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UMC Repository: Recent submissions

  • Geometry and Symmetry of Willis’ Circle and Middle Cerebral Artery Aneurysms Development 
    Sturiale, Carmelo Lucio; Scerrati, Alba; Ricciardi, Luca; Rustemi, Oriela; Auricchio, Anna Maria; Norri, Nicolò; Piazza, Amedeo; Raneri, Fabio; Benato, Alberto; Albanese, Alessio; Mangiola, Annunziato; Zotta, Donato Carlo; D’Andrea, Giancarlo; Picotti, Veronica; Raco, Antonino; Volpin, Lorenzo; Trevisi, Gianluca (Multidisciplinary Digital Publishing Institute (MDPI), 2024-05)
    Background: A relationship between the geometry and symmetry of Willis’ circle and intracranial aneurysms was reported for anterior communicating and posterior communicating (PCom) aneurysms. A similar association with the ...
  • Characteristics and immediate outcomes of patients who underwent percutaneous balloon mitral valvuloplasty at the Jakaya Kikwete Cardiac Institute, Tanzania 
    Mutagaywa, Reuben K.; Cramer, Maarten J.; Chillo, Pilly; Barongo, Aileen; Kifai, Engerasiya; Chamuleau, Steven; Eze-Nliam, Chete; Vera, Nelson B.; Nkya, Deogratias; Loth, Alex; Alencherry, Ben; Mongella, Stella; Mayala, Henry; Kisenge, Peter; Mwinchete, Salehe; Joseph, Alex B.; Kwesigabo, Gideon; Kamuhabwa, Appolinary; Albaghdadi, Mazen; Ghobrial, Joanna; Janabi, Mohamed (Clinics Cardive Publishing (PTY)Ltd, 2024-04)
    Background: For rheumatic mitral stenosis (MS), a multidisciplinary evaluation is mandatory to determine the optimal treatment: medical, percutaneous balloon mitral valvuloplasty (PBMV) or valve surgery. Clinical and imaging ...
  • Electronic Nicotine-Delivery Systems for Smoking Cessation. 
    Borm, Frank J.; Cohen, Sophie; Cohen, Danielle (Massachussetts Medical Society, 2024-05-16)
  • From long-term follow-up Recommendations for clinical practice to plain language summaries for childhood, adolescent, and young adult cancer survivors 
    van den Oever, Selina R.; Fuchs, Tessa; Levitt, Gill A.; Haupt, Riccardo; Mulder, Renée L.; Amariutei, Ana; Bardi, Edit; Becker, Tom; Brown, Morven; Gsell, Hannah; Hartogh, Jaap den; Essiaf, Samira; Muraca, Monica; Potter, Emma; Schneider, Carina; Sugden, Elaine; Tomášiková, Zuzana; Vermeulen, Herma; Kremer, Leontien C.M.; Skinner, Roderick; van der Pal, Helena J.H. (Elsevier, 2024-06)
    Background: Having sufficient knowledge of cancer diagnosis, treatment and late effects in survivors of childhood, adolescent, and young adult (CAYA) cancer is important for effective self-management and optimising health ...
  • Expertise in surgical neuro-oncology. Results of a survey by the EANS neuro-oncology section 
    Gousias, K.; Hoyer, A.; Mazurczyk, L. A.; Bartek, J.; Bruneau, M.; Celtikci, E.; Foroglou, N.; Freyschlag, C.; Grossman, R.; Jungk, C.; Metellus, P.; Netuka, D.; Rola, R.; Schucht, P.; Senft, C.; Signorelli, F.; Vincent, A. J.P.E.; Simon, M.; Robe, Pierre A.; for the EANS Surgical Neuro-oncology Expertise Survey working group (Elsevier, 2024)
    Introduction: Technical advances and the increasing role of interdisciplinary decision-making may warrant formal definitions of expertise in surgical neuro-oncology. Research question: The EANS Neuro-oncology Section felt ...
  • Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes 
    Pekayvaz, Kami; Losert, Corinna; Knottenberg, Viktoria; Gold, Christoph; van Blokland, Irene V.; Oelen, Roy; Groot, Hilde E.; Benjamins, Jan Walter; Brambs, Sophia; Kaiser, Rainer; Gottschlich, Adrian; Hoffmann, Gordon Victor; Eivers, Luke; Martinez-Navarro, Alejandro; Bruns, Nils; Stiller, Susanne; Akgöl, Sezer; Yue, Keyang; Polewka, Vivien; Escaig, Raphael; Joppich, Markus; Janjic, Aleksandar; Popp, Oliver; Kobold, Sebastian; Petzold, Tobias; Zimmer, Ralf; Enard, Wolfgang; Saar, Kathrin; Mertins, Philipp; Huebner, Norbert; van der Harst, Pim; Franke, Lude H.; van der Wijst, Monique G.P.; Massberg, Steffen; Heinig, Matthias; Nicolai, Leo; Stark, Konstantin (2024-06)
    Acute and chronic coronary syndromes (ACS and CCS) are leading causes of mortality. Inflammation is considered a key pathogenic driver of these diseases, but the underlying immune states and their clinical implications ...
  • New Insights in ATP Synthesis as Therapeutic Target in Cancer and Angiogenic Ocular Diseases 
    van Noorden, Cornelis J.F.; Yetkin-Arik, Bahar; Serrano Martinez, Paola; Bakker, Noëlle; van Breest Smallenburg, Mathilda E.; Schlingemann, Reinier O.; Klaassen, Ingeborg; Majc, Bernarda; Habic, Anamarija; Bogataj, Urban; Galun, S. Katrin; Vittori, Milos; Erdani Kreft, Mateja; Novak, Metka; Breznik, Barbara; Hira, Vashendriya V.V. (Histochemical Society Inc., 2024-05)
    Lactate and ATP formation by aerobic glycolysis, the Warburg effect, is considered a hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) also produce lactate and ATP ...
  • First-time surgical aortic valve replacement: Nationwide trends and outcomes from the Netherlands Heart Registration 
    Daeter, Edgar J.; De Beaufort, Hector W.L.; Roefs, Maaike M.; Van Boven, Wim Jan P.; Van Veghel, Dennis; Van Der Kaaij, Niels P.; Cardiothoracic Surgery Registration Committee of the Netherlands Heart Registration (Elsevier, 2024-05)
    OBJECTIVES: The aim of this study was to describe trends and outcomes for patients undergoing surgical aortic valve replacement (SAVR) in the Netherlands. METHODS: The Netherlands Heart Registration database was used to ...
  • Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits 
    van der Harst, Pim; Million Veteran Program; LifeLines Cohort Study; CHARGE Consortium; ICBP Consortium (2024-05-01)
    Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10-8) from the largest single-stage blood pressure (BP) genome-wide ...
  • Prognostic impact and causality of age on oncological outcomes in women with endometrial cancer: a multimethod analysis of the randomised PORTEC-1, PORTEC-2, and PORTEC-3 trials 
    Wakkerman, Famke C.; Wu, Jiqing; Putter, Hein; Jürgenliemk-Schulz, Ina M.; Jobsen, Jan J.; Lutgens, Ludy C.H.W.; Haverkort, Marie A.D.; de Jong, Marianne A.; Mens, Jan Willem M.; Wortman, Bastiaan G.; Nout, Remi A.; Léon-Castillo, Alicia; Powell, Melanie E.; Mileshkin, Linda R.; Katsaros, Dionyssios; Alfieri, Joanne; Leary, Alexandra; Singh, Naveena; de Boer, Stephanie M.; Nijman, Hans W.; Smit, Vincent T.H.B.M.; Bosse, Tjalling; Koelzer, Viktor H.; Creutzberg, Carien L.; Horeweg, Nanda (Lancet Publishing Group, 2024-06)
    Background: Numerous studies have shown that older women with endometrial cancer have a higher risk of recurrence and cancer-related death. However, it remains unclear whether older age is a causal prognostic factor, or ...
  • Diagnostic yield of molecular diagnostics for the atypical pathogens: diagnostic stewardship is warranted 
    Rigter, Marloes; van Roeden, Sonja E.; Barth, Roos; Wegdam-Blans, Marjolijn (Elsevier Limited, 2024-09)
  • Parallel use of low-complexity automated nucleic acid amplification tests and lateral flow urine lipoarabinomannan assays to detect tuberculosis disease in adults and adolescents living with HIV 
    Bjerrum, Stephanie; Yang, Bada; Åhsberg, Johanna; Nathavitharana, Ruvandhi R.; Olbrich, Laura; Jaganath, Devan; Kay, Alexander W.; Lundh, Andreas; Shah, Maunank (John Wiley & Sons Inc., 2024-05-13)
    Objectives: This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows:. To compare the diagnostic accuracy of parallel use of lateral flow urine lipoarabinomannan on urine and low-complexity ...
  • Value of Real-World Evidence for Treatment Selection: A Case Study in Colon Cancer 
    Shen, Lingjie; van Gestel, Anja; Prinsen, Peter; Vink, Geraldine; van Erning, Felice N.; Geleijnse, Gijs; Kaptein, Maurits (American Society of Clinical Oncology, 2024-05-15)
    PURPOSE Real-world evidence (RWE)—derived from analysis of real-world data (RWD)—has the potential to guide personalized treatment decisions. However, because of potential confounding, generating valid RWE is challenging. ...
  • Parallel use of low-complexity automated nucleic acid amplification tests on respiratory samples and stool with or without lateral flow lipoarabinomannan assays to detect pulmonary tuberculosis disease in children 
    Olbrich, Laura; Kay, Alexander W.; Bjerrum, Stephanie; Yang, Bada; Åhsberg, Johanna; Nathavitharana, Ruvandhi R.; Lundh, Andreas; Shah, Maunank; Jaganath, Devan (John Wiley & Sons Inc., 2024-05-13)
    Objectives: This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows:. To compare the diagnostic accuracy of the parallel use of low-complexity automated nucleic acid amplification tests on ...
  • FUME-TCRseq Enables Sensitive and Accurate Sequencing of the T-cell Receptor from Limited Input of Degraded RNA 
    Baker, Ann Marie; Nageswaran, Gayathri; Nenclares, Pablo; Ronel, Tahel; Smith, Kane; Kimberley, Christopher; Laclè, Miangela M.; Bhide, Shreerang; Harrington, Kevin J.; Melcher, Alan; Rodriguez-Justo, Manuel; Chain, Benny; Graham, Trevor A. (American Association for Cancer Research Inc., 2024-05-15)
    Genomic analysis of the T-cell receptor (TCR) reveals the strength, breadth, and clonal dynamics of the adaptive immune response to pathogens or cancer. The diversity of the TCR repertoire, however, means that sequencing ...
  • The Impact of Next-generation Sequencing on Interobserver Agreement and Diagnostic Accuracy of Desmoplastic Melanocytic Neoplasms 
    Chen, Alice; Sharma, Natasha; Patel, Pragi; Olivares, Shantel; Bahrami, Armita; Barnhill, Raymond L.; Blokx, Willeke A.M.; Bosenberg, Marcus; Busam, Klaus J.; De La Fouchardière, Arnaud; Duncan, Lyn M.; Elder, David E.; Ko, Jennifer S.; Landman, Gilles; Lazar, Alexander J.; Lezcano, Cecilia; Lowe, Lori; Maher, Nigel; Massi, Daniela; Messina, Jane; Mihic-Probst, Daniela; Parker, Douglas C.; Redpath, Margaret; Scolyer, Richard A.; Shea, Christopher R.; Spatz, Alan; Tron, Victor; Xu, Xiaowei; Yeh, Iwei; Jung Yun, Sook; Zembowicz, Artur; Gerami, Pedram (Lippincott Williams & Wilkins, 2024-06)
    Next-generation sequencing (NGS) is increasingly being utilized as an ancillary tool for diagnostically challenging melanocytic neoplasms. It is incumbent upon the pathology community to perform studies assessing the ...
  • Longitudinal follow-up of taste function and trigeminal perception in COVID-19 patients with olfactory dysfunction – The COVORTS study 
    Boesveldt, Sanne; Postma, Elbrich M.; Boek, Wilbert; Kamalski, Digna M.A.; van Dijk, Birgit (Elsevier, 2024-06)
    Background & Aims: Chemosensory dysfunction is one of the hallmarks of a COVID-19 infection. While most patients recover within a few weeks after infection, in 5–10% of the patients chemosensory dysfunction turns into a ...
  • Development and therapeutic evaluation of 5D3(CC-MLN8237)3.2 antibody-theranostic conjugates for PSMA-positive prostate cancer therapy 
    Liatsou, Ioanna; Assefa, Betelhem; Liyanage, Wathsala; Surasinghe, Sharmane; Nováková, Zora; Bařinka, Cyril; Gabrielson, Kathleen; Raman, Venu; Artemov, Dmitri; Hapuarachchige, Sudath (Frontiers Media S. A., 2024-05)
    Prostate cancer (PC) is an aggressive cancer that can progress rapidly and eventually become castrate-resistant prostate cancer (CRPC). Stage IV metastatic castrate-resistant prostate cancer (mCRPC) is an incurable late-stage ...
  • CNTN4 modulates neural elongation through interplay with APP 
    Bamford, Rosemary A.; Zuko, Amila; Eve, Madeline; Sprengers, Jan J.; Post, Harm; Taggenbrock, Renske L.R.E.; Fäβler, Dominique; Mehr, Annika; Jones, Owen J.R.; Kudzinskas, Aurimas; Gandawijaya, Josan; Müller, Ulrike C.; Kas, Martien J.H.; Burbach, J. Peter H.; Oguro-Ando, Asami (Royal Society Publishing, 2024-05-15)
    The neuronal cell adhesion molecule contactin-4 (CNTN4) is genetically associated with autism spectrum disorder (ASD) and other psychiatric disorders. Cntn4-deficient mouse models have previously shown that CNTN4 plays ...
  • Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 
    Kayode, Gbenga A.; GBD 2021 Risk Factors Collaborators (Elsevier Limited, 2024-05-18)
    Background: Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to ...