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UMC Repository: Recent submissions

  • Delirium detection using relative delta power based on 1 minute single-channel EEG: a multicentre study 
    Numan, T.; van den Boogaard, M.; Kamper, A. M.; Rood, P. J.T.; Peelen, L. M.; Slooter, Arjen JC; Abawi, Masieh; van den Boogaard, Mark; Claassen, Jurgen AHR; Coesmans, Michael; Dautzenberg, Paul; Dhondt, Ton ADF; Diraoui, Shiraz B.; Eikelenboom, Piet; Emmelot-Vonk, Marielle H.; Faaij, Richard A.; van Gool, Willem A.; Groot, Erwin R.; Hagestein-de Bruijn, Carla; Hovens, Jacqueline GFM; van der Jagt, Mathieu; de Jonghe, Anne Marieke; Kamper, Adriaan M.; Koek, Huiberdine L.; van der Kooi, Arendina W.; Kromkamp, Marjan; Lagro, Joep; Leentjens, Albert FG; Lefeber, Geert J.; Leijten, Frans S.; Leue, Carsten; de Man, Tjarda; van Marum, Robert J.; van der Mast, Roos C.; van Munster, Barbara C.; Numan, T.; Osse, Robert Jan; Barbara Portier, C.; Rius Ottenheim, Nathaly; Rood, Paul JT; Röder, Christian H.; Schoon, Yvonne; Slooter, Arjen JC; Tromp, Arjen; van der Vlugt, Joris B.; Vondeling, Ariël M.; Wassenaar, Annelies; Weinstein, Henry; Witlox, Joost; van Zanten, Jeroen S.; Dutch Delirium Detection Study Group (Oxford University Press, 2019-01)
    Background: Delirium is frequently unrecognised. EEG shows slower frequencies (i.e. below 4 Hz) during delirium, which might be useful in improving delirium recognition. We studied the discriminative performance of a brief ...
  • Predictors of short-term and long-term mortality in critically ill patients admitted to the intensive care unit following allogeneic stem cell transplantation 
    van der Heiden, P. L. J.; Arbous, M. S.; van Beers, E. J.; van den Bergh, W. M.; le Cessie, S.; Demandt, A. M. P.; Eefting, M.; Hess, C.; Kusadasi, N.; Marijt, W. A. F.; van Mook, W. N. K. A.; Mueller, M. C. A.; Tuinman, P. R.; van Vliet, M.; van Westerloo, D. J.; Blijlevens, N. M. A. (Springer Nature, 2019-03)
    Historically, the mortality of patients admitted to the ICU after allogeneic stem cell transplantation (alloSCT) is high. Advancements in transplantation procedures, infectious monitoring and supportive care may have ...
  • The prevalence of pseudoxanthoma elasticum: Revised estimations based on genotyping in a high vascular risk cohort 
    Kranenburg, Guido; Baas, Annette F.; de Jong, Pim A.; Asselbergs, Folkert W.; Visseren, Frank L.J.; Spiering, Wilko; SMART Study Group (Elsevier Masson SAS, 2019-02)
    Background: Pseudoxanthoma elasticum (PXE), an autosomal recessive systemic calcification disorder, is caused by mutations in the ABCC6-gene and associated with severe visual impairment and peripheral arterial disease. ...
  • Histocompatibility 
    Spierings, HT; Fleischhauer, Katharina (2019)
    Immune-mediated rejection of tissue allografts was first described in 1945 by the British immunologist Peter Medawar, followed by the discovery of the major histocompatibility complex (MHC) carrying the histocompatibility ...
  • CRISPR/Cas9-mediated exploration and disruption of herpes simplex virus type 1 
    van Diemen, Ferdy Rudolf (Utrecht University, 2019-06-20)
    Herpesviruses are widespread human pathogens that establish lifelong infections in nearly the entire population. Following primary infection, these viruses can enter a latent state characterized by minimal viral gene ...
  • Improving and extending treatment modalities in Graft versus Host Disease 
    van der Wagen, Lotte Emilia (Utrecht University, 2019-06-27)
    Despite the application of allogeneic stem cell transplantation (SCT) since 1957 we have not been able to eradicate Graft versus Host Disease (GVHD) as a significant contributor of treatment related mortality (TRM) and ...
  • Towards MRI-guided rectal cancer boost radiotherapy 
    Kleijnen, J.-P.J.E. (Utrecht University, 2019-07-11)
    This thesis focuses on filling the knowledge gaps for an effective introduction of MRI-guided boost treatments for rectal cancer. Also existing knowledge on CTV motion is redefined, using the benefits of MRI’s superior ...
  • Treatment de-escalation for early-stage breast cancer: MRI-guided single dose preoperative ablative radiotherapy 
    Charaghvandi, Kejal-Ramona (Utrecht University, 2019-06-18)
    Breast cancer is the number one oncological burden in women across the globe. Given the increase breast cancer survivorship and knowledge on side effects of cancer therapies, patient reported outcomes have gained importance. ...
  • Hypothalamic-Pituitary Injury after Childhood Cancer and Central Nervous System Tumors: Risk Factors, Course and Consequences 
    van Iersel, Laura (Utrecht University, 2019-07-04)
    The survival rate of childhood cancer is currently estimated at 80%. In up to 60% of childhood cancer survivors, endocrine disorders, such as hypothalamic-pituitary (HP) dysfunction, are reported. To improve screening ...
  • Recurrence Following Resection of Pancreatic Cancer 
    Groot, Vincent Paul (Utrecht University, 2019-06-27)
    Disease recurrence after resection of pancreatic cancer unfortunately remains common and marks a critical and emotional time point in the care of these patients. A more accurate understanding of disease failure after ...
  • Genetic characterization of amyotrophic lateral sclerosis 
    Dekker, Annelot Marije (Utrecht University, 2019-03-21)
    Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that leads to progressive muscle wasting and weakness, eventually resulting in swallowing difficulties and respiratory failure. There is no cure, and ...
  • Gross tumour delineation on computed tomography and positron emission tomography-computed tomography in oesophageal cancer: A nationwide study 
    Nowee, M. E.; Voncken, F. E. M.; Kotte, A. N. T. J.; Goense, L.; van Rossum, P. S. N.; van Lier, A. L. H. M. W.; Heijmink, S. W.; Aleman, B. M. P.; Nijkamp, J.; Meijer, G. J.; Lips, I. M.; Braam, P. M.; Buijsen, J.; Ceha, H. M.; Dewit, L.; Franssen, J. H.; van Gestel, K.; Grootenboers, D. A. R. H.; Intven, M.; Jansen, E. P. M.; Kerkmeijer, L. G. W.; Mul, V. E.; Muller, K.; Neelis, K. J.; Oppedijk, V; Rozema, T.; Spruit, P. H. (Elsevier Ireland Ltd, 2019-01)
    Background and purpose: Accurate delineation of the primary tumour is vital to the success of radiotherapy and even more important for successful boost strategies, aiming for improved local control in oesophageal cancer ...
  • Examining the independent and joint effects of molecular genetic liability and environmental exposures in schizophrenia: results from the EUGEI study 
    Genetic Risk and Outcome of Psychosis (GROUP) Investigators (Wiley-Blackwell, 2019-06)
    Schizophrenia is a heritable complex phenotype associated with a background risk involving multiple common genetic variants of small effect and a multitude of environmental exposures. Early twin and family studies using ...
  • 10Kin1day: A Bottom-Up Neuroimaging Initiative 
    van den Heuvel, Martijn P.; Scholtens, Lianne H.; van der Burgh, Hannelore K.; Agosta, Federica; Alloza, Clara; Arango, Celso; Auyeung, Bonnie; Baron-Cohen, Simon; Basaia, Silvia; Benders, Manon J. N. L.; Beyer, Frauke; Booij, Linda; Braun, Kees P. J.; Busatto Filho, Geraldo; Cahn, Wiepke; Cannon, Dara M.; Chaim-Avancini, Tiffany M.; Chan, Sandra S. M.; Chen, Eric Y. H.; Crespo-Facorro, Benedicto; Crone, Eveline A.; Dannlowski, Udo; de Zwarte, Sonja M. C.; Dietsche, Bruno; Donohoe, Gary; Du Plessis, Stefan; Durston, Sarah; Diaz-Caneja, Covadonga M.; Diaz-Zuluaga, Ana M.; Emsley, Robin; Filippi, Massimo; Frodl, Thomas; Gorges, Martin; Graff, Beata; Grotegerd, Dominik; Gasecki, Dariusz; Hall, Julie M.; Holleran, Laurena; Holt, Rosemary; Hopman, Helene J.; Jansen, Andreas; Janssen, Joost; Jodzio, Krzysztof; Jancke, Lutz; Kaleda, Vasiliy G.; Kassubek, Jan; Masouleh, Shahrzad Kharabian; Kircher, Tilo; Koevoets, Martijn G. J. C.; Kostic, Vladimir S.; Krug, Axel; Lawrie, Stephen M.; Lebedeva, Irina S.; Lee, Edwin H. M.; Lett, Tristram A.; Lewis, Simon J. G.; Liem, Franziskus; Lombardo, Michael, V; Lopez-Jaramillo, Carlos; Margulies, Daniel S.; Markett, Sebastian; Marques, Paulo; Martinez-Zalacain, Ignacio; McDonald, Calm; McIntosh, Andrew M.; McPhilemy, Genevieve; Meinert, Susanne L.; Menchon, Jose M.; Montag, Christian; Moreira, Pedro S.; Morgado, Pedro; Mothersill, David O.; Merillat, Susan; Mueller, Hans-Peter; Nabulsi, Leila; Najt, Pablo; Narkiewicz, Krzysztof; Naumczyk, Patrycja; Oranje, Bob; Ortiz-Garcia de la Foz, Victor; Peper, Jiska S.; Pineda, Julian A.; Rasser, Paul E.; Redlich, Ronny; Repple, Jonathan; Reuter, Martin; Rosa, Pedro G. P.; Ruigrok, Amber N., V; Sabisz, Agnieszka; Schell, Ulrich; Seedat, Soraya; Serpa, Mauricio H.; Skouras, Stavros; Soriano-Mas, Cares; Sousa, Nuno; Szurowska, Edyta; Tomyshev, Alexander S.; Tordesillas-Gutierrez, Diana; Valk, Sofie L.; van den Berg, Leonard H.; van Erp, Theo G. M.; van Haren, Neeltje E. M.; van Leeuwen, Judith M. C.; Villringer, Arno; Vinkers, Christiaan C. H.; Vollmar, Christian; Waller, Lea; Walter, Henrik; Whalley, Heather C.; Witkowska, Marta; Witte, A. Veronica; Zanetti, Marcus, V; Zhang, Rui; de Lange, Siemon C. (Frontiers Media S. A., 2019-05-09)
    We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000+ existing MRI connectivity datasets during a 3-day workshop. In this ...
  • A systematic approach to interpreting the cardiopulmonary exercise test in pediatrics 
    Van Brussel, Marco; Bongers, Bart C.; Hulzebos, Erik H.J.; Burghard, Marcella; Takken, Tim (Human Kinetics Publishers Inc., 2019-05-01)
    The use of cardiopulmonary exercise testing in pediatrics provides critical insights into potential physiological causes of unexplained exercise-related complaints or symptoms, as well as specific pathophysiological patterns ...
  • Cross-sectional study of association between socioeconomic indicators and chronic kidney disease in rural–urban Ghana: the RODAM study 
    Adjei, David N; Stronks, Karien; Adu, Dwomoa; Beune, Erik; Meeks, Karlijn; Smeeth, Liam; Addo, Juliet; Owusu-Dabo, Ellis; Klipstein-Grobusch, Kerstin; Mockenhaupt, Frank P; Danquah, Ina; Spranger, Joachim; Bahendeka, Silver; De-Graft Aikins, Ama; Agyemang, Charles (BMJ Publishing Group, 2019-05-01)
    Objectives Studies from high-income countries suggest higher prevalence of chronic kidney disease (CKD) among individuals in low socioeconomic groups. However, some studies from low/middle-income countries show the reverse ...
  • Using Mobile Health to Support Clinical Decision-Making to Improve Maternal and Neonatal Health Outcomes in Ghana: Insights of Frontline Health Worker Information Needs 
    Amoakoh, Hannah Brown; Klipstein-Grobusch, Kerstin; Grobbee, Diederick E; Amoakoh-Coleman, Mary; Oduro-Mensah, Ebenezer; Sarpong, Charity; Frimpong, Edith; Kayode, Gbenga A; Agyepong, Irene Akua; Ansah, Evelyn K (JMIR Publications Inc., 2019)
    Background: Developing and maintaining resilient health systems in low-resource settings like Ghana requires innovative approaches that adapt technology to context to improve health outcomes. One such innovation was a ...
  • Radiotherapy Late Effects and Osteogenesis Imperfecta: Dos and Don'ts in Clinical Practice 
    Lodeweges, Joyce E.; van Dijk, Fleur S.; Verhoeff, Joost J. C. (S. Karger AG, 2019)
    In radiation oncology, little is known about possible difficulties in patients with Osteogenesis Imperfecta (OI). Because radiotherapy can cause various side-effects including bone, soft tissue and cardiovascular toxicities, ...
  • Extended thoracic lymph node dissection in robotic-assisted minimal invasive esophagectomy (RAMIE) for patients with superior mediastinal lymph node metastasis 
    van der Horst, Sylvia; de Maat, Michiel F G; van der Sluis, Pieter C; Ruurda, Jelle P; van Hillegersberg, Richard (AME Publishing Company, 2019-03)
    Background: Robot-assisted surgery may have a role in improving oncological outcomes in esophagectomy. Especially in the anatomical areas in the chest that are more difficult to reach in open surgery (including the superior ...
  • Robot-assisted minimally invasive esophagectomy (RAMIE) improves perioperative outcomes: a review 
    Kingma, B Feike; de Maat, Michiel F G; van der Horst, Sylvia; van der Sluis, Pieter C; Ruurda, Jelle P; van Hillegersberg, Richard (Pioneer Bioscience Publishing Company (PBPC), 2019-04)
    Robotic assisted minimal invasive esophagectomy (RAMIE) is increasingly applied as a clinically and oncologically safe technique in the surgical treatment of esophageal cancer. This review focuses on the advantages and ...