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Now showing items 24281-24300 of 40729

Prognostic Value of Lymph Node Yield on Overall Survival in Esophageal Cancer Patients: A Systematic Review and Meta-analysis

Visser, Els; Markar, Sheraz R; Ruurda, Jelle P; Hanna, George B; van Hillegersberg, Richard (Lippincott Williams & Wilkins, 2019-02)

OBJECTIVE: This meta-analysis determines whether increased lymph node yield improves survival in patients with esophageal cancer undergoing esophagectomy with or without neoadjuvant therapy. BACKGROUND: Esophagectomy ...
Insufficient implementation of the SDD concept may yield invalid conclusions Reply

Wittekamp, B. H.; Bonten, M. J. M. (Netherlands Society of Intensive Care, 2019-03)
PTH decreases in vitro human cartilage regeneration without affecting hypertrophic differentiation

Rutgers, Marijn; Bach, Frances; Vonk, Luciënne; Akrum, Vanessa; van Boxtel, Antonette; Dhert, Wouter; Creemers, Laura (Public Library of Science, 2019)

Regenerated cartilage formed after Autologous Chondrocyte Implantation may be of suboptimal quality due to postulated hypertrophic changes. Parathyroid hormone-related peptide, containing the parathyroid hormone sequence ...
Exome array analysis of rare and low frequency variants in amyotrophic lateral sclerosis

Dekker, Annelot M; Diekstra, Frank P; Pulit, Sara L; Tazelaar, Gijs H P; van der Spek, Rick A; van Rheenen, Wouter; van Eijk, Kristel R; Calvo, Andrea; Brunetti, Maura; Damme, Philip Van; Robberecht, Wim; Hardiman, Orla; McLaughlin, Russell; Chiò, Adriano; Sendtner, Michael; Ludolph, Albert C; Weishaupt, Jochen H; Pardina, Jesus S Mora; van den Berg, Leonard H; Veldink, Jan H (Nature Publishing Group, 2019-12-01)

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects 1 in ~350 individuals. Genetic association studies have established ALS as a multifactorial disease with heritability estimated at ~61%, ...
Comparison of Place-versus-Pitch Mismatch between a Perimodiolar and Lateral Wall Cochlear Implant Electrode Array in Patients with Single-Sided Deafness and a Cochlear Implant

Peters, JPM; Bennink, E; van Zanten, GA (S. Karger AG, 2019-04-17)

Background: In electric-acoustic pitch matching experiments in patients with single-sided deafness and a cochlear implant, the observed “mismatch” between perceived pitch and predicted pitch, based on the amended Greenwood ...
Decontamination Strategies for Critically Ill Patients-Reply

Wittekamp, Bastiaan H; Plantinga, Nienke L; Bonten, Marc J M (American Medical Association, 2019-04-09)
Op weg naar ‘de beste DOAC’?

van Doorn, Sander; Rutten, Frans H.; Geersing, Geert Jan (Bohn Stafleu van Loghum, 2019-03-21)

Direct oral anticoagulants (DOACs) are increasingly being prescribed for stroke prevention in patients with atrial fibrillation or for treating venous thromboembolism. In this short overview, we provide some guidance on ...
Patterns of re-irradiation for recurrent gliomas and validation of a prognostic score

Post, Cathalijne C B; Kramer, Miranda C A; Smid, Ernst J; van der Weide, Hiske L; Kleynen, Catharina E; Heesters, Mart A A M; Verhoeff, Joost J C (Elsevier Ireland Ltd, 2019-01)

Purpose or objective: Re-irradiation is a generally accepted method for salvage treatment in patients with recurrent glioma. However, no standard radiation regimen has been defined. This study aims to compare the efficacy ...
Procedural Clinical Complications, Case-Fatality Risks, and Risk Factors in Endovascular and Neurosurgical Treatment of Unruptured Intracranial Aneurysms: A Systematic Review and Meta-analysis

Algra, Annemijn M.; Lindgren, Antti; Vergouwen, Mervyn D.I.; Greving, Jacoba P.; Van Der Schaaf, Irene C.; Van Doormaal, Tristan P.C.; Rinkel, Gabriel J.E. (American Medical Association, 2019-03)

Importance: The risk of procedural clinical complications and the case-fatality rate (CFR) from preventive treatment of unruptured intracranial aneurysms varies between studies and may depend on treatment modality and risk ...
A Human(e) Factor in Clinical Decision Support Systems

Bezemer, Tim; De Groot, Mark C.H.; Blasse, Enja; Ten Berg, Maarten J.; Kappen, Teus H.; Bredenoord, Annelien L.; Van Solinge, Wouter W.; Hoefer, Imo E.; Haitjema, Saskia (Journal of medical Internet Research, 2019-03-19)

The overwhelming amount, production speed, multidimensionality, and potential value of data currently available-often simplified and referred to as big data -exceed the limits of understanding of the human brain. At the ...
Impact of Free-Choice Diets High in Fat and Different Sugars on Metabolic Outcome and Anxiety-Like Behavior in Rats

Peris-Sampedro, Fiona; Mounib, Myriam; Schéle, Erik; Edvardsson, Christian E; Stoltenborg, Iris; Adan, Roger A H; Dickson, Suzanne L (John Wiley & Sons Inc., 2019-03)

OBJECTIVE: Rats were exposed to free-choice diets (fat plus one of two different sugar solutions, glucose or sucrose), and the metabolic consequences and impact on locomotor activity and anxiety-like behavior were explored. ...
Limbic control over the homeostatic need for sodium

Verharen, Jeroen P H; Roelofs, Theresia J M; Menting-Henry, Shanice; Luijendijk, Mieneke C M; Vanderschuren, Louk J M J; Adan, Roger A H (Nature Publishing Group, 2019-12-01)

The homeostatic need for sodium is one of the strongest motivational drives known in animals. Although the brain regions involved in the sensory detection of sodium levels have been mapped relatively well, data about the ...
An Intersectional Approach to Target Neural Circuits With Cell- and Projection-Type Specificity: Validation in the Mesolimbic Dopamine System

Kakava-Georgiadou, Nefeli; Zwartkruis, Maria M; Bullich-Vilarrubias, Clara; Luijendijk, Mieneke C M; Garner, Keith M; van der Plasse, Geoffrey; Adan, Roger A H (Frontiers Media S. A., 2019-02-28)

Development of tools to manipulate activity of specific neurons is important for dissecting the function of neural circuits. Viral vectors and conditional transgenic animal lines that target recombinases to specific cells ...
Empirical evidence of the impact of study characteristics on the performance of prediction models: A meta-epidemiological study

Damen, Johanna A A G; Debray, Thomas P A; Pajouheshnia, Romin; Reitsma, Johannes B; Scholten, Rob J P M; Moons, Karel G M; Hooft, Lotty (BMJ Publishing Group, 2019-04-01)

Objectives To empirically assess the relation between study characteristics and prognostic model performance in external validation studies of multivariable prognostic models. Design Meta-epidemiological study. Data sources ...
Long-term follow-up after MIPO Philos plating for proximal humerus fractures

Frima, H; Michelitsch, C; Beks, R B; Houwert, R M; Acklin, Y P; Sommer, C (Springer-Verlag, 2019-02)

INTRODUCTION: Minimally invasive plate osteosynthesis (MIPO) has been described as a suitable technique for the treatment of proximal humerus fractures, but long-term functional results have never been reported. The aim ...
Intramedullary Fixation Versus Plate Fixation of Distal Fibular Fractures: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Observational Studies

Tas, David B; Smeeing, Diederik P J; Emmink, Benjamin L; Govaert, Geertje A M; Hietbrink, Falco; Leenen, Luke P H; Houwert, Roderick M (Academic Press Inc., 2019-01)

Intramedullary fixation (IMF) has been described as a minimally invasive alternative to open reduction and internal fixation for operative treatment of distal fibular fractures in case of compromised soft tissue or severe ...
Operative treatment versus nonoperative treatment of Achilles tendon ruptures: systematic review and meta-analysis

Ochen, Yassine; Beks, Reinier B; van Heijl, Mark; Hietbrink, Falco; Leenen, Luke P H; van der Velde, Detlef; Heng, Marilyn; van der Meijden, Olivier; Groenwold, Rolf H H; Houwert, R Marijn (BMJ Publishing Group, 2019-01-07)

Objectives To compare re-rupture rate, complication rate, and functional outcome after operative versus nonoperative treatment of Achilles tendon ruptures; to compare re-rupture rate after early and late full weight bearing; ...
The ethics of genome editing in non-human animals: A systematic review of reasons reported in the academic literature

de Graeff, N; Jongsma, Karin; Johnston, Josephine; Hartley, Sarah; Bredenoord, AL (Royal Society Publishing, 2019-03-25)

In recent years, new genome editing technologies have emerged that can edit the genome of non-human animals with progressively increasing efficiency. Despite ongoing academic debate about the ethical implications of these ...
Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure

Bosch, Lena; de Haan, Judith; Seijkens, Tom; van Tiel, Claudia; Brans, Maike; Pasterkamp, Gerard; Lutgens, Esther; de Jager, Saskia (Elsevier Ireland Ltd, 2019-03-15)

Background: CD40 signalling is involved in chronic inflammation, a condition that plays an important role in non-ischemic heart failure (HF). Small molecule inhibitors of CD40-TRAF6 have shown to be effective in multiple ...
Developments in euthanasia practice in the Netherlands: Balancing professional responsibility and the patient’s autonomy

Kouwenhoven, Pauline S.C.; van Thiel, Ghislaine J.M.W.; van der Heide, Agnes; Rietjens, Judith A.C.; van Delden, Johannes J.M. (Informa Healthcare, 2019-01-02)

In 2015, euthanasia accounted for 4.5% of deaths in the Netherlands, of which 93% were performed by a GP. Historically, a conflict of physician’s duties—to alleviate unbearable suffering and at the same time preserve the ...

Now showing items 24281-24300 of 40729