; Kroes, Hester Y.; de Jong-Hesse, Yvonne; Kamermans, Maarten; Ingeborgh van den Born, L.; Klaver, Caroline C W; RD5000 Consortium (Elsevier, 2017-10-01)
    Purpose It is unknown which retinal cells are involved in the retina-to-sclera signaling cascade causing myopia. As inherited retinal dystrophies (IRD) are characterized by dysfunction of a single retinal cell type and ...
  • A qualitative study on acceptable levels of risk for pregnant women in clinical research 
    Van Der Zande, Indira S.E.; Van Der Graaf, Rieke; Oudijk, Martijn A.; Van Delden, Johannes J.M. (BioMed Central, 2017-05-15)
    Background: There is ambiguity with regard to what counts as an acceptable level of risk in clinical research in pregnant women and there is no input from stakeholders relative to such research risks. The aim of our paper ...
  • Commentary on "Physical Exercise and Physical Activity for Children and Adolescents with Juvenile Idiopathic Arthritis: A Literature Review" 
    Van Der Torre, Patrick; Van Brussel, Marco (Lippincott Williams & Wilkins, 2017-07-01)
  • Health losses at the end of life: a Bayesian mixed beta regression approach 
    Gheorghe, Maria; Picavet, H. Susan J; Verschuren, Monique; Brouwer, Werner B. F.; van Baal, Pieter H. M. (Wiley-Blackwell, 2017-06)
    The relationship between aging, health and healthcare expenditures is of central importance to academics and public policy makers. Generally, it is observed that, with advancing age, health deteriorates and healthcare ...