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UMC Repository: Recent submissions

  • Azacitidine maintenance after intensive chemotherapy improves DFS in older AML patients 
    Huls, Gerwin; Chitu, Dana A; Havelange, Violaine; Jongen-Lavrencic, Mojca; van de Loosdrecht, Arjan A; Biemond, Bart J; Sinnige, Harm; Hodossy, Beata; Graux, Carlos; van Marwijk Kooy, Rien; de Weerdt, Okke; Breems, Dimitri; Klein, Saskia; Kuball, Jürgen; Deeren, Dries; Terpstra, Wim; Vekemans, Marie-Christiane; Ossenkoppele, Gert J; Vellenga, Edo; Löwenberg, Bob (Elsevier, 2019-03-28)
    The prevention of relapse is the major therapeutic challenge in older patients with acute myeloid leukemia (AML) who have obtained a complete remission (CR) on intensive chemotherapy. In this randomized phase 3 study ...
  • Identification of a Loss-of-Function Mutation in the Context of Glutaminase Deficiency and Neonatal Epileptic Encephalopathy 
    Rumping, Lynne; Büttner, Benjamin; Maier, Oliver; Rehmann, Holger; Lequin, Maarten; Schlump, Jan Ulrich; Schmitt, Bernhard; Schiebergen-Bronkhorst, Birgit; Prinsen, Hubertus C.M.T.; Losa, Michele; Fingerhut, Ralph; Lemke, Johannes R.; Zwartkruis, Fried J.T.; Houwen, Roderick H.J.; Jans, Judith J.M.; Verhoeven-Duif, Nanda M.; Van Hasselt, Peter M.; Jamra, Rami (American Medical Association, 2019-03-01)
    Importance: The identification and understanding of the monogenic causes of neurodevelopmental disorders are of high importance for personalized treatment and genetic counseling. Objective: To identify and characterize ...
  • Epidural analgesia after minimally invasive esophagectomy: efficacy and complication profile 
    Kingma, B F; Visser, E; Marsman, M; Ruurda, J P; van Hillegersberg, R (Wiley-Blackwell, 2019-08)
    Adequate postoperative pain management is essential to facilitate uneventful recovery after esophagectomy. Although epidural analgesia is the gold standard, it is not satisfactory in all patients. The aim of this study is ...
  • Sentinel Node Biopsy in Clinical Stage I Testicular Cancer Enables Early Detection of Occult Metastatic Disease 
    Blok, Joost M; Kerst, J Martijn; Vegt, Erik; Brouwer, Oscar R; Meijer, Richard P; Bosch, J L H Ruud; Bex, Axel; van der Poel, Henk G; Horenblas, Simon (Wiley-Blackwell, 2019-09)
    Objectives: To report the long-term results of the sentinel node (SN) approach in patients with clinical stage I testicular tumours in our facility. Patients and Methods: We conducted an analysis of 27 consecutive patients ...
  • Impact of postoperative complications on outcomes after oesophagectomy for cancer 
    Goense, L; Meziani, J; Ruurda, J P; van Hillegersberg, R (John Wiley & Sons Inc., 2019-01)
    BACKGROUND: To allocate healthcare resources optimally, complication-related quality initiatives should target complications that have the greatest overall impact on outcomes after surgery. The aim of this study was to ...
  • Pulmonary diffusion capacity predicts major complications after esophagectomy for patients with esophageal cancer 
    Goense, L; Meziani, J; Bülbül, M; Braithwaite, S A; van Hillegersberg, R; Ruurda, J P (Wiley-Blackwell, 2019-03)
    A reduced forced expiratory volume in one second (FEV 1) is a well-recognized risk factor for complications after esophagectomy. Lung diffusing capacity for carbon monoxide (DLCO) is not routinely integrated in the risk ...
  • Transcriptional and epigenetic profiling of nutrient-deprived cells to identify novel regulators of autophagy 
    Peeters, J. G.C.; Picavet, L. W.; Coenen, S. G.J.M.; Mauthe, M.; Vervoort, S. J.; Mocholi, E.; de Heus, C.; Klumperman, J.; Vastert, S. J.; Reggiori, F.; Coffer, P. J.; Mokry, M.; van Loosdregt, J. (Landes Bioscience, 2019-01-02)
    Macroautophagy (hereafter autophagy) is a lysosomal degradation pathway critical for maintaining cellular homeostasis and viability, and is predominantly regarded as a rapid and dynamic cytoplasmic process. To increase our ...
  • Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies 
    Stokman, Marijn F.; Bijnsdorp, Irene V.; Schelfhorst, Tim; Pham, Thang V.; Piersma, Sander R.; Knol, Jaco C.; Giles, Rachel H.; Bongers, Ernie M.H.F.; Knoers, Nine V.A.M.; Lilien, Marc R.; Jiménez, Connie R.; Renkema, Kirsten Y. (Elsevier, 2019-02-10)
    Nephronophthisis is one of the leading genetic causes of end-stage renal disease in childhood. Early diagnostics and prognostics for nephronophthisis are currently limited. We aimed to identify non-invasive protein biomarkers ...
  • Adversarial Optimization for Joint Registration and Segmentation in Prostate CT Radiotherapy 
    Elmahdy, Mohamed S.; Wolterink, Jelmer M.; Sokooti, Hessam; Išgum, Ivana; Staring, Marius (Springer, 2019-01-01)
    Joint image registration and segmentation has long been an active area of research in medical imaging. Here, we reformulate this problem in a deep learning setting using adversarial learning. We consider the case in which ...
  • Graph Convolutional Networks for Coronary Artery Segmentation in Cardiac CT Angiography 
    Wolterink, Jelmer M.; Leiner, Tim; Išgum, Ivana (Springer, 2019-01-01)
    Detection of coronary artery stenosis in coronary CT angiography (CCTA) requires highly personalized surface meshes enclosing the coronary lumen. In this work, we propose to use graph convolutional networks (GCNs) to predict ...
  • Muenke syndrome: long-term outcome of a syndrome-specific treatment protocol 
    den Ottelander, Bianca K; de Goederen, Robbin; van Veelen, Marie-Lise C; van de Beeten, Stephanie D C; Lequin, Maarten H; Dremmen, Marjolein H G; Loudon, Sjoukje E; Telleman, Marieke A J; de Gier, Henriëtte H W; Wolvius, Eppo B; Tjoa, Stephen T H; Versnel, Sarah L; Joosten, Koen F M; Mathijssen, Irene M J (American Association of Neurological Surgeons, 2019-10)
    OBJECTIVE The authors evaluated the long-term outcome of their treatment protocol for Muenke syndrome, which includes a single craniofacial procedure. METHODS This was a prospective observational cohort study of Muenke ...
  • MRI-guided definition of cerebrospinal fluid distribution around cranial and sacral nerves: implications for brain tumors and craniospinal irradiation 
    Wood, Amber M; Lequin, Maarten H; Philippens, Marielle M; Seravalli, Enrica; Plasschaert, Sabine L; van den Heuvel-Eibrink, Marry M; Janssens, Geert O (Informa Healthcare, 2019-12-02)
    Background: The SIOPE-Brain Tumor Group recently published a guideline on craniospinal target volume delineation for highly conformal radiotherapy. In order to spare critical structures like e.g., the lens or cochlea, ...
  • New Techniques for Optimization of Donor Lungs/Hearts 
    Braithwaite, Sue A; van der Kaaij, Niels P (W.B. Saunders, 2019-12)
    Injuries sustained by donor heart and lung allografts during the transplantation process are multiple and cumulative. Optimization of allograft function plays an essential role in short- and long-term outcomes after ...
  • Prevention of Cardiac Surgery-Associated Acute Kidney Injury: A Review of Current Strategies 
    Jacob, Kirolos A; Leaf, David E (W.B. Saunders, 2019-12)
    Acute kidney injury is a common and often severe postoperative complication after cardiac surgery, and is associated with poor short-term and long-term outcomes. Numerous randomized controlled trials have been conducted ...
  • Identification of thoracic injuries by emergency medical services providers among trauma patients 
    van Rein, Eveline A J; Lokerman, Robin D; van der Sluijs, Rogier; Hjortnaes, Jesper; Lichtveld, Rob A; Leenen, Luke P H; van Heijl, Mark (Elsevier Limited, 2019-05)
    INTRODUCTION: Severe thoracic injuries are time sensitive and adequate triage to a facility with a high-level of trauma care is crucial. The emergency medical services (EMS) providers are required to identify patients with ...
  • Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis 
    Zheng, Kang H; Tsimikas, Sotirios; Pawade, Tania; Kroon, Jeffrey; Jenkins, William S A; Doris, Mhairi K; White, Audrey C; Timmers, Nyanza K L M; Hjortnaes, Jesper; Rogers, Maximillian A; Aikawa, Elena; Arsenault, Benoit J; Witztum, Joseph L; Newby, David E; Koschinsky, Marlys L; Fayad, Zahi A; Stroes, Erik S G; Boekholdt, S Matthijs; Dweck, Marc R (Elsevier, 2019-05-07)
    BACKGROUND: Lipoprotein(a) [Lp(a)], a major carrier of oxidized phospholipids (OxPL), is associated with an increased incidence of aortic stenosis (AS). However, it remains unclear whether elevated Lp(a) and OxPL drive ...
  • Correlation between ultrasonic and radiographic imaging of developmental dysplasia of the hip 
    Spaans, A. J.; Beek, F. J.A.; Uiterwaal, C. S.P.M.; Pruijs, J. E.H.; Sakkers, R. J. (Springer-Verlag, 2019-04-01)
    Purpose: The correlation between the degree of developmental hip dysplasia (DDH) measured on ultrasound images compared with that measured on radiographs is not clear. Most studies have compared ultrasonography (US) and ...
  • In Reply to David and Kamrava 
    Juliet van Son, Marieke; Peters, Max; Moerland, Marinus A.; van der Voort van Zyp, Jochem R.N. (Elsevier, 2019-08-01)
  • The association between frailty and MRI features of cerebral small vessel disease 
    BioCog consortium (Nature Publishing Group, 2019-08-05)
    Frailty is a common syndrome in older individuals that is associated with poor cognitive outcome. The underlying brain correlates of frailty are unclear. The aim of this study was to investigate the association between ...
  • Overall and disease-specific survival of Hodgkin lymphoma survivors who subsequently developed gastrointestinal cancer 
    Rigter, Lisanne S.; Schaapveld, Michael; Janus, Cecile P.M.; Krol, Augustinus D.G.; van der Maazen, Richard W.M.; Roesink, Judith; Zijlstra, Josee M.; van Imhoff, Gustaaf W.; Poortmans, Philip M.P.; Beijert, Max; Lugtenburg, Pieternella J.; Visser, Otto; Snaebjornsson, Petur; van Eggermond, Anna M.; Aleman, Berthe M.P.; van Leeuwen, Flora E.; van Leerdam, Monique E. (John Wiley & Sons Inc., 2019-01-01)
    BACKGROUND: Hodgkin lymphoma (HL) survivors have an increased risk of gastrointestinal (GI) cancer. This study aims to evaluate whether survival of patients who survived HL and developed GI cancer differs from survival of ...