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UMC Repository: Recent submissions

  • A Human Hematopoietic Niche Model Supporting Hematopoietic Stem and Progenitor Cells In Vitro 
    Braham, Maaike V. J.; Yim, Amelie S. P. Li; Mateos, Jara Garcia; Minnema, Monique C.; Dhert, Wouter J. A.; Oner, F. Cumhur; Robin, Catherine; Alblas, Jacqueline (John Wiley & Sons Inc., 2019-05-23)
    Niches in the bone marrow regulate hematopoietic stem and progenitor cell (HSPC) fate and behavior through cell–cell interactions and soluble factor secretion. The niche‐HSPC crosstalk is a very complex process not completely ...
  • Huge variation in obtaining ethical permission for a non-interventional observational study in Europe 
    de Lange, Dylan W; Guidet, Bertrand; Andersen, Finn H; Artigas, Antonio; Bertolini, Guidio; Moreno, Rui; Christensen, Steffen; Cecconi, Maurizio; Agvald-Ohman, Christina; Gradisek, Primoz; Jung, Christian; Marsh, Brian J; Oeyen, Sandra; Bollen Pinto, Bernardo; Szczeklik, Wojciech; Watson, Ximena; Zafeiridis, Tilemachos; Flaatten, Hans (BioMed Central, 2019-06-03)
    BACKGROUND: Ethical approval (EA) must be obtained before medical research can start. We describe the differences in EA for an pseudonymous, non-interventional, observational European study. METHODS: Sixteen European ...
  • Visualizing the cellular route of entry of a cystine-knot peptide with Xfect transfection reagent by electron microscopy 
    Gao, Xinxin; De Mazière, Ann; Iaea, David B; Arthur, Christopher P; Klumperman, Judith; Ciferri, Claudio; Hannoush, Rami N (Nature Publishing Group, 2019-05-06)
    Cystine-knot peptides are attractive templates in drug discovery due to a number of features they possess including their 3D conformation, physicochemical stability and synthetic tractability. Yet, their cellular uptake ...
  • CORVET, CHEVI and HOPS – Multisubunit tethers of the endo-lysosomal system in health and disease 
    van der Beek, Jan; Jonker, Caspar; van der Welle, Reini; Liv, Nalan; Klumperman, Judith (Company of Biologists Ltd, 2019-05-01)
    Multisubunit tethering complexes (MTCs) are multitasking hubs that form a link between membrane fusion, organelle motility and signaling. CORVET, CHEVI and HOPS are MTCs of the endo-lysosomal system. They regulate the major ...
  • Clinical value of (dedicated) 3 Tesla and 7 Tesla MRI for cT1 glottic carcinoma: A feasibility study 
    van Egmond, Sylvia L.; Vonck, Bernard M. D.; Bluemink, Johanna J.; Pameijer, Frank A.; Dankbaar, Jan Willem; Stegeman, Inge; Philippens, Marielle E. P.; van den Berg, Cornelis A. T.; Janssen, Luuk M.; Terhaard, Chris H. (Wiley-Blackwell, 2019-02)
    Objective: To assess the feasibility of the clinical use of 3 Tesla and 7 Tesla Magnetic Resonance Imaging for early (cT1) glottic carcinoma, including structural assessment of technical image quality and visibility of the ...
  • Anti-fibrotic Effects of Cardiac Progenitor Cells in a 3D-Model of Human Cardiac Fibrosis 
    Bracco Gartner, Tom C L; Deddens, Janine C; Mol, Emma A; Magin Ferrer, Marina; van Laake, Linda W; Bouten, Carlijn V C; Khademhosseini, Ali; Doevendans, Pieter A; Suyker, Willem J L; Sluijter, Joost P G; Hjortnaes, Jesper (Frontiers Media S. A., 2019-04-26)
    Cardiac fibroblasts play a key role in chronic heart failure. The conversion from cardiac fibroblast to myofibroblast as a result of cardiac injury, will lead to excessive matrix deposition and a perpetuation of pro-fibrotic ...
  • Reducing pulmonary complications after esophagectomy for cancer 
    Seesing, Maarten F J; Kingma, B Feike; Weijs, Teus J; Ruurda, Jelle P; van Hillegersberg, Richard (Pioneer Bioscience Publishing Company (PBPC), 2019-04)
    The cornerstone of curative care for esophageal cancer is neoadjuvant chemoradiotherapy followed by esophagectomy with a radical lymphadenectomy. An esophagectomy is a major and complex surgical procedure and is often ...
  • Comparison of preputioplasty and circumcision in distal hypospadias correction: long-term follow-up 
    van den Dungen, I. A. L.; Rynja, S. P.; Bosch, J. L. H. R.; de Jong, T. P. V. M.; de Kort, L. M. O. (Elsevier, 2019-02)
    Objective A normal penile cosmesis is an important goal in distal hypospadias repair. Depending on cultural standards, repairs are combined with a preputioplasty or circumcision to attain a ‘normal’ penile appearance. ...
  • Intracellular Penetration and Effects of Antibiotics on Staphylococcus aureus Inside Human Neutrophils: A Comprehensive Review 
    Bongers, Suzanne; Hellebrekers, Pien; Leenen, Luke P H; Koenderman, Leo; Hietbrink, Falco (Multidisciplinary Digital Publishing Institute (MDPI), 2019-05-04)
    Neutrophils are important assets in defense against invading bacteria like staphylococci. However, (dysfunctioning) neutrophils can also serve as reservoir for pathogens that are able to survive inside the cellular ...
  • Extracellular vesicles in synovial fluid from juvenile horses: No age-related changes in the quantitative profile 
    Boere, J.; van de Lest, C. H.A.; de Grauw, J. C.; Plomp, S. G.M.; Libregts, S. F.W.M.; Arkesteijn, G. J.A.; Malda, J.; Wauben, M. H.M.; van Weeren, P. R. (Bailliere Tindall Ltd, 2019-02-01)
    Extracellular vesicle (EV) concentration, characteristics and function in equine synovial fluid (SF) during normal growth and development has not previously been studied. Isolation of EVs was performed in SF from three ...
  • Responsible data sharing in international health research: A systematic review of principles and norms 
    Kalkman, Shona; Mostert, Menno; Gerlinger, Christoph; van Delden, Johannes J. M.; van Thiel, Ghislaine J. M. W. (BioMed Central, 2019-03-28)
    BACKGROUND: Large-scale linkage of international clinical datasets could lead to unique insights into disease aetiology and facilitate treatment evaluation and drug development. Hereto, multi-stakeholder consortia are ...
  • Identifying Treatment Modalities for a Multidisciplinary and Blended Care Intervention for Patients With Moderate Medically Unexplained Physical Symptoms: Qualitative Study Among Professionals 
    Van Westrienen, Paula Elisabeth; Pisters, Martijn F.; Gerrits, Marloes; Veenhof, Cindy; De Wit, Niek J. (JMIR Publications Inc., 2019-04-12)
    Background: Medically unexplained physical symptoms (MUPS) are a substantial health problem in primary care with a high burden for patients, general practitioners, and the health care system. Most studies focus on chronic ...
  • Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model 
    Rudnik-Jansen, Imke; Schrijver, Karin; Woike, Nina; Tellegen, Anna; Versteeg, Sabine; Thies, Jens; Emans, Pieter; Mihov, George; Eijkelkamp, Niels; Tryfonidou, Marianna; Creemers, Laura (Informa Healthcare, 2019-12)
    Inflammation of the synovium and joint capsule is a main driver of pain in an osteoarthritic (OA) joint. Triamcinolone acetonide (TAA) is a classical corticosteroid that reduces synovitis and alleviates pain, albeit ...
  • Identification of human D lactate dehydrogenase deficiency 
    Monroe, Glen R; van Eerde, Albertien M; Tessadori, Federico; Duran, Karen J; Savelberg, Sanne M C; van Alfen, Johanna C; Terhal, Paulien A; van der Crabben, Saskia N; Lichtenbelt, Klaske D; Fuchs, Sabine A; Gerrits, Johan; van Roosmalen, Markus J; van Gassen, Koen L; van Aalderen, Mirjam; Koot, Bart G; Oostendorp, Marlies; Duran, Marinus; Visser, Gepke; de Koning, Tom J; Calì, Francesco; Bosco, Paolo; Geleijns, Karin; de Sain-van der Velden, Monique G M; Knoers, Nine V; Bakkers, Jeroen; Verhoeven-Duif, Nanda M; van Haaften, Gijs; Jans, Judith J (Nature Publishing Group, 2019-04-01)
    Phenotypic and biochemical categorization of humans with detrimental variants can provide valuable information on gene function. We illustrate this with the identification of two different homozygous variants resulting in ...
  • EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research 
    Seppala, L. J.; van der Velde, N.; Masud, T.; Blain, H.; Petrovic, M.; van der Cammen, T. J.; Szczerbinska, K.; Hartikainen, S.; Kenny, R. A.; Ryg, J.; Eklund, P.; Topinkova, E.; Mair, A.; Laflamme, L.; Thaler, H.; Bahat, G.; Gutierrez-Valencia, M.; Caballero-Mora, M. A.; Landi, F.; Emmelot-Vonk, M. H.; Cherubini, A.; Baeyens, J. P.; Correa-Perez, A.; Gudmundsson, A.; Marengoni, A.; O'Mahony, D.; Parekh, N.; Pisa, F. E.; Rajkumar, C.; Wehling, M.; Ziere, G. (Springer Science and Business Media Deutschland GmbH, 2019-04)
    Falls are under-recognized as adverse drug events. Healthcare professionals are reluctant to withdraw fall-risk-increasing medications. The EuGMS Task and Finish group on fall-risk-increasing drugs (FRIDs) proposes in this ...
  • National cohort study on postoperative risks after surgery for submucosal invasive colorectal cancer 
    Dutch T1 Colorectal Cancer Working Group (Royal College of General Practitioners, 2019-04-01)
    Background: The decision to perform surgery for patients with T1 colorectal cancer hinges on the estimated risk of lymph node metastasis, residual tumour and risks of surgery. The aim of this observational study was to ...
  • Transitional safety incidents as reported by patients and healthcare professionals in the Netherlands: A descriptive study 
    Poldervaart, Judith M.; van Melle, Marije A.; Reijnders, Leida J.; de Wit, Niek J.; Zwart, Dorien L. (Informa Healthcare, 2019-04-03)
    Background: Care transitions between general practice and hospital are hazardous regarding patient safety. For developing an improvement strategy adjusted to local settings, understanding of type and potential causes of ...
  • Circle of Willis variations in migraine patients with ischemic stroke 
    Hamming, Arend M.; van Walderveen, Marianne A. A.; Mulder, Inge A.; van der Schaaf, Irene C.; Kappelle, L. Jaap; Velthuis, Birgitta K.; Ferrari, Michel D.; Terwindt, Gisela M.; Visser, Marieke C.; Schonewille, Wouter; Algra, Ale; Wermer, Marieke J. H.; Majoie, C. B.; Roos, Y. B.; Duijm, L. E.; Keizer, K.; van der Lugt, A.; Dippel, D. W.; Droogh-de Greeve, K. E.; Bienfait, H. P.; Lycklama a Nijeholt, G. J.; Boiten, J.; Duyndam, D.; Kwa, V., I; Meijer, F. J.; van Dijk, E. J.; Kesselring, F. O.; Hofmeijer, J.; Vos, J. A.; van Rooij, W. J.; de Kort, P. L.; Pleiter, C. C.; Bakker, S. L.; Bot, J.; Velthuis, Birgitta K.; Dankbaar, J. W.; Mali, W. P.; van Seeters, T.; Horsch, A. D.; Niesten, J. M.; Biessels, G. J.; Luitse, M. J.; van der Graaf, Y. (John Wiley & Sons Inc., 2019-03)
    Objectives Migraine is a risk factor for stroke, which might be explained by a higher prevalence in anatomical variants in the circle of Willis (CoW). Here, we compared the presence of CoW variants in patients with stroke ...
  • Automated CT quantification methods for the assessment of interstitial lung disease in collagen vascular diseases: A systematic review 
    van Royen, Florien S.; Moll, Sofia A.; van Laar, Jacob M.; van Montfrans, Joris M.; de Jong, Pim A.; Mohamed Hoesein, Firdaus A.A. (Elsevier Ireland Ltd, 2019-03-01)
    Interstitial lung disease (ILD) is highly prevalent in collagen vascular diseases and reduction of ILD is an important therapeutic target. To that end, reliable quantification of pulmonary disease severity is of great ...
  • Incidence, angiographic and clinical predictors, and impact of stent thrombosis: a 6-year survey of 6,545 consecutive patients 
    Rozemeijer, R.; Wong, C. Wing; Leenders, G.; Timmers, L.; Koudstaal, S.; Rittersma, S. Z.; Kraaijeveld, A.; Bots, M.; Doevendans, P.; Stella, P.; Voskuil, M. (Bohn Stafleu van Loghum, 2019-06)
    Objective: We sought to determine the incidence, angiographic predictors, and impact of stent thrombosis (ST). Background: Given the high mortality after ST, this study emphasises the importance of ongoing efforts to ...