Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

  • Does Older Age Lead to Higher Risk for Neutropenia in Patients Treated with Paclitaxel? 
    Crombag, Marie-Rose B S; Koolen, Stijn L W; Wijngaard, Sophie; Joerger, Markus; Dorlo, Thomas P C; van Erp, Nielka P; Mathijssen, Ron H J; Beijnen, Jos H; Huitema, Alwin D R (Springer New York, 2019-10-15)
    PURPOSE: There is ongoing concern regarding increased toxicity from paclitaxel in elderly patients, particularly of severe neutropenia. Yet, data so far is controversial and this concern is not supported by a clinically ...
  • 5-Fluorouracil treatment induces characteristic T>G mutations in human cancer 
    Christensen, Sharon; Van der Roest, Bastiaan; Besselink, Nicolle; Janssen, Roel; Boymans, Sander; Martens, John W M; Yaspo, Marie-Laure; Priestley, Peter; Kuijk, Ewart; Cuppen, Edwin; Van Hoeck, Arne (Nature Publishing Group, 2019-10-08)
    5-Fluorouracil (5-FU) is a chemotherapeutic drug commonly used for the treatment of solid cancers. It is proposed that 5-FU interferes with nucleotide synthesis and incorporates into DNA, which may have a mutational impact ...
  • Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients 
    Ooft, Salo N; Weeber, Fleur; Dijkstra, Krijn K; McLean, Chelsea M; Kaing, Sovann; van Werkhoven, Erik; Schipper, Luuk; Hoes, Louisa; Vis, Daniel J; van de Haar, Joris; Prevoo, Warner; Snaebjornsson, Petur; van der Velden, Daphne; Klein, Michelle; Chalabi, Myriam; Boot, Henk; van Leerdam, Monique; Bloemendal, Haiko J; Beerepoot, Laurens V; Wessels, Lodewyk; Cuppen, Edwin; Clevers, Hans; Voest, Emile E (American Association for the Advancement of Science, 2019-10-09)
    There is a clear and unmet clinical need for biomarkers to predict responsiveness to chemotherapy for cancer. We developed an in vitro test based on patient-derived tumor organoids (PDOs) from metastatic lesions to identify ...
  • The molecular genetic make-up of male breast cancer 
    Moelans, Cathy B.; de Ligt, Joep; van der Groep, Petra; Prins, Pjotr; Besselink, Nicolle J. M.; Hoogstraat, Marlous; ter Hoeve, Natalie D.; Lacle, Miangela M.; Kornegoor, Robert; van der Pol, Carmen C.; de Leng, Wendy W. J.; Barbe, Ellis; van der Vegt, Bert; Martens, John; Bult, Peter; Smit, Vincent T. H. B. M.; Koudijs, Marco J.; Nijman, Isaac J.; Voest, Emile E.; Selenica, Pier; Weigelt, Britta; Reis-Filho, Jorge S.; van der Wall, Elsken; Cuppen, Edwin; van Diest, Paul J. (BioScientifica Ltd., 2019-10)
    Male breast cancer (MBC) is extremely rare and accounts for less than 1% of all breast malignancies. Therefore, clinical management of MBC is currently guided by research on the disease in females. In this study, DNA ...
  • Identification and Characterization of a Transcribed Distal Enhancer Involved in Cardiac Kcnh2 Regulation 
    van den Boogaard, Malou; van Weerd, Jan Hendrik; Bawazeer, Amira C; Hooijkaas, Ingeborg B; van de Werken, Harmen J G; Tessadori, Federico; de Laat, Wouter; Barnett, Phil; Bakkers, Jeroen; Christoffels, Vincent M (Cell Press, 2019-09-03)
    The human ether-a-go-go-related gene KCNH2 encodes the voltage-gated potassium channel underlying IKr, a current critical for the repolarization phase of the cardiac action potential. Mutations in KCNH2 that cause a reduction ...
  • De Novo Heterozygous POLR2A Variants Cause a Neurodevelopmental Syndrome with Profound Infantile-Onset Hypotonia 
    Haijes, Hanneke A.; Koster, Maria J.E.; Rehmann, Holger; Li, Dong; Hakonarson, H.; Cappuccio, Gerarda; Hancarova, Miroslava; Lehalle, Daphne; Reardon, Willie; Schaefer, G. Bradley; Lehman, Anna; van de Laar, Ingrid M.B.H.; Tesselaar, Coranne D.; Turner, Clesson; Goldenberg, A.; Patrier, Sophie; Thevenon, Julien; Pinelli, Michele; Brunetti-Pierri, Nicola; Prchalová, Darina; Havlovicová, Markéta; Vlckova, Markéta; Sedláček, Zdeněk; Lopez, E.; Ragoussis, Vassilis; Pagnamenta, Alistair T.; Kini, Usha; Vos, Harmjan R.; van Es, Robert M.; van Schaik, Richard F.M.A.; van Essen, Ton A.J.; Kibaek, M.; Taylor, Jenny C.; Sullivan, Jennifer; Shashi, Vandana; Petrovski, S.; Fagerberg, Christina; Martin, Donna M.; van Gassen, Koen L.I.; Pfundt, R.; Falk, Marni J.; McCormick, Elizabeth M.; Timmers, H. T.Marc; van Hasselt, Peter M. (Cell Press, 2019-08-01)
    The RNA polymerase II complex (pol II) is responsible for transcription of all ∼21,000 human protein-encoding genes. Here, we describe sixteen individuals harboring de novo heterozygous variants in POLR2A, encoding RPB1, ...
  • MDH1 deficiency is a metabolic disorder of the malate–aspartate shuttle associated with early onset severe encephalopathy 
    Broeks, Melissa H.; Shamseldin, Hanan E.; Alhashem, Amal; Hashem, Mais; Abdulwahab, Firdous; Alshedi, Tarfa; Alobaid, Iman; Zwartkruis, Fried; Westland, Denise; Fuchs, Sabine; Verhoeven-Duif, Nanda M.; Jans, Judith J.M.; Alkuraya, Fowzan S. (Springer-Verlag, 2019-12)
    The reversible oxidation of l-malate to oxaloacetate is catalyzed by NAD(H)-dependent malate dehydrogenase (MDH). MDH plays essential roles in the malate–aspartate shuttle and the tricarboxylic acid cycle. These metabolic ...
  • Critical design considerations for time-to-event endpoints in amyotrophic lateral sclerosis clinical trials 
    van Eijk, Ruben P A; Nikolakopoulos, Stavros; Roes, Kit C B; Middelkoop, Bas M; Ferguson, Toby A; Shaw, Pamela J; Leigh, P Nigel; Al-Chalabi, Ammar; Eijkemans, Marinus J C; van den Berg, Leonard H (BMJ Publishing Group, 2019-12)
    Background: Funding and resources for low prevalent neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) are limited, and optimising their use is vital for efficient drug development. In this study, we ...
  • Natural helix 9 mutants of PPARγ differently affect its transcriptional activity 
    Broekema, Marjoleine F.; Massink, Maarten P.G.; Donato, Cinzia; de Ligt, Joep; Schaarschmidt, Joerg; Borgman, Anouska; Schooneman, Marieke G.; Melchers, Diana; Gerding, Martin N.; Houtman, René; Bonvin, Alexandre M.J.J.; Majithia, Amit R.; Monajemi, Houshang; van Haaften, Gijs W.; Soeters, Maarten R.; Kalkhoven, Eric (Elsevier, 2019-02-01)
    Objective: The nuclear receptor PPARγ is the master regulator of adipocyte differentiation, distribution, and function. In addition, PPARγ induces terminal differentiation of several epithelial cell lineages, including ...
  • Gene-gene and gene-environment interactions in lipodystrophy: Lessons learned from natural PPARγ mutants 
    Broekema, M. F.; Savage, D. B.; Monajemi, H.; Kalkhoven, E. (Elsevier, 2019-05-01)
    Monogenic lipodystrophies are a heterogeneous group of rare disorders characterized by a lack of adipose tissue (AT), all of which predispose patients to the development of insulin resistance and its related metabolic ...
  • A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues 
    Klotz, Barbara J; Oosterhoff, Loes A; Utomo, Lizette; Lim, Khoon S; Vallmajo-Martin, Queralt; Clevers, Hans; Woodfield, Tim B F; Rosenberg, Antoine J W P; Malda, Jos; Ehrbar, Martin; Spee, Bart; Gawlitta, Debby (John Wiley & Sons Inc., 2019-10)
    For creating functional tissue analogues in tissue engineering, stem cells require very specific 3D microenvironments to thrive and mature. Demanding (stem) cell types that are used nowadays can find such an environment ...
  • DGAT2 partially compensates for lipid-induced ER stress in human DGAT1-deficient intestinal stem cells[S] 
    van Rijn, Jorik M; van Hoesel, Marliek; de Heus, Cecilia; van Vugt, Anke H M; Klumperman, Judith; Nieuwenhuis, Edward; Houwen, Roderick H J; Middendorp, Sabine (American Society for Biochemistry and Molecular Biology Inc., 2019-10)
    Dietary lipids are taken up as FAs by the intestinal epithelium and converted by diacylglycerol acyltransferase (DGAT) enzymes into triglycerides, which are packaged in chylomicrons or stored in cytoplasmic lipid droplets ...
  • SNR optimized P-31 functional MRS to detect mitochondrial and extracellular pH change during visual stimulation 
    Hendriks, Arjan D; van der Kemp, Wybe J M; Luijten, Peter R; Petridou, Natalia; Klomp, Dennis W J (John Wiley & Sons Inc., 2019-11)
    Summary: Energy metabolism of the human visual cortex was investigated by performing 31P functional MRS. Introduction: The human brain is known to be the main glucose demanding organ of the human body and neuronal activity ...
  • The era of alternative designs to connect randomized clinical trials and real-world data 
    Derksen, Jeroen W G; May, Anne M; Koopman, Miriam (Nature Publishing Group, 2019-09)
  • Esophageal Resection, Gastric Tube Reconstruction, and Omental Flap Coverage of Iatrogenic Aortoesophageal Fistula After Secondary Thoracic Stentgraft Infection: A Case Report 
    Slieker, Fons J B; Ruurda, Jelle P; Hazenberg, Constantijn E V B (Elsevier, 2019-08)
    Secondary stent graft infection is a life-threatening complication after thoracic endovascular aortic repair (TEVAR). There is no consensus on optimal treatment strategy, but combined antibiotic and surgical treatment is ...
  • Prognostic Value of Brain Metastasis Free Interval in Patients with Breast Cancer Brain Metastases 
    Hulsbergen, Alexander F C; Lamba, Nayan; Claes, An; Kavouridis, Vasileios; Lin, Nancy U; Smith, Timothy R; Verhoeff, Joost J C; Broekman, Marike L D (Elsevier, 2019-08)
    Background: In patients with breast cancer brain metastases (BCBM), time between primary tumor diagnosis and appearance of brain metastases varies widely. Despite being a readily available clinical parameter, it remains ...
  • Added value of intra-operative ultrasound to determine the resectability of locally advanced pancreatic cancer following FOLFIRINOX chemotherapy (IMAGE): a prospective multicenter study 
    Dutch Pancreatic Cancer Group (John Wiley & Sons Inc., 2019-10)
    BACKGROUND: Determining the resectability of locally advanced pancreatic cancer (LAPC) after FOLFIRINOX chemotherapy is challenging because CT-scans cannot reliably assess vascular involvement. This study evaluates the ...
  • Imaging strategies in the management of gastric cancer: current role and future potential of MRI 
    Borggreve, Alicia S; Goense, Lucas; Brenkman, Hylke J F; Mook, Stella; Meijer, Gert J; Wessels, Frank J; Verheij, Marcel; Jansen, Edwin P M; van Hillegersberg, Richard; van Rossum, Peter S N; Ruurda, Jelle P (Oxford University Press, 2019-05)
    Accurate preoperative staging of gastric cancer and the assessment of tumor response to neoadjuvant treatment is of importance for treatment and prognosis. Current imaging techniques, mainly endoscopic ultrasonography ...
  • The EBMT activity survey report 2017: a focus on allogeneic HCT for nonmalignant indications and on the use of non-HCT cell therapies 
    European Society for Blood and Marrow Transplantation (EBMT) (Springer Nature, 2019-10)
    Hematopoietic cell transplantation (HCT) is widely used for acquired and congenital disorders of the hematopoietic system. Number of transplants done in Europe and associated countries continues to rise with 45,418 HCT in ...
  • Validation of a novel stand-alone software tool for image guided cardiac catheter therapy 
    van Es, René; van den Broek, Hans T; van der Naald, Mira; de Jong, Leon; Nieuwenhuis, Eliane R; Kraaijeveld, Adriaan O; Doevendans, Pieter A; Chamuleau, Steven A J; van Slochteren, Frebus J (Springer Netherlands, 2019-02)
    Comparison of the targeting accuracy of a new software method for MRI-fluoroscopy guided endomyocardial interventions with a clinically available 3D endocardial electromechanical mapping system. The new CARTBox2 software ...